{"id":"https://openalex.org/W4411575823","doi":"https://doi.org/10.3390/plants14131933","title":"Synthesis of Epoxyoxirenes: Phytotoxic Activity and Enzymatic Target Identification","display_name":"Synthesis of Epoxyoxirenes: Phytotoxic Activity and Enzymatic Target Identification","publication_year":2025,"publication_date":"2025-06-24","ids":{"openalex":"https://openalex.org/W4411575823","doi":"https://doi.org/10.3390/plants14131933","pmid":"https://pubmed.ncbi.nlm.nih.gov/40647942"},"language":"en","primary_location":{"id":"doi:10.3390/plants14131933","doi":"https://doi.org/10.3390/plants14131933","is_oa":true,"landing_page_url":"https://doi.org/10.3390/plants14131933","pdf_url":"https://www.mdpi.com/2223-7747/14/13/1933/pdf?version=1750728368","source":{"id":"https://openalex.org/S4210230202","display_name":"Plants","issn_l":"2223-7747","issn":["2223-7747"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plants","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2223-7747/14/13/1933/pdf?version=1750728368","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5118605148","display_name":"Kamylla C. F. de Faria","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146165071","display_name":"Universidade Federal de Vi\u00e7osa","ror":"https://ror.org/0409dgb37","country_code":"BR","type":"education","lineage":["https://openalex.org/I146165071"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Kamylla C. F. de Faria","raw_affiliation_strings":["Department of Chemistry, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil","institution_ids":["https://openalex.org/I146165071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042155882","display_name":"Elson S. Alvarenga","orcid":"https://orcid.org/0000-0002-7333-0006","observed_orcids":["https://orcid.org/0000-0002-7333-0006"]},"institutions":[{"id":"https://openalex.org/I146165071","display_name":"Universidade Federal de Vi\u00e7osa","ror":"https://ror.org/0409dgb37","country_code":"BR","type":"education","lineage":["https://openalex.org/I146165071"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Elson S. Alvarenga","raw_affiliation_strings":["Department of Chemistry, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-7333-0006","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil","institution_ids":["https://openalex.org/I146165071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039696075","display_name":"Denilson Ferreira de Oliveira","orcid":"https://orcid.org/0000-0001-9326-8716","observed_orcids":["https://orcid.org/0000-0001-9326-8716"]},"institutions":[{"id":"https://openalex.org/I1315085146","display_name":"Universidade Federal de Lavras","ror":"https://ror.org/0122bmm03","country_code":"BR","type":"education","lineage":["https://openalex.org/I1315085146"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Denilson F. Oliveira","raw_affiliation_strings":["Department of Chemistry, Universidade Federal de Lavras, Lavras 37203-202, MG, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-9326-8716","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Universidade Federal de Lavras, Lavras 37203-202, MG, Brazil","institution_ids":["https://openalex.org/I1315085146"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084965933","display_name":"V. Ba\u012da","orcid":"https://orcid.org/0000-0002-6820-1250","observed_orcids":["https://orcid.org/0000-0002-6820-1250"]},"institutions":[{"id":"https://openalex.org/I146165071","display_name":"Universidade Federal de Vi\u00e7osa","ror":"https://ror.org/0409dgb37","country_code":"BR","type":"education","lineage":["https://openalex.org/I146165071"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vitor C. Baia","raw_affiliation_strings":["Department of Chemistry, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-6820-1250","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil","institution_ids":["https://openalex.org/I146165071"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054235259","display_name":"Armin Franz Isenmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136482","display_name":"Federal Center for Technological Education of Minas Gerais","ror":"https://ror.org/04ch49185","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210136482"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Armin F. Isenmann","raw_affiliation_strings":["Department of Metallurgy and Chemistry, Centro Federal de Educa\u00e7\u00e3o Tecnol\u00f3gica de Minas Gerais, Timoteo 35180-008, MG, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metallurgy and Chemistry, Centro Federal de Educa\u00e7\u00e3o Tecnol\u00f3gica de Minas Gerais, Timoteo 35180-008, MG, Brazil","institution_ids":["https://openalex.org/I4210136482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5042155882"],"corresponding_institution_ids":["https://openalex.org/I146165071"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1158574,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"13","first_page":"1933","last_page":"1933"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10774","display_name":"Weed Control and Herbicide Applications","score":0.8798999786376953,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10774","display_name":"Weed