{"id":"https://openalex.org/W4411706276","doi":"https://doi.org/10.3389/fncel.2025.1613618","title":"Circulating exosomes with unique lipid signature in relapsing remitting multiple sclerosis","display_name":"Circulating exosomes with unique lipid signature in relapsing remitting multiple sclerosis","publication_year":2025,"publication_date":"2025-06-27","ids":{"openalex":"https://openalex.org/W4411706276","doi":"https://doi.org/10.3389/fncel.2025.1613618","pmid":"https://pubmed.ncbi.nlm.nih.gov/40656682","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12245768"},"language":"en","primary_location":{"id":"doi:10.3389/fncel.2025.1613618","doi":"https://doi.org/10.3389/fncel.2025.1613618","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2025.1613618","pdf_url":"https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2025.1613618/pdf","source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2025.1613618/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037404026","display_name":"Claudia Palazzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudia Palazzo","raw_affiliation_strings":["Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118656801","display_name":"Ilaria Asci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ilaria Asci","raw_affiliation_strings":["Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044304932","display_name":"Silvia Russo","orcid":"https://orcid.org/0000-0002-4542-5112","observed_orcids":["https://orcid.org/0000-0002-4542-5112"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Russo","raw_affiliation_strings":["Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067201119","display_name":"Cinzia Buccoliero","orcid":"https://orcid.org/0009-0000-1523-5193","observed_orcids":["https://orcid.org/0009-0000-1523-5193"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cinzia Buccoliero","raw_affiliation_strings":["Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103310580","display_name":"Vincenzo Mangialardi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Mangialardi","raw_affiliation_strings":["Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076277566","display_name":"Pasqua Abbrescia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pasqua Abbrescia","raw_affiliation_strings":["Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084661253","display_name":"Onofrio Valente","orcid":"https://orcid.org/0000-0002-6894-4644","observed_orcids":["https://orcid.org/0000-0002-6894-4644"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Onofrio Valente","raw_affiliation_strings":["Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052342987","display_name":"Maddalena Ruggieri","orcid":"https://orcid.org/0000-0001-7419-570X","observed_orcids":["https://orcid.org/0000-0001-7419-570X"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maddalena Ruggieri","raw_affiliation_strings":["Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061592086","display_name":"Damiano Paolicelli","orcid":"https://orcid.org/0000-0002-8645-1763","observed_orcids":["https://orcid.org/0000-0002-8645-1763"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Damiano Paolicelli","raw_affiliation_strings":["Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010981951","display_name":"Simona Lobasso","orcid":"https://orcid.org/0000-0003-3566-4547","observed_orcids":["https://orcid.org/0000-0003-3566-4547"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Simona Lobasso","raw_affiliation_strings":["Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085075000","display_name":"Antonio Frigeri","orcid":"https://orcid.org/0000-0002-5284-2934","observed_orcids":["https://orcid.org/0000-0002-5284-2934"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Frigeri","raw_affiliation_strings":["Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010981951"],"corresponding_institution_ids":["https://openalex.org/I5561750"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.5454,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.80292275,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"19","issue":null,"first_page":"1613618","last_page":"1613618"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.9049999713897705},{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/serum-exosomes","display_name":"serum exosomes","score":0.7940000295639038},{"id":"https://openalex.org/keywords/lipid-biomarkers","display_name":"lipid biomarkers","score":0.7730000019073486},{"id":"https://openalex.org/keywords/phosphatidic-acid","display_name":"phosphatidic