{"id":"https://openalex.org/W4411590006","doi":"https://doi.org/10.1016/j.redox.2025.103739","title":"Iron-catalyzed oxidative stress compromises cancer promotional effect of BRCA2 haploinsufficiency through mitochondria-targeted ferroptosis","display_name":"Iron-catalyzed oxidative stress compromises cancer promotional effect of BRCA2 haploinsufficiency through mitochondria-targeted ferroptosis","publication_year":2025,"publication_date":"2025-06-24","ids":{"openalex":"https://openalex.org/W4411590006","doi":"https://doi.org/10.1016/j.redox.2025.103739","pmid":"https://pubmed.ncbi.nlm.nih.gov/40609478"},"language":"en","primary_location":{"id":"doi:10.1016/j.redox.2025.103739","doi":"https://doi.org/10.1016/j.redox.2025.103739","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.redox.2025.103739","pdf_url":null,"source":{"id":"https://openalex.org/S2764928002","display_name":"Redox Biology","issn_l":"2213-2317","issn":["2213-2317"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.redox.2025.103739","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103201360","display_name":"Yuki K. Maeda","orcid":"https://orcid.org/0000-0001-6460-029X","observed_orcids":["https://orcid.org/0000-0001-6460-029X","https://orcid.org/0009-0002-8168-8646"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Maeda","raw_affiliation_strings":["Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025125509","display_name":"Yashiro Motooka","orcid":"https://orcid.org/0000-0002-4230-7559","observed_orcids":["https://orcid.org/0000-0002-4230-7559"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yashiro Motooka","raw_affiliation_strings":["Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003321158","display_name":"Shinya Akatsuka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinya Akatsuka","raw_affiliation_strings":["Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102017194","display_name":"Hideaki Tanaka","orcid":"https://orcid.org/0009-0000-0142-0574","observed_orcids":["https://orcid.org/0009-0000-0142-0574"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideaki Tanaka","raw_affiliation_strings":["Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan; Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8560, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan; Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8560, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065319313","display_name":"Tomoji Mashimo","orcid":"https://orcid.org/0000-0001-7543-7301","observed_orcids":["https://orcid.org/0000-0001-7543-7301"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoji Mashimo","raw_affiliation_strings":["Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan; Division of Genome Engineering, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan; Division of Genome Engineering, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069594191","display_name":"Shinya Toyokuni","orcid":"https://orcid.org/0000-0002-5757-1109","observed_orcids":["https://orcid.org/0000-0002-5757-1109"]},"institutions":[{"id":"https://openalex.org/I4390039267","display_name":"Tokai National Higher Education and Research System","ror":"https://ror.org/04d139241","country_code":null,"type":"education","lineage":["https://openalex.org/I4390039267"]},{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shinya Toyokuni","raw_affiliation_strings":["Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan; Center for Low-temperature Plasma Sciences, Nagoya University, Furo-Cho, Chikusa-ku, Nagoya, 464-8603, Japan; Center for Integrated Sciences of Low-temperature Plasma Core Research (iPlasma Core), Tokai National Higher Education and Research System, Furo-Cho, Chikusa-ku, Nagoya, 464-8603, Japan. Electronic address: toyokuni@med.nagoya-u.ac.jp"],"raw_orcid":"https://orcid.org/0000-0002-5757-1109","affiliations":[{"raw_affiliation_string":"Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan; Center for Low-temperature Plasma Sciences, Nagoya University, Furo-Cho, Chikusa-ku, Nagoya, 464-8603, Japan; Center for Integrated Sciences of Low-temperature Plasma Core Research (iPlasma Core), Tokai National Higher Education and Research System, Furo-Cho, Chikusa-ku, Nagoya, 464-8603, Japan. Electronic address: toyokuni@med.nagoya-u.ac.jp","institution_ids":["https://openalex.org/I4390039267","https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5069594191"],"corresponding_institution_ids":["https://openalex.org/I4390039267","https://openalex.org/I60134161"],"apc_list":{"value":4310,"currency":"USD","value_usd":4310},"apc_paid":{"value":4310,"currency":"USD","value_usd":4310},"fwci":3.0377,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.91781163,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"85","issue":null,"first_page":"103739","last_page":"103739"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/fenton-reaction","display_name":"Fenton reaction","score":0.8700000047683716},{"id":"https://openalex.org/keywords/renal-carcinogenesis","display_name":"renal carcinogenesis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/ferric-nitrilotriacetate","display_name":"ferric nitrilotriacetate","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cdkn2a-deletion","display_name":"CDKN2A