{"id":"https://openalex.org/W4411585641","doi":"https://doi.org/10.1007/s12265-025-10647-6","title":"The Immediate Cardiovascular and Mitochondrial Response in Ischemic Cardiogenic Shock","display_name":"The Immediate Cardiovascular and Mitochondrial Response in Ischemic Cardiogenic Shock","publication_year":2025,"publication_date":"2025-06-24","ids":{"openalex":"https://openalex.org/W4411585641","doi":"https://doi.org/10.1007/s12265-025-10647-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/40555857"},"language":"en","primary_location":{"id":"doi:10.1007/s12265-025-10647-6","doi":"https://doi.org/10.1007/s12265-025-10647-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12265-025-10647-6","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12265-025-10647-6.pdf","source":{"id":"https://openalex.org/S62013175","display_name":"Journal of Cardiovascular Translational Research","issn_l":"1937-5387","issn":["1937-5387","1937-5395"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Translational Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s12265-025-10647-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5094172928","display_name":"Oskar Kj\u00e6rgaard H\u00f8rsdal","orcid":"https://orcid.org/0000-0003-1009-3768","observed_orcids":["https://orcid.org/0000-0003-1009-3768"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Oskar Kj\u00e6rgaard H\u00f8rsdal","raw_affiliation_strings":["Department of Cardiology, Aarhus University Hospital, Palle Juul Jensens Boulevard 99, 8200, Aarhus N, Denmark. osho@clin.au.dk","Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. osho@clin.au.dk"],"raw_orcid":"https://orcid.org/0000-0003-1009-3768","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Aarhus University Hospital, Palle Juul Jensens Boulevard 99, 8200, Aarhus N, Denmark. osho@clin.au.dk","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. osho@clin.au.dk","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063525017","display_name":"Peter Hartmund Frederiksen","orcid":"https://orcid.org/0000-0003-3712-7980","observed_orcids":["https://orcid.org/0000-0003-3712-7980"]},"institutions":[{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Peter Hartmund Frederiksen","raw_affiliation_strings":["Department of Cardiology, Odense University Hospital, Odense, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-3712-7980","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Odense University Hospital, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036199110","display_name":"Ole Kristian Lerche Helgestad","orcid":"https://orcid.org/0000-0003-3847-8758","observed_orcids":["https://orcid.org/0000-0003-3847-8758"]},"institutions":[{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ole Kristian Lerche Helgestad","raw_affiliation_strings":["Department of Cardiology, Odense University Hospital, Odense, Denmark","Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-3847-8758","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Odense University Hospital, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763"]},{"raw_affiliation_string":"Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033626510","display_name":"Hanne Berg Ravn","orcid":"https://orcid.org/0000-0003-4702-5195","observed_orcids":["https://orcid.org/0000-0003-4702-5195"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Hanne Berg Ravn","raw_affiliation_strings":["Department of Anesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark","Department of Clinical Research, University of Southern Denmark, Odense, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-4702-5195","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763"]},{"raw_affiliation_string":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100668347","display_name":"Jacob Eifer M\u00f8ller","orcid":"https://orcid.org/0000-0003-2873-5845","observed_orcids":["https://orcid.org/0000-0003-2873-5845","https://orcid.org/0000-0001-7147-9328"]},"institutions":[{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jacob Eifer M\u00f8ller","raw_affiliation_strings":["Department of Cardiology, Odense University Hospital, Odense, Denmark","Heart Center, Copenhagen University Hospital, Rigshospitalet, , Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-2873-5845","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Odense University Hospital, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763"]},{"raw_affiliation_string":"Heart