{"id":"https://openalex.org/W4411577360","doi":"https://doi.org/10.7554/elife.106826","title":"Midbrain somatostatin-expressing cells control pain-suppression during defensive states","display_name":"Midbrain somatostatin-expressing cells control pain-suppression during defensive states","publication_year":2025,"publication_date":"2025-06-24","ids":{"openalex":"https://openalex.org/W4411577360","doi":"https://doi.org/10.7554/elife.106826","pmid":"https://pubmed.ncbi.nlm.nih.gov/43004867","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13750795"},"language":"en","primary_location":{"id":"doi:10.7554/elife.106826","doi":"https://doi.org/10.7554/elife.106826","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.106826","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.106826","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087598716","display_name":"N\u00e2nci Winke","orcid":"https://orcid.org/0009-0008-7756-0379","observed_orcids":["https://orcid.org/0009-0008-7756-0379"]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210125684","display_name":"Neurocentre Magendie","ror":"https://ror.org/02xx07v13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210125684"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nanci Winke","raw_affiliation_strings":["INSERM, Neurocentre Magendie","Univ. Bordeaux, Neurocentre Magendie","INSERM, Neurocentre Magendie, U1215","Univ. Bordeaux, Neurocentre Magendie, U1215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, Neurocentre Magendie","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210125684"]},{"raw_affiliation_string":"Univ. Bordeaux, Neurocentre Magendie","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I4210125684"]},{"raw_affiliation_string":"INSERM, Neurocentre Magendie, U1215","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210125684"]},{"raw_affiliation_string":"Univ. Bordeaux, Neurocentre Magendie, U1215","institution_ids":["https://openalex.org/I4210125684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029187004","display_name":"Franck Aby","orcid":"https://orcid.org/0000-0003-1594-8163","observed_orcids":["https://orcid.org/0000-0003-1594-8163"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210087077","display_name":"Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives","ror":"https://ror.org/001695n52","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4210087077","https://openalex.org/I4210096427"]},{"id":"https://openalex.org/I4210133144","display_name":"Institut Interdisciplinaire de Neuroscience","ror":"https://ror.org/032j53342","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210133144"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Frank Aby","raw_affiliation_strings":["Univ. Bordeaux, CNRS, Institute for Neurodegenerative Diseases","Interdisciplinary Institute for Neuroscience (IINS, CNRS UMR 5297), University of Bordeaux"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Bordeaux, CNRS, Institute for Neurodegenerative Diseases","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210087077"]},{"raw_affiliation_string":"Interdisciplinary Institute for Neuroscience (IINS, CNRS UMR 5297), University of Bordeaux","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210133144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015767542","display_name":"Daniel Jercog","orcid":"https://orcid.org/0000-0003-3849-9196","observed_orcids":["https://orcid.org/0000-0003-3849-9196"]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210125684","display_name":"Neurocentre Magendie","ror":"https://ror.org/02xx07v13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210125684"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Daniel Jercog","raw_affiliation_strings":["INSERM, Neurocentre Magendie","Univ. Bordeaux, Neurocentre Magendie","INSERM, Neurocentre Magendie, U1215","Univ. Bordeaux, Neurocentre Magendie, U1215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, Neurocentre Magendie","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210125684"]},{"raw_affiliation_string":"Univ. Bordeaux, Neurocentre Magendie","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I4210125684"]},{"raw_affiliation_string":"INSERM, Neurocentre Magendie, U1215","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210125684"]},{"raw_affiliation_string":"Univ. Bordeaux, Neurocentre Magendie, U1215","institution_ids":["https://openalex.org/I4210125684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115861770","display_name":"Coline Riffault","orcid":"https://orcid.org/0009-0005-1580-3265","observed_orcids":["https://orcid.org/0009-0005-1580-3265"]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210125684","display_name":"Neurocentre