{"id":"https://openalex.org/W4411761934","doi":"https://doi.org/10.22391/fppc.1615053","title":"The role of acemetacin in pain management","display_name":"The role of acemetacin in pain management","publication_year":2025,"publication_date":"2025-06-27","ids":{"openalex":"https://openalex.org/W4411761934","doi":"https://doi.org/10.22391/fppc.1615053"},"language":"en","primary_location":{"id":"doi:10.22391/fppc.1615053","doi":"https://doi.org/10.22391/fppc.1615053","is_oa":true,"landing_page_url":"https://doi.org/10.22391/fppc.1615053","pdf_url":null,"source":{"id":"https://openalex.org/S4210215500","display_name":"Family practice and palliative care","issn_l":"2458-8865","issn":["2458-8865","2459-1505"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Family Practice and Palliative Care","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.22391/fppc.1615053","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101610851","display_name":"H\u00fcseyin Can","orcid":"https://orcid.org/0000-0002-4686-7879","observed_orcids":["https://orcid.org/0000-0002-4686-7879"]},"institutions":[{"id":"https://openalex.org/I250383648","display_name":"Izmir K\u00e2tip \u00c7elebi University","ror":"https://ror.org/024nx4843","country_code":"TR","type":"education","lineage":["https://openalex.org/I250383648"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"H\u00fcseyin Can","raw_affiliation_strings":["Department of Family Medicine, Faculty of Medicine, \u0130zmir Katip \u00c7elebi University, \u0130zmir"],"raw_orcid":"https://orcid.org/0000-0002-4686-7879","affiliations":[{"raw_affiliation_string":"Department of Family Medicine, Faculty of Medicine, \u0130zmir Katip \u00c7elebi University, \u0130zmir","institution_ids":["https://openalex.org/I250383648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053518731","display_name":"Mehmet Arslan","orcid":"https://orcid.org/0000-0003-2791-4622","observed_orcids":["https://orcid.org/0000-0003-2791-4622"]},"institutions":[{"id":"https://openalex.org/I132257509","display_name":"Izmir University","ror":"https://ror.org/013h3xr51","country_code":"TR","type":"education","lineage":["https://openalex.org/I132257509"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet Arslan","raw_affiliation_strings":["Department of Family Medicine, \u00c7i\u011fli Training and Research Hospital, \u0130zmir"],"raw_orcid":"https://orcid.org/0000-0003-2791-4622","affiliations":[{"raw_affiliation_string":"Department of Family Medicine, \u00c7i\u011fli Training and Research Hospital, \u0130zmir","institution_ids":["https://openalex.org/I132257509"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013083161","display_name":"Elif Keskin Arslan","orcid":"https://orcid.org/0000-0001-9538-4817","observed_orcids":["https://orcid.org/0000-0001-9538-4817"]},"institutions":[{"id":"https://openalex.org/I4387152504","display_name":"Bak\u0131r\u00e7ay \u00dcniversitesi","ror":"https://ror.org/017v96566","country_code":null,"type":"education","lineage":["https://openalex.org/I4387152504"]}],"countries":[],"is_corresponding":false,"raw_author_name":"Elif Keskin Arslan","raw_affiliation_strings":["Department of Medical Pharmacology, Faculty of Medicine, \u0130zmir Bak\u0131r\u00e7ay University, \u0130zmir"],"raw_orcid":"https://orcid.org/0000-0001-9538-4817","affiliations":[{"raw_affiliation_string":"Department of Medical Pharmacology, Faculty of Medicine, \u0130zmir Bak\u0131r\u00e7ay University, \u0130zmir","institution_ids":["https://openalex.org/I4387152504"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2173642,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"2","first_page":"34","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.7289999723434448,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.7289999723434448,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.1103999987244606,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.10899999737739563,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acemetacin","display_name":"acemetacin","score":1.0},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.7129999995231628},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9039999842643738},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.6769999861717224},{"id":"https://openalex.org/keywords/pain-management","display_name":"pain