{"id":"https://openalex.org/W4411535239","doi":"https://doi.org/10.1016/j.biopha.2025.118286","title":"Pyroptosis in acute respiratory distress syndrome and pulmonary fibrosis","display_name":"Pyroptosis in acute respiratory distress syndrome and pulmonary fibrosis","publication_year":2025,"publication_date":"2025-06-23","ids":{"openalex":"https://openalex.org/W4411535239","doi":"https://doi.org/10.1016/j.biopha.2025.118286","pmid":"https://pubmed.ncbi.nlm.nih.gov/40555044"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopha.2025.118286","doi":"https://doi.org/10.1016/j.biopha.2025.118286","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2025.118286","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.biopha.2025.118286","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jinfeng Liao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I4210118397","display_name":"Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital","ror":"https://ror.org/01qh26a66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210118397"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinfeng Liao","raw_affiliation_strings":["Department of Dermatology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711","https://openalex.org/I4210118397"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yangbo Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yangbo Liang","raw_affiliation_strings":["School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100423673","display_name":"Zheng Liu","orcid":"https://orcid.org/0000-0002-1242-819X","observed_orcids":["https://orcid.org/0000-0002-1242-819X"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zheng Liu","raw_affiliation_strings":["Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100888263","display_name":"Xie Qin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120234","display_name":"Zhongnan Hospital of Wuhan University","ror":"https://ror.org/01v5mqw79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120234"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qin Xie","raw_affiliation_strings":["Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210120234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100666318","display_name":"Jinming Zhang","orcid":"https://orcid.org/0000-0003-3974-9329","observed_orcids":["https://orcid.org/0000-0003-3974-9329","https://orcid.org/0000-0002-7657-1526"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin-Ming Zhang","raw_affiliation_strings":["Department of Integrative Biology and Pharmacology (IBP) McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Pharmacology (IBP) McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77030, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045584835","display_name":"Siyuan Song","orcid":"https://orcid.org/0000-0002-6872-1360","observed_orcids":["https://orcid.org/0000-0002-6872-1360"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Si-Yuan Song","raw_affiliation_strings":["Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: si-yuan.song@bcm.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: si-yuan.song@bcm.edu","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101460685","display_name":"Xiaobo Huang","orcid":"https://orcid.org/0000-0002-4692-1433","observed_orcids":["https://orcid.org/0000-0002-4692-1433"]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I4210118397","display_name":"Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital","ror":"https://ror.org/01qh26a66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210118397"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaobo Huang","raw_affiliation_strings":["Center for Critical Care Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: drhuangxb@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Critical Care Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: drhuangxb@163.com","institution_ids":["https://openalex.org/I150229711","https://openalex.org/I4210118397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001923391","display_name":"Luhong Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I4210118397","display_name":"Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital","ror":"https://ror.org/01qh26a66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210118397"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Luhong Cao","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China. Electronic address: caoluhong@med.uestc.