deletion","score":0.800000011920929},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9079999923706055},{"id":"https://openalex.org/keywords/aldehydes","display_name":"aldehydes","score":0.5210000276565552},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.7400000095367432},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C68838962","wikidata":"https://www.wikidata.org/wiki/Q852654","display_name":"Haploinsufficiency","level":4,"score":0.916344404220581},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8264808058738708},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7109278440475464},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5211098790168762},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.49440646171569824},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4483363926410675},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42205026745796204},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3600918650627136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35533371567726135},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21932119131088257},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.21931612491607666},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20986822247505188},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18065527081489563}],"mesh":[{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024682","descriptor_name":"BRCA2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024682","descriptor_name":"BRCA2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024682","descriptor_name":"BRCA2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024682","descriptor_name":"BRCA2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024682","descriptor_name":"BRCA2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024682","descriptor_name":"BRCA2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024682","descriptor_name":"BRCA2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024682","descriptor_name":"BRCA2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024682","descriptor_name":"BRCA2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024682","descriptor_name":"BRCA2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057895","descriptor_name":"Haploinsufficiency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057895","descriptor_name":"Haploinsufficiency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057895","descriptor_name":"Haploinsufficiency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057895","descriptor_name":"Haploinsufficiency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057895","descriptor_name":"Haploinsufficiency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.redox.2025.103739","doi":"https://doi.org/10.1016/j.redox.2025.103739","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.redox.2025.103739","pdf_url":null,"source":{"id":"https://openalex.org/S2764928002","display_name":"Redox Biology","issn_l":"2213-2317","issn":["2213-2317"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biology","raw_type":"journal-article"},{"id":"pmid:40609478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40609478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox biology","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01152:0007385894","doi":null,"is_oa":true,"landing_page_url":"https://nagoya.repo.nii.ac.jp/records/2014476","pdf_url":"https://nagoya.repo.nii.ac.jp/record/2014476/files/k15783_abstract.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},{"id":"pmh:oai:pubmedcentral.nih.gov:12270739","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12270739","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Redox Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:2065d149d7d64611b46545290b612c8d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2065d149d7d64611b46545290b612c8d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Redox Biology, Vol 85, Iss , Pp 103739- (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.redox.2025.103739","doi":"https://doi.org/10.1016/j.redox.2025.103739","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.redox.2025.103739","pdf_url":null,"source":{"id":"https://openalex.org/S2764928002","display_name":"Redox Biology","issn_l":"2213-2317","issn":["2213-2317"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.5299999713897705,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G162569597","display_name":null,"funder_award_id":"JP19H05462","funder_id":"https://openalex.org/F4320338075","funder_display_name":"Core Research for Evolutional Science and Technology"},{"id":"https://openalex.org/G1668838327","display_name":null,"funder_award_id":"JP19H05462","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G1856896906","display_name":null,"funder_award_id":"JP20H05502","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G338994770","display_name":null,"funder_award_id":"JP16H06276","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G3636497729","display_name":null,"funder_award_id":"JPMJCR19H4","funder_id":"https://openalex.org/F4320338075","funder_display_name":"Core Research for Evolutional Science and Technology"},{"id":"https://openalex.org/G4404939833","display_name":null,"funder_award_id":"Aa210038","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6159120681","display_name":null,"funder_award_id":"JPMJCR19H4","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6582761226","display_name":"Development of \"super-bio-functions\" by plasma-activated biological substances","funder_award_id":"19H05462","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G697504518","display_name":null,"funder_award_id":"#JP16H06276","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7986517618","display_name":null,"funder_award_id":"JP20H05502","funder_id":"https://openalex.org/F4320338075","funder_display_name":"Core Research for Evolutional Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320322916","display_name":"Nagoya University","ror":"https://ror.org/04chrp450"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320338075","display_name":"Core Research for Evolutional Science and