{"id":"https://openalex.org/W4411580641","doi":"https://doi.org/10.3390/cancers17132117","title":"Immunosuppressive Tumor Microenvironment of Osteosarcoma","display_name":"Immunosuppressive Tumor Microenvironment of Osteosarcoma","publication_year":2025,"publication_date":"2025-06-24","ids":{"openalex":"https://openalex.org/W4411580641","doi":"https://doi.org/10.3390/cancers17132117","pmid":"https://pubmed.ncbi.nlm.nih.gov/40647416"},"language":"en","primary_location":{"id":"doi:10.3390/cancers17132117","doi":"https://doi.org/10.3390/cancers17132117","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers17132117","pdf_url":"https://www.mdpi.com/2072-6694/17/13/2117/pdf?version=1750765675","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/17/13/2117/pdf?version=1750765675","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009136875","display_name":"Aaron Michael Taylor","orcid":"https://orcid.org/0000-0002-2544-5888","observed_orcids":["https://orcid.org/0000-0002-2544-5888"]},"institutions":[{"id":"https://openalex.org/I4405260184","display_name":"The Jackson Laboratory for Genomic Medicine","ror":"https://ror.org/03cew3973","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Michael Taylor","raw_affiliation_strings":["The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA"],"raw_orcid":"https://orcid.org/0000-0002-2544-5888","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","institution_ids":["https://openalex.org/I4405260184"]},{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA","institution_ids":["https://openalex.org/I4405260184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018158757","display_name":"Jianting Sheng","orcid":"https://orcid.org/0000-0003-3532-3259","observed_orcids":["https://orcid.org/0000-0003-3532-3259"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianting Sheng","raw_affiliation_strings":["Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston, TX 77030, USA"],"raw_orcid":"https://orcid.org/0000-0003-3532-3259","affiliations":[{"raw_affiliation_string":"Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967058","display_name":"Patrick Kwok Shing Ng","orcid":"https://orcid.org/0000-0003-0364-7443","observed_orcids":["https://orcid.org/0000-0003-0364-7443"]},"institutions":[{"id":"https://openalex.org/I4405260184","display_name":"The Jackson Laboratory for Genomic Medicine","ror":"https://ror.org/03cew3973","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Kwok Shing Ng","raw_affiliation_strings":["The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA"],"raw_orcid":"https://orcid.org/0000-0003-0364-7443","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","institution_ids":["https://openalex.org/I4405260184"]},{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA","institution_ids":["https://openalex.org/I4405260184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102911656","display_name":"Jeffrey M. Harder","orcid":"https://orcid.org/0000-0003-3832-3553","observed_orcids":["https://orcid.org/0000-0003-3832-3553"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey M. Harder","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME 04609","The Jackson Laboratory, Bar Harbor, ME 04609, USA"],"raw_orcid":"https://orcid.org/0000-0003-3832-3553","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME 04609","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME 04609, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081505957","display_name":"Parveen Kumar","orcid":"https://orcid.org/0000-0003-2739-273X","observed_orcids":["https://orcid.org/0000-0003-2739-273X"]},"institutions":[{"id":"https://openalex.org/I4405260184","display_name":"The Jackson Laboratory for Genomic Medicine","ror":"https://ror.org/03cew3973","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parveen Kumar","raw_affiliation_strings":["The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","institution_ids":["https://openalex.org/I4405260184"]},{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA","institution_ids":["https://openalex.org/I4405260184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066003058","display_name":"Ju Young Ahn","orcid":"https://orcid.org/0000-0002-0946-4157","observed_orcids":["https://orcid.org/0000-0002-0946-4157"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ju Young Ahn","raw_affiliation_strings":["Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA","Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113129486","display_name":"Yuliang Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuliang Cao","raw_affiliation_strings":["Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108059765","display_name":"Alissa M. Dzis","orcid":"https://orcid.org/0009-0008-5898-5507","observed_orcids":["https://orcid.org/0009-0008-5898-5507"]},"institutions":[{"id":"https://openalex.org/I4405260184","display_name":"The Jackson Laboratory for Genomic Medicine","ror":"https://ror.org/03cew3973","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alissa