acid","score":0.9380000233650208},{"id":"https://openalex.org/keywords/lysophosphatidylcholine","display_name":"lysophosphatidylcholine","score":0.9890000224113464},{"id":"https://openalex.org/keywords/membrane-lipid-homeostasis","display_name":"membrane lipid homeostasis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/bis-monoacylglycero-phosphate","display_name":"bis(monoacylglycero)phosphate","score":0.9200000166893005},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.9318505525588989},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.6298388242721558},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.6144764423370361},{"id":"https://openalex.org/C2778596009","wikidata":"https://www.wikidata.org/wiki/Q410548","display_name":"Lysophosphatidylcholine","level":5,"score":0.5474775433540344},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49596962332725525},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4050655663013458},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.39880356192588806},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36112821102142334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3072549104690552},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2526646852493286},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.20483648777008057},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.18472829461097717},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.1225937008857727},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fncel.2025.1613618","doi":"https://doi.org/10.3389/fncel.2025.1613618","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2025.1613618","pdf_url":"https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2025.1613618/pdf","source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},{"id":"pmid:40656682","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40656682","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cellular neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12245768","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12245768/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Neurosci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a72e5f6bbf5644b49d665688774ad952","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a72e5f6bbf5644b49d665688774ad952","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular Neuroscience, Vol 19 (2025)","raw_type":"article"},{"id":"pmh:oai:ricerca.uniba.it:11586/544715","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11586/544715","pdf_url":null,"source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3389/fncel.2025.1613618","doi":"https://doi.org/10.3389/fncel.2025.1613618","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2025.1613618","pdf_url":"https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2025.1613618/pdf","source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411706276.pdf","grobid_xml":"https://content.openalex.org/works/W4411706276.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W843693155","https://openalex.org/W1828576284","https://openalex.org/W1839188703","https://openalex.org/W1971459623","https://openalex.org/W1971916732","https://openalex.org/W1982468254","https://openalex.org/W1982733885","https://openalex.org/W1983748299","https://openalex.org/W1985009628","https://openalex.org/W2011309282","https://openalex.org/W2023260280","https://openalex.org/W2026620576","https://openalex.org/W2039352830","https://openalex.org/W2053665120","https://openalex.org/W2060437747","https://openalex.org/W2062364627","https://openalex.org/W2065936039","https://openalex.org/W2069849155","https://openalex.org/W2071471299","https://openalex.org/W2071618517","https://openalex.org/W2072167135","https://openalex.org/W2112600207","https://openalex.org/W2508312148","https://openalex.org/W2577813713","https://openalex.org/W2588373779","https://openalex.org/W2634243099","https://openalex.org/W2801069891","https://openalex.org/W2807882529","https://openalex.org/W2887269406","https://openalex.org/W2914242215","https://openalex.org/W2981254076","https://openalex.org/W2982360228","https://openalex.org/W3006900426","https://openalex.org/W3008155203","https://openalex.org/W3017078364","https://openalex.org/W3162697382","https://openalex.org/W3213675969","https://openalex.org/W4210329408","https://openalex.org/W4211048507","https://openalex.org/W4253381763","https://openalex.org/W4298111725","https://openalex.org/W4