{"id":"https://openalex.org/W4411715708","doi":"https://doi.org/10.1101/2025.06.23.661120","title":"Sensitizing Immune-Refractory Ovarian Tumors via p53 Mutation-Tailored Immunotherapy","display_name":"Sensitizing Immune-Refractory Ovarian Tumors via p53 Mutation-Tailored Immunotherapy","publication_year":2025,"publication_date":"2025-06-27","ids":{"openalex":"https://openalex.org/W4411715708","doi":"https://doi.org/10.1101/2025.06.23.661120","pmid":"https://pubmed.ncbi.nlm.nih.gov/40666944","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12262552"},"language":"en","primary_location":{"id":"doi:10.1101/2025.06.23.661120","doi":"https://doi.org/10.1101/2025.06.23.661120","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.06.23.661120","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.1101/2025.06.23.661120","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064061010","display_name":"Rishita Chatterjee","orcid":"https://orcid.org/0000-0001-8484-3897","observed_orcids":["https://orcid.org/0000-0001-8484-3897"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Rishita Chatterjee","raw_affiliation_strings":["Department of Immunology and Regenerative Biology, Systems immunology, Weizmann Institute of Science, Rehovot, 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Regenerative Biology, Systems immunology, Weizmann Institute of Science, Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023044464","display_name":"Arturo Simoni Nieves","orcid":"https://orcid.org/0000-0002-1353-260X","observed_orcids":["https://orcid.org/0000-0002-1353-260X"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Arturo Simoni-Nieves","raw_affiliation_strings":["Department of Immunology and Regenerative Biology, Systems immunology, Weizmann Institute of Science, Rehovot, 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Regenerative Biology, Systems immunology, Weizmann Institute of Science, Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013974314","display_name":"An Nhien Truong","orcid":"https://orcid.org/0000-0002-0277-6983","observed_orcids":["https://orcid.org/0000-0002-0277-6983"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"An Truong","raw_affiliation_strings":["Cancer Research UK and Department of Oncology, University of Cambridge Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK and Department of Oncology, University of Cambridge Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011594133","display_name":"Moshit Lindzen","orcid":"https://orcid.org/0000-0002-4485-1355","observed_orcids":["https://orcid.org/0000-0002-4485-1355"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Moshit Lindzen","raw_affiliation_strings":["Department of Immunology and Regenerative Biology, Systems immunology, Weizmann Institute of Science, Rehovot, 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Regenerative Biology, Systems immunology, Weizmann Institute of Science, Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124696330","display_name":"Furkan Ozmen","orcid":"https://orcid.org/0000-0002-1128-9458","observed_orcids":["https://orcid.org/0000-0002-1128-9458"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4390039369","display_name":"OHSU Knight Cancer Institute","ror":"https://ror.org/002shna07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Furkan Ozmen","raw_affiliation_strings":["Division of Oncological Sciences, Knight Cancer Institute, Oregon Health and Science University, Portland Oregon 97201 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncological Sciences, Knight Cancer Institute, Oregon Health and Science University, Portland Oregon 97201 USA","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christopher Cherry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Cherry","raw_affiliation_strings":["Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060524369","display_name":"Pascale Zwicky","orcid":"https://orcid.org/0000-0003-0419-2153","observed_orcids":["https://orcid.org/0000-0003-0419-2153"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Pascale Zwicky","raw_affiliation_strings":["Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021692215","display_name":"Saptaparna Mukherjee","orcid":"https://orcid.org/0000-0002-8704-481X","observed_orcids":["https://orcid.org/0000-0002-8704-481X"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Saptaparna Mukherjee","raw_affiliation_strings":["Francis Crick Institute, London NW1 1AT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Francis Crick Institute, London NW1 1AT, UK","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106839968","display_name":"Boobash-Raj Selvadurai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Boobash-Raj Selvadurai","raw_affiliation_strings":["Department of Immunology and Regenerative Biology, Systems immunology, Weizmann Institute of Science, Rehovot, 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Regenerative Biology, Systems immunology, Weizmann Institute of Science, Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110347197","display_name":"Tomer Meir Salame","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Tomer-Meir