{"id":"https://openalex.org/W4411558264","doi":"https://doi.org/10.3390/ijms26136016","title":"Genetic Biomarkers Associated with Dynamic Transitions of Human Papillomavirus (HPV) Infection\u2013Precancerous\u2013Cancer of Cervix for Navigating Precision Prevention","display_name":"Genetic Biomarkers Associated with Dynamic Transitions of Human Papillomavirus (HPV) Infection\u2013Precancerous\u2013Cancer of Cervix for Navigating Precision Prevention","publication_year":2025,"publication_date":"2025-06-23","ids":{"openalex":"https://openalex.org/W4411558264","doi":"https://doi.org/10.3390/ijms26136016","pmid":"https://pubmed.ncbi.nlm.nih.gov/40649795","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12250414"},"language":"en","primary_location":{"id":"doi:10.3390/ijms26136016","doi":"https://doi.org/10.3390/ijms26136016","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26136016","pdf_url":"https://www.mdpi.com/1422-0067/26/13/6016/pdf?version=1750674471","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/26/13/6016/pdf?version=1750674471","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084968644","display_name":"Pallop Siewchaisakul","orcid":"https://orcid.org/0000-0003-4738-1915","observed_orcids":["https://orcid.org/0000-0003-4738-1915"]},"institutions":[{"id":"https://openalex.org/I48076826","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25","country_code":"TH","type":"education","lineage":["https://openalex.org/I48076826"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Pallop Siewchaisakul","raw_affiliation_strings":["Faculty of Public Health, Chiang Mai University, Chiang Mai 50200, Thailand"],"raw_orcid":"https://orcid.org/0000-0003-4738-1915","affiliations":[{"raw_affiliation_string":"Faculty of Public Health, Chiang Mai University, Chiang Mai 50200, Thailand","institution_ids":["https://openalex.org/I48076826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009503576","display_name":"Jean Ching\u2010Yuan Fann","orcid":"https://orcid.org/0000-0001-7662-4467","observed_orcids":["https://orcid.org/0000-0001-7662-4467"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jean Ching-Yuan Fann","raw_affiliation_strings":["Department of Health Services Administration, College of Public Health, China Medical University, Taichung 406040, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Services Administration, College of Public Health, China Medical University, Taichung 406040, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035034705","display_name":"Meng\u2010Kan Chen","orcid":"https://orcid.org/0000-0003-1372-705X","observed_orcids":["https://orcid.org/0000-0003-1372-705X"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Meng-Kan Chen","raw_affiliation_strings":["Department of Family Medicine, National Taiwan University Hospital Hsinchu Branch, Hsinchu 302058, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family Medicine, National Taiwan University Hospital Hsinchu Branch, Hsinchu 302058, Taiwan","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058671980","display_name":"Chen-Yang Hsu","orcid":"https://orcid.org/0000-0001-8586-0277","observed_orcids":["https://orcid.org/0000-0001-8586-0277"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chen-Yang Hsu","raw_affiliation_strings":["Master of Public Health Program, College of Public Health, National Taiwan University, Taipei 100025, Taiwan","Taiwan Association of Medical Screening, Taipei 103015, Taiwan"],"raw_orcid":"https://orcid.org/0000-0001-8586-0277","affiliations":[{"raw_affiliation_string":"Master of Public Health Program, College of Public Health, National Taiwan University, Taipei 100025, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Taiwan Association of Medical Screening, Taipei 103015, Taiwan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5035034705","https://openalex.org/A5058671980"],"corresponding_institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210131804"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":2.186,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.85284543,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"26","issue":"13","first_page":"6016","last_page":"6016"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.8610000014305115},{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.9629999995231628},{"id":"https://openalex.org/keywords/genetic-biomarkers","display_name":"genetic biomarkers","score":0.7940000295639038},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.925000011920929},{"id":"https://openalex.org/keywords/cervical-precancerous-lesions","display_name":"cervical precancerous lesions","score":0.6660000085830688},{"id":"https://openalex.org/keywords/low-grade-squamous-intraepithelial-lesion","display_name":"low-grade squamous intraepithelial lesion","score":0.8149999976158142},{"id":"https://openalex.org/keywords/high-grade-squamous-intraepithelial-lesion","display_name":"high-grade squamous intraepithelial lesion","score":0.996999979019165},{"id":"https://openalex.org/keywords/natural-history-model","display_name":"natural history model","score":0.5720000267028809},{"id":"https://openalex.org/keywords/personalized-risk-assessment","display_name":"individual risk assessment","score":0.7860000133514404},{"id":"https://openalex.org/keywords/personalized-prevention","display_name":"personalized prevention","score":0.8100000023841858},{"id":"https://openalex.org/keywords/pap-smear-screening","display_name":"Pap smear screening","score":0.7580000162124634},{"id":"https://openalex.org/keywords/hpv-testing","display_name":"HPV testing","score":0.906000018119812},{"id":"https://openalex.org/keywords/hpv-vaccination","display_name":"HPV vaccination","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cervical-cancer-elimination","display_name":"cervical cancer elimination","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C2994532551","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papillomavirus","level":2,"score":0.6661168336868286},{"id":"https://openalex.org/C2777740455","wikidata":"https://www.wikidata.org/wiki/Q666412","display_name":"Cervix","level":3,"score":0.615878701210022},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.4835934042930603},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4491257667541504},{"id":"https://openalex.org/C2780234812","wikidata":"https://www.wikidata.org/wiki/Q1787013","display_name":"Cancer