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China. Electronic address: caoluhong@med.uestc.edu.cn","institution_ids":["https://openalex.org/I150229711","https://openalex.org/I4210118397"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100364899","display_name":"Yi Wang","orcid":"https://orcid.org/0000-0001-9921-0304","observed_orcids":["https://orcid.org/0000-0001-9921-0304","https://orcid.org/0000-0002-9907-133X"]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I4210118397","display_name":"Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital","ror":"https://ror.org/01qh26a66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210118397"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yi Wang","raw_affiliation_strings":["Center for Critical Care Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Translational Clinical Immunology Medicine Key Laboratory, Sichuan Provincial People's Hospital, Chengdu, China. Electronic address: w_yi2022@163.com"],"raw_orcid":"https://orcid.org/0000-0001-9921-0304","affiliations":[{"raw_affiliation_string":"Center for Critical Care Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Translational Clinical Immunology Medicine Key Laboratory, Sichuan Provincial People's Hospital, Chengdu, China. Electronic address: w_yi2022@163.com","institution_ids":["https://openalex.org/I150229711","https://openalex.org/I4210118397"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5001923391","https://openalex.org/A5045584835","https://openalex.org/A5100364899","https://openalex.org/A5101460685"],"corresponding_institution_ids":["https://openalex.org/I150229711","https://openalex.org/I181547552","https://openalex.org/I4210118397"],"apc_list":{"value":3610,"currency":"USD","value_usd":3610},"apc_paid":{"value":3610,"currency":"USD","value_usd":3610},"fwci":4.0771,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.95314512,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"189","issue":null,"first_page":"118286","last_page":"118286"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":1.0},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":1.0},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":1.0},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9900000095367432},{"id":"https://openalex.org/keywords/gasdermin-d","display_name":"gasdermin D","score":0.9789999723434448},{"id":"https://openalex.org/keywords/necroptosis","display_name":"necroptosis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":1.0},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.9779999852180481},{"id":"https://openalex.org/keywords/fibroblast-activation","display_name":"fibroblast activation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/extracellular-matrix-deposition","display_name":"extracellular matrix deposition","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7260000109672546},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.890999972820282},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.716670036315918},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6985981464385986},{"id":"https://openalex.org/C2909621147","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"Acute respiratory distress","level":3,"score":0.6041498780250549},{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.550365686416626},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5480440258979797},{"id":"https://openalex.org/C17172800","wikidata":"https://www.wikidata.org/wiki/Q7263707","display_name":"Pyroptosis","level":4,"score":0.5319491028785706},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.5048819184303284},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.5034262537956238},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.4670148491859436},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.4468982517719269},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3870469331741333},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3353000581264496},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.32414722442626953},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24575823545455933},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.10421961545944214},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.06793591380119324},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000069292","descriptor_name":"Pyroptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000069292","descriptor_name":"Pyroptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biopha.2025.118286","doi":"https://doi.org/10.1016/j.biopha.2025.118286","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2025.118286","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:40555044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40555044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.biopha.2025.118286","doi":"https://doi.org/10.1016/j.biopha.2025.118286","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2025.118286","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2057226658","display_name":null,"funder_award_id":"2024YFHZ0234","funder_id":"https://openalex.org/F4320333335","funder_display_name":"Sichuan