{"id":"https://openalex.org/W4411572575","doi":"https://doi.org/10.3389/fimmu.2025.1585284","title":"Correlation between microneutralization test and a multiplexed immunoassay for evaluation of monkeypox and vaccinia virus antibodies before and after smallpox vaccination","display_name":"Correlation between microneutralization test and a multiplexed immunoassay for evaluation of monkeypox and vaccinia virus antibodies before and after smallpox vaccination","publication_year":2025,"publication_date":"2025-06-23","ids":{"openalex":"https://openalex.org/W4411572575","doi":"https://doi.org/10.3389/fimmu.2025.1585284","pmid":"https://pubmed.ncbi.nlm.nih.gov/40625755","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12229994"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2025.1585284","doi":"https://doi.org/10.3389/fimmu.2025.1585284","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1585284","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1585284/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1585284/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021990885","display_name":"Serena Marchi","orcid":"https://orcid.org/0000-0002-6817-2461","observed_orcids":["https://orcid.org/0000-0002-6817-2461"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Serena Marchi","raw_affiliation_strings":["Department of Molecular and Developmental Medicine, University of Siena, Siena,\u00a0Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Developmental Medicine, University of Siena, Siena,\u00a0Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064775398","display_name":"Giulia Piccini","orcid":"https://orcid.org/0000-0001-8090-7910","observed_orcids":["https://orcid.org/0000-0001-8090-7910"]},"institutions":[{"id":"https://openalex.org/I4210164598","display_name":"VisMederi (Italy)","ror":"https://ror.org/05sv6xe54","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210164598"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Piccini","raw_affiliation_strings":["VisMederi Srl, Siena,\u00a0Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VisMederi Srl, Siena,\u00a0Italy","institution_ids":["https://openalex.org/I4210164598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051625434","display_name":"Edmond J. Remarque","orcid":"https://orcid.org/0000-0002-5412-6958","observed_orcids":["https://orcid.org/0000-0002-5412-6958"]},"institutions":[{"id":"https://openalex.org/I2802500869","display_name":"Biomedical Primate Research Centre","ror":"https://ror.org/02ahxbh87","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I2802500869"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Edmond J. Remarque","raw_affiliation_strings":["Department of Virology, Biomedical Primate Research Centre, Rijswijk,\u00a0Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Biomedical Primate Research Centre, Rijswijk,\u00a0Netherlands","institution_ids":["https://openalex.org/I2802500869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079599344","display_name":"Giulia Roscia","orcid":"https://orcid.org/0009-0001-6999-0175","observed_orcids":["https://orcid.org/0009-0001-6999-0175"]},"institutions":[{"id":"https://openalex.org/I4210164598","display_name":"VisMederi (Italy)","ror":"https://ror.org/05sv6xe54","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210164598"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Roscia","raw_affiliation_strings":["VisMederi Srl, Siena,\u00a0Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VisMederi Srl, Siena,\u00a0Italy","institution_ids":["https://openalex.org/I4210164598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015994695","display_name":"Bianca Semplici","orcid":"https://orcid.org/0009-0005-8914-1866","observed_orcids":["https://orcid.org/0009-0005-8914-1866"]},"institutions":[{"id":"https://openalex.org/I4210164598","display_name":"VisMederi (Italy)","ror":"https://ror.org/05sv6xe54","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210164598"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Bianca Semplici","raw_affiliation_strings":["VisMederi Srl, Siena,\u00a0Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VisMederi Srl, Siena,\u00a0Italy","institution_ids":["https://openalex.org/I4210164598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025950200","display_name":"Paolo Cantaloni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164598","display_name":"VisMederi (Italy)","ror":"https://ror.org/05sv6xe54","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210164598"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Cantaloni","raw_affiliation_strings":["VisMederi Srl, Siena,\u00a0Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VisMederi Srl, Siena,\u00a0Italy","institution_ids":["https://openalex.org/I4210164598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092618043","display_name":"Noemi Guerrini","orcid":"https://orcid.org/0009-0001-8998-9446","observed_orcids":["https://orcid.org/0009-0001-8998-9446"]},"institutions":[{"id":"https://openalex.org/I4210164598","display_name":"VisMederi (Italy)","ror":"https://ror.org/05sv6xe54","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210164598"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Noemi Guerrini","raw_affiliation_strings":["VisMederi Srl, Siena,\u00a0Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VisMederi Srl, Siena,\u00a0Italy","institution_ids":["https://openalex.org/I4210164598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099088988","display_name":"Roberta Zannella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164598","display_name":"VisMederi (Italy)","ror":"https://ror.org/05sv6xe54","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210164598"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberta Zannella","raw_affiliation_strings":["VisMederi Srl, Siena,\u00a0Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VisMederi Srl, Siena,\u00a0Italy","institution_ids":["https://openalex.org/I4210164598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017948671","display_name":"Rosa Coluccio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164598","display_name":"VisMederi (Italy)","ror":"https://ror.org/05sv6xe54","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210164598"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rosa Coluccio","raw_affiliation_strings":["VisMederi Srl, Siena,\u00a0Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VisMederi Srl, Siena,\u00a0Italy","institution_ids":["https://openalex.org/I4210164598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016357982","display_name":"Linda Benincasa","orcid":"https://orcid.org/0000-0001-8828-9694","observed_orcids":["https://orcid.org/0000-0001-8828-9694"]},"institutions":[{"id":"https://openalex.org/I4210164598","display_name":"VisMederi (Italy)","ror":"https://ror.org/05sv6xe54","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210164598"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Linda Benincasa","raw_affiliation_strings":["VisMederi Srl, Siena,\u00a0Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VisMederi Srl, Siena,\u00a0Italy","institution_ids":["https://openalex.org/I4210164598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092237631","display_name":"Niccol\u00f2 Solfanelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164598","display_name":"VisMederi (Italy)","ror":"https://ror.org/05sv6xe54","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210164598"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Niccol\u00f2 Solfanelli","raw_affiliation_strings":["VisMederi Srl, Siena,\u00a0Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VisMederi Srl, Siena,\u00a0Italy","institution_ids":["https://openalex.org/I4210164598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031231745","display_name":"Claudia Maria Trombetta","orcid":"https://orcid.org/0000-0001-7229-9919","observed_orcids":["https://orcid.org/0000-0001-7229-9919"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudia Maria Trombetta","raw_affiliation_strings":["Department of Molecular and Developmental Medicine, University of Siena, Siena,\u00a0Italy","VaepiX, Joint Research Laboratory, University of Siena, Siena,\u00a0Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Developmental Medicine, University of Siena, Siena,\u00a0Italy","institution_ids":["https://openalex.org/I102064193"]},{"raw_affiliation_string":"VaepiX, Joint Research Laboratory, University of Siena, Siena,\u00a0Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078728203","display_name":"Emanuele Montomoli","orcid":"https://orcid.org/0000-0001-7595-4974","observed_orcids":["https://orcid.org/0000-0001-7595-4974"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]},{"id":"https://openalex.org/I4210140448","display_name":"VisMederi Research","ror":"https://ror.org/04h4yst66","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210140448"]},{"id":"https://openalex.org/I4210164598","display_name":"VisMederi (Italy)","ror":"https://ror.org/05sv6xe54","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210164598"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emanuele Montomoli","raw_affiliation_strings":["Department of Molecular and Developmental Medicine, University of Siena, Siena,\u00a0Italy","VaepiX, Joint Research Laboratory, University of Siena, Siena,\u00a0Italy","VisMederi Research Srl, Siena,\u00a0Italy","VisMederi Srl, Siena,\u00a0Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Developmental Medicine, University of Siena, Siena,\u00a0Italy","institution_ids":["https://openalex.org/I102064193"]},{"raw_affiliation_string":"VaepiX, Joint Research Laboratory, University of Siena, Siena,\u00a0Italy","institution_ids":["https://openalex.org/I102064193"]},{"raw_affiliation_string":"VisMederi Research Srl, Siena,\u00a0Italy","institution_ids":["https://openalex.org/I4210140448"]},{"raw_affiliation_string":"VisMederi Srl, Siena,\u00a0Italy","institution_ids":["https://openalex.org/I4210164598"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070486956","display_name":"Alessandro Manenti","orcid":"https://orcid.org/0000-0002-4027-7296","observed_orcids":["https://orcid.org/0000-0002-4027-7296"]},"institutions":[{"id":"https://openalex.org/I4210164598","display_name":"VisMederi (Italy)","ror":"https://ror.org/05sv6xe54","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210164598"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Manenti","raw_affiliation_strings":["VisMederi Srl, Siena,\u00a0Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VisMederi Srl, Siena,\u00a0Italy","institution_ids":["https://openalex.org/I4210164598"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5021990885"],"corresponding_institution_ids":["https://openalex.org/I102064193"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":3.0069,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.90701876,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"16","issue":null,"first_page":"1585284","last_page":"1585284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mpox","display_name":"monkeypox","score":0.8939999938011169},{"id":"https://openalex.org/keywords/monkeypox-virus","display_name":"monkeypox virus","score":0.8050000071525574},{"id":"https://openalex.org/keywords/vaccinia-virus","display_name":"vaccinia virus","score":0.9539999961853027},{"id":"https://openalex.org/keywords/smallpox-vaccination","display_name":"smallpox vaccination","score":0.968999981880188},{"id":"https://openalex.org/keywords/immunological-cross-reactivity","display_name":"immunological cross-reactivity","score":0.7789999842643738},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.9620000123977661},{"id":"https://openalex.org/keywords/binding-antibodies","display_name":"binding antibodies","score":0.7329999804496765},{"id":"https://openalex.org/keywords/igg-response","display_name":"IgG antibody response","score":0.7099999785423279},{"id":"https://openalex.org/keywords/multiplex-immunoassay","display_name":"multiplex immunoassay","score":0.8799999952316284},{"id":"https://openalex.org/keywords/microneutralization-assay","display_name":"microneutralization","score":0.7889999747276306},{"id":"https://openalex.org/keywords/epitopes","display_name":"antigenic determinants","score":0.7720000147819519},{"id":"https://openalex.org/keywords/correlates-of-protection","display_name":"correlates of protection","score":0.7440000176429749},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C2778011067","wikidata":"https://www.wikidata.org/wiki/Q382370","display_name":"Monkeypox","level":5,"score":0.8954445123672485},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7787282466888428},{"id":"https://openalex.org/C2781356689","wikidata":"https://www.wikidata.org/wiki/Q1986297","display_name":"Vaccinia","level":4,"score":0.760355532169342},{"id":"https://openalex.org/C2778417375","wikidata":"https://www.wikidata.org/wiki/Q12214","display_name":"Smallpox","level":3,"score":0.6257398724555969},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.6184741854667664},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.6179362535476685},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5033659338951111},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49814796447753906},{"id":"https://openalex.org/C2779272165","wikidata":"https://www.wikidata.org/wiki/Q1037810","display_name":"Smallpox