{"id":"https://openalex.org/W4411589739","doi":"https://doi.org/10.1016/j.cpsurg.2025.101845","title":"Analysis of risk factors for perineural invasion and efficacy of adjuvant chemotherapy in patients with intrahepatic cholangiocarcinoma","display_name":"Analysis of risk factors for perineural invasion and efficacy of adjuvant chemotherapy in patients with intrahepatic cholangiocarcinoma","publication_year":2025,"publication_date":"2025-06-24","ids":{"openalex":"https://openalex.org/W4411589739","doi":"https://doi.org/10.1016/j.cpsurg.2025.101845","pmid":"https://pubmed.ncbi.nlm.nih.gov/40812989"},"language":"en","primary_location":{"id":"doi:10.1016/j.cpsurg.2025.101845","doi":"https://doi.org/10.1016/j.cpsurg.2025.101845","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cpsurg.2025.101845","pdf_url":null,"source":{"id":"https://openalex.org/S84847770","display_name":"Current Problems in Surgery","issn_l":"0011-3840","issn":["0011-3840","1535-6337"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Problems in Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.cpsurg.2025.101845","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100350270","display_name":"Qi Li","orcid":"https://orcid.org/0000-0003-2120-2261","observed_orcids":["https://orcid.org/0000-0003-2120-2261","https://orcid.org/0009-0000-8617-4420"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Li","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhenqi Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenqi Tang","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001063666","display_name":"Hengchao Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hengchao Liu","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102001455","display_name":"Xue Feng","orcid":"https://orcid.org/0000-0001-8626-4661","observed_orcids":["https://orcid.org/0000-0001-8626-4661"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Xue","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103120309","display_name":"Yali Cheng","orcid":"https://orcid.org/0000-0002-5202-3533","observed_orcids":["https://orcid.org/0000-0002-5202-3533"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yali Cheng","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chen Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Chen","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101808393","display_name":"Dong Hui Zhang","orcid":"https://orcid.org/0000-0002-1391-6152","observed_orcids":["https://orcid.org/0000-0002-1391-6152"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Zhang","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006924320","display_name":"Zhimin Geng","orcid":"https://orcid.org/0000-0003-2645-9808","observed_orcids":["https://orcid.org/0000-0003-2645-9808"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhimin Geng","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address: gengzhimin@mail.xjtu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0003-2645-9808","affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address: gengzhimin@mail.xjtu.edu.cn","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006924320"],"corresponding_institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"],"apc_list":{"value":2780,"currency":"USD","value_usd":2780},"apc_paid":{"value":2780,"currency":"USD","value_usd":2780},"fwci":0.8732,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.72570326,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"70","issue":null,"first_page":"101845","last_page":"101845"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intrahepatic-cholangiocarcinoma","display_name":"intrahepatic cholangiocarcinoma","score":0.9789999723434448},{"id":"https://openalex.org/keywords/perineural-invasion","display_name":"perineural invasion","score":1.0},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.9509999752044678},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.9810000061988831},{"id":"https://openalex.org/keywords/ca19-9","display_name":"CA19-9","score":0.9129999876022339},{"id":"https://openalex.org/keywords/hepatolithiasis","display_name":"hepatolithiasis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/vascular-invasion","display_name":"vascular invasion","score":0.8199999928474426},{"id":"https://openalex.org/keywords/nodal-stage","display_name":"N stage","score":0.9120000004768372},{"id":"https://openalex.org/keywords/tumor-number","display_name":"tumor number","score":0.6140000224113464},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7170000076293945},{"id":"https://openalex.org/keywords/recurrence-free-survival","display_name":"recurrence-free survival","score":0.9580000042915344},{"id":"https://openalex.org/keywords/curative-resection","display_name":"curative resection","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9637647867202759},{"id":"https://openalex.org/C2777154038","wikidata":"https://www.wikidata.org/wiki/Q7168585","display_name":"Perineural invasion","level":3,"score":0.7610293030738831},{"id":"https://openalex.org/C2909135397","wikidata":"https://www.wikidata.org/wiki/Q124292","display_name":"Intrahepatic Cholangiocarcinoma","level":2,"score":0.7290780544281006},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6003960967063904},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5835297107696533},{"id":"https://openalex.org/C3018227240","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant chemotherapy","level":4,"score":0.5805065035820007},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5573148131370544},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.51856929063797},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.353748619556427},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2826445996761322},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.cpsurg.2025.101845","doi":"https://doi.org/10.1016/j.cpsurg.2025.101845","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cpsurg.2025.101845","pdf_url":null,"source":{"id":"https://openalex.org/S84847770","display_name":"Current Problems in Surgery","issn_l":"0011-3840","issn":["0011-3840","1535-6337"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Problems in Surgery","raw_type":"journal-article"},{"id":"pmid:40812989","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40812989","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current problems in surgery","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:cbb97775f061468e8566743b4c2d2224","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cbb97775f061468e8566743b4c2d2224","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Problems in Surgery, Vol 70, Iss , Pp 101845- (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.cpsurg.2025.101845","doi":"https://doi.org/10.1016/j.cpsurg.2025.101845","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cpsurg.2025.101845","pdf_url":null,"source":{"id":"https://openalex.org/S84847770","display_name":"Current Problems in Surgery","issn_l":"0011-3840","issn":["0011-3840","1535-6337"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Problems in Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W658604617","https://openalex.org/W1532654778","https://openalex.org/W1970145694","https://openalex.org/W2026604057","https://openalex.org/W2026859755","https://openalex.org/W2734695458","https://openalex.org/W2899194342","https://openalex.org/W2924865280","https://openalex.org/W2973596517","https://openalex.org/W3001852452","https://openalex.org/W3001975949","https://openalex.org/W3007119058","https://openalex.org/W3013395753","https://openalex.org/W3112258248","https://openalex.org/W3164186109","https://openalex.org/W4200475175","https://openalex.org/W4226078383","https://openalex.org/W4226256512","https://openalex.org/W4306803151","https://openalex.org/W4308541748","https://openalex.org/W4308883000","https://openalex.org/W4309927438","https://openalex.org/W4321224840","https://openalex.org/W4376630646","https://openalex.org/W4384306047","https://openalex.org/W4385330658","https://openalex.org/W4389453143","https://openalex.org/W4390350166","https://openalex.org/W6714181803","https://openalex.org/W6839365509","https://openalex.org/W6845754854"],"related_works":["https://openalex.org/W2794191114","https://openalex.org/W3024050243","https://openalex.org/W4251003423","https://openalex.org/W1970145694","https://openalex.org/W2012877968","https://openalex.org/W2338866768","https://openalex.org/W2060098092","https://openalex.org/W2094828916","https://openalex.org/W2412926293","https://openalex.org/W4405401105"],"abstract_inverted_index":{"The":[0],"prognostic":[1,105],"significance":[2],"of":[3,51,66],"perineural":[4],"invasion":[5],"(PNI)":[6],"in":[7,53,75,226,242,256],"intrahepatic":[8],"cholangiocarcinoma":[9],"(ICC)":[10],"has":[11],"gained":[12],"increasing":[13],"attention.":[14],"There":[15],"is":[16,232],"still":[17],"controversy":[18],"over":[19],"whether":[20],"PNI":[21,46,59,143,231],"can":[22,251],"be":[23],"used":[24,103],"as":[25,201],"a":[26,76],"basis":[27],"for":[28,45,73,104,115,142,164,192,237],"selecting":[29],"individuals":[30],"who":[31,69,111],"benefit":[32],"from":[33],"adjuvant":[34],"chemotherapy":[35],"(ACT).":[36],"This":[37],"study":[38],"aims":[39],"to":[40,60,121],"identify":[41],"the":[42,49,88,108,254],"risk":[43,140,162,190,235],"factors":[44,141,163,191],"and":[47,91,96,135,157,185,221,240,249],"assess":[48],"impact":[50],"ACT":[52,170,198,213,250],"ICC":[54,74,227,245,257],"patients":[55,68,110,228,243,258],"with":[56,94,197,229,244,259],"or":[57],"without":[58],"guide":[61],"clinical":[62],"decision-making.":[63],"A":[64],"total":[65],"254":[67,109],"underwent":[70,112],"curative-intent":[71,113,247],"resection":[72,114],"high-volume":[77],"medical":[78],"center":[79],"were":[80,119,138,160,188],"retrospectively":[81],"analyzed.":[82],"Survival":[83],"analysis":[84,125,148,210],"was":[85,171],"conducted":[86],"using":[87],"Kaplan-Meier":[89],"method":[90],"log-rank":[92],"test,":[93],"univariate":[95],"multivariate":[97],"Cox":[98],"proportional":[99],"hazards":[100],"regression":[101],"models":[102],"analysis.":[106],"Among":[107],"ICC,":[116],"46":[117],"(17.1%)":[118],"found":[120],"combine":[122],"PNI.":[123,230,260],"Multivariate":[124],"revealed":[126],"that":[127,150,212],"CA":[128],"19-9":[129],"level,":[130,152,181],"hepatolithiasis,":[131,153],"major":[132],"vascular":[133],"invasion,":[134],"N":[136,158,186],"stage":[137,159,187],"independent":[139,161,173,189,203,234],"(":[144,166,176,194,206,218,223],"P":[145,167,177,195,207,219,224],"<0.05).":[146,178,208],"Prognosis":[147],"showed":[149,211],"CA19-9":[151],"tumor":[154,182],"numbers,":[155,183],"PNI,":[156,184],"OS":[165,217,239],"<0.05),":[168,196],"while":[169],"an":[172,202,233],"protective":[174,204],"factor":[175,205,236],"Similarly,":[179],"CA125":[180],"RFS":[193,222,241],"also":[199],"serving":[200],"Subgroup":[209],"effectively":[214],"prolonged":[215],"median":[216],"=0.041)":[220],"=0.007)":[225],"both":[238],"after":[246],"resection,":[248],"significantly":[252],"improve":[253],"prognosis":[255]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}