Province Science and Technology Support Program"},{"id":"https://openalex.org/G2721945981","display_name":null,"funder_award_id":"2024-YF05-01315-SN","funder_id":"https://openalex.org/F4320336736","funder_display_name":"Chengdu Science and Technology Program"},{"id":"https://openalex.org/G43548690","display_name":null,"funder_award_id":"81802504","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320333335","display_name":"Sichuan Province Science and Technology Support Program","ror":null},{"id":"https://openalex.org/F4320336736","display_name":"Chengdu Science and Technology Program","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":329,"referenced_works":["https://openalex.org/W1511076563","https://openalex.org/W1561041814","https://openalex.org/W1615432648","https://openalex.org/W1811981061","https://openalex.org/W1847056372","https://openalex.org/W1864325817","https://openalex.org/W1882905539","https://openalex.org/W1970136916","https://openalex.org/W1971915082","https://openalex.org/W1980325398","https://openalex.org/W1985042500","https://openalex.org/W1985538633","https://openalex.org/W1985970823","https://openalex.org/W1987535382","https://openalex.org/W1997128330","https://openalex.org/W2003146474","https://openalex.org/W2007506634","https://openalex.org/W2012803552","https://openalex.org/W2014094896","https://openalex.org/W2021442163","https://openalex.org/W2023122823","https://openalex.org/W2067114754","https://openalex.org/W2070565843","https://openalex.org/W2073581978","https://openalex.org/W2074577396","https://openalex.org/W2074987160","https://openalex.org/W2077220086","https://openalex.org/W2077579488","https://openalex.org/W2095068660","https://openalex.org/W2108450330","https://openalex.org/W2111822935","https://openalex.org/W2113046689","https://openalex.org/W2114389121","https://openalex.org/W2120094753","https://openalex.org/W2127749277","https://openalex.org/W2135550253","https://openalex.org/W2140637559","https://openalex.org/W2141476820","https://openalex.org/W2143102054","https://openalex.org/W2155538302","https://openalex.org/W2157201603","https://openalex.org/W2159590959","https://openalex.org/W2164406361","https://openalex.org/W2166682453","https://openalex.org/W2174617543","https://openalex.org/W2178911832","https://openalex.org/W2182355171","https://openalex.org/W2237306814","https://openalex.org/W2271955507","https://openalex.org/W2307082245","https://openalex.org/W2333014531","https://openalex.org/W2346799309","https://openalex.org/W2404648903","https://openalex.org/W2418806051","https://openalex.org/W2431987552","https://openalex.org/W2461756806","https://openalex.org/W2462773201","https://openalex.org/W2509338162","https://openalex.org/W2513733166","https://openalex.org/W2517997111","https://openalex.org/W2560541542","https://openalex.org/W2586409557","https://openalex.org/W2593928562","https://openalex.org/W2597638604","https://openalex.org/W2601031157","https://openalex.org/W2607106027","https://openalex.org/W2610356532","https://openalex.org/W2610420640","https://openalex.org/W2619512829","https://openalex.org/W2620893430","https://openalex.org/W2660634700","https://openalex.org/W2753642667","https://openalex.org/W2762087180","https://openalex.org/W2765337093","https://openalex.org/W2765606412","https://openalex.org/W2767322121","https://openalex.org/W2768333226","https://openalex.org/W2775627464","https://openalex.org/W2781934183","https://openalex.org/W2785555044","https://openalex.org/W2788068015","https://openalex.org/W2788640168","https://openalex.org/W2790572647","https://openalex.org/W2791304894","https://openalex.org/W2791761634","https://openalex.org/W2793866905","https://openalex.org/W2794112735","https://openalex.org/W2797873249","https://openalex.org/W2802595885","https://openalex.org/W2884445384","https://openalex.org/W2884494766","https://openalex.org/W2887547606","https://openalex.org/W2890668604","https://openalex.org/W2895588157","https://