{"id":"https://openalex.org/W4411619459","doi":"https://doi.org/10.1007/s00213-025-06844-5","title":"Antidepressant-like effects of Ashwagandha (Withania Somnifera) on chronic unpredictable mild stress-induced depression in adolescent rats","display_name":"Antidepressant-like effects of Ashwagandha (Withania Somnifera) on chronic unpredictable mild stress-induced depression in adolescent rats","publication_year":2025,"publication_date":"2025-06-25","ids":{"openalex":"https://openalex.org/W4411619459","doi":"https://doi.org/10.1007/s00213-025-06844-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/40560204","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12881086"},"language":"en","primary_location":{"id":"doi:10.1007/s00213-025-06844-5","doi":"https://doi.org/10.1007/s00213-025-06844-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00213-025-06844-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00213-025-06844-5.pdf","source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00213-025-06844-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055072961","display_name":"G\u00fcl \u015eahika G\u00f6kdemir","orcid":"https://orcid.org/0000-0002-8691-1504","observed_orcids":["https://orcid.org/0000-0002-8691-1504"]},"institutions":[{"id":"https://openalex.org/I217764696","display_name":"Mardin Artuklu University","ror":"https://ror.org/0396cd675","country_code":"TR","type":"education","lineage":["https://openalex.org/I217764696"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Gul Sahika Gokdemir","raw_affiliation_strings":["Faculty of Medicine, Department of Physiology, Mardin Artuklu University, Mardin, Turkey. gulsahikagokdemir@artuklu.edu.tr","Faculty of Medicine, Department of Physiology, Mardin Artuklu University, Mardin, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-8691-1504","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Physiology, Mardin Artuklu University, Mardin, Turkey. gulsahikagokdemir@artuklu.edu.tr","institution_ids":["https://openalex.org/I217764696"]},{"raw_affiliation_string":"Faculty of Medicine, Department of Physiology, Mardin Artuklu University, Mardin, Turkey","institution_ids":["https://openalex.org/I217764696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051046633","display_name":"U\u011fur \u015eeker","orcid":"https://orcid.org/0000-0002-1693-6378","observed_orcids":["https://orcid.org/0000-0002-1693-6378"]},"institutions":[{"id":"https://openalex.org/I217764696","display_name":"Mardin Artuklu University","ror":"https://ror.org/0396cd675","country_code":"TR","type":"education","lineage":["https://openalex.org/I217764696"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ugur Seker","raw_affiliation_strings":["Faculty of Medicine, Department of Histology and Embryology, Mardin Artuklu University, Mardin, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-1693-6378","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Histology and Embryology, Mardin Artuklu University, Mardin, Turkey","institution_ids":["https://openalex.org/I217764696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084803797","display_name":"Nazan Baksi","orcid":"https://orcid.org/0000-0002-2758-913X","observed_orcids":["https://orcid.org/0000-0002-2758-913X"]},"institutions":[{"id":"https://openalex.org/I123466251","display_name":"Dicle University","ror":"https://ror.org/0257dtg16","country_code":"TR","type":"education","lineage":["https://openalex.org/I123466251"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Nazan Baksi","raw_affiliation_strings":["Faculty of Veterinary, Department of Laboratory Animals, Dicle University, Diyarbak\u0131r, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-2758-913X","affiliations":[{"raw_affiliation_string":"Faculty of Veterinary, Department of Laboratory Animals, Dicle University, Diyarbak\u0131r, Turkey","institution_ids":["https://openalex.org/I123466251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079892815","display_name":"Mukadder Baylan","orcid":"https://orcid.org/0000-0002-4461-6822","observed_orcids":["https://orcid.org/0000-0002-4461-6822"]},"institutions":[{"id":"https://openalex.org/I123466251","display_name":"Dicle University","ror":"https://ror.org/0257dtg16","country_code":"TR","type":"education","lineage":["https://openalex.org/I123466251"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mukadder Baylan","raw_affiliation_strings":["Faculty of Medicine, Department of Physiology, Dicle University, Diyarbak\u0131r, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Physiology, Dicle University, Diyarbak\u0131r, Turkey","institution_ids":["https://openalex.org/I123466251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041238236","display_name":"Berjan Demirta\u015f","orcid":"https://orcid.org/0000-0002-0371-6376","observed_orcids":["https://orcid.org/0000-0002-0371-6376"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Berjan Demirta\u015f","raw_affiliation_strings":["Vocational School Veterinary Medicine, Plant and Animal Production, Equine and Training Program, Istanbul University-Cerrahpa\u015fa, \u0130stanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-0371-6376","affiliations":[{"raw_affiliation_string":"Vocational School Veterinary Medicine, Plant and Animal Production, Equine and Training Program, Istanbul University-Cerrahpa\u015fa, \u0130stanbul, Turkey","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004448044","display_name":"Mehmet Tahir