{"id":"https://openalex.org/W4411665487","doi":"https://doi.org/10.54905/disssi.v19i43.e8dd2063","title":"Preliminary Standardization and Antifungal Potential of the Ethanol Extract of Emilia praetermissa leaf on Candida albicans and Aspergillus niger","display_name":"Preliminary Standardization and Antifungal Potential of the Ethanol Extract of Emilia praetermissa leaf on Candida albicans and Aspergillus niger","publication_year":2025,"publication_date":"2025-06-25","ids":{"openalex":"https://openalex.org/W4411665487","doi":"https://doi.org/10.54905/disssi.v19i43.e8dd2063"},"language":"en","primary_location":{"id":"doi:10.54905/disssi.v19i43.e8dd2063","doi":"https://doi.org/10.54905/disssi.v19i43.e8dd2063","is_oa":true,"landing_page_url":"https://doi.org/10.54905/disssi.v19i43.e8dd2063","pdf_url":"https://discoveryjournals.org/drugdiscovery/current_issue/2025/v19/n43/e8dd2063.pdf#zoom=125","source":{"id":"https://openalex.org/S4387997631","display_name":"Drug Discovery","issn_l":"2278-540X","issn":["2278-540X","2278-5396"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://discoveryjournals.org/drugdiscovery/current_issue/2025/v19/n43/e8dd2063.pdf#zoom=125","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037686837","display_name":"Lawrence Uchenna Nwankwo","orcid":"https://orcid.org/0000-0003-1612-0114","observed_orcids":["https://orcid.org/0000-0003-1612-0114"]},"institutions":[{"id":"https://openalex.org/I193555791","display_name":"Delta State University","ror":"https://ror.org/04ty8dh37","country_code":"NG","type":"education","lineage":["https://openalex.org/I193555791"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Lawrence U Nwankwo","raw_affiliation_strings":["Department of Pharmacognosy and Traditional Medicine , Faculty of Pharmacy , Delta State Unversity , Abraka , Nigeria; +2348137794601 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy and Traditional Medicine , Faculty of Pharmacy , Delta State Unversity , Abraka , Nigeria; +2348137794601 ,","institution_ids":["https://openalex.org/I193555791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021168652","display_name":"Christiana Orevaoghene Akpo","orcid":"https://orcid.org/0000-0002-0582-6907","observed_orcids":["https://orcid.org/0000-0002-0582-6907"]},"institutions":[{"id":"https://openalex.org/I193555791","display_name":"Delta State University","ror":"https://ror.org/04ty8dh37","country_code":"NG","type":"education","lineage":["https://openalex.org/I193555791"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Christiana O Akpo","raw_affiliation_strings":["Department of Medical Laboratory Science , Faculty of Sciences , Delta State University , Abraka , Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Science , Faculty of Sciences , Delta State University , Abraka , Nigeria","institution_ids":["https://openalex.org/I193555791"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5118641229","display_name":"Uyoyo M Ukpe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193555791","display_name":"Delta State University","ror":"https://ror.org/04ty8dh37","country_code":"NG","type":"education","lineage":["https://openalex.org/I193555791"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Uyoyo M Ukpe","raw_affiliation_strings":["Department of Pharmacognosy and Traditional Medicine , Faculty of Pharmacy , Delta State Unversity , Abraka , Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy and Traditional Medicine , Faculty of Pharmacy , Delta State Unversity , Abraka , Nigeria","institution_ids":["https://openalex.org/I193555791"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I193555791"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"43","first_page":"1","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.8374000191688538,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.8374000191688538,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.15410000085830688,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antifungal-activity","display_name":"antifungal activity","score":0.8379999995231628},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9909999966621399},{"id":"https://openalex.org/keywords/aspergillus-niger","display_name":"Aspergillus niger","score":1.0},{"id":"https://openalex.org/keywords/ethanolic-leaf-extract","display_name":"ethanolic leaf extract","score":0.8769999742507935},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.9350000023841858},{"id":"https://openalex.org/keywords/phytochemical-screening","display_name":"phytochemical screening","score":0.7319999933242798},{"id":"https://openalex.org/keywords/fungal-infection","display_name":"fungal infection","score":0.7210000157356262},{"id":"https://openalex.org/keywords/fluconazole-comparison","display_name":"fluconazole comparison","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C2775960407","wikidata":"https://www.wikidata.org/wiki/Q132014","display_name":"Aspergillus