Magendie","ror":"https://ror.org/02xx07v13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210125684"]},{"id":"https://openalex.org/I4210156675","display_name":"Centre Hospitalier Charles Perrens","ror":"https://ror.org/04q33ey84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210156675"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Coline Riffault","raw_affiliation_strings":["INSERM, Neurocentre Magendie","Univ. Bordeaux, Neurocentre Magendie","Centre de R\u00e9f\u00e9rence R\u00e9gional des Pathologies Anxieuses et de la D\u00e9pression, P\u00f4le de Psychiatrie G\u00e9n\u00e9rale et Universitaire, Centre Hospitalier Charles Perrens","INSERM, Neurocentre Magendie, U1215","Univ. Bordeaux, Neurocentre Magendie, U1215"],"raw_orcid":"https://orcid.org/0009-0005-1580-3265","affiliations":[{"raw_affiliation_string":"INSERM, Neurocentre Magendie","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210125684"]},{"raw_affiliation_string":"Univ. Bordeaux, Neurocentre Magendie","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I4210125684"]},{"raw_affiliation_string":"Centre de R\u00e9f\u00e9rence R\u00e9gional des Pathologies Anxieuses et de la D\u00e9pression, P\u00f4le de Psychiatrie G\u00e9n\u00e9rale et Universitaire, Centre Hospitalier Charles Perrens","institution_ids":["https://openalex.org/I4210156675"]},{"raw_affiliation_string":"INSERM, Neurocentre Magendie, U1215","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210125684"]},{"raw_affiliation_string":"Univ. Bordeaux, Neurocentre Magendie, U1215","institution_ids":["https://openalex.org/I4210125684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069609048","display_name":"Rabia Bouali\u2010Benazzouz","orcid":"https://orcid.org/0000-0002-1519-7833","observed_orcids":["https://orcid.org/0000-0002-1519-7833"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210087077","display_name":"Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives","ror":"https://ror.org/001695n52","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4210087077","https://openalex.org/I4210096427"]},{"id":"https://openalex.org/I4210125684","display_name":"Neurocentre Magendie","ror":"https://ror.org/02xx07v13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210125684"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Rabia Bouali-Benazzouz","raw_affiliation_strings":["Univ. Bordeaux, CNRS, Institute for Neurodegenerative Diseases","INSERM, Neurocentre Magendie, U1215","Univ. Bordeaux, Neurocentre Magendie, U1215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Bordeaux, CNRS, Institute for Neurodegenerative Diseases","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210087077"]},{"raw_affiliation_string":"INSERM, Neurocentre Magendie, U1215","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210125684"]},{"raw_affiliation_string":"Univ. Bordeaux, Neurocentre Magendie, U1215","institution_ids":["https://openalex.org/I4210125684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013266964","display_name":"Juliette Viellard","orcid":"https://orcid.org/0000-0002-8416-7048","observed_orcids":["https://orcid.org/0000-0002-8416-7048"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210087077","display_name":"Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives","ror":"https://ror.org/001695n52","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4210087077","https://openalex.org/I4210096427"]},{"id":"https://openalex.org/I4210125684","display_name":"Neurocentre Magendie","ror":"https://ror.org/02xx07v13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210125684"]},{"id":"https://openalex.org/I4210133144","display_name":"Institut Interdisciplinaire de Neuroscience","ror":"https://ror.org/032j53342","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210133144"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Juliette Viellard","raw_affiliation_strings":["INSERM, Neurocentre Magendie","Univ. Bordeaux, CNRS, Institute for Neurodegenerative Diseases","Univ. Bordeaux, Neurocentre Magendie","Interdisciplinary Institute for Neuroscience (IINS, CNRS UMR 5297), University of Bordeaux"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, Neurocentre Magendie","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210125684"]},{"raw_affiliation_string":"Univ. Bordeaux, CNRS, Institute for Neurodegenerative Diseases","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210087077"]},{"raw_affiliation_string":"Univ. Bordeaux, Neurocentre