{"id":"https://openalex.org/W4411802486","doi":"https://doi.org/10.1159/000546772","title":"Metabolomic Profiling Identifies Early Biomarkers of Frailty, Balance Impairment, and Fall Risks in Older Adults","display_name":"Metabolomic Profiling Identifies Early Biomarkers of Frailty, Balance Impairment, and Fall Risks in Older Adults","publication_year":2025,"publication_date":"2025-06-30","ids":{"openalex":"https://openalex.org/W4411802486","doi":"https://doi.org/10.1159/000546772","pmid":"https://pubmed.ncbi.nlm.nih.gov/40587952"},"language":"en","primary_location":{"id":"doi:10.1159/000546772","doi":"https://doi.org/10.1159/000546772","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000546772","pdf_url":null,"source":{"id":"https://openalex.org/S190989491","display_name":"Gerontology","issn_l":"0304-324X","issn":["0304-324X","1423-0003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gerontology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5118707773","display_name":"Alina Zhawatibai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]},{"id":"https://openalex.org/I4210093739","display_name":"First Affiliated Hospital of Jiangxi Medical College","ror":"https://ror.org/00g3pqv36","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093739"]},{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Alina Zhawatibai","raw_affiliation_strings":["Department of Geriatrics, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I141649914","https://openalex.org/I4210093739","https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080834877","display_name":"Huanbing Liu","orcid":"https://orcid.org/0009-0005-2511-0681","observed_orcids":["https://orcid.org/0009-0005-2511-0681"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]},{"id":"https://openalex.org/I4210093739","display_name":"First Affiliated Hospital of Jiangxi Medical College","ror":"https://ror.org/00g3pqv36","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093739"]},{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huanbing Liu","raw_affiliation_strings":["Department of Geriatrics, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I141649914","https://openalex.org/I4210093739","https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101401502","display_name":"An Xie","orcid":"https://orcid.org/0000-0002-7113-5039","observed_orcids":["https://orcid.org/0000-0002-7113-5039"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]},{"id":"https://openalex.org/I4210093739","display_name":"First Affiliated Hospital of Jiangxi Medical College","ror":"https://ror.org/00g3pqv36","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093739"]},{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"An Xie","raw_affiliation_strings":["Department of Rehabilitation Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I141649914","https://openalex.org/I4210093739","https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086014881","display_name":"He Zhou","orcid":"https://orcid.org/0000-0003-4278-2891","observed_orcids":["https://orcid.org/0000-0003-4278-2891"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"He Zhou","raw_affiliation_strings":["Shenzhen Mass Medical Co. Ltd., Shenzhen, China, mxzhouhe@hotmail.com"],"raw_orcid":"https://orcid.org/0000-0003-4278-2891","affiliations":[{"raw_affiliation_string":"Shenzhen Mass Medical Co. Ltd., Shenzhen, China, mxzhouhe@hotmail.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073305217","display_name":"Jingwei Jiang","orcid":"https://orcid.org/0000-0002-9163-3633","observed_orcids":["https://orcid.org/0000-0002-9163-3633","https://orcid.org/0009-0006-0846-1903"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]},{"id":"https://openalex.org/I4210093739","display_name":"First Affiliated Hospital of Jiangxi Medical College","ror":"https://ror.org/00g3pqv36","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093739"]},{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingwei Jiang","raw_affiliation_strings":["Department of Geriatrics, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I141649914","https://openalex.org/I4210093739","https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Na Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]},{"id":"https://openalex.org/I4210093739","display_name":"First Affiliated Hospital of Jiangxi Medical College","ror":"https://ror.org/00g3pqv36","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093739"]},{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Yuan","raw_affiliation_strings":["Department of Geriatrics, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I141649914","https://openalex.org/I4210093739","https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jun Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]},{"id":"https://openalex.org/I4210093739","display_name":"First Affiliated Hospital of Jiangxi Medical College","ror":"https://ror.org/00g3pqv36","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093739"]},{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Wang","raw_affiliation_strings":["Department of Geriatrics, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I141649914","https://openalex.org/I4210093739","https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118707774","display_name":"Chuancai Dan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]},{"id":"https://openalex.org/I4210093739","display_name":"First Affiliated Hospital of Jiangxi Medical