{"id":"https://openalex.org/W4411625331","doi":"https://doi.org/10.18586/msufbd.1706381","title":"Integrated Analysis of the In Vitro Response of Melissa officinalis subsp. officinalis to Copper Oxide Nanoparticles","display_name":"Integrated Analysis of the In Vitro Response of Melissa officinalis subsp. officinalis to Copper Oxide Nanoparticles","publication_year":2025,"publication_date":"2025-06-25","ids":{"openalex":"https://openalex.org/W4411625331","doi":"https://doi.org/10.18586/msufbd.1706381"},"language":"en","primary_location":{"id":"doi:10.18586/msufbd.1706381","doi":"https://doi.org/10.18586/msufbd.1706381","is_oa":true,"landing_page_url":"https://doi.org/10.18586/msufbd.1706381","pdf_url":"https://dergipark.org.tr/en/download/article-file/4902117","source":{"id":"https://openalex.org/S4210195899","display_name":"Mu\u015f Alparslan \u00dcniversitesi Fen Bilimleri Dergisi","issn_l":"2147-7930","issn":["2147-7930","2149-6455"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mu\u015f Alparslan \u00dcniversitesi Fen Bilimleri Dergisi","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://dergipark.org.tr/en/download/article-file/4902117","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007361129","display_name":"Ersan Bekta\u015f","orcid":"https://orcid.org/0000-0001-9030-6908","observed_orcids":["https://orcid.org/0000-0001-9030-6908"]},"institutions":[{"id":"https://openalex.org/I148202161","display_name":"Giresun University","ror":"https://ror.org/05szaq822","country_code":"TR","type":"education","lineage":["https://openalex.org/I148202161"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ersan Bekta\u015f","raw_affiliation_strings":["G\u0130RESUN \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":"https://orcid.org/0000-0001-9030-6908","affiliations":[{"raw_affiliation_string":"G\u0130RESUN \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I148202161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066999328","display_name":"H\u00fcseyin \u015eahin","orcid":"https://orcid.org/0000-0002-6018-1494","observed_orcids":["https://orcid.org/0000-0002-6018-1494"]},"institutions":[{"id":"https://openalex.org/I148202161","display_name":"Giresun University","ror":"https://ror.org/05szaq822","country_code":"TR","type":"education","lineage":["https://openalex.org/I148202161"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"H\u00fcseyin \u015eahin","raw_affiliation_strings":["G\u0130RESUN \u00dcN\u0130VERS\u0130TES\u0130, ESP\u0130YE MESLEK Y\u00dcKSEKOKULU"],"raw_orcid":"https://orcid.org/0000-0002-6018-1494","affiliations":[{"raw_affiliation_string":"G\u0130RESUN \u00dcN\u0130VERS\u0130TES\u0130, ESP\u0130YE MESLEK Y\u00dcKSEKOKULU","institution_ids":["https://openalex.org/I148202161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042064295","display_name":"Halil \u0130brahim G\u00fcler","orcid":"https://orcid.org/0000-0002-7261-6790","observed_orcids":["https://orcid.org/0000-0002-7261-6790"]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Halil \u0130brahim G\u00fcler","raw_affiliation_strings":["KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF SCIENCE"],"raw_orcid":"https://orcid.org/0000-0002-7261-6790","affiliations":[{"raw_affiliation_string":"KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF SCIENCE","institution_ids":["https://openalex.org/I162720556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003413725","display_name":"Kadriye \u0130nan","orcid":"https://orcid.org/0000-0002-5909-588X","observed_orcids":["https://orcid.org/0000-0002-5909-588X"]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Kadriye \u0130nan","raw_affiliation_strings":["KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF SCIENCE"],"raw_orcid":"https://orcid.org/0000-0002-5909-588X","affiliations":[{"raw_affiliation_string":"KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF SCIENCE","institution_ids":["https://openalex.org/I162720556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064538813","display_name":"Kaan Kaltal\u0131o\u011flu","orcid":"https://orcid.org/0000-0002-4995-2657","observed_orcids":["https://orcid.org/0000-0002-4995-2657"]},"institutions":[{"id":"https://openalex.org/I148202161","display_name":"Giresun University","ror":"https://ror.org/05szaq822","country_code":"TR","type":"education","lineage":["https://openalex.org/I148202161"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Kaan Kaltal\u0131o\u011flu","raw_affiliation_strings":["G\u0130RESUN \u00dcN\u0130VERS\u0130TES\u0130, ESP\u0130YE MESLEK Y\u00dcKSEKOKULU"],"raw_orcid":"https://orcid.org/0000-0002-4995-2657","affiliations":[{"raw_affiliation_string":"G\u0130RESUN \u00dcN\u0130VERS\u0130TES\u0130, ESP\u0130YE MESLEK Y\u00dcKSEKOKULU","institution_ids":["https://openalex.org/I148202161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5118623165","display_name":"Nilhan Elif