Magendie","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I4210125684"]},{"raw_affiliation_string":"Interdisciplinary Institute for Neuroscience (IINS, CNRS UMR 5297), University of Bordeaux","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210133144"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Delphine Girard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210125684","display_name":"Neurocentre Magendie","ror":"https://ror.org/02xx07v13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210125684"]},{"id":"https://openalex.org/I4210133144","display_name":"Institut Interdisciplinaire de Neuroscience","ror":"https://ror.org/032j53342","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210133144"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Delphine Girard","raw_affiliation_strings":["INSERM, Neurocentre Magendie","Univ. Bordeaux, Neurocentre Magendie","INSERM, Neurocentre Magendie, U1215","Interdisciplinary Institute for Neuroscience (IINS, CNRS UMR 5297), University of Bordeaux"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, Neurocentre Magendie","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210125684"]},{"raw_affiliation_string":"Univ. Bordeaux, Neurocentre Magendie","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I4210125684"]},{"raw_affiliation_string":"INSERM, Neurocentre Magendie, U1215","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210125684"]},{"raw_affiliation_string":"Interdisciplinary Institute for Neuroscience (IINS, CNRS UMR 5297), University of Bordeaux","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210133144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047201355","display_name":"Zo\u00e9 Grivet","orcid":"https://orcid.org/0000-0001-9101-1212","observed_orcids":["https://orcid.org/0000-0001-9101-1212"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210087077","display_name":"Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives","ror":"https://ror.org/001695n52","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4210087077","https://openalex.org/I4210096427"]},{"id":"https://openalex.org/I4210125684","display_name":"Neurocentre Magendie","ror":"https://ror.org/02xx07v13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210125684"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Zoe Grivet","raw_affiliation_strings":["Univ. Bordeaux, CNRS, Institute for Neurodegenerative Diseases","INSERM, Neurocentre Magendie, U1215","Univ. Bordeaux, Neurocentre Magendie, U1215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Bordeaux, CNRS, Institute for Neurodegenerative Diseases","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210087077"]},{"raw_affiliation_string":"INSERM, Neurocentre Magendie, U1215","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210125684"]},{"raw_affiliation_string":"Univ. Bordeaux, Neurocentre Magendie, U1215","institution_ids":["https://openalex.org/I4210125684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043880888","display_name":"Marc Landry","orcid":"https://orcid.org/0000-0003-3936-324X","observed_orcids":["https://orcid.org/0000-0003-3936-324X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210087077","display_name":"Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives","ror":"https://ror.org/001695n52","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4210087077","https://openalex.org/I4210096427"]},{"id":"https://openalex.org/I4210133144","display_name":"Institut Interdisciplinaire de Neuroscience","ror":"https://ror.org/032j53342","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210133144"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marc Landry","raw_affiliation_strings":["Univ. Bordeaux, CNRS, Institute for Neurodegenerative Diseases","Interdisciplinary Institute for Neuroscience (IINS, CNRS UMR 5297), University of Bordeaux"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Bordeaux, CNRS, Institute for Neurodegenerative Diseases","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210087077"]},{"raw_affiliation_string":"Interdisciplinary Institute for Neuroscience (IINS, CNRS UMR 5297), University of Bordeaux","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210133144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054481859","display_name":"Laia Castell","orcid":"https://orcid.org/0000-0001-8755-9795","observed_orcids":["https://orcid.org/0000-0001-8755-9795"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210133144","display_name":"Institut Interdisciplinaire de Neuroscience","ror":"https://ror.org/032j53342","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210133144"]},{"id":"https://openalex.org/I4210156758","display_name":"Institut