{"id":"https://openalex.org/W4411665679","doi":"https://doi.org/10.1016/j.crmicr.2025.100430","title":"Cell wall polysaccharide alters the surface electric potential of Lacticaseibacillus paracasei strain Shirota and enhances acid tolerance","display_name":"Cell wall polysaccharide alters the surface electric potential of Lacticaseibacillus paracasei strain Shirota and enhances acid tolerance","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4411665679","doi":"https://doi.org/10.1016/j.crmicr.2025.100430","pmid":"https://pubmed.ncbi.nlm.nih.gov/40686846","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12272108"},"language":"en","primary_location":{"id":"doi:10.1016/j.crmicr.2025.100430","doi":"https://doi.org/10.1016/j.crmicr.2025.100430","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.crmicr.2025.100430","pdf_url":null,"source":{"id":"https://openalex.org/S4210236417","display_name":"Current Research in Microbial Sciences","issn_l":"2666-5174","issn":["2666-5174"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Research in Microbial Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.crmicr.2025.100430","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Kosuke Kato","orcid":"https://orcid.org/0000-0003-1622-5725","observed_orcids":["https://orcid.org/0000-0003-1622-5725"]},"institutions":[{"id":"https://openalex.org/I4210153337","display_name":"Yakult Central Institute","ror":"https://ror.org/04gcc2383","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210153337"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kosuke Kato","raw_affiliation_strings":["Yakult Central Institute, 5-11 Izumi Kunitachi-shi, Tokyo 186-8650, Japan"],"raw_orcid":"https://orcid.org/0000-0003-1622-5725","affiliations":[{"raw_affiliation_string":"Yakult Central Institute, 5-11 Izumi Kunitachi-shi, Tokyo 186-8650, Japan","institution_ids":["https://openalex.org/I4210153337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109362489","display_name":"Madoka Nakamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153337","display_name":"Yakult Central Institute","ror":"https://ror.org/04gcc2383","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210153337"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Madoka Nakamura","raw_affiliation_strings":["Yakult Central Institute, 5-11 Izumi Kunitachi-shi, Tokyo 186-8650, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yakult Central Institute, 5-11 Izumi Kunitachi-shi, Tokyo 186-8650, Japan","institution_ids":["https://openalex.org/I4210153337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090716904","display_name":"Masaki Serata","orcid":"https://orcid.org/0000-0003-2307-8794","observed_orcids":["https://orcid.org/0000-0003-2307-8794"]},"institutions":[{"id":"https://openalex.org/I4210153337","display_name":"Yakult Central Institute","ror":"https://ror.org/04gcc2383","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210153337"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Serata","raw_affiliation_strings":["Yakult Central Institute, 5-11 Izumi Kunitachi-shi, Tokyo 186-8650, Japan"],"raw_orcid":"https://orcid.org/0000-0003-2307-8794","affiliations":[{"raw_affiliation_string":"Yakult Central Institute, 5-11 Izumi Kunitachi-shi, Tokyo 186-8650, Japan","institution_ids":["https://openalex.org/I4210153337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108642486","display_name":"Takekazu Okumura","orcid":"https://orcid.org/0009-0008-2071-9545","observed_orcids":["https://orcid.org/0009-0008-2071-9545"]},"institutions":[{"id":"https://openalex.org/I4210153337","display_name":"Yakult Central Institute","ror":"https://ror.org/04gcc2383","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210153337"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takekazu Okumura","raw_affiliation_strings":["Yakult Central Institute, 5-11 Izumi Kunitachi-shi, Tokyo 186-8650, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yakult Central Institute, 5-11 Izumi Kunitachi-shi, Tokyo 