M. Dzis","raw_affiliation_strings":["The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA"],"raw_orcid":"https://orcid.org/0009-0008-5898-5507","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","institution_ids":["https://openalex.org/I4405260184"]},{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA","institution_ids":["https://openalex.org/I4405260184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027683331","display_name":"Nathaniel Jillette","orcid":"https://orcid.org/0000-0003-3328-4401","observed_orcids":["https://orcid.org/0000-0003-3328-4401"]},"institutions":[{"id":"https://openalex.org/I4405260184","display_name":"The Jackson Laboratory for Genomic Medicine","ror":"https://ror.org/03cew3973","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathaniel L. Jillette","raw_affiliation_strings":["The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA"],"raw_orcid":"https://orcid.org/0000-0003-3328-4401","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","institution_ids":["https://openalex.org/I4405260184"]},{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA","institution_ids":["https://openalex.org/I4405260184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040559928","display_name":"Andrew E. Goodspeed","orcid":"https://orcid.org/0000-0001-7055-7128","observed_orcids":["https://orcid.org/0000-0001-7055-7128"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Goodspeed","raw_affiliation_strings":["University of Colorado Anschutz Medical Campus, Aurora, CO 80045","University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA"],"raw_orcid":"https://orcid.org/0000-0001-7055-7128","affiliations":[{"raw_affiliation_string":"University of Colorado Anschutz Medical Campus, Aurora, CO 80045","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063933814","display_name":"Avery Bodlak","orcid":"https://orcid.org/0000-0001-9207-1532","observed_orcids":["https://orcid.org/0000-0001-9207-1532"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Avery Bodlak","raw_affiliation_strings":["University of Colorado Anschutz Medical Campus, Aurora, CO 80045","University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Anschutz Medical Campus, Aurora, CO 80045","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034665524","display_name":"Qian Wu","orcid":"https://orcid.org/0000-0001-7646-8329","observed_orcids":["https://orcid.org/0000-0001-7646-8329"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qian Wu","raw_affiliation_strings":["University of Connecticut School of Medicine, Farmington, CT 06032","University of Connecticut School of Medicine, Farmington, CT 06032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut School of Medicine, Farmington, CT 06032","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]},{"raw_affiliation_string":"University of Connecticut School of Medicine, Farmington, CT 06032, USA","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028526364","display_name":"Michael S. Isakoff","orcid":"https://orcid.org/0000-0003-4790-9919","observed_orcids":["https://orcid.org/0000-0003-4790-9919"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I4210101648","display_name":"Connecticut Children's Medical Center","ror":"https://ror.org/01a1jjn24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210101648"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael S. Isakoff","raw_affiliation_strings":["Connecticut Children\u2019s Medical Center, Hartford, CT 06106","University of Connecticut School of Medicine, Farmington, CT 06032","Connecticut Children's Medical Center, Hartford, CT 06106, USA","University of Connecticut School of Medicine, Farmington, CT 06032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connecticut Children\u2019s Medical Center, Hartford, CT 06106","institution_ids":["https://openalex.org/I4210101648"]},{"raw_affiliation_string":"University of Connecticut School of Medicine, Farmington, CT 06032","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]},{"raw_affiliation_string":"Connecticut Children's Medical Center, Hartford, CT 06106, USA","institution_ids":["https://openalex.org/I4210101648"]},{"raw_affiliation_string":"University of Connecticut School of Medicine, Farmington, CT 06032, USA","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043408006","display_name":"Joshy George","orcid":"https://orcid.org/0000-0001-8510-8229","observed_orcids":["https://orcid.org/0000-0001-8510-8229"]},"institutions":[{"id":"https://openalex.org/I4405260184","display_name":"The Jackson Laboratory for Genomic Medicine","ror":"https://ror.org/03cew3973","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshy George","raw_affiliation_strings":["The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA"],"raw_orcid":"https://orcid.org/0000-0001-8510-8229","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","institution_ids":["https://openalex.org/I4405260184"]},{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA","institution_ids":["https://openalex.org/I4405260184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126714579","display_name":"Jessica