niger","level":2,"score":0.8854244947433472},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.8585795760154724},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.7107657790184021},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5039865374565125},{"id":"https://openalex.org/C2779175654","wikidata":"https://www.wikidata.org/wiki/Q335130","display_name":"Aspergillus","level":2,"score":0.4700329005718231},{"id":"https://openalex.org/C74600772","wikidata":"https://www.wikidata.org/wiki/Q193237","display_name":"Fungicide","level":2,"score":0.4532023072242737},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.44407713413238525},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41997572779655457},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.23248758912086487},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19815748929977417},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.19037672877311707}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.54905/disssi.v19i43.e8dd2063","doi":"https://doi.org/10.54905/disssi.v19i43.e8dd2063","is_oa":true,"landing_page_url":"https://doi.org/10.54905/disssi.v19i43.e8dd2063","pdf_url":"https://discoveryjournals.org/drugdiscovery/current_issue/2025/v19/n43/e8dd2063.pdf#zoom=125","source":{"id":"https://openalex.org/S4387997631","display_name":"Drug Discovery","issn_l":"2278-540X","issn":["2278-540X","2278-5396"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.54905/disssi.v19i43.e8dd2063","doi":"https://doi.org/10.54905/disssi.v19i43.e8dd2063","is_oa":true,"landing_page_url":"https://doi.org/10.54905/disssi.v19i43.e8dd2063","pdf_url":"https://discoveryjournals.org/drugdiscovery/current_issue/2025/v19/n43/e8dd2063.pdf#zoom=125","source":{"id":"https://openalex.org/S4387997631","display_name":"Drug Discovery","issn_l":"2278-540X","issn":["2278-540X","2278-5396"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411665487.pdf","grobid_xml":"https://content.openalex.org/works/W4411665487.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W3012530939"],"related_works":["https://openalex.org/W2957166577","https://openalex.org/W2615430212","https://openalex.org/W1502551948","https://openalex.org/W7009755311","https://openalex.org/W4283700574","https://openalex.org/W7097048190","https://openalex.org/W2188758233","https://openalex.org/W2737414006","https://openalex.org/W4410964598","https://openalex.org/W2489849507"],"abstract_inverted_index":{"Fungal":[0],"infections":[1],"caused":[2],"by":[3],"Candida":[4,54,90,132,137,195],"albicans":[5,55,91,133,196],"and":[6,30,56,70,92,134,149,197],"Aspergillus":[7,57,93,135,167,198],"niger":[8,199],"has":[9],"become":[10],"a":[11,162],"rampant":[12],"global":[13],"health":[14],"challenge,":[15],"particularly":[16],"among":[17],"immunosuppressed":[18],"individuals.Conventional":[19],"antifungal":[20,44,78,95,128,214],"drugs":[21],"are":[22],"available":[23],"with":[24],"setbacks":[25],"such":[26],"as":[27],"drug":[28],"resistance":[29],"adverse":[31],"effects,":[32],"prompting":[33],"the":[34,43,81,104,110,139,150,157,169,186],"need":[35],"for":[36,193],"alternative":[37],"therapies.This":[38],"research":[39],"aims":[40],"to":[41,102],"evaluate":[42],"efficacy":[45],"of":[46,49,80,89,112,122,142,165,172,209],"Ethanol":[47,207],"Extract":[48,208],"Emilia":[50,61,123,210],"praetermissa":[51,124,211],"leaf":[52,63,125,212],"against":[53,86,130,216],"niger.In":[58],"this":[59],"study,":[60],"Praetermissa":[62],"was":[64,73,84,118,144,174,181,200],"extracted":[65],"using":[66,75,97],"cold":[67],"maceration":[68],"technique.Phytochemical":[69],"Physicochemical":[71],"tests":[72,96],"evaluated":[74,85],"standard":[76],"procedures.The":[77],"effect":[79],"plant":[82],"extract":[83,121],"laboratory":[87],"isolates":[88],"niger.Standard":[94],"microdilution":[98],"method":[99,117],"were":[100],"performed":[101],"determine":[103],"minimum":[105],"inhibitory":[106],"concentrations":[107],"(MICs).To":[108],"ascertain":[109],"zones":[111],"inhibition,":[113],"agar":[114],"well":[115],"diffusion":[116],"employed.The":[119],"ethanol":[120],"demonstrated":[126],"significant":[127],"activity":[129,215],"both":[131,194],"niger.For":[136],"albicans,":[138],"highest":[140,180],"zone":[141,164,171],"inhibition":[143,173],"seen":[145],"at":[146,152,175,182],"300":[147,183],"mg/mL":[148,177],"least":[151,170],"18.75":[153,176],"mg/mL.However,":[154],"when":[155],"compared,":[156],"positive":[158],"control":[159,187],"(Fluconazole)":[160,188],"had":[161,189],"higher":[163],"inhibition.For":[166],"niger,":[168],"while":[178],"its":[179],"mg/mL.In":[184],"contrast,":[185],"no":[190],"effect.The":[191],"MIC":[192],"37.5":[201],"mg/mL.This":[202],"study":[203],"therefore,":[204],"suggests":[205],"that":[206],"possesses":[213],"tested":[217],"isolates.":[218]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-10-10T00:00:00"}