Center, Copenhagen University Hospital, Rigshospitalet, , Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025152450","display_name":"Henrik Wiggers","orcid":"https://orcid.org/0000-0002-9753-4142","observed_orcids":["https://orcid.org/0000-0002-9753-4142"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Henrik Wiggers","raw_affiliation_strings":["Department of Cardiology, Aarhus University Hospital, Palle Juul Jensens Boulevard 99, 8200, Aarhus N, Denmark","Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-9753-4142","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Aarhus University Hospital, Palle Juul Jensens Boulevard 99, 8200, Aarhus N, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066472039","display_name":"Roni Ranghoej Nielsen","orcid":"https://orcid.org/0000-0001-9228-3869","observed_orcids":["https://orcid.org/0000-0001-9228-3869"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Roni Rangh\u00f8j Nielsen","raw_affiliation_strings":["Department of Cardiology, Aarhus University Hospital, Palle Juul Jensens Boulevard 99, 8200, Aarhus N, Denmark","Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-9228-3869","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Aarhus University Hospital, Palle Juul Jensens Boulevard 99, 8200, Aarhus N, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035025940","display_name":"Nigopan Gopalasingam","orcid":"https://orcid.org/0009-0006-6363-7406","observed_orcids":["https://orcid.org/0009-0006-6363-7406"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Nigopan Gopalasingam","raw_affiliation_strings":["Department of Cardiology, Aarhus University Hospital, Palle Juul Jensens Boulevard 99, 8200, Aarhus N, Denmark","Department of Cardiology, G\u00f8dstrup Hospital, G\u00f8dstrup, Denmark","Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0009-0006-6363-7406","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Aarhus University Hospital, Palle Juul Jensens Boulevard 99, 8200, Aarhus N, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Department of Cardiology, G\u00f8dstrup Hospital, G\u00f8dstrup, Denmark","institution_ids":[]},{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005296045","display_name":"Kristoffer Berg Hansen","orcid":"https://orcid.org/0000-0002-5110-0656","observed_orcids":["https://orcid.org/0000-0002-5110-0656"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kristoffer Berg-Hansen","raw_affiliation_strings":["Department of Cardiology, Aarhus University Hospital, Palle Juul Jensens Boulevard 99, 8200, Aarhus N, Denmark","Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-5110-0656","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Aarhus University Hospital, Palle Juul Jensens Boulevard 99, 8200, Aarhus N, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5094172928"],"corresponding_institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2802335433"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":0.7227,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.63929478,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"18","issue":"5","first_page":"1204","last_page":"1217"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12082","display_name":"Takotsubo Cardiomyopathy and Associated Phenomena","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiogenic-shock","display_name":"cardiogenic shock","score":0.9480000138282776},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.9700000286102295},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.6460000276565552},{"id":"https://openalex.org/keywords/left-ventricular-contractility","display_name":"left ventricular contractility","score":0.796999990940094},{"id":"https://openalex.org/keywords/diastolic-dysfunction","display_name":"diastolic dysfunction","score":0.8069999814033508},{"id":"https://openalex.org/keywords/coronary-microembolization","display_name":"coronary microembolization","score":0.7440000176429749},{"id":"https://openalex.org/keywords/pig-model","display_name":"porcine model","score":0.8230000138282776},{"id":"https://openalex.org/keywords/forward-flow","display_name":"forward flow","score":0.5709999799728394},{"id":"https://openalex.org/keywords/afterload","display_name":"afterload","score":0.5429999828338623},{"id":"https://openalex.org/keywords/endomyocardial-biopsy","display_name":"endomyocardial