D. S. Grassmann","orcid":"https://orcid.org/0000-0001-9076-452X","observed_orcids":["https://orcid.org/0000-0001-9076-452X"]},"institutions":[{"id":"https://openalex.org/I4405260184","display_name":"The Jackson Laboratory for Genomic Medicine","ror":"https://ror.org/03cew3973","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica D.S. Grassmann","raw_affiliation_strings":["The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA"],"raw_orcid":"https://orcid.org/0000-0001-9076-452X","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","institution_ids":["https://openalex.org/I4405260184"]},{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA","institution_ids":["https://openalex.org/I4405260184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058698907","display_name":"Diane Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260184","display_name":"The Jackson Laboratory for Genomic Medicine","ror":"https://ror.org/03cew3973","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane Luo","raw_affiliation_strings":["The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","institution_ids":["https://openalex.org/I4405260184"]},{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA","institution_ids":["https://openalex.org/I4405260184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064831324","display_name":"William F. Flynn","orcid":"https://orcid.org/0000-0001-6533-0340","observed_orcids":["https://orcid.org/0000-0001-6533-0340"]},"institutions":[{"id":"https://openalex.org/I4405260184","display_name":"The Jackson Laboratory for Genomic Medicine","ror":"https://ror.org/03cew3973","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William F. Flynn","raw_affiliation_strings":["The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA"],"raw_orcid":"https://orcid.org/0000-0001-6533-0340","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","institution_ids":["https://openalex.org/I4405260184"]},{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA","institution_ids":["https://openalex.org/I4405260184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031323586","display_name":"Elise T. Courtois","orcid":"https://orcid.org/0000-0002-8749-2719","observed_orcids":["https://orcid.org/0000-0002-8749-2719"]},"institutions":[{"id":"https://openalex.org/I4405260184","display_name":"The Jackson Laboratory for Genomic Medicine","ror":"https://ror.org/03cew3973","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elise T. Courtois","raw_affiliation_strings":["The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA"],"raw_orcid":"https://orcid.org/0000-0002-8749-2719","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","institution_ids":["https://openalex.org/I4405260184"]},{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA","institution_ids":["https://openalex.org/I4405260184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008270331","display_name":"Paul Robson","orcid":"https://orcid.org/0000-0002-0191-3958","observed_orcids":["https://orcid.org/0000-0002-0191-3958"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I4405260184","display_name":"The Jackson Laboratory for Genomic Medicine","ror":"https://ror.org/03cew3973","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Robson","raw_affiliation_strings":["The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA","University of Connecticut School of Medicine, Farmington, CT 06032, USA"],"raw_orcid":"https://orcid.org/0000-0002-0191-3958","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","institution_ids":["https://openalex.org/I4405260184"]},{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA","institution_ids":["https://openalex.org/I4405260184"]},{"raw_affiliation_string":"University of Connecticut School of Medicine, Farmington, CT 06032, USA","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045599016","display_name":"Masanori Hayashi","orcid":"https://orcid.org/0000-0002-9508-0159","observed_orcids":["https://orcid.org/0000-0002-9508-0159"]},"institutions":[{"id":"https://openalex.org/I4210096275","display_name":"Children's Hospital Colorado","ror":"https://ror.org/00mj9k629","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096275"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masanori Hayashi","raw_affiliation_strings":["Children\u2019s Hospital Colorado, Aurora, CO 80045","University of Colorado Anschutz Medical Campus, Aurora, CO 80045","Children's Hospital Colorado, Aurora, CO 80045, USA","University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA"],"raw_orcid":"https://orcid.org/0000-0002-9508-0159","affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital Colorado, Aurora, CO 80045","institution_ids":["https://openalex.org/I4210096275"]},{"raw_affiliation_string":"University of Colorado Anschutz Medical Campus, Aurora, CO 80045","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Children's Hospital Colorado, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I4210096275"]},{"raw_affiliation_string":"University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033101703","display_name":"Alini