de G\u00e9nomique Fonctionnelle","ror":"https://ror.org/043wmc583","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210156758"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laia Castell","raw_affiliation_strings":["Universit\u00e9 de Montpellier, Institut de g\u00e9nomique fonctionnelle (IGF), CNRS","Interdisciplinary Institute for Neuroscience (IINS, CNRS UMR 5297), University of Bordeaux"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Montpellier, Institut de g\u00e9nomique fonctionnelle (IGF), CNRS","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210156758"]},{"raw_affiliation_string":"Interdisciplinary Institute for Neuroscience (IINS, CNRS UMR 5297), University of Bordeaux","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210133144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080375606","display_name":"Emmanuel Valjent","orcid":"https://orcid.org/0000-0002-1034-606X","observed_orcids":["https://orcid.org/0000-0002-1034-606X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210134790","display_name":"Institute for Neurosciences of Montpellier","ror":"https://ror.org/0428ctr80","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210134790"]},{"id":"https://openalex.org/I4210156758","display_name":"Institut de G\u00e9nomique Fonctionnelle","ror":"https://ror.org/043wmc583","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210156758"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emmanuel Valjent","raw_affiliation_strings":["INM, Univ. Montpellier, Inserm","Universit\u00e9 de Montpellier, Institut de g\u00e9nomique fonctionnelle (IGF), CNRS","Universit\u00e9 de Montpellier, Institut de g\u00e9nomique fonctionnelle (IGF), CNRS, Inserm"],"raw_orcid":"https://orcid.org/0000-0002-1034-606X","affiliations":[{"raw_affiliation_string":"INM, Univ. Montpellier, Inserm","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210134790"]},{"raw_affiliation_string":"Universit\u00e9 de Montpellier, Institut de g\u00e9nomique fonctionnelle (IGF), CNRS","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210156758"]},{"raw_affiliation_string":"Universit\u00e9 de Montpellier, Institut de g\u00e9nomique fonctionnelle (IGF), CNRS, Inserm","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210156758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032781033","display_name":"St\u00e9phane Val\u00e9rio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210125684","display_name":"Neurocentre Magendie","ror":"https://ror.org/02xx07v13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210125684"]},{"id":"https://openalex.org/I4210156758","display_name":"Institut de G\u00e9nomique Fonctionnelle","ror":"https://ror.org/043wmc583","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210156758"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Stephane Valerio","raw_affiliation_strings":["INSERM, Neurocentre Magendie","Univ. Bordeaux, Neurocentre Magendie","Universit\u00e9 de Montpellier, Institut de g\u00e9nomique fonctionnelle (IGF), CNRS, Inserm"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, Neurocentre Magendie","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210125684"]},{"raw_affiliation_string":"Univ. Bordeaux, Neurocentre Magendie","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I4210125684"]},{"raw_affiliation_string":"Universit\u00e9 de Montpellier, Institut de g\u00e9nomique fonctionnelle (IGF), CNRS, Inserm","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210156758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077668926","display_name":"Pascal Fossat","orcid":"https://orcid.org/0000-0001-5117-0817","observed_orcids":["https://orcid.org/0000-0001-5117-0817"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210087077","display_name":"Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives","ror":"https://ror.org/001695n52","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4210087077","https://openalex.org/I4210096427"]},{"id":"https://openalex.org/I4210125684","display_name":"Neurocentre Magendie","ror":"https://ror.org/02xx07v13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210125684"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Pascal Fossat","raw_affiliation_strings":["Univ. Bordeaux, CNRS, Institute for Neurodegenerative Diseases","INSERM, Neurocentre Magendie, U1215","Univ. Bordeaux, Neurocentre Magendie, U1215"],"raw_orcid":"https://orcid.org/0000-0001-5117-0817","affiliations":[{"raw_affiliation_string":"Univ. Bordeaux, CNRS, Institute for Neurodegenerative