College","ror":"https://ror.org/00g3pqv36","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093739"]},{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuancai Dan","raw_affiliation_strings":["Department of Geriatrics, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I141649914","https://openalex.org/I4210093739","https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041639230","display_name":"Sujun Li","orcid":"https://orcid.org/0000-0001-5233-2005","observed_orcids":["https://orcid.org/0000-0001-5233-2005"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]},{"id":"https://openalex.org/I4210093739","display_name":"First Affiliated Hospital of Jiangxi Medical College","ror":"https://ror.org/00g3pqv36","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093739"]},{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sujun Li","raw_affiliation_strings":["JiangXi Key Laboratory of Transfusion Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JiangXi Key Laboratory of Transfusion Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I141649914","https://openalex.org/I4210093739","https://openalex.org/I4210164024"]}]},{"author_position":"last","author":{"id":null,"display_name":"Shu Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]},{"id":"https://openalex.org/I4210093739","display_name":"First Affiliated Hospital of Jiangxi Medical College","ror":"https://ror.org/00g3pqv36","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093739"]},{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu Wang","raw_affiliation_strings":["Department of Geriatrics, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I141649914","https://openalex.org/I4210093739","https://openalex.org/I4210164024"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1285,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.86534161,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"71","issue":"9","first_page":"705","last_page":"722"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.06319999694824219,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10114","display_name":"Balance, Gait, and Falls Prevention","score":0.04600000008940697,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/frailty","display_name":"frailty","score":0.9860000014305115},{"id":"https://openalex.org/keywords/balance-disorders","display_name":"balance disorders","score":0.9710000157356262},{"id":"https://openalex.org/keywords/fall-risk","display_name":"fall risk","score":0.9879999756813049},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.9909999966621399},{"id":"https://openalex.org/keywords/early-biomarkers","display_name":"early biomarkers","score":0.7820000052452087},{"id":"https://openalex.org/keywords/plasma-metabolomics","display_name":"plasma metabolomics","score":0.7919999957084656},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.6850000023841858},{"id":"https://openalex.org/keywords/sphingolipid-signaling","display_name":"sphingolipid signaling","score":0.9940000176429749},{"id":"https://openalex.org/keywords/fatty-acid-metabolism","display_name":"fatty acid metabolism","score":1.0},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6600000262260437},{"id":"https://openalex.org/keywords/fall-prevention","display_name":"fall prevention","score":0.7570000290870667},{"id":"https://openalex.org/keywords/age-classification","display_name":"age classification","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.8365275859832764},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.7587599754333496},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6234424710273743},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.5004444122314453},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.41163185238838196},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.354595422744751},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2885861396789551}],"mesh":[{"descriptor_ui":"D000058","descriptor_name":"Accidental Falls","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000058","descriptor_name":"Accidental Falls","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000058","descriptor_name":"Accidental Falls","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000058","descriptor_name":"Accidental Falls","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D000058","descriptor_name":"Accidental Falls","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D000058","descriptor_name":"Accidental Falls","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000203","descriptor_name":"Activities of Daily Living","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000203","descriptor_name":"Activities of Daily Living","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000203","descriptor_name":"Activities of Daily Living","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004856","descriptor_name":"Postural Balance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004856","descriptor_name":"Postural Balance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004856","descriptor_name":"Postural Balance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015577","descriptor_name":"Geriatric Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015577","descriptor_name":"Geriatric Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015577","descriptor_name":"Geriatric Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016330","descriptor_name":"Frail Elderly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016330","descriptor_name":"Frail Elderly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016330","descriptor_name":"Frail