{"id":"https://openalex.org/W4411575744","doi":"https://doi.org/10.15605/jafes.039.s1.148","title":"THE MALADIES OF CUSHING SYNDROME","display_name":"THE MALADIES OF CUSHING SYNDROME","publication_year":2024,"publication_date":"2024-07-17","ids":{"openalex":"https://openalex.org/W4411575744","doi":"https://doi.org/10.15605/jafes.039.s1.148"},"language":"en","primary_location":{"id":"doi:10.15605/jafes.039.s1.148","doi":"https://doi.org/10.15605/jafes.039.s1.148","is_oa":true,"landing_page_url":"https://doi.org/10.15605/jafes.039.s1.148","pdf_url":"https://asean-endocrinejournal.org/index.php/JAFES/article/download/4693/4131","source":{"id":"https://openalex.org/S2737532273","display_name":"Journal of the ASEAN Federation of Endocrine Societies","issn_l":"0857-1074","issn":["0857-1074","2308-118X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319565","host_organization_name":"ASEAN Federation of Endocrine Societies","host_organization_lineage":["https://openalex.org/P4310319565"],"host_organization_lineage_names":["ASEAN Federation of Endocrine Societies"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the ASEAN Federation of Endocrine Societies","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://asean-endocrinejournal.org/index.php/JAFES/article/download/4693/4131","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107464905","display_name":"Jackie Tan","orcid":"https://orcid.org/0000-0002-1573-888X","observed_orcids":["https://orcid.org/0000-0002-1573-888X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie En Tan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100898197","display_name":"Florence Hui Sieng Tan","orcid":"https://orcid.org/0000-0002-1258-6788","observed_orcids":["https://orcid.org/0000-0002-1258-6788"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Florence Hui Sieng Tan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072629898","display_name":"Yueh Chien Kuan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yueh Chien Kuan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019492918","display_name":"Pei Lin Chan","orcid":"https://orcid.org/0000-0002-6528-7853","observed_orcids":["https://orcid.org/0000-0002-6528-7853"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pei Lin Chan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"S1","first_page":"87","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.7807999849319458,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.7807999849319458,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.03959999978542328,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.03880000114440918,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ectopic-acth-syndrome","display_name":"ectopic ACTH syndrome","score":0.9679999947547913},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.921999990940094},{"id":"https://openalex.org/keywords/hypercortisolism","display_name":"hypercortisolism","score":0.8820000290870667},{"id":"https://openalex.org/keywords/hypokalemia","display_name":"hypokalemia","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8640000224113464},{"id":"https://openalex.org/keywords/edema","display_name":"edema","score":0.6880000233650208},{"id":"https://openalex.org/keywords/new-onset-diabetes","display_name":"new-onset diabetes","score":0.824999988079071},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.609000027179718},{"id":"https://openalex.org/keywords/metabolic-alkalosis","display_name":"metabolic alkalosis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/spironolactone","display_name":"spironolactone","score":0.8759999871253967},{"id":"https://openalex.org/keywords/ketoconazole","display_name":"ketoconazole","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dexamethasone-suppression-test","display_name":"dexamethasone suppression test","score":0.8619999885559082},{"id":"https://openalex.org/keywords/pneumocystis-jirovecii-pneumonia","display_name":"Pneumocystis carinii pneumonia","score":0.8939999938011169},{"id":"https://openalex.org/keywords/conservative-treatment","display_name":"conservative treatment","score":0.5509999990463257},{"id":"https://openalex.org/keywords/palliative-care","display_name":"palliative care","score":0.9390000104904175}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9797288179397583},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3291233777999878}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.15605/jafes.039.s1.148","doi":"https://doi.org/10.15605/jafes.039.s1.148","is_oa":true,"landing_page_url":"https://doi.org/10.15605/jafes.039.s1.148","pdf_url":"https://asean-endocrinejournal.org/index.php/JAFES/article/download/4693/4131","source":{"id":"https://openalex.org/S2737532273","display_name":"Journal of the ASEAN Federation of Endocrine Societies","issn_l":"0857-1074","issn":["0857-1074","2308-118X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319565","host_organization_name":"ASEAN Federation of Endocrine Societies","host_organization_lineage":["https://openalex.org/P4310319565"],"host_organization_lineage_names":["ASEAN Federation of Endocrine Societies"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the ASEAN Federation of Endocrine