openalex.org/W2895833591","https://openalex.org/W2898289679","https://openalex.org/W2899747393","https://openalex.org/W2900507152","https://openalex.org/W2900826101","https://openalex.org/W2902151677","https://openalex.org/W2902352533","https://openalex.org/W2905515875","https://openalex.org/W2906021714","https://openalex.org/W2909223530","https://openalex.org/W2909355137","https://openalex.org/W2921978320","https://openalex.org/W2922442234","https://openalex.org/W2935369648","https://openalex.org/W2936083981","https://openalex.org/W2943293743","https://openalex.org/W2943448364","https://openalex.org/W2949199708","https://openalex.org/W2953818499","https://openalex.org/W2966209008","https://openalex.org/W2968636595","https://openalex.org/W2989083977","https://openalex.org/W2990249901","https://openalex.org/W2990400835","https://openalex.org/W2999534343","https://openalex.org/W3006826877","https://openalex.org/W3007395171","https://openalex.org/W3007940623","https://openalex.org/W3008990592","https://openalex.org/W3009912996","https://openalex.org/W3011500848","https://openalex.org/W3012580065","https://openalex.org/W3013522609","https://openalex.org/W3015228903","https://openalex.org/W3015312656","https://openalex.org/W3016811071","https://openalex.org/W3021694738","https://openalex.org/W3022848360","https://openalex.org/W3024589383","https://openalex.org/W3025847192","https://openalex.org/W3030325615","https://openalex.org/W3031736683","https://openalex.org/W3033356077","https://openalex.org/W3037768701","https://openalex.org/W3039649812","https://openalex.org/W3039983944","https://openalex.org/W3040807962","https://openalex.org/W3041595964","https://openalex.org/W3042257644","https://openalex.org/W3043317565","https://openalex.org/W3046369848","https://openalex.org/W3082740036","https://openalex.org/W3084494759","https://openalex.org/W3085383577","https://openalex.org/W3093718898","https://openalex.org/W3094414160","https://openalex.org/W3101453601","https://openalex.org/W3108493784","https://openalex.org/W3109926113","https://openalex.org/W3111777746","https://openalex.org/W3113055144","https://openalex.org/W3119025267","https://openalex.org/W3121784232","https://openalex.org/W3126399969","https://openalex.org/W3126538466","https://openalex.org/W3127741461","https://openalex.org/W3133604326","https://openalex.org/W3135203598","https://openalex.org/W3142080073","https://openalex.org/W3144674846","https://openalex.org/W3144862265","https://openalex.org/W3147064716","https://openalex.org/W3152675680","https://openalex.org/W3154948946","https://openalex.org/W3155840290","https://openalex.org/W3160678286","https://openalex.org/W3163520065","https://openalex.org/W3168768836","https://openalex.org/W3173948537","https://openalex.org/W3178172899","https://openalex.org/W3180265186","https://openalex.org/W3180985662","https://openalex.org/W3189968138","https://openalex.org/W3191470838","https://openalex.org/W3194088110","https://openalex.org/W3194430494","https://openalex.org/W3197859532","https://openalex.org/W3199073110","https://openalex.org/W3200053343","https://openalex.org/W3200394304","https://openalex.org/W3200524431","https://openalex.org/W3201469539","https://openalex.org/W3201573027","https://openalex.org/W3201800866","https://openalex.org/W3202771662","https://openalex.org/W3203698568","https://openalex.org/W3206257957","https://openalex.org/W3207663138","https://openalex.org/W3216766663","https://openalex.org/W4200020595","https://openalex.org/W4200066948","https://openalex.org/W4200183522","https://openalex.org/W4206435642","https://openalex.org/W4206559022","https://openalex.org/W4210775218","https://openalex.org/W4211098639","https://openalex.org/W4212811245","https://openalex.org/W4220693354","https://openalex.org/W4220973584","https://openalex.org/W4223578396","https://openalex.org/W4225384737","https://openalex.org/W4226029737","https://openalex.org/W4226367800","https://openalex.org/W4237441880","https://openalex.org/W4281401914","https://openalex.org/W4281484545","https://openalex.org/W4282828410","https://openalex.org/W4282984520","https://openalex.org/W4283511006","https://openalex.org/W4283645756","https://openalex.org/W4283741485","https://openalex.org/W4283758424","https://openalex.org/W4285042952","https://openalex.org/W4285243914","https://openalex.org/W4285386170","https://openalex.org/W4285794323","https://openalex.org/W4287985527","https://openalex.org/W4288052404","https://openalex.org/W4292646897","https://openalex.org/W4293554