G\u00f6kdemir","orcid":"https://orcid.org/0000-0002-5546-9653","observed_orcids":["https://orcid.org/0000-0002-5546-9653"]},"institutions":[{"id":"https://openalex.org/I217764696","display_name":"Mardin Artuklu University","ror":"https://ror.org/0396cd675","country_code":"TR","type":"education","lineage":["https://openalex.org/I217764696"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet Tahir Gokdemir","raw_affiliation_strings":["Faculty of Medicine, Emergency Department, Mardin Artuklu University, Mardin, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-5546-9653","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Emergency Department, Mardin Artuklu University, Mardin, Turkey","institution_ids":["https://openalex.org/I217764696"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5055072961"],"corresponding_institution_ids":["https://openalex.org/I217764696"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":10.192,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.98139034,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"243","issue":"1","first_page":"117","last_page":"132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.029400000348687172,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ashwagandha","display_name":"Withania somnifera","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adolescent-depression","display_name":"adolescent depression","score":0.9210000038146973},{"id":"https://openalex.org/keywords/chronic-unpredictable-mild-stress","display_name":"chronic unpredictable mild stress","score":0.9760000109672546},{"id":"https://openalex.org/keywords/antidepressant-effects","display_name":"antidepressant effects","score":0.8529999852180481},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.859000027179718},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8999999761581421},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.8920000195503235},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9589999914169312},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.7429999709129333},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.828000009059906},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9380000233650208},{"id":"https://openalex.org/keywords/sertraline","display_name":"sertraline","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ayurvedic-herbs","display_name":"Ayurvedic herbs","score":0.6700000166893005},{"id":"https://openalex.org/keywords/depression-like-behavior","display_name":"depression-like behavior","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C136569192","wikidata":"https://www.wikidata.org/wiki/Q4880745","display_name":"Behavioural despair test","level":4,"score":0.8156100511550903},{"id":"https://openalex.org/C2780069950","wikidata":"https://www.wikidata.org/wiki/Q852660","display_name":"Withania somnifera","level":3,"score":0.7737196683883667},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.6512298583984375},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.6402416229248047},{"id":"https://openalex.org/C2777669559","wikidata":"https://www.wikidata.org/wiki/Q407617","display_name":"Sertraline","level":4,"score":0.6047824025154114},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.48211240768432617},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4460570812225342},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.41734638810157776},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4062860608100891},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.39959701895713806},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38875967264175415},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.35559722781181335},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33255845308303833},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.31472355127334595},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11388814449310303},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08805632591247559},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.0858483612537384},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020280","descriptor_name":"Sertraline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032341","descriptor_name":"Withania","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00213-025-06844-5","doi":"https://doi.org/10.1007/s00213-025-06844-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00213-025-06844-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00213-025-06844-5.pdf","source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11688734","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12881086","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40560204","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40560204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12881086","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12881086/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology (Berl)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s00213-025-06844-5","doi":"https://doi.org/10.1007/s00213-025-06844-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00213-025-06844-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00213-025-06844-5.pdf","source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411619459.pdf","grobid_xml":"https://content.openalex.org/works/W4411619459.