Control and Herbicide Applications","score":0.8798999786376953,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.02290000021457672,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herbicide-development","display_name":"herbicide development","score":0.7089999914169312},{"id":"https://openalex.org/keywords/phytotoxicity","display_name":"phytotoxicity","score":0.9700000286102295},{"id":"https://openalex.org/keywords/target-protein-identification","display_name":"protein target identification","score":0.7680000066757202},{"id":"https://openalex.org/keywords/diels-alder-reaction","display_name":"Diels-Alder reaction","score":0.8659999966621399},{"id":"https://openalex.org/keywords/maleic-anhydride","display_name":"maleic anhydride","score":0.8190000057220459},{"id":"https://openalex.org/keywords/furan","display_name":"furan","score":0.9039999842643738},{"id":"https://openalex.org/keywords/epoxides","display_name":"epoxides","score":0.6100000143051147},{"id":"https://openalex.org/keywords/seedling-growth-inhibition","display_name":"seedling growth inhibition","score":0.7360000014305115},{"id":"https://openalex.org/keywords/bidens-pilosa","display_name":"Bidens pilosa","score":0.9409999847412109},{"id":"https://openalex.org/keywords/lettuce","display_name":"lettuce","score":0.7879999876022339},{"id":"https://openalex.org/keywords/allium-cepa","display_name":"onion","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cucumis-sativum","display_name":"Cucumis sativum","score":0.9390000104904175},{"id":"https://openalex.org/keywords/wheat","display_name":"wheat","score":0.9789999723434448},{"id":"https://openalex.org/keywords/imides","display_name":"imides","score":0.5730000138282776},{"id":"https://openalex.org/keywords/epoxidation","display_name":"epoxidation","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.7354410886764526},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5800502896308899},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4397085905075073},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41209572553634644},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36732813715934753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30146265029907227},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.1684182584285736}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/plants14131933","doi":"https://doi.org/10.3390/plants14131933","is_oa":true,"landing_page_url":"https://doi.org/10.3390/plants14131933","pdf_url":"https://www.mdpi.com/2223-7747/14/13/1933/pdf?version=1750728368","source":{"id":"https://openalex.org/S4210230202","display_name":"Plants","issn_l":"2223-7747","issn":["2223-7747"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plants","raw_type":"journal-article"},{"id":"pmid:40647942","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40647942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plants (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12251973","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12251973","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plants (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:af309a52fb334c9fb719112d005ef7cb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/af309a52fb334c9fb719112d005ef7cb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plants, Vol 14, Iss 13, p 1933 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/plants14131933","doi":"https://doi.org/10.3390/plants14131933","is_oa":true,"landing_page_url":"https://doi.org/10.3390/plants14131933","pdf_url":"https://www.mdpi.com/2223-7747/14/13/1933/pdf?version=1750728368","source":{"id":"https://openalex.org/S4210230202","display_name":"Plants","issn_l":"2223-7747","issn":["2223-7747"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plants","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5666999816894531,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2963780696","display_name":null,"funder_award_id":"Processo APQ-00752-24","funder_id":"https://openalex.org/F4320322980","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais"},{"id":"https://openalex.org/G5144769874","display_name":null,"funder_award_id":"Processo: 313898/2021-9","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"}],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322980","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","ror":"https://ror.org/00nc55f03"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411575823.pdf","grobid_xml":"https://content.openalex.org/works/W4411575823.grobid-xml"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W1870048299","https://openalex.org/W1875496156","https://openalex.org/W1918363244","https://openalex.org/W1963625735","https://openalex.org/W1980243607","https://openalex.org/W1995808589","https://openalex.org/W1996295408","https://openalex.org/W2002139565","https://openalex.org/W2007343854","https://openalex.org/W2009368375","https://openalex.org/W2020768841","https://openalex.org/W2022006134","https://openalex.org/W2033241989","https://openalex.org/W2033513011","https://openalex.org/W2041282815","https