Salame","raw_affiliation_strings":["Flow Cytometry Unit, Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Flow Cytometry Unit, Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nitin Gupta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Nitin Gupta","raw_affiliation_strings":["Department of Immunology and Regenerative Biology, Systems immunology, Weizmann Institute of Science, Rehovot, 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Regenerative Biology, Systems immunology, Weizmann Institute of Science, Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031229155","display_name":"Suvendu Giri","orcid":"https://orcid.org/0000-0002-7595-1359","observed_orcids":["https://orcid.org/0000-0002-7595-1359"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Suvendu Giri","raw_affiliation_strings":["Department of Immunology and Regenerative Biology, Systems immunology, Weizmann Institute of Science, Rehovot, 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Regenerative Biology, Systems immunology, Weizmann Institute of Science, Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037137127","display_name":"Lior Kramarski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Lior Kramarski","raw_affiliation_strings":["Department of Immunology and Regenerative Biology, Systems immunology, Weizmann Institute of Science, Rehovot, 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Regenerative Biology, Systems immunology, Weizmann Institute of Science, Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027161884","display_name":"Yahel Avraham","orcid":"https://orcid.org/0000-0002-6068-4892","observed_orcids":["https://orcid.org/0000-0002-6068-4892"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yahel Avraham","raw_affiliation_strings":["Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134885214","display_name":"Eviatar Weizman","orcid":"https://orcid.org/0000-0001-6549-891X","observed_orcids":["https://orcid.org/0000-0001-6549-891X"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Eviatar Weizman","raw_affiliation_strings":["The Mantoux Bioinformatics institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mantoux Bioinformatics institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084714497","display_name":"Tugba Y. Ozmen","orcid":"https://orcid.org/0000-0002-7861-6759","observed_orcids":["https://orcid.org/0000-0002-7861-6759"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4390039369","display_name":"OHSU Knight Cancer Institute","ror":"https://ror.org/002shna07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tugba Ozmen","raw_affiliation_strings":["Division of Oncological Sciences, Knight Cancer Institute, Oregon Health and Science University, Portland Oregon 97201 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncological Sciences, Knight Cancer Institute, Oregon Health and Science University, Portland Oregon 97201 USA","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034212588","display_name":"Ashish Noronha","orcid":"https://orcid.org/0000-0002-3415-6113","observed_orcids":["https://orcid.org/0000-0002-3415-6113"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashish Noronha","raw_affiliation_strings":["Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045660933","display_name":"Priyasmita Chakrabarti","orcid":"https://orcid.org/0000-0001-9075-521X","observed_orcids":["https://orcid.org/0000-0001-9075-521X"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Priyasmita Chakrabarti","raw_affiliation_strings":["Department of Immunology and Regenerative Biology, Systems immunology, Weizmann Institute of Science, Rehovot, 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Regenerative Biology, Systems immunology, Weizmann Institute of Science, Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101633605","display_name":"Deepthi Ramesh-Kumar","orcid":"https://orcid.org/0000-0002-8987-2213","observed_orcids":["https://orcid.org/0000-0002-8987-2213"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Deepthi Ramesh-Kumar","raw_affiliation_strings":["Department of Immunology and Regenerative Biology, Systems immunology, Weizmann Institute of Science, Rehovot, 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Regenerative Biology, Systems immunology, Weizmann Institute of Science, Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011616773","display_name":"Julian Downward","orcid":"https://orcid.org/0000-0002-2331-4729","observed_orcids":["https://orcid.org/0000-0002-2331-4729"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julian Downward","raw_affiliation_strings":["Francis Crick Institute, London NW1 1AT, UK"],"raw_orcid":"https://orcid.org/0000-0002-2331-4729","affiliations":[{"raw_affiliation_string":"Francis Crick Institute, London NW1 1AT, UK","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004644725","display_name":"Rony Dahan","orcid":"https://orcid.org/0000-0002-8420-7601","observed_orcids":["https://orcid.org/0000-0002-8420-7601"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Rony Dahan","raw_affiliation_strings":["Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048280875","display_name":"Ido