vaccine","level":5,"score":0.487886905670166},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4348718822002411},{"id":"https://openalex.org/C2909788366","wikidata":"https://www.wikidata.org/wiki/Q12214","display_name":"Variola virus","level":5,"score":0.4341513216495514},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3321496248245239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29506683349609375},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.057745158672332764},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007118","descriptor_name":"Immunoassay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008993","descriptor_name":"Monkeypox virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012899","descriptor_name":"Smallpox","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012899","descriptor_name":"Smallpox","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D012900","descriptor_name":"Smallpox Vaccine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012900","descriptor_name":"Smallpox Vaccine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014616","descriptor_name":"Vaccinia virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D045908","descriptor_name":"Mpox, Monkeypox","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D045908","descriptor_name":"Mpox, Monkeypox","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.3389/fimmu.2025.1585284","doi":"https://doi.org/10.3389/fimmu.2025.1585284","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1585284","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1585284/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11038384","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12229994","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40625755","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40625755","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12229994","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12229994/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:usiena-air.unisi.it:11365/1300700","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12229994/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12229994/pdf/fimmu-16-1585284.pdf","source":{"id":"https://openalex.org/S4377196319","display_name":"Use Siena air (University of Siena)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102064193","host_organization_name":"University of Siena","host_organization_lineage":["https://openalex.org/I102064193"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:4215d2e0ce754099a2df579673ea5fef","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4215d2e0ce754099a2df579673ea5fef","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 16 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2025.1585284","doi":"https://doi.org/10.3389/fimmu.2025.1585284","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1585284","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1585284/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411572575.pdf","grobid_xml":"https://content.openalex.org/works/W4411572575.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W91734313","https://openalex.org/W1515844392","https://openalex.org/W1888269040","https://openalex.org/W1905216348","https://openalex.org/W1967259478","https://openalex.org/W1981640984","https://openalex.org/W1984731389","https://openalex.org/W1991404926","https://openalex.org/W2041833892","https://openalex.org/W2067023698","https://openalex.org/W2078406439","https://openalex.org/W2118944388","https://openalex.org/W2128033630","https://openalex.org/W2153210428","https://openalex.org/W2155151751","https://openalex.org/W2166157172","https://openalex.org/W2532821028","https://openalex.org/W4296010508","https://openalex.org/W4307343290","https://openalex.org/W4381249996","https://openalex.org/W4381487501","https://openalex.org/W4381664434","https://openalex.org/W4382023093","https://openalex.org/W4383999285","https://openalex.org/W4385406496","https://openalex.org/W4386988034","https://openalex.org/W4387265596","https://openalex.org/W4387330371","https://openalex.org/W4389478453","https://openalex.org/W4399097048","https://openalex.org/W4399532467","https://openalex.org/W4401474297","https://openalex.org/W4402147293","https://openalex.org/W4403515617","https://openalex.org/W4407892693"],"related_works":["https://openalex.org/W4399532467","https://openalex.org/W7124291504","https://