Societies","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.15605/jafes.039.s1.148","doi":"https://doi.org/10.15605/jafes.039.s1.148","is_oa":true,"landing_page_url":"https://doi.org/10.15605/jafes.039.s1.148","pdf_url":"https://asean-endocrinejournal.org/index.php/JAFES/article/download/4693/4131","source":{"id":"https://openalex.org/S2737532273","display_name":"Journal of the ASEAN Federation of Endocrine Societies","issn_l":"0857-1074","issn":["0857-1074","2308-118X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319565","host_organization_name":"ASEAN Federation of Endocrine Societies","host_organization_lineage":["https://openalex.org/P4310319565"],"host_organization_lineage_names":["ASEAN Federation of Endocrine Societies"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the ASEAN Federation of Endocrine Societies","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411575744.pdf","grobid_xml":"https://content.openalex.org/works/W4411575744.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2886820424","https://openalex.org/W4390819830","https://openalex.org/W2097260671","https://openalex.org/W4410217518","https://openalex.org/W4413630105","https://openalex.org/W4386827114","https://openalex.org/W2128556017","https://openalex.org/W2057616720","https://openalex.org/W2973070419","https://openalex.org/W2901432612"],"abstract_inverted_index":{"INTRODOUCTION/BACKGROUNDEctopic":[0],"ACTH":[1,159,175],"secretion":[2],"(EAS)":[3],"occurs":[4],"in":[5,189,277],"1.6-6%":[6],"of":[7,9,23,40,58,62,69,203,255],"cases":[8],"small-cell":[10],"lung":[11,75,86,111,265],"carcinoma":[12],"(SCLC).":[13],"Diagnosis":[14],"can":[15],"be":[16],"challenging":[17],"due":[18],"to":[19,197,237,271,282,300,312],"a":[20,37],"wide":[21],"variety":[22],"clinical":[24],"manifestations.":[25],"CASEA":[26],"58-year-old":[27],"male":[28],"smoker":[29],"presented":[30],"with":[31,54,77,88,98,110,113,132,143,152,187,223,259,264,305],"acute":[32],"respiratory":[33],"distress.":[34],"He":[35,121,205],"had":[36,125],"2-month":[38],"history":[39],"worsening":[41],"dyspnoea,":[42],"generalized":[43,78],"oedema":[44,260],"and":[45,66,116,118,124,130,142,150,158,183,191,218,225,247,261,285,302,309],"reduced":[46,196,310],"effort":[47],"tolerance.":[48],"At":[49],"presentation,":[50],"he":[51,248],"was":[52,108,122,148,206],"tachypnoeic":[53],"an":[55],"oxygen":[56],"saturation":[57],"90%,":[59],"blood":[60],"pressure":[61],"187/94":[63],"mm":[64],"Hg":[65],"heart":[67],"rate":[68],"103":[70],"beats/minute.":[71],"Examination":[72],"revealed":[73,93],"bilateral":[74],"crepitations":[76],"pitting":[79],"oedema.":[80],"A":[81,105],"CXR":[82],"showed":[83],"multiple":[84],"ill-defined":[85],"masses":[87],"pulmonary":[89],"infiltrates.":[90],"Laboratory":[91],"results":[92],"hypokalaemia":[94,133],"(potassium":[95],"2.4":[96],"mmol/L)":[97],"metabolic":[99,192],"alkalosis":[100],"(pH":[101],"7.58,":[102],"HCO":[103],"46.9).":[104],"CT":[106],"TAP":[107],"consistent":[109],"malignancy":[112,266],"lymphangitis,":[114],"carcinomatosis":[115],"bone":[117],"liver":[119],"metastases.":[120],"oxygen-dependent":[123],"persistent":[126],"hyperglycaemia":[127],"(HbA1c":[128],"7.7%)":[129],"hypertension":[131,258],"requiring":[134],">3":[135],"antihypertensive":[136],"agents.":[137],"Despite":[138],"not":[139],"being":[140],"cushingoid-looking":[141],"no":[144],"hyperpigmentation,":[145],"ectopic":[146],"CS":[147],"suspected":[149],"confirmed":[151,180],"grossly":[153],"elevated":[154],"cortisol":[155],"(>1740":[156],"nmol/L)":[157],"level":[160,195],"57.1":[161],"pmol/L":[162],"(1.6-":[163],"13.9),":[164],"non-suppressible":[165],"by":[166],"high":[167],"dose":[168],"dexamethasone":[169],"suppression":[170],"test":[171],"(cortisol":[172],">1750":[173],"nmol/L,":[174],"57.9":[176],"pmol/L).":[177],"Lung":[178],"biopsy":[179],"SCLC.":[181],"Spironolactone":[182],"ketoconazole":[184],"were":[185,227],"started,":[186],"improvement":[188],"BP":[190],"parameters.":[193],"Cortisol":[194],"352":[198],"nmol/L":[199],"within":[200],"3":[201],"weeks":[202],"treatment.":[204,314],"planned":[207],"for":[208,230,244,288],"palliative":[209,252],"chemotherapy":[210],"but":[211],"desaturated":[212],"further.":[213],"Therapeutic":[214],"anticoagulant,":[215],"IV":[216],"piperacillintazobactam":[217],"Pneumocystis":[219],"pneumonia":[220],"(PCP)":[221],"treatment":[222,246,281],"clindamycin":[224],"primaquine":[226],"added.":[228],"PCR":[229],"PCP":[231],"returned":[232],"as":[233,295],"positive":[234],"later.":[235],"Due":[236],"his":[238],"poor":[239],"ECOG":[240],"score,":[241],"family":[242],"opted":[243],"conservative":[245],"succumbed":[249],"later":[250],"on":[251],"care.":[253],"CONCLUSIONPresence":[254],"profound":[256],"hypokalaemia,":[257],"new-onset":[262],"diabetes":[263],"should":[267],"alert":[268],"the":[269],"clinicians":[270],"possible":[272],"EAS.":[273],"The":[274],"intense":[275],"hypercortisolism":[276,284],"EAS":[278,296],"requires":[279],"prompt":[280],"reduce":[283],"targeted":[286],"therapy":[287],"associated":[289,304],"co-morbidities.":[290],"Early":[291],"diagnosis":[292],"is":[293,303],"important":[294],"confers":[297],"poorer":[298],"prognosis":[299],"SCLC":[301],"more":[306],"extensive":[307],"disease":[308],"response":[311],"firstline":[313]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2025-10-10T00:00:00"}