Trujillo-Paolillo","orcid":"https://orcid.org/0000-0001-6609-196X","observed_orcids":["https://orcid.org/0000-0001-6609-196X"]},"institutions":[{"id":"https://openalex.org/I4210094761","display_name":"Support group for adolescents and children with cancer","ror":"https://ror.org/007492963","country_code":"BR","type":"nonprofit","lineage":["https://openalex.org/I4210094761"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Alini Trujillo Paolillo","raw_affiliation_strings":["Hospital do GRAACC, S\u00e3o Paulo, Brazil","Hospital do GRAACC, S\u00e3o Paulo 04039-001, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital do GRAACC, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210094761"]},{"raw_affiliation_string":"Hospital do GRAACC, S\u00e3o Paulo 04039-001, Brazil","institution_ids":["https://openalex.org/I4210094761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071344353","display_name":"Ant\u00f4nio S\u00e9rgio Petrilli","orcid":"https://orcid.org/0000-0002-5392-0535","observed_orcids":["https://orcid.org/0000-0002-5392-0535"]},"institutions":[{"id":"https://openalex.org/I4210094761","display_name":"Support group for adolescents and children with cancer","ror":"https://ror.org/007492963","country_code":"BR","type":"nonprofit","lineage":["https://openalex.org/I4210094761"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Antonio Sergio Petrilli","raw_affiliation_strings":["Hospital do GRAACC, S\u00e3o Paulo 04039-001, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital do GRAACC, S\u00e3o Paulo 04039-001, Brazil","institution_ids":["https://openalex.org/I4210094761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078590679","display_name":"S\u00edlvia Regina Caminada de Toledo","orcid":"https://orcid.org/0000-0001-7808-3393","observed_orcids":["https://orcid.org/0000-0001-7808-3393"]},"institutions":[{"id":"https://openalex.org/I4210094761","display_name":"Support group for adolescents and children with cancer","ror":"https://ror.org/007492963","country_code":"BR","type":"nonprofit","lineage":["https://openalex.org/I4210094761"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Silvia Regina Caminada de Toledo","raw_affiliation_strings":["Hospital do GRAACC, S\u00e3o Paulo, Brazil","Hospital do GRAACC, S\u00e3o Paulo 04039-001, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-7808-3393","affiliations":[{"raw_affiliation_string":"Hospital do GRAACC, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210094761"]},{"raw_affiliation_string":"Hospital do GRAACC, S\u00e3o Paulo 04039-001, Brazil","institution_ids":["https://openalex.org/I4210094761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058235375","display_name":"Fabiola Balarezo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302163369","display_name":"Hartford Hospital","ror":"https://ror.org/00gt5xe03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302163369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabiola Sara Balarezo","raw_affiliation_strings":["Hartford Hospital, Hartford, CT 06106","Hartford Hospital, Hartford, CT 06106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hartford Hospital, Hartford, CT 06106","institution_ids":["https://openalex.org/I1302163369"]},{"raw_affiliation_string":"Hartford Hospital, Hartford, CT 06106, USA","institution_ids":["https://openalex.org/I1302163369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046277397","display_name":"Adam D. Lindsay","orcid":"https://orcid.org/0000-0002-4188-9681","observed_orcids":["https://orcid.org/0000-0002-4188-9681"]},"institutions":[{"id":"https://openalex.org/I1302163369","display_name":"Hartford Hospital","ror":"https://ror.org/00gt5xe03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302163369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam D. Lindsay","raw_affiliation_strings":["Hartford Hospital, Hartford, CT 06106","Hartford Hospital, Hartford, CT 06106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hartford Hospital, Hartford, CT 06106","institution_ids":["https://openalex.org/I1302163369"]},{"raw_affiliation_string":"Hartford Hospital, Hartford, CT 06106, USA","institution_ids":["https://openalex.org/I1302163369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077636119","display_name":"Bang H. Hoang","orcid":"https://orcid.org/0000-0002-2950-3221","observed_orcids":["https://orcid.org/0000-0002-2950-3221"]},"institutions":[{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bang Hoang","raw_affiliation_strings":["Montefiore Medical Center, Bronx, NY 10467","Montefiore Medical Center, Bronx, NY 10467, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montefiore Medical Center, Bronx, NY 10467","institution_ids":["https://openalex.org/I1335289525"]},{"raw_affiliation_string":"Montefiore Medical Center, Bronx, NY 10467, USA","institution_ids":["https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109196697","display_name":"Stephen T. C. Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen T.C. Wong","raw_affiliation_strings":["Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA","Departments of Radiology, Neuroscience, Pathology and Laboratory Medicine, Weill Cornell Medicine, Cornell University, New York, NY 14853, USA","Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Departments of Radiology, Neuroscience, Pathology and Laboratory Medicine, Weill Cornell Medicine, Cornell University, New York, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056977708","display_name":"Ching C. Lau","orcid":"https://orcid.org/0000-0001-9173-8366","observed_orcids":["https://orcid.org/0000-0001-9173-8366"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I4210101648","display_name":"Connecticut Children's Medical Center","ror":"https://ror.org/01a1jjn24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210101648"]},{"id":"https://openalex.org/I4405260184","display_name":"The Jackson Laboratory for Genomic Medicine","ror":"https://ror.org/03cew3973","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ching C. Lau","raw_affiliation_strings":["Connecticut Children\u2019s Medical Center, Hartford, CT 06106","The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","University of Connecticut School of Medicine, Farmington, CT 06032","Connecticut Children's Medical Center, Hartford, CT 06106, USA","The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA","University of Connecticut School of Medicine, Farmington, CT 06032, USA"],"raw_orcid":"https://orcid.org/0000-0001-9173-8366","affiliations":[{"raw_affiliation_string":"Connecticut Children\u2019s Medical Center, Hartford, CT 06106","institution_ids":["https://openalex.org/I4210101648"]},{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032","institution_ids":["https://openalex.org/I4405260184"]},{"raw_affiliation_string":"University of Connecticut School of Medicine, Farmington, CT 06032","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]},{"raw_affiliation_string":"Connecticut Children's Medical Center, Hartford, CT 06106, USA","institution_ids":["https://openalex.org/I4210101648"]},{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA","institution_ids":["https://openalex.org/I4405260184"]},{"raw_affiliation_string":"University of Connecticut School of Medicine, Farmington, CT 06032, USA","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5056977708"],"corresponding_institution_ids":["https://openalex.org/I140172145","https://openalex.org/I4210101648","https://openalex.org/I4405260184","https://openalex.org/I75929689"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":16.6079,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.995023,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"17","issue":"13","first_page":"2117","last_page":"2117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.01940000057220459,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":1.0},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.9290000200271606},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.9940000176429749},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/exhausted-t-cells","display_name":"exhausted T cells","score":0.9350000023841858},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.890999972820282},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.8130000233650208},{"id":"https://openalex.org/keywords/tumor-subtypes","display_name":"tumor subtypes","score":0.7319999933242798},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.7860000133514404},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.8295053839683533},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5680727958679199},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5652621984481812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45080748200416565},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.16427385807037354}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/cancers17132117","doi":"https://doi.org/10.3390/cancers17132117","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers17132117","pdf_url":"https://www.mdpi.com/2072-6694/17/13/2117/pdf?version=1750765675","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"doi:10.1101/2023.11.01.565008","doi":"https://doi.org/10.1101/2023.11.01.565008","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.11.01.565008","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/11/16/2023.11.01.565008.