{"id":"https://openalex.org/W4411544174","doi":"https://doi.org/10.1152/physiol.2025.40.s1.0743","title":"Deciphering the cardioprotective role of UFM1 modification in cardiac physiopathological remodeling","display_name":"Deciphering the cardioprotective role of UFM1 modification in cardiac physiopathological remodeling","publication_year":2025,"publication_date":"2025-05-01","ids":{"openalex":"https://openalex.org/W4411544174","doi":"https://doi.org/10.1152/physiol.2025.40.s1.0743"},"language":"en","primary_location":{"id":"doi:10.1152/physiol.2025.40.s1.0743","doi":"https://doi.org/10.1152/physiol.2025.40.s1.0743","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2025.40.s1.0743","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019538554","display_name":"Varsha Tandra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Varsha Tandra","raw_affiliation_strings":["Augusta University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Augusta University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102859552","display_name":"Juan D. Ayala","orcid":"https://orcid.org/0000-0003-0732-3657","observed_orcids":["https://orcid.org/0000-0003-0732-3657"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Ayala","raw_affiliation_strings":["NCSU"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NCSU","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118593701","display_name":"maryam Rezaei gazik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryam R Gazik","raw_affiliation_strings":["Augusta University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Augusta University","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093529383","display_name":"John Sibley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Sibley","raw_affiliation_strings":["Augusta University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Augusta University","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100776448","display_name":"Nagendra Singh","orcid":"https://orcid.org/0000-0003-2540-6990","observed_orcids":["https://orcid.org/0000-0003-2540-6990"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nagendra Singh","raw_affiliation_strings":["Augusta University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Augusta University","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079586020","display_name":"Masaaki Komatsu","orcid":"https://orcid.org/0000-0001-7672-7722","observed_orcids":["https://orcid.org/0000-0001-7672-7722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masaaki Komatsu","raw_affiliation_strings":["Juntendo Educational Foundation, Tokyo Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Juntendo Educational Foundation, Tokyo Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100688139","display_name":"Honglin Li","orcid":"https://orcid.org/0000-0002-3604-0982","observed_orcids":["https://orcid.org/0000-0002-3604-0982"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Honglin Li","raw_affiliation_strings":["Augusta University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Augusta University","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049288749","display_name":"Huabo Su","orcid":"https://orcid.org/0000-0002-8475-2685","observed_orcids":["https://orcid.org/0000-0002-8475-2685"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huabo Su","raw_affiliation_strings":["Augusta University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Augusta University","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100428336","display_name":"Jie Li","orcid":"https://orcid.org/0000-0003-2400-9790","observed_orcids":["https://orcid.org/0000-0003-2400-9790","https://orcid.org/0000-0003-3902-642X"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Li","raw_affiliation_strings":["Augusta University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Augusta University","institution_ids":["https://openalex.org/I25041050"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019538554"],"corresponding_institution_ids":["https://openalex.org/I25041050"],"apc_list":null,"apc_paid":null,"fwci":0.2483,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.4119828,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"40","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.17309999465942383,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ufmylation","display_name":"UFMylation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/ufm1","display_name":"UFM1","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.8920000195503235},{"id":"https://openalex.org/keywords/dilated-cardiomyopathy","display_name":"dilated cardiomyopathy","score":0.9409999847412109},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9409999847412109},{"id":"https://openalex.org/keywords/er-stress-response","display_name":"ER stress response","score":0.6470000147819519},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-homeostasis","display_name":"endoplasmic