management","score":0.6579999923706055},{"id":"https://openalex.org/keywords/prodrugs","display_name":"prodrugs","score":0.652999997138977},{"id":"https://openalex.org/keywords/gastrointestinal-side-effects","display_name":"gastrointestinal adverse effects","score":0.8510000109672546},{"id":"https://openalex.org/keywords/acute-pain","display_name":"acute pain","score":0.6029999852180481},{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":0.9629999995231628},{"id":"https://openalex.org/keywords/opioid-alternatives","display_name":"opioid alternatives","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C2983098980","wikidata":"https://www.wikidata.org/wiki/Q621261","display_name":"Pain management","level":2,"score":0.5584626793861389},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.36527493596076965},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32333818078041077},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.29405438899993896}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.22391/fppc.1615053","doi":"https://doi.org/10.22391/fppc.1615053","is_oa":true,"landing_page_url":"https://doi.org/10.22391/fppc.1615053","pdf_url":null,"source":{"id":"https://openalex.org/S4210215500","display_name":"Family practice and palliative care","issn_l":"2458-8865","issn":["2458-8865","2459-1505"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Family Practice and Palliative Care","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/1615053","doi":null,"is_oa":false,"landing_page_url":"https://dergipark.org.tr/tr/pub/fppc/issue/90953/1615053","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Family Practice and Palliative Care","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.22391/fppc.1615053","doi":"https://doi.org/10.22391/fppc.1615053","is_oa":true,"landing_page_url":"https://doi.org/10.22391/fppc.1615053","pdf_url":null,"source":{"id":"https://openalex.org/S4210215500","display_name":"Family practice and palliative care","issn_l":"2458-8865","issn":["2458-8865","2459-1505"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Family Practice and Palliative Care","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W14215417","https://openalex.org/W431875436","https://openalex.org/W2015698186","https://openalex.org/W2030256423","https://openalex.org/W2039932246","https://openalex.org/W2044421678","https://openalex.org/W2095427741","https://openalex.org/W2140375010","https://openalex.org/W2300625108","https://openalex.org/W2342763860","https://openalex.org/W2416646982","https://openalex.org/W4224294703","https://openalex.org/W4239230897","https://openalex.org/W4285390607","https://openalex.org/W4381094653","https://openalex.org/W4390974489"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166"],"abstract_inverted_index":{"Analgesics":[0],"can":[1],"be":[2],"divided":[3],"into":[4],"three":[5],"main":[6,71],"groups":[7],"as":[8,80],"non-opioid,":[9],"opioid,":[10],"and":[11,43,61,67,84,86,121,126],"adjuvant":[12],"treatment":[13,36,63],"options.":[14],"In":[15,98],"this":[16],"review,":[17],"the":[18,25,31,50,87,90],"place":[19],"of":[20,75,82,89],"acemetacin,":[21],"which":[22],"is":[23,40,58,93,101,106],"among":[24],"non-steroidal":[26],"anti-inflammatory":[27],"drugs":[28],"(NSAIDs)":[29],"in":[30,34,49,128],"non-opioid":[32],"group,":[33],"pain":[35,129],"was":[37],"evaluated.":[38],"Acemetacin":[39],"a":[41,102,110,115],"prodrug":[42],"acts":[44],"by":[45],"converting":[46],"to":[47,96],"indomethacin":[48],"body.":[51],"Clinical":[52],"studies":[53],"have":[54],"shown":[55],"that":[56,105],"acemetacin":[57,76,100],"an":[59],"effective":[60,107],"safe":[62],"option":[64,104],"for":[65],"acute":[66],"chronic":[68],"pain.":[69],"The":[70],"gastrointestinal":[72,117],"side":[73,91,118],"effects":[74,92],"are":[77],"complaints":[78],"such":[79],"loss":[81],"appetite":[83],"nausea,":[85],"severity":[88],"usually":[94],"mild":[95],"moderate.":[97],"conclusion,":[99],"good":[103],"orally,":[108],"has":[109,114],"sufficient":[111],"analgesic":[112],"effect,":[113],"low":[116],"effect":[119],"profile,":[120],"does":[122],"not":[123],"cause":[124],"tolerance":[125],"addiction":[127],"treatment.":[130]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}