{"id":"https://openalex.org/W4411673601","doi":"https://doi.org/10.7554/elife.106269.3.sa0","title":"eLife Assessment: Divergent C. elegans toxin alleles are suppressed by distinct mechanisms","display_name":"eLife Assessment: Divergent C. elegans toxin alleles are suppressed by distinct mechanisms","publication_year":2025,"publication_date":"2025-06-26","ids":{"openalex":"https://openalex.org/W4411673601","doi":"https://doi.org/10.7554/elife.106269.3.sa0"},"language":"en","primary_location":{"id":"doi:10.7554/elife.106269.3.sa0","doi":"https://doi.org/10.7554/elife.106269.3.sa0","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.106269.3.sa0","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"volume":null,"type":"peer-review","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.106269.3.sa0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045621140","display_name":"Vincent J. Lynch","orcid":"https://orcid.org/0000-0001-5311-3824","observed_orcids":["https://orcid.org/0000-0001-5311-3824"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vincent J Lynch","raw_affiliation_strings":["University at Buffalo, State University of New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University at Buffalo, State University of New York","institution_ids":["https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045621140"],"corresponding_institution_ids":["https://openalex.org/I63190737"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.5346999764442444,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.5346999764442444,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.14720000326633453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10174","display_name":"Animal Behavior and Reproduction","score":0.06870000064373016,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toxin-antidote-system","display_name":"toxin-antidote system","score":0.9670000076293945},{"id":"https://openalex.org/keywords/selfish-genetic-elements","display_name":"selfish genetic elements","score":0.9169999957084656},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8090000152587891},{"id":"https://openalex.org/keywords/reproductive-isolation","display_name":"reproductive isolation","score":0.6430000066757202},{"id":"https://openalex.org/keywords/genetic-conflict","display_name":"genetic conflict","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6371569037437439},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5477239489555359},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4788258373737335},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.47017258405685425},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.4260620176792145},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.36075466871261597},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3500745892524719},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2467445731163025}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7554/elife.106269.3.sa0","doi":"https://doi.org/10.7554/elife.106269.3.sa0","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.106269.3.sa0","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},{"id":"doi:10.7554/elife.106269.2.sa3","doi":"https://doi.org/10.7554/elife.106269.2.sa3","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.106269.2.sa3","pdf_url":"https://elifesciences.org/reviewed-preprints/106269v2.pdf","source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},{"id":"doi:10.7554/elife.106269.1.sa2","doi":"https://doi.org/10.7554/elife.106269.1.sa2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.106269.1.sa2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"}],"best_oa_location":{"id":"doi:10.7554/elife.106269.3.sa0","doi":"https://doi.org/10.7554/elife.106269.3.sa0","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.106269.3.sa0","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337349","display_name":"NIH Office of the Director","ror":"https://ror.org/00fj8a872"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411673601.pdf","grobid_xml":"https://content.openalex.org/works/W4411673601.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1539869680","https://openalex.org/W1910292850","https://openalex.org/W1964128403","https://openalex.org/W1980355894","https://openalex.org/W1995048848","https://openalex.org/W1998224653","https://openalex.org/W2013163897","https://openalex.org/W2015423672","https://openalex.org/W2029147584","https://openalex.org/W2038489248","https://openalex.org/W2055821550","https://openalex.org/W2065938201","https://openalex.org/W2081984868","https://openalex.org/W2102218399","https://openalex.org/W2103953005","https://openalex.org/W2107527116","https://openalex.org/W2113906105","https://openalex.org/W2120347292","https://openalex.org/W2122984483","https://openalex.org/W2125957866","https://openalex.org/W2131852558","https://openalex.org/W2154222068","https://openalex.org/W2283384766","https://openalex.org/W2429539248","https://openalex.org/W2529350482","https://openalex.org/W2612254897","https://openalex.org/W2735593947","https://openalex.org/W2787719063","https://openalex.org/W2789843538","https://openalex.org/W2799603881","https://openalex.org/W2883477364","https://openalex.org/W2906767856","https://openalex.org/W2950857885","https://openalex.org/W2951796795","https://openalex.org/W2997290079","https://openalex.org/W3026042380","https://openalex.org/W3083839405","https://openalex.org/W3093681411","https://openalex.org/W3118568829","https://openalex.org/W3120958127","https://openalex.org/W3126380682","https://openalex.org/W3138886768","https://openalex.org/W3142233419","https://openalex.org/W3190875492","https://openalex.org/W4206097133","https://openalex.org/W4223515049","https://openalex.org/W4320857482","https://openalex.org/W4323347462","https://openalex.org/W4387892861","https://openalex.org/W4400140710","https://openalex.org/W4401940669","https://openalex.org/W4403920008","https://openalex.org/W4407256147"],"related_works":["https://openalex.org/W6910961276","https://openalex.org/W4416823924","https://openalex.org/W4387892861","https://openalex.org/W6976787204","https://openalex.org/W3120958127","https://openalex.org/W6963604580","https://openalex.org/W7168269674","https://openalex.org/W3083028983","https://openalex.org/W7141165879","https://openalex.org/W2149292210"],"abstract_inverted_index":{"eLife":[0],"AssessmentThis":[1],"important":[2],"study":[3],"identifies":[4],"a":[5],"new":[6],"toxin/antidote":[7],"(T/A)":[8],"system":[9],"in":[10,45],"the":[11],"model":[12],"nematode":[13],"C.":[14],"elegans.These":[15],"results":[16],"suggest":[17],"there":[18],"are":[19],"alternative":[20],"mechanisms":[21],"to":[22,43],"neutralize":[23],"selfish":[24],"genetic":[25],"elements.The":[26],"authors":[27],"present":[28],"solid":[29],"data":[30],"that":[31],"robustly":[32],"support":[33],"their":[34],"central":[35],"conclusion.This":[36],"work":[37],"will":[38],"be":[39],"of":[40],"broad":[41],"interest":[42],"investigators":[44],"evolutionary":[46],"biology":[47],"and":[48],"reproductive":[49],"biology.":[50]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-10-10T00:00:00"}