Amit","orcid":"https://orcid.org/0000-0003-2968-877X","observed_orcids":["https://orcid.org/0000-0003-2968-877X","https://orcid.org/0009-0001-1324-5694","https://orcid.org/0009-0001-3021-6799"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ido Amit","raw_affiliation_strings":["Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006560755","display_name":"Victor E. Velculescu","orcid":"https://orcid.org/0000-0003-1195-438X","observed_orcids":["https://orcid.org/0000-0003-1195-438X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor Velculescu","raw_affiliation_strings":["Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051525398","display_name":"James D. Brenton","orcid":"https://orcid.org/0000-0002-5738-6683","observed_orcids":["https://orcid.org/0000-0002-5738-6683"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James Brenton","raw_affiliation_strings":["Cancer Research UK and Department of Oncology, University of Cambridge Cambridge, UK"],"raw_orcid":"https://orcid.org/0000-0002-5738-6683","affiliations":[{"raw_affiliation_string":"Cancer Research UK and Department of Oncology, University of Cambridge Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gordon Mills","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4390039369","display_name":"OHSU Knight Cancer Institute","ror":"https://ror.org/002shna07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gordon Mills","raw_affiliation_strings":["Division of Oncological Sciences, Knight Cancer Institute, Oregon Health and Science University, Portland Oregon 97201 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncological Sciences, Knight Cancer Institute, Oregon Health and Science University, Portland Oregon 97201 USA","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036387444","display_name":"Moshe Oren","orcid":"https://orcid.org/0000-0003-4311-7172","observed_orcids":["https://orcid.org/0000-0003-4311-7172"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Moshe Oren","raw_affiliation_strings":["Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001348816","display_name":"Yosef Yarden","orcid":"https://orcid.org/0000-0001-8578-0250","observed_orcids":["https://orcid.org/0000-0001-8578-0250"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Yosef Yarden","raw_affiliation_strings":["Department of Immunology and Regenerative Biology, Systems immunology, Weizmann Institute of Science, Rehovot, 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Regenerative Biology, Systems immunology, Weizmann Institute of Science, Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5001348816"],"corresponding_institution_ids":["https://openalex.org/I53964585"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.14579999446868896,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-grade-serous-ovarian-carcinoma","display_name":"high-grade serous ovarian cancer","score":0.902999997138977},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/p53-r172h","display_name":"p53 R172H","score":0.8939999938011169},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.574999988079071},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8949999809265137},{"id":"https://openalex.org/keywords/pd-1-pd-l1-axis","display_name":"PD-1/PD-L1 axis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/amphiregulin","display_name":"amphiregulin","score":0.9279999732971191},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.7360000014305115},{"id":"https://openalex.org/keywords/m1-macrophages","display_name":"M1 macrophages","score":0.824999988079071},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.890999972820282},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8930000066757202},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9399999976158142},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.777999997138977},{"id":"https://openalex.org/keywords/organoids","display_name":"organoids","score":0.609000027179718},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6886894702911377},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.6328132748603821},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5888754725456238},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5554717183113098},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5475141406059265},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5217995643615723},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29574310779571533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2542378306388855},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10878360271453857},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07381808757781982},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2025.06.23.661120","doi":"https://doi.org/10.1101/2025.06.23.661120","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.06.23.661120","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40666944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40666944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12262552","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12262552","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2025.06.23.661120","doi":"https://doi.org/10.1101/2025.06.23.661120","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.06.23.661120","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000896419","display_name":"Systematic