{"id":"https://openalex.org/W4411540656","doi":"https://doi.org/10.1016/j.leukres.2025.107738","title":"HDAC inhibitors repress Tek and Angpt1 expression and proliferation in RUNX1-MECOM-type leukemia cells","display_name":"HDAC inhibitors repress Tek and Angpt1 expression and proliferation in RUNX1-MECOM-type leukemia cells","publication_year":2025,"publication_date":"2025-06-23","ids":{"openalex":"https://openalex.org/W4411540656","doi":"https://doi.org/10.1016/j.leukres.2025.107738","pmid":"https://pubmed.ncbi.nlm.nih.gov/40570741"},"language":"en","primary_location":{"id":"doi:10.1016/j.leukres.2025.107738","doi":"https://doi.org/10.1016/j.leukres.2025.107738","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.leukres.2025.107738","pdf_url":null,"source":{"id":"https://openalex.org/S136942575","display_name":"Leukemia Research","issn_l":"0145-2126","issn":["0145-2126","1873-5835"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044169149","display_name":"Fumi Nakamura","orcid":"https://orcid.org/0009-0008-8554-1864","observed_orcids":["https://orcid.org/0009-0008-8554-1864"]},"institutions":[{"id":"https://openalex.org/I78274823","display_name":"Dokkyo Medical University","ror":"https://ror.org/05k27ay38","country_code":"JP","type":"education","lineage":["https://openalex.org/I78274823"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumi Nakamura","raw_affiliation_strings":["Department of Hematology and Oncology, Dokkyo Medical University, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Dokkyo Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I78274823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027350953","display_name":"Yuka Nakamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78274823","display_name":"Dokkyo Medical University","ror":"https://ror.org/05k27ay38","country_code":"JP","type":"education","lineage":["https://openalex.org/I78274823"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuka Nakamura","raw_affiliation_strings":["Department of Hematology and Oncology, Dokkyo Medical University, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Dokkyo Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I78274823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027375742","display_name":"Ko Sasaki","orcid":"https://orcid.org/0000-0001-8521-9316","observed_orcids":["https://orcid.org/0000-0001-8521-9316"]},"institutions":[{"id":"https://openalex.org/I78274823","display_name":"Dokkyo Medical University","ror":"https://ror.org/05k27ay38","country_code":"JP","type":"education","lineage":["https://openalex.org/I78274823"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ko Sasaki","raw_affiliation_strings":["Department of Hematology and Oncology, Dokkyo Medical University, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Dokkyo Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I78274823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090016849","display_name":"Ieharu Yamazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136772","display_name":"BML (Japan)","ror":"https://ror.org/04vr3cf25","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210136772"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ieharu Yamazaki","raw_affiliation_strings":["Department of Electron Microscope, BML General Research Institute, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electron Microscope, BML General Research Institute, Saitama, Japan","institution_ids":["https://openalex.org/I4210136772"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087133884","display_name":"Yoichi Imai","orcid":"https://orcid.org/0000-0002-2938-6133","observed_orcids":["https://orcid.org/0000-0002-2938-6133"]},"institutions":[{"id":"https://openalex.org/I78274823","display_name":"Dokkyo Medical University","ror":"https://ror.org/05k27ay38","country_code":"JP","type":"education","lineage":["https://openalex.org/I78274823"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoichi Imai","raw_affiliation_strings":["Department of Hematology and Oncology, Dokkyo Medical University, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Dokkyo Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I78274823"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110125362","display_name":"Kinuko Mitani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78274823","display_name":"Dokkyo Medical University","ror":"https://ror.org/05k27ay38","country_code":"JP","type":"education","lineage":["https://openalex.org/I78274823"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kinuko Mitani","raw_affiliation_strings":["Department of Hematology and Oncology, Dokkyo Medical University, Tochigi, Japan. Electronic address: mitanik@dokkyomed.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Dokkyo Medical University, Tochigi, Japan. Electronic address: mitanik@dokkyomed.ac.jp","institution_ids":["https://openalex.org/I78274823"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110125362"],"corresponding_institution_ids":["https://openalex.org/I78274823"],"apc_list":{"value":3910,"currency":"USD","value_usd":3910},"apc_paid":null,"fwci":2.6155,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.88353157,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"156","issue":null,"first_page":"107738","last_page":"107738"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.5019999742507935,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.5019999742507935,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.4097000062465668,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.03550000116229057,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9129999876022339},{"id":"https://openalex.org/keywords/acute-megakaryoblastic-leukemia","display_name":"acute megakaryoblastic leukemia","score":0.9240000247955322},{"id":"https://openalex.org/keywords/traditional-ecological-knowledge","display_name":"traditional ecological knowledge","score":0.5180000066757202},{"id":"https://openalex.org/keywords/angiopoietin-1","display_name":"angiopoietin-1","score":0.9169999957084656},{"id":"https://openalex.org/keywords/autocrine-loop","display_name":"autocrine loop","score":0.8989999890327454},{"id":"https://openalex.org/keywords/trichostatin-a","display_name":"trichostatin A","score":0.949999988079071},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":1.0},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.824999988079071},{"id":"https://openalex.org/keywords/megakaryopoiesis","display_name":"megakaryopoiesis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.6930000185966492},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5357059240341187},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.49782395362854004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40788376331329346},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3581577241420746},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3067452311515808}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015973","descriptor_name":"Gene Expression Regulation, Leukemic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042683","descriptor_name":"Angiopoietin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D042683","descriptor_name":"Angiopoietin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050676","descriptor_name":"Core Binding Factor Alpha 2 Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.leukres.2025.107738","doi":"https://doi.org/10.1016/j.leukres.2025.107738","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.leukres.2025.107738","pdf_url":null,"source":{"id":"https://openalex.org/S136942575","display_name":"Leukemia Research","issn_l":"0145-2126","issn":["0145-2126","1873-5835"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia Research","raw_type":"journal-article"},{"id":"pmid:40570741","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40570741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W154704142","https://openalex.org/W1578441131","https://openalex.org/W1968450434","https://openalex.org/W1970772467","https://openalex.org/W2004754097","https://openalex.org/W2018501703","https://openalex.org/W2037157001","https://openalex.org/W2041914091","https://openalex.org/W2060610551","https://openalex.org/W2062948859","https://openalex.org/W2080162976","https://openalex.org/W2080309772","https://openalex.org/W2084535571","https://openalex.org/W2090005139","https://openalex.org/W2096637671","https://openalex.org/W2099540110","https://openalex.org/W2111188650","https://openalex.org/W2121960517","https://openalex.org/W2148806087","https://openalex.org/W2404234615","https://openalex.org/W2577917182","https://openalex.org/W2591153485","https://openalex.org/W2614973415","https://openalex.org/W2893869225","https://openalex.org/W2945762505","https://openalex.org/W2984496473","https://openalex.org/W3017314278","https://openalex.org/W4295467725","https://openalex.org/W4307043580","https://openalex.org/W4366998064","https://openalex.org/W6674374959","https://openalex.org/W6682098288"],"related_works":["https://openalex.org/W2041914091","https://openalex.org/W2019549706","https://openalex.org/W4405052705","https://openalex.org/W1968450434","https://openalex.org/W3103632752","https://openalex.org/W2887416507","https://openalex.org/W4414959343","https://openalex.org/W7100867629","https://openalex.org/W2743880308","https://openalex.org/W4405044171"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-10-10T00:00:00"}