186-8650, Japan","institution_ids":["https://openalex.org/I4210153337"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210153337"],"apc_list":{"value":2680,"currency":"USD","value_usd":2680},"apc_paid":{"value":2680,"currency":"USD","value_usd":2680},"fwci":1.0511,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.70801666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"9","issue":null,"first_page":"100430","last_page":"100430"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-wall-polysaccharides","display_name":"cell wall polysaccharides","score":0.9120000004768372},{"id":"https://openalex.org/keywords/acid-tolerance","display_name":"acid resistance","score":0.878000020980835},{"id":"https://openalex.org/keywords/surface-potential","display_name":"surface potential","score":0.9549999833106995},{"id":"https://openalex.org/keywords/ionic-stress","display_name":"ionic stress","score":0.7120000123977661},{"id":"https://openalex.org/keywords/cupric-oxide","display_name":"cupric oxide","score":0.6589999794960022},{"id":"https://openalex.org/keywords/hydroxide-ion","display_name":"hydroxide ion","score":0.6420000195503235},{"id":"https://openalex.org/keywords/lactic-acid-bacteria","display_name":"lactic acid bacteria","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.7251155376434326},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.6422742605209351},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.45231691002845764},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39472511410713196},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3647092878818512},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2545773983001709},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16905736923217773},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.08730724453926086}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.crmicr.2025.100430","doi":"https://doi.org/10.1016/j.crmicr.2025.100430","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.crmicr.2025.100430","pdf_url":null,"source":{"id":"https://openalex.org/S4210236417","display_name":"Current Research in Microbial Sciences","issn_l":"2666-5174","issn":["2666-5174"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Research in Microbial Sciences","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.5206670","doi":"https://doi.org/10.2139/ssrn.5206670","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5206670","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:12272108","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12272108/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12272108/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Res Microb Sci","raw_type":"Text"},{"id":"pmid:40686846","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40686846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current research in microbial sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:06b71937b8d04615890467fa6c354498","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/06b71937b8d04615890467fa6c354498","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Research in Microbial Sciences, Vol 9, Iss , Pp 100430- (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.crmicr.2025.100430","doi":"https://doi.org/10.1016/j.crmicr.2025.100430","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.crmicr.2025.100430","pdf_url":null,"source":{"id":"https://openalex.org/S4210236417","display_name":"Current Research in Microbial Sciences","issn_l":"2666-5174","issn":["2666-5174"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Research in Microbial Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327436","display_name":"Yakult Honsha","ror":"https://ror.org/03wmnrc91"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411665679.pdf","grobid_xml":"https://content.openalex.org/works/W4411665679.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W631813388","https://openalex.org/W1830634312","https://openalex.org/W1955950601","https://openalex.org/W1965978316","https://openalex.org/W1972739064","https://openalex.org/W1984936173","https://openalex.org/W1991627727","https://openalex.org/W1996645901","https://openalex.org/W1997834802","https://openalex.org/W2003897459","https://openalex.org/W2008303278","https://openalex.org/W2017532476","https://openalex.org/W2020458316","https://openalex.org/W2038334406","https://openalex.org/W2040011766","https://openalex.org/W2055463902","https://openalex.org/W2067278100","https://openalex.org/W2077718313","https://openalex