biopsy","score":0.7049999833106995},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2776850375","wikidata":"https://www.wikidata.org/wiki/Q2477062","display_name":"Cardiogenic shock","level":3,"score":0.9004409313201904},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6369888782501221},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5829139947891235},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5369510650634766},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.17653292417526245}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D034421","descriptor_name":"Sus scrofa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034421","descriptor_name":"Sus scrofa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034421","descriptor_name":"Sus scrofa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034421","descriptor_name":"Sus scrofa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1007/s12265-025-10647-6","doi":"https://doi.org/10.1007/s12265-025-10647-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12265-025-10647-6","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12265-025-10647-6.pdf","source":{"id":"https://openalex.org/S62013175","display_name":"Journal of Cardiovascular Translational Research","issn_l":"1937-5387","issn":["1937-5387","1937-5395"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Translational Research","raw_type":"journal-article"},{"id":"pmid:40555857","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40555857","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular translational research","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/26986471-7568-49c8-ae98-2834b382554a","doi":null,"is_oa":true,"landing_page_url":"https://pure.au.dk/portal/en/publications/26986471-7568-49c8-ae98-2834b382554a","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"H\u00f8rsdal, O K, Frederiksen, P H, Helgestad, O K L, Ravn, H B, M\u00f8ller, J E, Wiggers, H, Nielsen, R R, Gopalasingam, N & Berg-Hansen, K 2025, 'The Immediate Cardiovascular and Mitochondrial Response in Ischemic Cardiogenic Shock', Journal of Cardiovascular Translational Research, vol. 18, no. 5, pp. 1204-1217. https://doi.org/10.1007/s12265-025-10647-6","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:sdu.dk:openaire/4b888af2-8b39-4dd7-8269-076a297128e3","doi":null,"is_oa":true,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/4b888af2-8b39-4dd7-8269-076a297128e3","pdf_url":"https://findresearcher.sdu.dk/ws/files/299340944/s12265-025-10647-6.pdf","source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"H\u00f8rsdal, O K, Frederiksen, P H, Helgestad, O K L, Ravn, H B, M\u00f8ller, J E, Wiggers, H, Nielsen, R R, Gopalasingam, N & Berg-Hansen, K 2025, 'The Immediate Cardiovascular and Mitochondrial Response in Ischemic Cardiogenic Shock', Journal of Cardiovascular Translational Research, vol. 18, no. 5, pp. 1204-1217. https://doi.org/10.1007/s12265-025-10647-6","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:11437966","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12630187","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12630187/pdf/12265_2025_Article_10647.pdf","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s12265-025-10647-6","doi":"https://doi.org/10.1007/s12265-025-10647-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12265-025-10647-6","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12265-025-10647-6.pdf","source":{"id":"https://openalex.org/S62013175","display_name":"Journal of Cardiovascular Translational Research","issn_l":"1937-5387","issn":["1937-5387","1937-5395"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Translational Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309928","display_name":"Aarhus Universitet","ror":"https://ror.org/01aj84f44"},{"id":"https://openalex.org/F4320321665","display_name":"Aase og Ejnar Danielsens Fond","ror":"https://ror.org/02hcraz70"},{"id":"https://openalex.org/F4320322556","display_name":"Snedkermester Sophus Jacobsen og Hustru Astrid Jacobsens Fond","ror":"https://ror.org/04zsejd80"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411585641.pdf","grobid_xml":"https://content.openalex.org/works/W4411585641.