{"id":"https://openalex.org/W4411633302","doi":"https://doi.org/10.2139/ssrn.5297235","title":"Baseline Serum Metabolites Predict Fractures in a Subset of Accord Participants Who Were Black","display_name":"Baseline Serum Metabolites Predict Fractures in a Subset of Accord Participants Who Were Black","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4411633302","doi":"https://doi.org/10.2139/ssrn.5297235"},"language":"en","primary_location":{"id":"doi:10.2139/ssrn.5297235","doi":"https://doi.org/10.2139/ssrn.5297235","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5297235","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.5297235","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090276973","display_name":"Carolyn Chlebek","orcid":"https://orcid.org/0000-0003-4782-3912","observed_orcids":["https://orcid.org/0000-0003-4782-3912"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carolyn Chlebek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005645945","display_name":"Valerie Bussberg","orcid":"https://orcid.org/0009-0003-6830-3788","observed_orcids":["https://orcid.org/0009-0003-6830-3788"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valerie Bussberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058081424","display_name":"Niven R. Narain","orcid":"https://orcid.org/0000-0001-6769-1748","observed_orcids":["https://orcid.org/0000-0001-6769-1748"]},"institutions":[{"id":"https://openalex.org/I4405267205","display_name":"BPGbio, Inc. (United States)","ror":"https://ror.org/01npdv581","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niven  R. Narain","raw_affiliation_strings":["BPGbio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BPGbio","institution_ids":["https://openalex.org/I4405267205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008685777","display_name":"Michael A. Kiebish","orcid":"https://orcid.org/0000-0002-5678-0072","observed_orcids":["https://orcid.org/0000-0002-5678-0072"]},"institutions":[{"id":"https://openalex.org/I4405267205","display_name":"BPGbio, Inc. (United States)","ror":"https://ror.org/01npdv581","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael  A. Kiebish","raw_affiliation_strings":["BPGbio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BPGbio","institution_ids":["https://openalex.org/I4405267205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040638450","display_name":"Yu\u2010Hua Tseng","orcid":"https://orcid.org/0000-0003-2053-9559","observed_orcids":["https://orcid.org/0000-0003-2053-9559"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu-Hua Tseng","raw_affiliation_strings":["Harvard University - Harvard Medical School","Harvard University - Harvard Medical School, 25 Shattuck St, Boston, MA 02115, United States","Harvard University - Section on Integrative Physiology and Metabolism"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University - Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard University - Harvard Medical School, 25 Shattuck St, Boston, MA 02115, United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard University - Section on Integrative Physiology and Metabolism","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047044979","display_name":"Clifford james Rosen","orcid":"https://orcid.org/0000-0003-3436-8199","observed_orcids":["https://orcid.org/0000-0003-3436-8199"]},"institutions":[{"id":"https://openalex.org/I1334536514","display_name":"Maine Medical Center","ror":"https://ror.org/03g5f5777","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334536514"]},{"id":"https://openalex.org/I4210102705","display_name":"MaineHealth","ror":"https://ror.org/017xncd55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102705"]},{"id":"https://openalex.org/I4210123774","display_name":"Maine Medical Center","ror":"https://ror.org/034c1gc25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102705","https://openalex.org/I4210123774"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"clifford  J. rosen","raw_affiliation_strings":["MaineHealth - Maine Medical Center","MaineHealth - Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MaineHealth - Maine Medical Center","institution_ids":["https://openalex.org/I1334536514","https://openalex.org/I4210102705","https://openalex.org/I4210123774"]},{"raw_affiliation_string":"MaineHealth - Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, United States","institution_ids":["https://openalex.org/I1334536514","https://openalex.org/I4210102705","https://openalex.org/I4210123774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044204492","display_name":"Matthew D. Lynes","orcid":"https://orcid.org/0000-0003-0746-0854","observed_orcids":["https://orcid.org/0000-0003-0746-0854"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew  D. Lynes","raw_affiliation_strings":["Harvard University - Section on Integrative Physiology and Metabolism"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University - Section on Integrative Physiology and Metabolism","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5044204492"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.953000009059906},{"id":"https://openalex.org/keywords/fracture-risk","display_name":"fracture risk","score":0.8510000109672546},{"id":"https://openalex.org/keywords/serum-metabolites","display_name":"serum metabolites","score":0.9150000214576721},{"id":"https://openalex.org/keywords/metabolomics","display_name":"metabolomics","score":0.7799999713897705},{"id":"https://openalex.org/keywords/black-patients","display_name":"Black patients","score":0.7490000128746033},{"id":"https://openalex.org/keywords/bone-fragility","display_name":"bone fragility","score":0.6499999761581421},{"id":"https://openalex.org/keywords/hippuric-acid","display_name":"hippuric acid","score":0.8809999823570251},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.9980000257492065},{"id":"https://openalex.org/keywords/accord-trial","display_name":"ACCORD trial","score":0.656000018119812},{"id":"https://openalex.org/keywords/fracture-prediction","display_name":"fracture prediction","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C12725497","wikidata":"https://www.wikidata.org/wiki/Q810247","display_name":"Baseline (sea)","level":2,"score":0.7193741798400879},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41550785303115845},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37648770213127136},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3266025483608246},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.32375937700271606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22543108463287354},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.07445451617240906},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2139/ssrn.5297235","doi":"https://doi.org/10.2139/ssrn.5297235","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5297235","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2139/ssrn.5297235","doi":"https://doi.org/10.2139/ssrn.5297235","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5297235","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7163142571","https://openalex.org/W4308138744","https://openalex.org/W4404454150","https://openalex.org/W4367175182","https://openalex.org/W7125435760","https://openalex.org/W4200004260","https://openalex.org/W7096300784","https://openalex.org/W7133565900","https://openalex.org/W4410703094","https://openalex.org/W3046160536"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}