prevention","level":3,"score":0.4275381565093994},{"id":"https://openalex.org/C2776270601","wikidata":"https://www.wikidata.org/wiki/Q9055203","display_name":"Papillomaviridae","level":4,"score":0.42056775093078613},{"id":"https://openalex.org/C2778580637","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"HPV infection","level":4,"score":0.41597625613212585},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4108158349990845},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3934726417064667},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24532362818717957},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16937783360481262}],"mesh":[{"descriptor_ui":"D000094302","descriptor_name":"Human Papillomavirus Viruses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D013624","descriptor_name":"Taiwan","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms26136016","doi":"https://doi.org/10.3390/ijms26136016","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26136016","pdf_url":"https://www.mdpi.com/1422-0067/26/13/6016/pdf?version=1750674471","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:40649795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40649795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12250414","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12250414/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/ijms26136016","doi":"https://doi.org/10.3390/ijms26136016","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26136016","pdf_url":"https://www.mdpi.com/1422-0067/26/13/6016/pdf?version=1750674471","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411558264.pdf","grobid_xml":"https://content.openalex.org/works/W4411558264.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1580407389","https://openalex.org/W1585236254","https://openalex.org/W1916375638","https://openalex.org/W1937958569","https://openalex.org/W1939049663","https://openalex.org/W1977106431","https://openalex.org/W1980141592","https://openalex.org/W2015054763","https://openalex.org/W2016742004","https://openalex.org/W2019958453","https://openalex.org/W2020398039","https://openalex.org/W2036190704","https://openalex.org/W2060432285","https://openalex.org/W2100884338","https://openalex.org/W2111515458","https://openalex.org/W2115256214","https://openalex.org/W2119594769","https://openalex.org/W2124370773","https://openalex.org/W2125223938","https://openalex.org/W2131980563","https://openalex.org/W2141921059","https://openalex.org/W2145807088","https://openalex.org/W2149866054","https://openalex.org/W2331157589","https://openalex.org/W2787965113","https://openalex.org/W2946331436","https://openalex.org/W2990906960","https://openalex.org/W2991895141","https://openalex.org/W3116678580","https://openalex.org/W3119956543","https://openalex.org/W3203741105","https://openalex.org/W4301398590","https://openalex.org/W4388980203","https://openalex.org/W4389617045","https://openalex.org/W4391938810","https://openalex.org/W4396535740","https://openalex.org/W4397023159","https://openalex.org/W4398229357","https://openalex.org/W4398262298","https://openalex.org/W4401011850","https://openalex.org/W4403114309","https://openalex.org/W4403701148","https://openalex.org/W4406099723","https://openalex.org/W4406823739"],"related_works":["https://openalex.org/W4391418136","https://openalex.org/W2622817473","https://openalex.org/W2944723089","https://openalex.org/W6920736713","https://openalex.org/W2151501050","https://openalex.org/W7215027665","https://openalex.org/W2113839478","https://openalex.org/W7140129888","https://openalex.org/W2945038826","https://openalex.org/W2150799358"],"abstract_inverted_index":{"Precision":[0],"prevention":[1,170],"strategies":[2,119],"for":[3,12,123,167],"cervical":[4,42,68,140,153,175],"cancer":[5,141,176],"that":[6],"integrate":[7],"genetic":[8,27,156],"biomarkers":[9,157],"provide":[10],"opportunities":[11],"personalized":[13],"risk":[14,23,115],"assessment":[15,24],"and":[16,29,39,59,80,85,94,130,136],"optimized":[17],"preventive":[18,118],"measures.":[19],"An":[20],"HPV":[21,45,127,131],"infection-Precancerous-Cancer":[22],"model":[25,62,151],"incorporating":[26,86,155],"polymorphisms":[28],"DNA":[30,128],"methylation":[31],"was":[32],"developed":[33],"to":[34,82,144],"better":[35],"understand":[36],"the":[37,64,87,160,172],"regression":[38,90],"progression":[40],"of":[41,52,67,89,152,162,174],"lesions":[43,78],"by":[44,112],"infection":[46],"status.":[47],"Utilizing":[48],"a":[49,73],"virtual":[50],"cohort":[51],"300,000":[53],"Taiwanese":[54],"women":[55,105],"aged":[56],"30":[57],"years":[58],"older,":[60],"our":[61],"simulated":[63],"natural":[65],"history":[66],"cancer,":[69],"capturing":[70],"transitions":[71],"from":[72],"healthy":[74],"state":[75],"through":[76],"precancerous":[77],"(LSILs":[79],"HSILs)":[81],"invasive":[83],"carcinoma":[84],"possibility":[88],"between":[91],"states.":[92],"Genetic":[93],"epigenetic":[95],"markers":[96],"significantly":[97],"influenced":[98],"disease":[99],"transitions,":[100],"demonstrating":[101],"heterogeneous":[102],"risks":[103],"among":[104],"with":[106],"distinct":[107],"molecular":[108],"biomarker":[109],"profiles.":[110],"Guided":[111],"these":[113],"individual":[114],"profiles,":[116],"tailored":[117],"including":[120],"varying":[121],"intervals":[122],"Pap":[124],"smear":[125],"screening,":[126],"testing,":[129],"vaccination":[132],"showed":[133],"improved":[134],"efficiency":[135],"effectiveness":[137],"in":[138],"reducing":[139],"incidence":[142],"compared":[143],"uniform":[145],"approaches.":[146],"The":[147],"proposed":[148],"dynamic":[149],"transition":[150],"neoplasms":[154],"can":[158],"facilitate":[159],"development":[161],"an":[163],"individualized":[164],"risk-based":[165],"approach":[166],"guiding":[168],"precision":[169],"towards":[171],"goal":[173],"elimination.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-10-10T00:00:00"}