Characterization and Targeting of Neomorphic Drivers in Cancer","funder_award_id":"U01CA281902","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308854","display_name":"Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","ror":"https://ror.org/0001ew531"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1954528967","https://openalex.org/W1986758873","https://openalex.org/W1993060180","https://openalex.org/W2008264147","https://openalex.org/W2018221147","https://openalex.org/W2039921156","https://openalex.org/W2049497373","https://openalex.org/W2052853384","https://openalex.org/W2092921437","https://openalex.org/W2134318982","https://openalex.org/W2168213749","https://openalex.org/W2169908872","https://openalex.org/W2171249989","https://openalex.org/W2173135538","https://openalex.org/W2276764162","https://openalex.org/W2322116467","https://openalex.org/W2513362995","https://openalex.org/W2515153451","https://openalex.org/W2530508394","https://openalex.org/W2597062310","https://openalex.org/W2760995269","https://openalex.org/W2891365914","https://openalex.org/W2911735608","https://openalex.org/W2945590213","https://openalex.org/W2992128161","https://openalex.org/W2996550563","https://openalex.org/W3000319768","https://openalex.org/W3039456903","https://openalex.org/W3045498347","https://openalex.org/W3096800089","https://openalex.org/W3097756289","https://openalex.org/W3111251278","https://openalex.org/W3128227583","https://openalex.org/W3158651394","https://openalex.org/W3159068051","https://openalex.org/W3164639797","https://openalex.org/W3164646834","https://openalex.org/W3180421332","https://openalex.org/W3185036246","https://openalex.org/W4220913709","https://openalex.org/W4224219550","https://openalex.org/W4225114447","https://openalex.org/W4226033466","https://openalex.org/W4280559744","https://openalex.org/W4283590972","https://openalex.org/W4290737584","https://openalex.org/W4292265462","https://openalex.org/W4295925311","https://openalex.org/W4295974729","https://openalex.org/W4304084233","https://openalex.org/W4308721502","https://openalex.org/W4312082534","https://openalex.org/W4321614209","https://openalex.org/W4376131706","https://openalex.org/W4385331136","https://openalex.org/W4385457156","https://openalex.org/W4389609207","https://openalex.org/W4390498530","https://openalex.org/W4393865656","https://openalex.org/W4396772962","https://openalex.org/W4398137273","https://openalex.org/W4400094490","https://openalex.org/W4403959937","https://openalex.org/W4406043162","https://openalex.org/W4406089394","https://openalex.org/W4407524165"],"related_works":["https://openalex.org/W4416449605","https://openalex.org/W4366602942","https://openalex.org/W4387234432","https://openalex.org/W2177274084","https://openalex.org/W3040414646","https://openalex.org/W4402169861","https://openalex.org/W2144277728","https://openalex.org/W2125877482","https://openalex.org/W4386035040","https://openalex.org/W3212173911"],"abstract_inverted_index":{"High-grade":[0],"serous":[1],"ovarian":[2],"cancer":[3],"demonstrates":[4],"limited":[5,82],"responsiveness":[6],"to":[7,14,76,131,143],"immune":[8],"checkpoint":[9],"inhibitors,":[10],"owing":[11],"in":[12],"part":[13],"immunosuppressive":[15,145],"environments":[16],"shaped":[17],"by":[18],"nearly":[19],"universal":[20],"p53":[21,30,64,142],"aberrations.":[22],"Utilizing":[23],"an":[24],"immunocompetent":[25],"mouse":[26],"model":[27],"and":[28,49,67,89,92,111],"individual":[29],"mutations,":[31],"we":[32],"identified":[33],"a":[34,70,133],"dependence":[35],"of":[36,41,54,62,104,113,141],"the":[37,50,119,123,129,139],"p53-R270H":[38],"mutation":[39],"(equivalent":[40],"human":[42],"R273H)":[43],"on":[44],"regulatory":[45],"T":[46,106],"cells":[47],"(Tregs)":[48],"PD-1/PD-L1":[51],"axis.":[52],"Analysis":[53],"patient":[55],"datasets":[56],"associated":[57],"R273H":[58],"with":[59],"elevated":[60],"levels":[61],"two":[63],"targets,":[65],"PD-L1":[66,90],"amphiregulin":[68],"(AREG),":[69],"Tregs":[71],"growth":[72],"factor.":[73],"In":[74,115],"contrast":[75],"p53-R172H":[77],"tumors,":[78],"where":[79],"there":[80],"was":[81],"activity,":[83],"dual":[84],"antibody":[85],"therapy":[86],"targeting":[87],"AREG":[88],"selectively":[91],"effectively":[93],"inhibited":[94],"R270H":[95],"tumors.":[96],"This":[97,126],"involved":[98],"polarization":[99],"toward":[100],"M1":[101],"macrophages,":[102],"infiltration":[103],"CD8+":[105],"cells,":[107],"diminished":[108],"Ly6G+":[109],"neutrophils":[110],"downregulation":[112],"interleukin-4.":[114],"patient-derived":[116],"R273C":[117],"organoids,":[118],"combination":[120],"treatment":[121],"reduced":[122],"CD4/CD8":[124],"ratio.":[125],"study":[127],"is":[128],"first":[130],"establish":[132],"mutation-tailored":[134],"therapeutic":[135],"approach":[136],"that":[137],"leverages":[138],"capacity":[140],"modulate":[144],"mechanisms.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2025-10-10T00:00:00"}