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40647416","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40647416","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12248827","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12248827","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmh:oai:mouseion.jax.org:stfb2025-1182","doi":null,"is_oa":true,"landing_page_url":"https://mouseion.jax.org/stfb2025/167","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 2025","raw_type":"text"}],"best_oa_location":{"id":"doi:10.3390/cancers17132117","doi":"https://doi.org/10.3390/cancers17132117","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers17132117","pdf_url":"https://www.mdpi.com/2072-6694/17/13/2117/pdf?version=1750765675","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6399999856948853,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1594814656","display_name":null,"funder_award_id":"RRID:SCR_022035","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G1837006622","display_name":"Spatiotemporal modeling of cancer-niche interactions in breast cancer bone metastasis","funder_award_id":"5u01ca253553-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G278894908","display_name":null,"funder_award_id":"P30CA034196","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2887688917","display_name":null,"funder_award_id":"P30 CA034196","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G3354087803","display_name":null,"funder_award_id":"P30CA06934","funder_id":"https://openalex.org/F4320333552","funder_display_name":"Cancer Center, University of Colorado"},{"id":"https://openalex.org/G3639620097","display_name":null,"funder_award_id":"19/18670-9","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G3839749366","display_name":null,"funder_award_id":"RRID:SCR_021984","funder_id":"https://openalex.org/F4320333552","funder_display_name":"Cancer Center, University of Colorado"},{"id":"https://openalex.org/G3843118034","display_name":null,"funder_award_id":"P30CA06934","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G403823770","display_name":null,"funder_award_id":"19/18670\u20139","funder_id":"https://openalex.org/F4320333552","funder_display_name":"Cancer Center, University of Colorado"},{"id":"https://openalex.org/G4727746083","display_name":null,"funder_award_id":"RRID:SCR_021984","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G639685034","display_name":null,"funder_award_id":"P30 CA06934","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6651787567","display_name":null,"funder_award_id":"RRID:SCR_021984","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G685945406","display_name":null,"funder_award_id":"U01CA253553","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G736768240","display_name":null,"funder_award_id":"RRID:SCR_022035","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7502412314","display_name":null,"funder_award_id":"RRID:SCR_022035","funder_id":"https://openalex.org/F4320333552","funder_display_name":"Cancer Center, University of Colorado"},{"id":"https://openalex.org/G7703821767","display_name":null,"funder_award_id":"P30 CA034196","funder_id":"https://openalex.org/F4320333552","funder_display_name":"Cancer Center, University of Colorado"},{"id":"https://openalex.org/G7847733079","display_name":"Cancer Center Support (CORE) Grant","funder_award_id":"2p30ca034196-24","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8230790880","display_name":null,"funder_award_id":"U01CA253553","funder_id":"https://openalex.org/F4320333552","funder_display_name":"Cancer Center, University of Colorado"},{"id":"https://openalex.org/G8834754978","display_name":null,"funder_award_id":"19/18670\u20139","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000110418","display_name":null,"funder_award_id":"P30 CA-034196","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000113943","display_name":null,"funder_award_id":"CA 034196","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000255858","display_name":null,"funder_award_id":"U01CA253553","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309422","display_name":"John S. Dunn Foundation","ror":"https://ror.org/03yhprz62"},{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333552","display_name":"Cancer Center, University of Colorado","ror":"https://ror.org/04cqn7d42"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411580641.pdf","grobid_xml":"https://content.openalex.org/works/W4411580641.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W1273150541","https://openalex.org/W1543079591","https://openalex.org/W1608544625","https://openalex.org/W1747617663","https://openalex.org/W1969847452","https://openalex.org/W1973315860","https://openalex.org/W1987731276","https://openalex.org/W2010256904","https://openalex.org/W2011817173","https://openalex.org/W2033896256","https://openalex.org/W2036177160","https://openalex.org/W2055957949","https://openalex.org/W2063680739","https://openalex.org/W2070602352","https://openalex.org/W2072671183","https://openalex.org/W2097501009","https://openalex.org/W2110305039","https://openalex.org/W2121121339","https://openalex.org/W2130389688","https://openalex.org/W2130746209","https://openalex.org/W2135627750","https://openalex.org/W2137460766","https://openalex.org/W2140795153","https://openalex.org/W2150586369","https://openalex.org/W2166275934","https://openalex.org/W2167083183","https://openalex.org/W2302088846","https://openalex.org/W2324349273","https://openalex.org/W2488076079","https://openalex.org/W2491306389","https://openalex.org/W2568514472","https://openalex.org/W2578418759","https://openalex.org/W2582393724","https://openalex.org/W2751044