309562767","https://openalex.org/W4309721936","https://openalex.org/W4384264172","https://openalex.org/W4387392501","https://openalex.org/W4388980096","https://openalex.org/W4389489847","https://openalex.org/W4390659791","https://openalex.org/W4390689460","https://openalex.org/W4391649568","https://openalex.org/W4391972344","https://openalex.org/W4394853470","https://openalex.org/W4395085378","https://openalex.org/W4399140969","https://openalex.org/W4399576614","https://openalex.org/W4399868535","https://openalex.org/W4402724150"],"related_works":["https://openalex.org/W4389447118","https://openalex.org/W2765115586","https://openalex.org/W3099748118","https://openalex.org/W2605842649","https://openalex.org/W2591872701","https://openalex.org/W4362639551","https://openalex.org/W4415946904","https://openalex.org/W7126044053","https://openalex.org/W2771537279","https://openalex.org/W2039352830"],"abstract_inverted_index":{"Exosomes":[0],"are":[1],"small,":[2],"membrane-bound":[3],"vesicles":[4],"secreted":[5],"by":[6,22],"most":[7,240],"cell":[8],"types":[9],"into":[10],"the":[11,33,37,51,73,142,186,253,264,272],"extracellular":[12,213],"environment.":[13],"They":[14],"play":[15],"a":[16,208,244,276],"crucial":[17],"role":[18,235],"in":[19,39,50,72,109,173,182,226,236,252,259,280],"intercellular":[20],"communication":[21],"transporting":[23],"bioactive":[24],"molecules,":[25],"including":[26,59],"proteins,":[27],"lipids,":[28],"and":[29,35,56,69,82,93,112,123,148],"RNAs,":[30],"thereby":[31],"influencing":[32],"phenotype":[34],"potentially":[36],"genotype":[38],"recipient":[40],"cells.":[41],"In":[42,77],"recent":[43],"years,":[44],"exosomes":[45,85,133,139,192,282],"have":[46],"gained":[47],"increasing":[48],"attention":[49],"study":[52,270],"of":[53,131,138,144,165,197,212,221,266],"pathophysiological":[54],"conditions":[55],"numerous":[57],"diseases,":[58],"multiple":[60],"sclerosis":[61],"(MS),":[62],"an":[63,219],"autoimmune":[64],"disorder":[65],"with":[66,88,178,231],"myelin":[67],"sheath":[68],"neuroaxonal":[70],"damage":[71],"central":[74],"nervous":[75],"system.":[76],"this":[78,269],"study,":[79],"we":[80],"isolated":[81,140],"purified":[83],"serum-derived":[84,281],"from":[86,141,283],"patients":[87,285],"relapsing":[89],"remitting":[90],"MS":[91,237],"(RR-MS)":[92],"characterized":[94],"their":[95,232],"lipid":[96,120,129,159,176,261,278],"profiles":[97,130],"using":[98,286],"matrix-assisted":[99],"laser":[100],"desorption":[101],"ionization-time-of-flight/mass":[102],"spectrometry":[103],"(MALDI-TOF/MS).":[104],"Lipid":[105],"analysis":[106,150,217],"was":[107,151,170,243],"performed":[108],"both":[110,174],"negative":[111],"positive":[113],"ion":[114],"modes":[115],"on":[116],"intact":[117],"exosomes,":[118,204],"bypassing":[119],"extraction":[121],"steps":[122],"significantly":[124,194],"reducing":[125],"sample-processing":[126],"time.":[127],"The":[128,161],"RR-MS":[132,191,227,284],"were":[134],"compared":[135,201],"to":[136,153,156,202,249,274],"those":[137],"serum":[143],"healthy":[145],"subjects":[146],"(HS),":[147],"statistical":[149],"applied":[152],"mass":[154],"spectra":[155],"identify":[157],"potential":[158,257],"biomarkers.":[160],"specific":[162],"phospholipid":[163],"marker":[164],"exosomal":[166],"membranes,":[167,229],"bis(monoacylglycero)phosphate":[168],"(BMP),":[169],"clearly":[171],"detected":[172],"MALDI":[175],"profiles,":[177],"no":[179],"significant":[180,241],"differences":[181],"its":[183],"content":[184],"between":[185],"two":[187],"sample":[188],"groups.":[189],"However,":[190],"exhibited":[193],"lower":[195,246],"levels":[196],"phosphatidic":[198],"acid":[199],"(PA)":[200],"HS":[203],"despite":[205],"PA":[206],"being":[207],"key":[209],"structural":[210],"component":[211],"vesicles.":[214],"Notably,":[215],"comparative":[216],"revealed":[218],"enrichment":[220],"several":[222],"lysophosphatidylcholine":[223],"(LPC)":[224],"species":[225],"exosome":[228],"aligning":[230],"known":[233],"proinflammatory":[234],"pathology.":[238],"Our":[239],"finding":[242],"markedly":[245],"phosphatidylcholine":[247],"(PC)":[248],"LPC":[250],"ratio":[251],"pathological":[254],"group":[255],"indicating":[256],"alterations":[258],"membrane":[260],"homeostasis.":[262],"To":[263],"best":[265],"our":[267],"knowledge,":[268],"is":[271],"first":[273],"report":[275],"distinct":[277],"signature":[279],"direct":[287],"MALDI-TOF/MS":[288],"analysis.":[289]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-10-10T00:00:00"}