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W15269726","https://openalex.org/W272453977","https://openalex.org/W326147307","https://openalex.org/W1636437150","https://openalex.org/W1662416816","https://openalex.org/W1963967066","https://openalex.org/W1966722662","https://openalex.org/W1972643467","https://openalex.org/W1972746769","https://openalex.org/W1977430165","https://openalex.org/W1978343268","https://openalex.org/W1981874044","https://openalex.org/W1985438873","https://openalex.org/W1993957844","https://openalex.org/W2002991717","https://openalex.org/W2003070777","https://openalex.org/W2003982930","https://openalex.org/W2004331086","https://openalex.org/W2020101444","https://openalex.org/W2020926765","https://openalex.org/W2027917639","https://openalex.org/W2062083110","https://openalex.org/W2064384646","https://openalex.org/W2069192879","https://openalex.org/W2089826164","https://openalex.org/W2093161489","https://openalex.org/W2108569388","https://openalex.org/W2111528871","https://openalex.org/W2125789411","https://openalex.org/W2138681644","https://openalex.org/W2155086247","https://openalex.org/W2159463723","https://openalex.org/W2167041343","https://openalex.org/W2511946169","https://openalex.org/W2552532188","https://openalex.org/W2604652480","https://openalex.org/W2744579607","https://openalex.org/W2796669719","https://openalex.org/W2808140956","https://openalex.org/W2891131877","https://openalex.org/W2910446113","https://openalex.org/W2921902092","https://openalex.org/W3043645303","https://openalex.org/W3048223325","https://openalex.org/W3090857188","https://openalex.org/W3107406382","https://openalex.org/W3180558542","https://openalex.org/W3196311686","https://openalex.org/W4205132401","https://openalex.org/W4224224527","https://openalex.org/W4283071686","https://openalex.org/W4296105000","https://openalex.org/W4360850703","https://openalex.org/W4387514081","https://openalex.org/W4388238778","https://openalex.org/W4389461025","https://openalex.org/W4390116315","https://openalex.org/W4390819543","https://openalex.org/W4392585137","https://openalex.org/W4393375316","https://openalex.org/W4394574979","https://openalex.org/W4395684343","https://openalex.org/W4396772567","https://openalex.org/W4399140177","https://openalex.org/W4399496122","https://openalex.org/W4402664589","https://openalex.org/W4405123892"],"related_works":["https://openalex.org/W4405891000","https://openalex.org/W7164816842","https://openalex.org/W7009329203","https://openalex.org/W4401854168","https://openalex.org/W4391848611","https://openalex.org/W4281835196","https://openalex.org/W3028445523","https://openalex.org/W3127980075","https://openalex.org/W2496349283","https://openalex.org/W3176821386"],"abstract_inverted_index":{"RATIONALE:":[0],"Adolescent":[1],"depression":[2,24,71,108],"is":[3,33,48],"often":[4],"linked":[5],"to":[6,66,90,106],"biological":[7],"changes":[8],"associated":[9],"with":[10,115],"stress.":[11,45],"However,":[12,46],"new":[13],"approaches":[14],"and":[15,21,27,44,75,77,130,141,155,173,175,179,200,202,206,215,234,252],"treatment":[16,221],"strategies":[17],"for":[18,256],"early":[19],"intervention":[20],"prevention":[22],"of":[23,42,70,81,231],"in":[25,39,51,86,109,166,192,210,227,246],"children":[26],"adolescents":[28],"are":[29],"still":[30],"limited.":[31],"Ashwagandha":[32,82,116,220,237,242],"an":[34],"Ayurvedic":[35],"herb":[36],"widely":[37],"used":[38,105],"the":[40,52,68,78,91,100,121,163,167,193,211,229],"management":[41],"anxiety":[43],"there":[47],"no":[49],"information":[50],"current":[53],"literature":[54],"on":[55,59,72,83],"its":[56],"potential":[57,255],"effect":[58,80],"adolescent":[60,87,110,247,258],"depression.":[61,259],"OBJECTIVES:":[62],"This":[63],"study":[64],"aimed":[65],"investigate":[67],"effects":[69,245],"proapoptotic":[73],"proteins":[74,171,198,233],"neuroinflammation":[76],"antidepressant":[79,122],"depression-like":[84],"symptoms":[85],"rats":[88],"exposed":[89],"Chronic":[92],"Unpredictable":[93],"Mild":[94],"Stress":[95],"(CUMS)":[96],"model.":[97],"METHODS:":[98],"In":[99],"study,":[101],"CUMS":[102,212],"model":[103],"was":[104,222],"induce":[107],"rats.":[111],"Rats":[112],"were":[113,133,146,160,189,208,218],"treated":[114],"or":[117],"Sertraline.":[118],"To":[119],"evaluate":[120],"effects,":[123],"behavioral":[124,149],"tests":[125],"as":[126,128,148,181,183],"well":[127,182],"biochemical":[129],"histological":[131],"analyses":[132],"performed.":[134],"Forced":[135],"Swim":[136],"Test":[137,140,145],"(FST),":[138],"Sucrose":[139],"Elevated":[142],"Plus":[143],"Maze":[144],"performed":[147],"tests.":[150],"Brain-derived":[151],"neurotrophic":[152],"factor":[153,158],"(BDNF)":[154],"nerve":[156],"growth":[157],"(NGF)":[159],"measured":[161],"by":[162],"ELISA":[164],"method":[165],"fronto-parietal":[168,194],"cortex.":[169,195],"Proapoptotic":[170,197],"(Bax":[172,199],"Caspase-3)":[174,201],"inflammatory":[176,203],"markers":[177,204],"(TNF-\u03b1":[178,205],"IL-1\u03b2),":[180],"glial":[184],"fibrillary":[185],"acidic":[186],"protein":[187],"(GFAP),":[188],"evaluated":[190],"immunohistochemically":[191],"RESULTS:":[196],"IL-1\u03b2)":[207],"increased":[209],"group.":[213],"BDNF":[214],"GFAP":[216],"levels":[217,230],"decreased.":[219],"more":[223],"effective":[224],"than":[225],"Sertraline":[226],"reducing":[228,249],"these":[232],"markers.":[235],"Additionally,":[236],"prevented":[238],"weight":[239],"loss.":[240],"CONCLUSIONS:":[241],"showed":[243],"antidepressant-like":[244],"rats,":[248],"apoptosis,":[250],"inflammation,":[251],"neuroinflammation,":[253],"suggesting":[254],"treating":[257]},"counts_by_year":[{"year":2026,"cited_by_count":10}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2025-10-10T00:00:00"}