openalex.org/W7203588703","https://openalex.org/W4323653706","https://openalex.org/W4387208827","https://openalex.org/W4381664434","https://openalex.org/W4312196656","https://openalex.org/W4386988034","https://openalex.org/W4391036003","https://openalex.org/W4407892693"],"abstract_inverted_index":{"Introduction:":[0],"Monkeypox":[1,23],"(mpox),":[2],"an":[3],"endemic":[4],"zoonotic":[5],"viral":[6],"disease":[7],"in":[8,16,51,83,129,146,175,272,291,298,324],"Central":[9],"and":[10,95,132,142,171,201,214,217,222,237,261,283,317,321,329],"Western":[11],"Africa,":[12,28],"gained":[13],"international":[14],"attention":[15],"2022":[17],"when":[18],"clade":[19,62],"IIb":[20],"of":[21,42,102,118,126,178,315,345],"the":[22,30,47,66,87,114,124,165,179,292,312,343],"virus":[24,78],"(MPXV)":[25],"spread":[26],"outside":[27],"prompting":[29],"World":[31],"Health":[32,40],"Organization":[33],"(WHO)":[34],"to":[35,54,155,168,232,247,267],"declare":[36],"it":[37],"a":[38,58,109,152,176,184,299],"Public":[39],"Emergency":[41],"International":[43],"Concern":[44],"(PHEIC).":[45],"Although":[46],"PHEIC":[48],"was":[49],"lifted":[50],"2023":[52],"due":[53],"declining":[55],"global":[56],"cases,":[57],"resurgence":[59],"caused":[60],"by":[61,92,163,194],"Ib":[63],"has":[64],"reinstated":[65],"emergency":[67],"status.":[68],"Current":[69],"mpox":[70,93],"vaccines,":[71],"based":[72],"on":[73],"live-attenuated":[74],"or":[75],"modified":[76],"vaccinia":[77],"(VACV),":[79],"have":[80,296],"historical":[81],"use":[82],"smallpox":[84,127],"prevention.":[85],"Understanding":[86],"humoral":[88],"immune":[89,230,302,325],"response":[90,117,167,303],"triggered":[91],"vaccination":[94,128],"infection,":[96],"as":[97,99,265],"well":[98],"identifying":[100],"correlates":[101],"protection,":[103],"remain":[104],"however":[105],"critical.":[106],"Methods:":[107],"In":[108],"previous":[110],"study,":[111],"we":[112],"evaluated":[113],"neutralizing":[115,137,262],"antibody":[116,138,263,319],"1,000":[119],"individuals,":[120],"half":[121,133],"born":[122,252,269],"before":[123,220,253],"cessation":[125],"Italy":[130],"(pre-1975)":[131],"after":[134,223,270],"(post-1979).":[135],"Higher":[136],"titers":[139,275],"against":[140,149,256],"MPXV":[141,170,200,209,316],"VACV":[143,173,248,318],"were":[144,192,276],"observed":[145],"subjects":[147],"vaccinated":[148,255],"smallpox,":[150,257],"indicating":[151],"cross-reactive":[153],"immunity":[154],"MPXV.":[156],"This":[157,278,307],"study":[158,308],"further":[159],"investigated":[160],"these":[161],"findings":[162],"analyzing":[164],"IgG":[166],"five":[169,172],"antigens":[174],"subset":[177],"previously":[180],"tested":[181],"cohort,":[182],"using":[183],"multiplex":[185],"immunoassay.":[186],"Serum":[187],"samples":[188],"from":[189,286],"370":[190],"individuals":[191,251],"grouped":[193],"neutralization":[195,274],"profile":[196],"(negative":[197],"for":[198,204,208,212,350],"both":[199,205],"VACV,":[202,213],"positive":[203,211],"viruses,":[206],"negative":[207],"but":[210],"vice":[215],"versa)":[216],"age":[218,328],"(born":[219],"1975":[221],"1979).":[224],"Results:":[225],"Our":[226],"data":[227],"revealed":[228],"stronger":[229,259],"responses":[231],"specific":[233],"antigens,":[234],"particularly":[235],"A35R/A33R":[236],"B6R/B5R,":[238],"with":[239],"MPXV-specific":[240],"binding":[241,260],"antibodies":[242],"showing":[243],"greater":[244],"cross-reactivity":[245,320],"compared":[246],"ones.":[249],"Furthermore,":[250],"1975,":[254],"exhibited":[258],"responses,":[264],"opposed":[266],"people":[268],"1979":[271],"whom":[273],"lower.":[277],"suggests":[279],"that":[280,335],"prior":[281],"VACV-vaccination":[282],"subsequent":[284],"boosting":[285],"potential":[287],"other":[288],"OPXV":[289],"encounters":[290],"older":[293],"population":[294],"may":[295],"resulted":[297],"more":[300,346],"VACV-specific":[301],"over":[304],"time.":[305],"Discussion:":[306],"provides":[309],"insights":[310],"into":[311],"antigenic":[313],"determinants":[314],"highlights":[322],"differences":[323],"profiles":[326],"across":[327],"exposure":[330],"groups.":[331],"Results":[332],"obtained":[333],"suggest":[334],"VACV-vaccine":[336],"imprinting":[337],"shapes":[338],"immunity,":[339],"which":[340],"could":[341],"guide":[342],"development":[344],"effective":[347],"vaccine":[348],"strategies":[349],"preventing":[351],"mpox.":[352]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-10-10T00:00:00"}