reticulum homeostasis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cardiomyocyte-specific-knockout","display_name":"cardiomyocyte-specific knockout","score":0.859000027179718},{"id":"https://openalex.org/keywords/aav9-gene-delivery","display_name":"AAV9 gene delivery","score":0.6790000200271606},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.5569999814033508},{"id":"https://openalex.org/keywords/protein-conjugation","display_name":"protein conjugation","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37488722801208496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36488455533981323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35237327218055725}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1152/physiol.2025.40.s1.0743","doi":"https://doi.org/10.1152/physiol.2025.40.s1.0743","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2025.40.s1.0743","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4388415930","https://openalex.org/W4403246330","https://openalex.org/W4225420844","https://openalex.org/W3212627164","https://openalex.org/W4389027409","https://openalex.org/W4312883275","https://openalex.org/W4414960101","https://openalex.org/W4412743228","https://openalex.org/W2919435136","https://openalex.org/W2911359696"],"abstract_inverted_index":{"Ufmylation":[0],"is":[1,56,82,87,242,276,283],"a":[2,9,41],"novel":[3],"ubiquitin-like":[4],"protein":[5,38],"modification":[6,160,181],"that":[7,35,54,227,240,254],"plays":[8],"critical":[10],"role":[11,21,71],"in":[12,22,58,65,72,182,218,279,297],"maintaining":[13,166],"the":[14,23,77,117,177,183,205,208,219,225,230,259,270,298],"homeostasis":[15,168],"of":[16,79,131,179,207,256],"different":[17],"tissues":[18],"but":[19,63],"its":[20,70],"heart":[24,85,231,260,262],"remains":[25],"poorly":[26],"understood.":[27],"UFM1":[28,105,159,180,195,220,228],"(ubiquitin-fold":[29],"modifier":[30],"1)":[31],"resembles":[32],"Ub-like":[33],"proteins":[34,81],"covalently":[36],"modifies":[37],"substrates":[39],"via":[40,196],"highly":[42],"conserved":[43],"E1":[44],"(UBA5)-E2":[45],"(UFC1)-E3":[46],"(UFL1)":[47],"enzymatic":[48],"cascade.":[49],"We":[50],"have":[51],"previously":[52],"reported":[53],"ufmylation":[55,78,241,257],"upregulated":[57],"compensated,":[59],"hypertrophic":[60],"mouse":[61],"hearts":[62,145],"decreased":[64],"failing":[66],"human":[67],"hearts.":[68],"However,":[69],"cardiac":[73,80,149,163,214,234,245,249],"remodeling":[74,164,215,250],"and":[75,125,151,169,192,216,247,253,275],"if":[76],"required":[83],"for":[84,244],"function":[86],"unknown.":[88],"To":[89,174],"further":[90,133,175],"address":[91],"this":[92],"question,":[93],"cardiomyocyte-specific":[94],"UFM1-knockout":[95],"(UFM1":[96],"CKO":[97,106,221],")":[98],"mice":[99,107,188],"were":[100],"characterized":[101],"during":[102],"aging.":[103],"The":[104,290],"developed":[108],"dilated":[109],"cardiomyopathy":[110],"at":[111,128,269],"resting":[112],"condition,":[113],"as":[114],"indicated":[115],"by":[116,135,165,232],"left":[118],"ventricle":[119],"(LV)":[120],"wall":[121],"thinning,":[122],"chamber":[123],"dilatation,":[124],"impaired":[126],"contractility":[127,150],"4":[129],"months":[130],"age,":[132],"exacerbated":[134,152],"6":[136],"months.":[137],"When":[138],"exposed":[139],"to":[140,261],"beta-adrenergic":[141],"agonist":[142],"Isoproterenol,":[143],"UFM1-deficient":[144,187],"exhibited":[146],"remarkably":[147],"worsened":[148],"fibrosis":[153],"compared":[154],"with":[155,189],"control":[156],"counterparts.":[157],"Mechanistically,":[158],"constrains":[161],"physiopathological":[162],"ER":[167,171],"regulating":[170],"stress":[172,252],"response.":[173],"understand":[176],"significance":[178],"heart,":[184],"we":[185],"replenished":[186],"cardiac-specific":[190],"WT":[191],"conjugation-deficient":[193,209],"mutant":[194,210],"AAV9.":[197],"Echocardiography":[198],"revealed":[199],"that,":[200],"unlike":[201],"wild-type":[202],"(WT)":[203],"UFM1,":[204],"overexpression":[206],"did":[211],"not":[212,295],"alleviate":[213],"dysfunction":[217],"heart.":[222],"This":[223,265],"validates":[224],"hypothesis":[226],"protects":[229],"modifying":[233],"proteins.":[235],"Overall,":[236],"these":[237],"results":[238],"demonstrate":[239],"essential":[243],"growth":[246],"pathological":[248],"upon":[251],"disruption":[255],"predisposes":[258],"failure.":[263],"AHA24POST1196232":[264],"abstract":[266],"was":[267,294],"presented":[268],"American":[271],"Physiology":[272,291],"Summit":[273],"2025":[274],"only":[277],"available":[278],"HTML":[280],"format.":[281],"There":[282],"no":[284],"downloadable":[285],"file":[286],"or":[287],"PDF":[288],"version.":[289],"editorial":[292],"board":[293],"involved":[296],"peer":[299],"review":[300],"process.":[301]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}