://openalex.org/W2046229956","https://openalex.org/W2064571598","https://openalex.org/W2084882191","https://openalex.org/W2090189231","https://openalex.org/W2094969706","https://openalex.org/W2108389384","https://openalex.org/W2117452252","https://openalex.org/W2125725340","https://openalex.org/W2131696731","https://openalex.org/W2132629607","https://openalex.org/W2136965329","https://openalex.org/W2151387311","https://openalex.org/W2154660190","https://openalex.org/W2155384593","https://openalex.org/W2168745915","https://openalex.org/W2169354492","https://openalex.org/W2169678694","https://openalex.org/W2184967920","https://openalex.org/W2293744162","https://openalex.org/W2296804791","https://openalex.org/W2327452962","https://openalex.org/W2407088810","https://openalex.org/W2420436228","https://openalex.org/W2507865599","https://openalex.org/W2509940280","https://openalex.org/W2516326580","https://openalex.org/W2521624147","https://openalex.org/W2560084377","https://openalex.org/W2573197589","https://openalex.org/W2588411907","https://openalex.org/W2621311359","https://openalex.org/W2733101172","https://openalex.org/W2762234555","https://openalex.org/W2765826089","https://openalex.org/W2767098598","https://openalex.org/W2771371289","https://openalex.org/W2773138591","https://openalex.org/W2783018199","https://openalex.org/W2791203388","https://openalex.org/W2792207297","https://openalex.org/W2800334848","https://openalex.org/W2871307427","https://openalex.org/W2899033272","https://openalex.org/W2900494285","https://openalex.org/W2939557109","https://openalex.org/W2964734018","https://openalex.org/W2981213519","https://openalex.org/W2999055523","https://openalex.org/W3035301748","https://openalex.org/W3042053643","https://openalex.org/W3076575848","https://openalex.org/W3092125766","https://openalex.org/W3112440234","https://openalex.org/W3150822386","https://openalex.org/W3154018702","https://openalex.org/W3158446307","https://openalex.org/W4220827275","https://openalex.org/W4235968347","https://openalex.org/W4255655703","https://openalex.org/W4281634371","https://openalex.org/W4283257383","https://openalex.org/W4283323725","https://openalex.org/W4289101759","https://openalex.org/W4295755745","https://openalex.org/W4298281524","https://openalex.org/W4308453367","https://openalex.org/W4309825545","https://openalex.org/W4313648388","https://openalex.org/W4317663883","https://openalex.org/W4319869915","https://openalex.org/W4383959810","https://openalex.org/W4385697675","https://openalex.org/W4386055296","https://openalex.org/W4386607594","https://openalex.org/W4391470364","https://openalex.org/W4391931391","https://openalex.org/W4394675907","https://openalex.org/W4405668773","https://openalex.org/W4409102519","https://openalex.org/W6645440663","https://openalex.org/W6849679685","https://openalex.org/W6854405757"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933"],"abstract_inverted_index":{"Chemical":[0],"control":[1],"is":[2],"key":[3],"to":[4,32,99,107,127],"minimizing":[5],"agricultural":[6],"losses,":[7],"driving":[8],"the":[9,20,34,38,114,124,151],"search":[10],"for":[11,150,162],"more":[12],"efficient":[13],"and":[14,27,60,78,104,135,166],"selective":[15],"herbicides.":[16],"This":[17],"study":[18],"reports":[19],"synthesis":[21],"of":[22,37,132,173],"epoxyoxirenes,":[23],"their":[24,171],"phytotoxic":[25],"evaluation,":[26],"an":[28],"in":[29,42,139],"silico":[30,140],"analysis":[31,141],"identify":[33],"protein":[35,148],"target":[36,149],"most":[39,152],"active":[40,153],"compound":[41],"plants.":[43],"Compounds":[44],"2\u201319":[45],"were":[46],"tested":[47],"on":[48],"Lactuca":[49],"sativa":[50],"spp.,":[51,54,57],"Allium":[52],"cepa":[53],"Cucumis":[55],"sativus":[56],"Triticum":[58],"aestivum,":[59],"Bidens":[61],"pilosa.":[62],"The":[63],"synthetic":[64],"route":[65],"began":[66],"with":[67,91,117,120],"anhydride":[68,77],"1,":[69],"obtained":[70],"via":[71],"a":[72,146],"Diels\u2013Alder":[73],"reaction":[74],"between":[75],"maleic":[76],"furan":[79],"(91%":[80],"yield).":[81],"Anhydride":[82],"1":[83],"was":[84],"converted":[85],"into":[86,170],"amides":[87],"2\u20137":[88,122],"through":[89],"reactions":[90],"aromatic":[92],"amines":[93],"(>92%":[94],"yields),":[95,103],"followed":[96],"by":[97],"cyclization":[98],"imides":[100],"8\u201313":[101],"(60\u201383%":[102],"subsequent":[105],"epoxidation":[106],"afford":[108],"epoxides":[109],"14\u201319":[110],"(62\u201398%":[111],"yields).":[112],"All":[113],"compounds":[115,121],"interfered":[116],"seedling":[118],"development,":[119],"showing":[123],"greatest":[125],"phytotoxicity":[126],"B.":[128],"pilosa":[129],"at":[130],"concentrations":[131],"500":[133],"\u03bcM":[134],"1000":[136],"\u03bcM.":[137],"An":[138],"suggested":[142],"plant":[143],"tubulin":[144],"as":[145,159],"potential":[147],"compounds.":[154],"These":[155],"findings":[156],"highlight":[157],"epoxyoxirenes":[158],"promising":[160],"scaffolds":[161],"novel":[163],"herbicide":[164],"development":[165],"support":[167],"further":[168],"investigation":[169],"mechanism":[172],"action.":[174]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}