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W118137810","https://openalex.org/W1158823519","https://openalex.org/W1582447064","https://openalex.org/W1777904247","https://openalex.org/W1912539338","https://openalex.org/W1994734582","https://openalex.org/W2011348831","https://openalex.org/W2030273408","https://openalex.org/W2036632357","https://openalex.org/W2040563429","https://openalex.org/W2042200677","https://openalex.org/W2043355876","https://openalex.org/W2046903335","https://openalex.org/W2047024906","https://openalex.org/W2055024395","https://openalex.org/W2058141079","https://openalex.org/W2068849227","https://openalex.org/W2077046566","https://openalex.org/W2078199847","https://openalex.org/W2082258689","https://openalex.org/W2088401784","https://openalex.org/W2088533676","https://openalex.org/W2095944485","https://openalex.org/W2100544483","https://openalex.org/W2107263417","https://openalex.org/W2112636786","https://openalex.org/W2119229486","https://openalex.org/W2122341467","https://openalex.org/W2129122528","https://openalex.org/W2135325091","https://openalex.org/W2137514565","https://openalex.org/W2137625635","https://openalex.org/W2143505819","https://openalex.org/W2148230219","https://openalex.org/W2151802250","https://openalex.org/W2151845379","https://openalex.org/W2166950143","https://openalex.org/W2212071945","https://openalex.org/W2215667781","https://openalex.org/W2248194776","https://openalex.org/W2602406480","https://openalex.org/W2755584350","https://openalex.org/W2792616880","https://openalex.org/W2859620496","https://openalex.org/W2911889151","https://openalex.org/W2930570773","https://openalex.org/W2979032726","https://openalex.org/W3012643941","https://openalex.org/W3214472249","https://openalex.org/W4210468558","https://openalex.org/W4252019796","https://openalex.org/W4375856273","https://openalex.org/W4386153206","https://openalex.org/W4387493315","https://openalex.org/W4392882585","https://openalex.org/W4394062010","https://openalex.org/W4399118229","https://openalex.org/W4399727810","https://openalex.org/W4401875215","https://openalex.org/W4403478884","https://openalex.org/W4406973458","https://openalex.org/W4408395003","https://openalex.org/W4408863865","https://openalex.org/W4409380194","https://openalex.org/W6661321137","https://openalex.org/W6681428421","https://openalex.org/W6833716630"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W3183948672","https://openalex.org/W3173606202","https://openalex.org/W3110381201","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2758277628","https://openalex.org/W2748952813","https://openalex.org/W1531601525"],"abstract_inverted_index":{"The":[0],"acute":[1],"pathophysiological":[2],"changes":[3],"after":[4],"myocardial":[5,20],"ischemia":[6],"complicated":[7],"by":[8],"cardiogenic":[9],"shock":[10],"(CS)":[11],"remain":[12],"poorly":[13],"defined,":[14],"especially":[15],"regarding":[16],"compensatory":[17],"mechanisms":[18],"and":[19,27,71,81,85,100,119,129,139],"mitochondrial":[21,28,120,130,141],"function.":[22],"We":[23],"investigated":[24],"immediate":[25],"cardiovascular":[26],"effects":[29],"in":[30,40,59,143],"a":[31,56],"porcine":[32],"model":[33],"of":[34,50,78,135],"ischemic":[35],"CS.":[36],"CS":[37,124],"was":[38,117,122],"induced":[39],"32":[41],"Danish":[42],"Landrace":[43],"pigs":[44],"(60":[45],"kg)":[46],"via":[47],"repeated":[48],"microembolization":[49],"the":[51,133],"left":[52,72],"coronary":[53,86],"artery":[54,70],"until":[55],"30%":[57],"reduction":[58],"cardiac":[60],"output":[61],"(CO)":[62],"or":[63],"mixed":[64,83],"venous":[65],"saturation.":[66],"Monitoring":[67],"included":[68],"pulmonary":[69],"ventricular":[73],"pressure-volume":[74],"catheters,":[75],"with":[76],"analysis":[77],"endomyocardial":[79],"biopsies":[80],"arterial,":[82],"venous,":[84],"sinus":[87],"blood":[88],"samples.":[89],"CO":[90],"deteriorated":[91],"promptly":[92],"due":[93],"to":[94,113],"decreased":[95],"stroke":[96],"volume.":[97],"Contractility":[98],"declined,":[99],"afterload":[101],"increased,":[102],"causing":[103],"rapid":[104],"ventriculo-arterial":[105],"decoupling.":[106],"Forward":[107],"flow":[108,138],"parameters":[109],"were":[110],"compromised":[111],"prior":[112],"pressure-parameters.":[114],"Diastolic":[115],"function":[116,142],"impaired":[118],"damage":[121],"observed.":[123],"rapidly":[125],"impairs":[126],"LV":[127],"hemodynamic":[128],"function,":[131],"highlighting":[132],"importance":[134],"monitoring":[136],"forward":[137],"targeting":[140],"treatment.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}