Uzun","orcid":"https://orcid.org/0009-0003-9187-0318","observed_orcids":["https://orcid.org/0009-0003-9187-0318"]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Nilhan Elif Uzun","raw_affiliation_strings":["KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF SCIENCE"],"raw_orcid":"https://orcid.org/0009-0003-9187-0318","affiliations":[{"raw_affiliation_string":"KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF SCIENCE","institution_ids":["https://openalex.org/I162720556"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2125,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.35395215,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"13","issue":"1","first_page":"179","last_page":"191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10014","display_name":"Plant Stress Responses and Tolerance","score":0.07039999961853027,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10240","display_name":"Plant tissue culture and regeneration","score":0.04650000110268593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cuo-nanoparticles","display_name":"copper oxide nanoparticles","score":0.9599999785423279},{"id":"https://openalex.org/keywords/melissa-officinalis","display_name":"lemon balm","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nanoparticle-phytotoxicity","display_name":"nanoparticle phytotoxicity","score":0.7580000162124634},{"id":"https://openalex.org/keywords/secondary-metabolites","display_name":"secondary metabolites","score":0.6520000100135803},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.6759999990463257},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9750000238418579},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9829999804496765},{"id":"https://openalex.org/keywords/essential-oil-composition","display_name":"essential oil composition","score":0.8009999990463257},{"id":"https://openalex.org/keywords/phenylpropanoid-biosynthesis","display_name":"phenylpropanoid biosynthesis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibition","display_name":"acetylcholinesterase inhibition","score":0.921999990940094},{"id":"https://openalex.org/keywords/monoamine-oxidase-inhibition","display_name":"monoamine oxidase inhibition","score":0.699999988079071},{"id":"https://openalex.org/keywords/hiv-1-reverse-transcriptase-inhibition","display_name":"HIV-1 reverse transcriptase inhibition","score":0.9079999923706055},{"id":"https://openalex.org/keywords/rosmarinic-acid","display_name":"rosmarinic acid","score":0.9440000057220459},{"id":"https://openalex.org/keywords/geranial","display_name":"geranial","score":0.6970000267028809},{"id":"https://openalex.org/keywords/neral","display_name":"neral","score":0.8999999761581421},{"id":"https://openalex.org/keywords/abiotic-elicitors","display_name":"abiotic elicitors","score":0.7049999833106995},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C2994321634","wikidata":"https://www.wikidata.org/wiki/Q148396","display_name":"Melissa officinalis","level":2,"score":0.8431214094161987},{"id":"https://openalex.org/C2780886089","wikidata":"https://www.wikidata.org/wiki/Q7079617","display_name":"Officinalis","level":2,"score":0.7956091165542603},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5720082521438599},{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.570225715637207},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5090686678886414},{"id":"https://openalex.org/C2781183027","wikidata":"https://www.wikidata.org/wiki/Q106920642","display_name":"Copper oxide","level":3,"score":0.4348655343055725},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.42104750871658325},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.348722904920578},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.28472864627838135},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2063462734222412},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.20193570852279663},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10509154200553894},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06657302379608154}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18586/msufbd.1706381","doi":"https://doi.org/10.18586/msufbd.1706381","is_oa":true,"landing_page_url":"https://doi.org/10.18586/msufbd.1706381","pdf_url":"https://dergipark.org.tr/en/download/article-file/4902117","source":{"id":"https://openalex.org/S4210195899","display_name":"Mu\u015f Alparslan \u00dcniversitesi Fen Bilimleri Dergisi","issn_l":"2147-7930","issn":["2147-7930","2149-6455"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mu\u015f Alparslan \u00dcniversitesi Fen Bilimleri Dergisi","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18586/msufbd.1706381","doi":"https://doi.org/10.18586/msufbd.1706381","is_oa":true,"landing_page_url":"https://doi.org/10.18586/msufbd.1706381","pdf_url":"https://dergipark.org.tr/en/download/article-file/4902117","source":{"id":"https://openalex.org/S4210195899","display_name":"Mu\u015f Alparslan \u00dcniversitesi Fen Bilimleri