Diseases","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210087077"]},{"raw_affiliation_string":"INSERM, Neurocentre Magendie, U1215","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210125684"]},{"raw_affiliation_string":"Univ. Bordeaux, Neurocentre Magendie, U1215","institution_ids":["https://openalex.org/I4210125684"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025599568","display_name":"Cyril Herry","orcid":"https://orcid.org/0000-0003-2973-0843","observed_orcids":["https://orcid.org/0000-0003-2973-0843"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210125684","display_name":"Neurocentre Magendie","ror":"https://ror.org/02xx07v13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210125684"]},{"id":"https://openalex.org/I4210133144","display_name":"Institut Interdisciplinaire de Neuroscience","ror":"https://ror.org/032j53342","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210133144"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Cyril Herry","raw_affiliation_strings":["INSERM, Neurocentre Magendie","Univ. Bordeaux, Neurocentre Magendie","Interdisciplinary Institute for Neuroscience (IINS, CNRS UMR 5297), University of Bordeaux"],"raw_orcid":"https://orcid.org/0000-0003-2973-0843","affiliations":[{"raw_affiliation_string":"INSERM, Neurocentre Magendie","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210125684"]},{"raw_affiliation_string":"Univ. Bordeaux, Neurocentre Magendie","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I4210125684"]},{"raw_affiliation_string":"Interdisciplinary Institute for Neuroscience (IINS, CNRS UMR 5297), University of Bordeaux","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210133144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5025599568","https://openalex.org/A5032781033","https://openalex.org/A5077668926"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210087077","https://openalex.org/I4210125684","https://openalex.org/I4210133144","https://openalex.org/I4210156758"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatostatin-neurons","display_name":"somatostatin neurons","score":0.8539999723434448},{"id":"https://openalex.org/keywords/ventrolateral-periaqueductal-gray","display_name":"ventrolateral periaqueductal gray","score":0.9700000286102295},{"id":"https://openalex.org/keywords/pain-inhibition","display_name":"pain inhibition","score":0.7080000042915344},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.8920000195503235},{"id":"https://openalex.org/keywords/defensive-behavior","display_name":"defensive behavior","score":0.7590000033378601},{"id":"https://openalex.org/keywords/fear","display_name":"fear","score":0.8999999761581421},{"id":"https://openalex.org/keywords/rostral-ventromedial-medulla","display_name":"rostral ventromedial medulla","score":0.9900000095367432},{"id":"https://openalex.org/keywords/long-range-projections","display_name":"long-range projections","score":0.5649999976158142},{"id":"https://openalex.org/keywords/optogenetic-manipulation","display_name":"optogenetic manipulation","score":0.640999972820282},{"id":"https://openalex.org/keywords/midbrain","display_name":"midbrain","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.8357031345367432},{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.7769812345504761},{"id":"https://openalex.org/C2991742891","wikidata":"https://www.wikidata.org/wiki/Q621261","display_name":"Pain control","level":2,"score":0.4996919631958008},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4914499521255493},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.44300898909568787},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3749035596847534},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.36147743463516235},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33619481325149536},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1882471740245819},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.1721528172492981},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.08976727724075317},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.08745327591896057}],"mesh":[{"descriptor_ui":"D000698","descriptor_name":"Analgesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005239","descriptor_name":"Fear","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010487","descriptor_name":"Periaqueductal