Technology","ror":"https://ror.org/00097mb19"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1953252470","https://openalex.org/W1970004294","https://openalex.org/W1970578083","https://openalex.org/W1971608726","https://openalex.org/W1984431444","https://openalex.org/W1984749304","https://openalex.org/W1986075282","https://openalex.org/W1989059483","https://openalex.org/W1990743609","https://openalex.org/W1994978498","https://openalex.org/W1997183854","https://openalex.org/W2021660655","https://openalex.org/W2030093162","https://openalex.org/W2037217405","https://openalex.org/W2054033215","https://openalex.org/W2056109978","https://openalex.org/W2057275651","https://openalex.org/W2061224075","https://openalex.org/W2068700852","https://openalex.org/W2071748490","https://openalex.org/W2077324620","https://openalex.org/W2078319346","https://openalex.org/W2078565981","https://openalex.org/W2081079264","https://openalex.org/W2084208752","https://openalex.org/W2107090468","https://openalex.org/W2108769238","https://openalex.org/W2118394016","https://openalex.org/W2150856927","https://openalex.org/W2163064788","https://openalex.org/W2167279371","https://openalex.org/W2167949525","https://openalex.org/W2346520058","https://openalex.org/W2525382275","https://openalex.org/W2606355783","https://openalex.org/W2621142869","https://openalex.org/W2751603883","https://openalex.org/W2762087180","https://openalex.org/W2893632651","https://openalex.org/W3088889662","https://openalex.org/W3177874667","https://openalex.org/W3190282454","https://openalex.org/W3203244097","https://openalex.org/W3208148345","https://openalex.org/W3208862760","https://openalex.org/W4223894169","https://openalex.org/W4242289937","https://openalex.org/W4281654770","https://openalex.org/W4284889683","https://openalex.org/W4288061550","https://openalex.org/W4390509113","https://openalex.org/W4391289539","https://openalex.org/W4392121736","https://openalex.org/W4394695379","https://openalex.org/W4394727544","https://openalex.org/W4396863952","https://openalex.org/W4402462094","https://openalex.org/W4403836620","https://openalex.org/W4406016540","https://openalex.org/W4407113747","https://openalex.org/W6641114833"],"related_works":["https://openalex.org/W2426440601","https://openalex.org/W2023680161","https://openalex.org/W149178150","https://openalex.org/W2394837403","https://openalex.org/W1977297750","https://openalex.org/W1531251285","https://openalex.org/W1518293118","https://openalex.org/W1965552903","https://openalex.org/W3007611709","https://openalex.org/W2053228778"],"abstract_inverted_index":{"Pathogenic":[0],"variants":[1],"in":[2,66,94,110,128,133,175,218,246],"BRCA2":[3,39,45,67,194,227,247],"are":[4,224],"hereditary":[5],"risks":[6],"for":[7,27,196,213],"various":[8],"cancers,":[9],"including":[10,34],"breast,":[11],"ovary,":[12],"pancreas":[13],"and":[14,36,162,220,228],"prostate.":[15],"Genomic":[16],"instability":[17],"due":[18],"to":[19,48,75,112,152],"insufficient":[20,193],"homologous":[21],"recombination":[22],"is":[23,59,238],"thought":[24],"as":[25],"responsible":[26],"carcinogenesis.":[28],"Reportedly,":[29],"endogenous":[30],"or":[31,148,216],"exogenous":[32],"aldehydes,":[33],"formaldehyde":[35],"acetaldehyde,":[37],"suppress":[38],"function.":[40],"However,":[41],"molecular":[42],"sequences":[43],"how":[44],"insufficiency":[46],"leads":[47],"carcinogenesis":[49,65,74,104,219,245],"remains":[50],"unelucidated.":[51],"To":[52],"assess":[53],"whether":[54],"Fenton":[55],"reaction-based":[56],"oxidative":[57,207,236],"stress":[58,208,237],"a":[60,76,240],"promotional":[61,100],"risk":[62],"factor":[63],"of":[64,83,124,136,143,164,179,244],"haploinsufficiency,":[68],"we":[69],"here":[70],"applied":[71],"iron-induced":[72],"renal":[73,103,125],"newly":[77],"established":[78],"rat":[79],"heterozygous":[80],"mutation":[81],"model":[82],"Brca2":[84],"(mutant,":[85],"T1942Kfs/+;":[86],"MUT).":[87],"Rat":[88],"MUT":[89,129,153,180],"model,":[90],"despite":[91],"significant":[92,131],"increase":[93,132],"spontaneous":[95],"malignant":[96],"tumors,":[97],"showed":[98,154],"no":[99],"effect":[101],"on":[102],"induced":[105],"by":[106,192],"ferric":[107],"nitrilotriacetate":[108],"(Fe-NTA)":[109],"contrast":[111],"our":[113],"previous":[114],"study":[115],"using":[116],"Brca1":[117],"mutant":[118],"rats.":[119],"Array-based":[120],"comparative":[121],"genome":[122],"hybridization":[123],"cell":[126,214],"carcinoma":[127],"revealed":[130],"the":[134,144,176],"frequency":[135],"homozygous":[137],"Cdkn2A":[138],"deletion.":[139],"Whereas":[140],"acute-phase":[141],"analysis":[142],"kidney":[145],"after":[146,181],"single":[147],"1-week":[149],"Fe-NTA":[150,183],"administration":[151],"suppressed":[155],"lipid":[156],"peroxidation,":[157],"consistent":[158],"with":[159,169,188],"ferroptosis-resistance,":[160],"ferroptosis":[161],"regeneration":[163],"tubular":[165],"cells":[166],"were":[167],"coexistent":[168],"higher":[170],"cytoplasmic":[171],"catalytic":[172],"Fe(II)":[173],"levels":[174],"subacute":[177],"phase":[178],"3-week":[182],"administration.":[184],"Mechanistically,":[185],"mitochondrial":[186],"dysfunction":[187],"excess":[189],"iron,":[190],"promoted":[191],"presumably":[195],"maintaining":[197],"DNA":[198],"integrity,":[199],"eventually":[200],"initiated":[201],"ferroptotic":[202],"process.":[203],"In":[204],"conclusion,":[205],"iron-dependent":[206],"plays":[209],"double-edged":[210],"roles":[211],"either":[212],"death":[215],"proliferation":[217],"its":[221],"biological":[222],"consequences":[223],"distinct":[225],"between":[226],"BRCA1":[229],"haploinsufficiency.":[230],"Our":[231],"results":[232],"suggest":[233],"that":[234],"iron-catalyzed":[235],"not":[239],"major":[241],"driving":[242],"force":[243],"pathogenic":[248],"variants.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2}],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2025-10-10T00:00:00"}