.org/W2081642445","https://openalex.org/W2085728487","https://openalex.org/W2093569327","https://openalex.org/W2098356192","https://openalex.org/W2100544978","https://openalex.org/W2103949437","https://openalex.org/W2114229205","https://openalex.org/W2120208347","https://openalex.org/W2121960517","https://openalex.org/W2130696295","https://openalex.org/W2133838892","https://openalex.org/W2141676495","https://openalex.org/W2146967501","https://openalex.org/W2155622354","https://openalex.org/W2159779488","https://openalex.org/W2188291479","https://openalex.org/W2246804058","https://openalex.org/W2497247634","https://openalex.org/W2763659886","https://openalex.org/W2765318835","https://openalex.org/W2915939486","https://openalex.org/W2962749783","https://openalex.org/W2968908989","https://openalex.org/W2980872576","https://openalex.org/W2997858194","https://openalex.org/W3134955477","https://openalex.org/W3160769215","https://openalex.org/W4211138637","https://openalex.org/W4247865999","https://openalex.org/W4294585259","https://openalex.org/W4385850825","https://openalex.org/W4400146731","https://openalex.org/W6769422130","https://openalex.org/W6772138035"],"related_works":["https://openalex.org/W4400146731","https://openalex.org/W2141976926","https://openalex.org/W2163292218","https://openalex.org/W2159878771","https://openalex.org/W1481181587","https://openalex.org/W7017833443","https://openalex.org/W4306404090","https://openalex.org/W1979442370","https://openalex.org/W2000447434","https://openalex.org/W2010364609"],"abstract_inverted_index":{"LCPS-1":[0,17,37,74,154],"is":[1],"a":[2,88],"cell":[3,170],"wall":[4],"polysaccharide":[5],"(CWPS)":[6],"of":[7,22,27,104,124,147,160,179,194,202,214,220],"Lacticaseibacillus":[8],"paracasei":[9],"(formerly":[10],"Lactobacillus":[11],"casei":[12],")":[13,82],"strain":[14,67],"Shirota":[15],"(LcS).":[16],"enhances":[18,38],"the":[19,25,105,115,122,142,156,165,169,177,180,192,198,218],"acid":[20],"tolerance":[21,178],"LcS;":[23],"however,":[24],"mechanism":[26],"action":[28],"remains":[29],"unclear.":[30],"This":[31,211],"study":[32],"aimed":[33],"to":[34,102,144,182],"elucidate":[35],"how":[36],"LcS":[39,58,85,109,136,161],"growth":[40,62,113],"and":[41,172,232],"survivability":[42],"under":[43],"acidic":[44],"conditions.":[45],"When":[46],"cultured":[47],"in":[48,97,121,196,229],"media":[49],"acidified":[50],"with":[51,208],"hydrochloric,":[52],"lactic,":[53],"or":[54],"acetic":[55],"acid,":[56],"wild-type":[57,108,135],"showed":[59,110],"significantly":[60,111],"more":[61,112,139,221],"than":[63,114,141],"an":[64],"LCPS-1-deficient":[65],"mutant":[66,116,143],"(":[68,93,117],"p":[69,94,118],"<":[70,95,119],"0.01),":[71],"indicating":[72],"that":[73,103,153],"confers":[75],"enhanced":[76,212],"protection":[77],"against":[78],"proton":[79],"(H":[80],"+":[81],"stress.":[83],"Wild-type":[84],"also":[86],"exhibited":[87],"significant":[89],"73\u201383":[90],"%":[91],"reduction":[92],"0.01)":[96,120],"negative":[98],"surface":[99,157,199],"potential":[100,159,201],"compared":[101],"mutant.":[106],"Additionally,":[107],"presence":[123],"cupric":[125],"oxide,":[126],"which":[127,204],"releases":[128],"bactericidal":[129],"Cu":[130],"2+":[131],"ions.":[132,149,210],"In":[133],"contrast,":[134],"was":[137],"slightly":[138],"susceptible":[140],"lethal":[145],"concentrations":[146],"hydroxide":[148],"These":[150,186],"findings":[151,187],"suggest":[152],"modulates":[155],"electric":[158,200],"cells,":[162],"thereby":[163],"influencing":[164],"interaction":[166],"strength":[167],"between":[168],"walls":[171],"environmental":[173,209],"ions,":[174],"ultimately":[175],"altering":[176],"cells":[181],"ionic":[183],"stress":[184],"factors.":[185],"provide":[188],"crucial":[189],"insights":[190],"into":[191],"role":[193],"CWPSs":[195],"modulating":[197],"microorganisms,":[203],"affects":[205],"microbial":[206],"interactions":[207],"understanding":[213],"CWPS":[215],"function":[216],"enables":[217],"development":[219],"resilient":[222],"probiotic":[223],"strains,":[224],"potentially":[225],"improving":[226],"their":[227],"efficacy":[228],"various":[230],"industrial":[231],"therapeutic":[233],"applications.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2025-06-26T00:00:00"}