Gray","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062308","descriptor_name":"Optogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.7554/elife.106826","doi":"https://doi.org/10.7554/elife.106826","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.106826","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"pmid:43004867","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43004867","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13750795","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13750795/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:2f07fe3c490048148a2a91c9dcba019f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2f07fe3c490048148a2a91c9dcba019f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 14 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7554/elife.106826","doi":"https://doi.org/10.7554/elife.106826","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.106826","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1547865271","https://openalex.org/W1738778520","https://openalex.org/W1979514882","https://openalex.org/W1980691164","https://openalex.org/W1981291046","https://openalex.org/W1991890303","https://openalex.org/W2001457444","https://openalex.org/W2006191998","https://openalex.org/W2027642651","https://openalex.org/W2030751218","https://openalex.org/W2033438673","https://openalex.org/W2039641259","https://openalex.org/W2044687772","https://openalex.org/W2047764118","https://openalex.org/W2054977744","https://openalex.org/W2062573581","https://openalex.org/W2062700118","https://openalex.org/W2064020250","https://openalex.org/W2066769755","https://openalex.org/W2069977347","https://openalex.org/W2079660727","https://openalex.org/W2090408408","https://openalex.org/W2091061257","https://openalex.org/W2098848290","https://openalex.org/W2104023610","https://openalex.org/W2114770633","https://openalex.org/W2125079193","https://openalex.org/W2127373397","https://openalex.org/W2138512124","https://openalex.org/W2140201388","https://openalex.org/W2167049110","https://openalex.org/W2168056696","https://openalex.org/W2283570944","https://openalex.org/W2415217866","https://openalex.org/W2596658472","https://openalex.org/W2642147666","https://openalex.org/W3003505716","https://openalex.org/W3021212401","https://openalex.org/W4288050281","https://openalex.org/W4313371689","https://openalex.org/W4315642092","https://openalex.org/W4387693917","https://openalex.org/W4406120486","https://openalex.org/W7221529924"],"related_works":["https://openalex.org/W4294630159","https://openalex.org/W4315642092","https://openalex.org/W4306776006","https://openalex.org/W4413785690","https://openalex.org/W2498842583","https://openalex.org/W2061995343","https://openalex.org/W4413847266","https://openalex.org/W1963803770","https://openalex.org/W7161631527","https://openalex.org/W4406616619"],"abstract_inverted_index":{"In":[0,120],"threatening":[1],"situations,":[2],"animals":[3],"exhibit":[4],"a":[5,15,64,149],"broad":[6],"range":[7],"of":[8,22,58,66,80,96,108,116,124,154],"behavioral":[9],"and":[10,35,40,70],"autonomic":[11],"responses.":[12],"As":[13],"such,":[14],"crucial":[16],"adaptive":[17],"response":[18],"is":[19,47],"the":[20,33,50,55,78,84,94,133,139,162],"inhibition":[21,107],"pain,":[23],"which":[24],"facilitates":[25],"relevant":[26],"defensive":[27,100,118,169],"behaviors":[28,42],"that":[29,105,130,164],"promote":[30],"survival.":[31],"Whereas":[32],"structures":[34],"mechanisms":[36,53],"involved":[37],"in":[38,75,83,93],"fear":[39,143],"pain":[41],"are":[43],"well":[44],"documented,":[45],"little":[46],"known":[48],"about":[49],"precise":[51],"neuronal":[52],"mediating":[54],"emotional":[56],"regulation":[57],"endogenous":[59],"pain-suppression.":[60],"Here,":[61],"we":[62],"used":[63],"combination":[65],"behavioral,":[67],"anatomical,":[68],"optogenetic,":[69],"electrophysiological":[71],"approaches":[72],"to":[73,132,161],"investigate,":[74],"male":[76],"mice,":[77],"role":[79],"somatostatin-expressing":[81],"cells":[82,112,129,159],"ventrolateral":[85],"periaqueductal":[86],"gray":[87],"matter":[88],"(SST":[89],"+":[90,110,127,157],"vlPAG":[91,111,128,158],"cells)":[92],"control":[95],"analgesia":[97,114,140,166],"induced":[98],"during":[99,168],"states.":[101,170],"Our":[102],"data":[103],"indicate":[104],"optogenetic":[106,122],"SST":[109,126,156],"promotes":[113],"irrespective":[115],"animal":[117],"state.":[119],"contrast,":[121],"activation":[123],"long-range":[125,155],"project":[131],"rostral":[134],"ventromedial":[135],"medulla":[136],"(RVM)":[137],"abolishes":[138],"mediated":[141],"by":[142],"behavior.":[144],"Together,":[145],"these":[146],"results":[147],"identify":[148],"novel":[150],"circuit":[151],"mechanism":[152],"composed":[153],"projecting":[160],"RVM":[163],"regulate":[165],"elicited":[167]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2025-10-10T00:00:00"}