Dergisi","issn_l":"2147-7930","issn":["2147-7930","2149-6455"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mu\u015f Alparslan \u00dcniversitesi Fen Bilimleri Dergisi","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G625265594","display_name":"\u00c7e\u015fitli Stres Fakt\u00f6rlerinin in vitro Ko\u015fullarda Yeti\u015ftirilen Melissa officinalis L. Fideleri \u00dczerindeki Fizyolojik, Biyokimyasal ve Molek\u00fcler Etkilerinin Ara\u015ft\u0131r\u0131lmas\u0131","funder_award_id":"121Z818","funder_id":"https://openalex.org/F4320322626","funder_display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu"}],"funders":[{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411625331.pdf","grobid_xml":"https://content.openalex.org/works/W4411625331.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W13907649","https://openalex.org/W34474056","https://openalex.org/W1447095829","https://openalex.org/W1970200789","https://openalex.org/W1971048984","https://openalex.org/W1992544322","https://openalex.org/W2012991711","https://openalex.org/W2040743177","https://openalex.org/W2060199860","https://openalex.org/W2087515552","https://openalex.org/W2101507920","https://openalex.org/W2113523531","https://openalex.org/W2114004260","https://openalex.org/W2148032599","https://openalex.org/W2212687567","https://openalex.org/W2255246778","https://openalex.org/W2261537439","https://openalex.org/W2266236934","https://openalex.org/W2489721378","https://openalex.org/W2559771858","https://openalex.org/W2586196364","https://openalex.org/W2594754422","https://openalex.org/W2609132363","https://openalex.org/W2950380131","https://openalex.org/W3012354102","https://openalex.org/W3198499769","https://openalex.org/W3208190781","https://openalex.org/W4385606038","https://openalex.org/W4385650554","https://openalex.org/W4404761429"],"related_works":["https://openalex.org/W4417288705","https://openalex.org/W7161500982","https://openalex.org/W4321482738","https://openalex.org/W3208190781","https://openalex.org/W4413867603","https://openalex.org/W7143524552","https://openalex.org/W4404459807","https://openalex.org/W4415355041","https://openalex.org/W2757436074","https://openalex.org/W6981410794"],"abstract_inverted_index":{"This":[0],"study":[1],"explores":[2],"the":[3,126,195,201],"in":[4,96,181,199],"vitro":[5],"effects":[6],"of":[7,55,135,161,197,204],"copper":[8],"oxide":[9],"nanoparticles":[10],"(CuO-NPs)":[11],"on":[12],"Melissa":[13,205],"officinalis":[14,17,206],"L.":[15],"subsp.":[16],"(lemon":[18],"balm)":[19],"by":[20],"evaluating":[21],"morphological,":[22],"biochemical,":[23],"and":[24,35,52,58,83,99,108,111,138,154,164,189],"molecular":[25],"responses.":[26],"Seedlings":[27],"were":[28],"treated":[29],"with":[30,92],"CuO-NPs":[31,176,198],"at":[32,88,168],"0.1,":[33],"1.0,":[34],"10.0":[36,70,89,169],"mg/L":[37,71,124],"to":[38],"assess":[39],"growth":[40],"parameters,":[41],"secondary":[42],"metabolite":[43],"production,":[44],"antioxidant":[45,94,190],"activity,":[46],"enzyme":[47],"inhibition,":[48,129],"essential":[49,145],"oil":[50,146],"composition,":[51],"gene":[53],"expression":[54],"PAL,":[56,162],"TAT,":[57,163],"RAS.":[59],"Low":[60],"CuO-NP":[61,149],"concentration":[62],"(0.1":[63],"mg/L)":[64],"significantly":[65],"enhanced":[66,172],"shoot":[67,78],"elongation,":[68],"while":[69,130],"induced":[72],"strong":[73],"root":[74],"proliferation":[75],"but":[76],"inhibited":[77],"growth.":[79],"Total":[80],"phenolic":[81],"(TPC)":[82],"flavonoid":[84],"(TFC)":[85],"contents":[86],"peaked":[87],"mg/L,":[90,170],"correlating":[91],"increased":[93,152],"activity":[95],"CUPRAC,":[97],"DPPH,":[98],"ABTS":[100],"assays.":[101],"HPLC":[102],"analysis":[103,142],"revealed":[104],"elevated":[105],"rosmarinic":[106],"acid":[107,113],"reduced":[109],"caffeic":[110],"p-coumaric":[112],"levels,":[114],"suggesting":[115],"pathway":[116],"redirection.":[117],"Enzyme":[118],"inhibition":[119,134],"assays":[120],"showed":[121],"that":[122],"1.0":[123],"yielded":[125],"strongest":[127],"AChE":[128],"higher":[131],"doses":[132],"improved":[133],"MAO,":[136],"urease,":[137],"HIV-1":[139],"RT.":[140],"GC-MS":[141],"indicated":[143],"altered":[144],"profiles":[147],"under":[148,207],"exposure,":[150],"including":[151],"geranial":[153],"neral":[155],"levels.":[156],"qRT-PCR":[157],"confirmed":[158],"dose-dependent":[159],"upregulation":[160],"RAS":[165],"genes,":[166],"particularly":[167],"supporting":[171],"phenylpropanoid":[173],"biosynthesis.":[174],"Collectively,":[175],"act":[177],"as":[178],"abiotic":[179],"elicitors":[180],"a":[182],"concentration-dependent":[183],"manner,":[184],"promoting":[185],"bioactive":[186],"compound":[187],"production":[188],"potential.":[191],"These":[192],"findings":[193],"highlight":[194],"potential":[196],"improving":[200],"phytochemical":[202],"quality":[203],"controlled":[208],"conditions.":[209]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
