{"id":"https://openalex.org/W4411720323","doi":"https://doi.org/10.54097/gff9dd26","title":"Research Progress on the Prevention and Treatment of Rheumatoid Arthritis (RA)","display_name":"Research Progress on the Prevention and Treatment of Rheumatoid Arthritis (RA)","publication_year":2025,"publication_date":"2025-06-27","ids":{"openalex":"https://openalex.org/W4411720323","doi":"https://doi.org/10.54097/gff9dd26"},"language":"en","primary_location":{"id":"doi:10.54097/gff9dd26","doi":"https://doi.org/10.54097/gff9dd26","is_oa":true,"landing_page_url":"https://doi.org/10.54097/gff9dd26","pdf_url":"https://hsetdata.com/index.php/ojs/article/download/862/804","source":{"id":"https://openalex.org/S4387281017","display_name":"Highlights in Science Engineering and Technology","issn_l":"2791-0210","issn":["2791-0210","3080-1761"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Highlights in Science, Engineering and Technology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://hsetdata.com/index.php/ojs/article/download/862/804","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yutianle Piao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yutianle Piao","raw_affiliation_strings":["Suzhou Scienece & Technology Town Foreign Language High School , Jiangsu , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suzhou Scienece & Technology Town Foreign Language High School , Jiangsu , China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19998707,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"144","issue":null,"first_page":"398","last_page":"403"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":1.0},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.6880000233650208},{"id":"https://openalex.org/keywords/environmental-risk-factors","display_name":"environmental risk factors","score":0.9549999833106995},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.6489999890327454},{"id":"https://openalex.org/keywords/air-pollution","display_name":"air pollution","score":0.8610000014305115},{"id":"https://openalex.org/keywords/anti-ccp-antibodies","display_name":"anti-CCP antibodies","score":0.7639999985694885},{"id":"https://openalex.org/keywords/early-detection-biomarkers","display_name":"early diagnosis biomarkers","score":0.7710000276565552},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"magnetic resonance imaging","score":0.453000009059906},{"id":"https://openalex.org/keywords/adalimumab","display_name":"adalimumab","score":0.871999979019165},{"id":"https://openalex.org/keywords/biological-agents","display_name":"biological agents","score":0.7450000047683716},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.972000002861023},{"id":"https://openalex.org/keywords/pediatric-rheumatoid-arthritis","display_name":"pediatric rheumatoid arthritis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/physical-therapy","display_name":"physiotherapy","score":0.8769999742507935},{"id":"https://openalex.org/keywords/electrotherapy","display_name":"electrotherapy","score":0.7979999780654907},{"id":"https://openalex.org/keywords/treatment-simplification","display_name":"treatment simplification","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.8537218570709229},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5894078016281128},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3785593807697296},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.36012616753578186}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.54097/gff9dd26","doi":"https://doi.org/10.54097/gff9dd26","is_oa":true,"landing_page_url":"https://doi.org/10.54097/gff9dd26","pdf_url":"https://hsetdata.com/index.php/ojs/article/download/862/804","source":{"id":"https://openalex.org/S4387281017","display_name":"Highlights in Science Engineering and Technology","issn_l":"2791-0210","issn":["2791-0210","3080-1761"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Highlights in Science, Engineering and Technology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.54097/gff9dd26","doi":"https://doi.org/10.54097/gff9dd26","is_oa":true,"landing_page_url":"https://doi.org/10.54097/gff9dd26","pdf_url":"https://hsetdata.com/index.php/ojs/article/download/862/804","source":{"id":"https://openalex.org/S4387281017","display_name":"Highlights in Science Engineering and Technology","issn_l":"2791-0210","issn":["2791-0210","3080-1761"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Highlights in Science, Engineering and Technology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411720323.pdf","grobid_xml":"https://content.openalex.org/works/W4411720323.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1978566354","https://openalex.org/W1983021892","https://openalex.org/W2120642456","https://openalex.org/W2125935509","https://openalex.org/W2145570513","https://openalex.org/W2567039436","https://openalex.org/W2754119638","https://openalex.org/W2803994274","https://openalex.org/W2969414211","https://openalex.org/W3005091869","https://openalex.org/W3044004190","https://openalex.org/W3199659728","https://openalex.org/W4239638431"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"Rheumatoid":[0],"arthritis":[1],"(RA)":[2],"is":[3,148],"an":[4],"autoimmune":[5],"disease":[6],"linked":[7],"to":[8,42,70,131,179],"group":[9],"A":[10],"type":[11],"B":[12],"haemolytic":[13],"streptococcus":[14],"infection,":[15],"characterized":[16],"by":[17],"acute":[18],"fever":[19],"and":[20,35,53,63,74,85,100,112,127,141,152,164,176,182],"migratory":[21],"joint":[22],"pain,":[23],"mainly":[24],"affecting":[25],"large":[26],"joints.":[27],"Its":[28],"pathogenesis":[29],"involves":[30],"genetics,":[31],"environmental":[32,64],"factors,":[33],"infections,":[34],"immune":[36,59],"dysfunction,":[37],"with":[38,118,155],"symptoms":[39],"fluctuating":[40],"due":[41],"weather":[43],"changes.":[44],"Recent":[45],"advances":[46],"in":[47,153],"RA":[48,93,119,132],"treatment":[49,87,102,177],"include":[50],"targeted":[51],"therapy":[52],"biological":[54],"agents,":[55],"alongside":[56],"research":[57,170],"on":[58,91,173],"abnormalities,":[60],"genetic":[61],"predisposition,":[62],"triggers.":[65],"Efforts":[66],"are":[67,115],"being":[68],"made":[69],"develop":[71],"sensitive":[72],"biomarkers":[73],"imaging":[75],"tools":[76],"for":[77],"early":[78,98,144],"diagnosis,":[79],"as":[80,82],"well":[81],"promoting":[83],"multidisciplinary":[84],"patient-centered":[86],"models.":[88],"However,":[89],"studies":[90],"pediatric":[92],"remain":[94],"limited,":[95],"particularly":[96],"regarding":[97],"diagnosis":[99],"age-specific":[101],"strategies.":[103],"Key":[104],"findings":[105],"from":[106],"literature":[107],"include:":[108],"1)":[109],"Certain":[110],"HLA":[111],"MHC":[113],"genes":[114],"strongly":[116],"associated":[117],"susceptibility;":[120],"2)":[121],"Smoking,":[122],"air":[123],"pollution,":[124],"alcohol,":[125],"caffeine,":[126],"humid-cold":[128],"environments":[129],"contribute":[130],"risk;":[133],"3)":[134],"ESR,":[135],"CRP,":[136],"anti-CCP,":[137],"anti-cyclo-citrulline":[138],"IgM":[139],"antibodies,":[140],"MRI":[142],"aid":[143],"diagnosis;":[145],"4)":[146],"Adalimumab":[147],"effective":[149],"both":[150],"alone":[151],"combination":[154],"other":[156],"drugs;":[157],"5)":[158],"Physical":[159],"therapies":[160],"like":[161],"hot/cold":[162],"compresses":[163],"electrotherapy":[165],"help":[166],"relieve":[167],"symptoms.":[168],"Future":[169],"should":[171],"focus":[172],"cost":[174],"reduction":[175],"simplification":[178],"improve":[180],"accessibility":[181],"patient":[183],"outcomes.":[184]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2025-10-10T00:00:00"}