Elderly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000546772","doi":"https://doi.org/10.1159/000546772","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000546772","pdf_url":null,"source":{"id":"https://openalex.org/S190989491","display_name":"Gerontology","issn_l":"0304-324X","issn":["0304-324X","1423-0003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gerontology","raw_type":"journal-article"},{"id":"pmid:40587952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40587952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gerontology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"No poverty","id":"https://metadata.un.org/sdg/1","score":0.6299999952316284}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1985126910","https://openalex.org/W2013130211","https://openalex.org/W2034656062","https://openalex.org/W2092996996","https://openalex.org/W2101115134","https://openalex.org/W2343977419","https://openalex.org/W2395679517","https://openalex.org/W2403304796","https://openalex.org/W2604674779","https://openalex.org/W2794219322","https://openalex.org/W2801442578","https://openalex.org/W2809905001","https://openalex.org/W2891009351","https://openalex.org/W2894291398","https://openalex.org/W2898536757","https://openalex.org/W2921913927","https://openalex.org/W2973928620","https://openalex.org/W2975817808","https://openalex.org/W2986159023","https://openalex.org/W3086019551","https://openalex.org/W3089163679","https://openalex.org/W3091889457","https://openalex.org/W3206188319","https://openalex.org/W4210479903","https://openalex.org/W4210496349","https://openalex.org/W4210839178","https://openalex.org/W4220708604","https://openalex.org/W4312036888","https://openalex.org/W4380290627","https://openalex.org/W4393036968","https://openalex.org/W4394748823","https://openalex.org/W4400335053","https://openalex.org/W4401585912","https://openalex.org/W4402093046","https://openalex.org/W4405405577"],"related_works":["https://openalex.org/W1996644818","https://openalex.org/W1965468642","https://openalex.org/W2093500216","https://openalex.org/W2053588008","https://openalex.org/W3101161779","https://openalex.org/W423371831","https://openalex.org/W2916376502","https://openalex.org/W2777729175","https://openalex.org/W2260452057","https://openalex.org/W4295779760"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1,124,219],"global":[2],"aging":[3],"population":[4],"poses":[5],"significant":[6,152,182],"challenges":[7],"to":[8,27,37,49,118,164,193,205,229,250],"healthcare,":[9],"with":[10,136,141,151,189,224,245],"frailty,":[11,50,210],"balance":[12,195,211],"impairment,":[13,212],"and":[14,53,89,92,108,113,169,196,213,232,240,254],"fall":[15,54,197,214,237],"risks":[16,55,186,215],"being":[17],"prominent":[18],"issues.":[19],"However,":[20],"the":[21,39,100,132,157,256],"conventional":[22],"clinical":[23,109,225,257],"assessments":[24,226],"often":[25],"fail":[26],"detect":[28],"early":[29,44,207],"signs":[30],"of":[31,41,46,79,209,221,259],"these":[32,252],"conditions.":[33],"This":[34],"study":[35],"aimed":[36],"explore":[38,255],"potential":[40],"metabolomics":[42,125],"in":[43,56,131,148,156,161,184,216,261],"identification":[45],"biomarkers":[47,208],"related":[48,163],"poor":[51,194],"balance,":[52],"older":[57,149,217],"adults.":[58,218],"METHODS:":[59],"We":[60,98],"analyzed":[61],"plasma":[62],"samples":[63],"from":[64],"110":[65],"participants":[66],"aged":[67],"25-98":[68],"years":[69],"using":[70],"untargeted":[71],"metabolomic":[72,103],"analysis.":[73],"Clinical":[74],"assessments,":[75],"including":[76],"Instrumental":[77],"Activities":[78],"Daily":[80],"Living":[81],"(IADL),":[82],"Morse":[83],"Fall":[84],"Risk":[85],"Scale,":[86],"Timed":[87],"Up":[88],"Go":[90],"(TUG),":[91],"Fried":[93],"Frailty":[94],"Criteria,":[95],"were":[96,116],"performed.":[97],"examined":[99],"correlation":[101],"between":[102],"results,":[104],"aging-related":[105,262],"blood":[106],"tests,":[107],"assessments.":[110],"Statistical":[111],"analysis":[112,115,126],"pathway":[114],"used":[117],"identify":[119,206],"key":[120],"metabolic":[121,153,179,190,222],"alterations.":[122],"RESULTS:":[123],"identified":[127],"914":[128],"metabolites":[129,138],"matching":[130],"human":[133],"metabolome":[134],"database,":[135],"293":[137],"significantly":[139],"correlated":[140],"age.":[142],"Metabolomic":[143],"profiles":[144,180,223],"showed":[145],"distinct":[146],"alterations":[147],"adults,":[150],"changes":[154],"observed":[155],"old-old":[158],"group,":[159],"particularly":[160],"pathways":[162],"lipid":[165],"metabolism,":[166],"sphingolipid":[167],"signaling,":[168],"fatty":[170],"acid":[171],"metabolism.":[172],"A":[173],"new":[174],"age":[175],"classification":[176],"based":[177],"on":[178],"revealed":[181],"differences":[183],"frailty":[185,241],"across":[187],"groups,":[188],"signatures":[191],"linked":[192],"risks.":[198],"CONCLUSION:":[199],"Metabolomics":[200,260],"offers":[201],"a":[202],"promising":[203],"approach":[204],"integration":[220],"could":[227],"lead":[228],"more":[230],"precise":[231],"personalized":[233],"healthcare":[234],"interventions,":[235],"improving":[236],"prevention":[238],"strategies":[239],"management.":[242],"Future":[243],"studies":[244],"larger":[246],"cohorts":[247],"are":[248],"needed":[249],"validate":[251],"findings":[253],"utility":[258],"healthcare.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-04T09:36:47.201465","created_date":"2025-10-10T00:00:00"}