391","https://openalex.org/W2762797139","https://openalex.org/W2765217312","https://openalex.org/W2768492030","https://openalex.org/W2783070348","https://openalex.org/W2791483720","https://openalex.org/W2801309958","https://openalex.org/W2883126472","https://openalex.org/W2897249806","https://openalex.org/W2921168633","https://openalex.org/W2944434638","https://openalex.org/W2949177718","https://openalex.org/W2951506174","https://openalex.org/W2952391626","https://openalex.org/W2953151710","https://openalex.org/W2954317599","https://openalex.org/W2980809851","https://openalex.org/W2984472267","https://openalex.org/W3007604420","https://openalex.org/W3014412460","https://openalex.org/W3014913757","https://openalex.org/W3017202750","https://openalex.org/W3023823988","https://openalex.org/W3110998212","https://openalex.org/W3126902084","https://openalex.org/W3128411524","https://openalex.org/W3129476455","https://openalex.org/W3157087909","https://openalex.org/W3163107279","https://openalex.org/W3164692211","https://openalex.org/W3164752908","https://openalex.org/W3180778035","https://openalex.org/W3193248358","https://openalex.org/W3202812053","https://openalex.org/W3209344343","https://openalex.org/W3217429854","https://openalex.org/W4200156483","https://openalex.org/W4220721336","https://openalex.org/W4220862436","https://openalex.org/W4226148881","https://openalex.org/W4240405582","https://openalex.org/W4281290502","https://openalex.org/W4281933908","https://openalex.org/W4286293734","https://openalex.org/W4286489005","https://openalex.org/W4286497648","https://openalex.org/W4297220316","https://openalex.org/W4304014325","https://openalex.org/W4307634455","https://openalex.org/W4313308037","https://openalex.org/W4313437324","https://openalex.org/W4313487922","https://openalex.org/W4321445485","https://openalex.org/W4322503534","https://openalex.org/W4322701952","https://openalex.org/W4388686951","https://openalex.org/W4396749239","https://openalex.org/W4396946088","https://openalex.org/W4399868663","https://openalex.org/W4401728872","https://openalex.org/W6636155457","https://openalex.org/W6664367076","https://openalex.org/W6777726183"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W2950308704"],"abstract_inverted_index":{"Abstract":[0],"Osteosarcoma":[1,154],"is":[2,182],"the":[3,47,54],"most":[4],"common":[5],"malignant":[6],"bone":[7],"tumor":[8,66,145],"in":[9,20],"children,":[10],"characterized":[11],"by":[12],"a":[13,71,148],"high":[14],"degree":[15],"of":[16,57,74,87,152,166,183],"genomic":[17,24],"instability,":[18],"resulting":[19],"copy-number":[21],"alterations":[22],"and":[23,90,105,108,122,129,140,147],"rearrangements":[25],"without":[26],"disease-defining":[27],"recurrent":[28],"mutations.":[29],"Clinical":[30],"trials":[31],"based":[32],"on":[33,64],"molecular":[34],"characterization":[35],"have":[36],"failed":[37],"to":[38,91,126,164],"find":[39],"new":[40],"effective":[41],"therapies":[42],"or":[43],"improve":[44],"outcomes":[45],"over":[46],"last":[48],"40":[49],"years.":[50],"To":[51],"better":[52],"understand":[53],"immune":[55],"microenvironment":[56],"osteosarcoma,":[58],"we":[59,116],"performed":[60],"single-cell":[61],"RNA":[62],"sequencing":[63],"six":[65,75],"biopsy":[67],"samples,":[68],"combined":[69],"with":[70,174],"previously-published":[72],"cohort":[73],"samples.":[76],"Additional":[77],"osteosarcoma":[78,141,195],"samples":[79],"were":[80],"profiled":[81],"using":[82],"spatial":[83,93],"transcriptomics":[84],"for":[85,160,169],"validation":[86],"discovered":[88],"subtypes":[89],"add":[92],"context.":[94],"Analysis":[95],"revealed":[96],"immunosuppressive":[97,131,192],"cells,":[98,124],"including":[99,172,180],"myeloid-derived":[100],"suppressor":[101],"cells":[102,142],"(MDSCs),":[103],"regulatory":[104,138],"exhausted":[106],"T-cells,":[107],"LAMP3+":[109],"dendritic":[110],"cells.":[111],"Using":[112],"cell-cell":[113],"communication":[114],"modeling,":[115],"identified":[117],"robust":[118],"interactions":[119,136],"between":[120],"MDSCs":[121],"other":[123],"leading":[125],"NF-\u03baB":[127],"upregulation":[128],"an":[130],"microenvironment,":[132],"as":[133,135],"well":[134],"involving":[137],"T-cells":[139],"that":[143,196],"promoted":[144],"progression":[146],"proangiogenic":[149],"niche.":[150],"Statement":[151],"Significance":[153],"patient":[155],"survival":[156],"has":[157],"remained":[158],"stagnant":[159],"several":[161,190],"decades":[162],"due":[163],"lack":[165],"successful":[167],"therapy":[168],"high-risk":[170],"patients,":[171],"those":[173],"metastatic":[175],"disease.":[176],"Identifying":[177],"novel":[178],"therapeutics":[179],"immunotherapies":[181],"great":[184],"clinical":[185],"importance.":[186],"Our":[187],"study":[188],"highlights":[189],"important":[191],"mechanisms":[193],"within":[194],"should":[197],"be":[198],"considered":[199],"when":[200],"developing":[201],"future":[202],"immunotherapies.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":22},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