492","https://openalex.org/W4294408678","https://openalex.org/W4294767945","https://openalex.org/W4294767986","https://openalex.org/W4296795926","https://openalex.org/W4298146632","https://openalex.org/W4304695386","https://openalex.org/W4306751663","https://openalex.org/W4306910625","https://openalex.org/W4307122187","https://openalex.org/W4307390045","https://openalex.org/W4308034309","https://openalex.org/W4309711138","https://openalex.org/W4311040528","https://openalex.org/W4311436944","https://openalex.org/W4311939469","https://openalex.org/W4311985923","https://openalex.org/W4313305840","https://openalex.org/W4313362255","https://openalex.org/W4313516679","https://openalex.org/W4313649737","https://openalex.org/W4315433471","https://openalex.org/W4315797453","https://openalex.org/W4318159367","https://openalex.org/W4319441466","https://openalex.org/W4323035539","https://openalex.org/W4323067152","https://openalex.org/W4323268172","https://openalex.org/W4323833061","https://openalex.org/W4324017976","https://openalex.org/W4327979807","https://openalex.org/W4328108224","https://openalex.org/W4365142537","https://openalex.org/W4366981310","https://openalex.org/W4367835093","https://openalex.org/W4376105087","https://openalex.org/W4376610247","https://openalex.org/W4377164067","https://openalex.org/W4377193457","https://openalex.org/W4377238095","https://openalex.org/W4378228077","https://openalex.org/W4379162632","https://openalex.org/W4381548955","https://openalex.org/W4382775544","https://openalex.org/W4385245704","https://openalex.org/W4385839916","https://openalex.org/W4386034053","https://openalex.org/W4386134044","https://openalex.org/W4386135462","https://openalex.org/W4386152998","https://openalex.org/W4386438221","https://openalex.org/W4386459903","https://openalex.org/W4386725418","https://openalex.org/W4386800554","https://openalex.org/W4388168940","https://openalex.org/W4388180828","https://openalex.org/W4388537101","https://openalex.org/W4388733926","https://openalex.org/W4388751206","https://openalex.org/W4389166352","https://openalex.org/W4389670879","https://openalex.org/W4389775042","https://openalex.org/W4389828607","https://openalex.org/W4390198292","https://openalex.org/W4390838116","https://openalex.org/W4390876401","https://openalex.org/W4391501079","https://openalex.org/W4391682767","https://openalex.org/W4392614972","https://openalex.org/W4392956254","https://openalex.org/W4393016060","https://openalex.org/W4393318695","https://openalex.org/W4393386048","https://openalex.org/W4394676350","https://openalex.org/W4394793871","https://openalex.org/W4399940266","https://openalex.org/W4400163552","https://openalex.org/W4400889948","https://openalex.org/W4401038499","https://openalex.org/W4401038821","https://openalex.org/W4402076926","https://openalex.org/W4402295637","https://openalex.org/W4402721301","https://openalex.org/W4402997455","https://openalex.org/W4403430378","https://openalex.org/W4404438136","https://openalex.org/W4405080130","https://openalex.org/W4405222561","https://openalex.org/W4406174593","https://openalex.org/W4407589494","https://openalex.org/W4408349042","https://openalex.org/W4408690907","https://openalex.org/W4409833902","https://openalex.org/W6792742948","https://openalex.org/W6802080570","https://openalex.org/W6808054448","https://openalex.org/W6841973864","https://openalex.org/W6848803869","https://openalex.org/W6850005502","https://openalex.org/W6851115266","https://openalex.org/W6856451014","https://openalex.org/W6857607134","https://openalex.org/W6859954806","https://openalex.org/W6859959791","https://openalex.org/W6861437421","https://openalex.org/W6874797044"],"related_works":["https://openalex.org/W361746133","https://openalex.org/W3109505888","https://openalex.org/W2058958688","https://openalex.org/W2493937886","https://openalex.org/W2325461875","https://openalex.org/W2335616073","https://openalex.org/W103021685","https://openalex.org/W2329701331","https://openalex.org/W3013904011","https://openalex.org/W2781222976"],"abstract_inverted_index":{"ARDS":[0,97,108],"(acute":[1],"respiratory":[2],"distress":[3],"syndrome)":[4],"and":[5,16,49,87,121,164,182],"PF":[6],"(pulmonary":[7],"fibrosis)":[8],"are":[9],"severe":[10,191],"pulmonary":[11],"conditions":[12],"with":[13,74,123],"significant":[14],"morbidity":[15],"mortality.":[17],"This":[18],"review":[19],"focuses":[20],"on":[21],"the":[22,46,59,94,104,124,131,140,161,165],"pyroptosis,":[23,119],"a":[24,33,52,80,115,171],"lytic,":[25],"pro-inflammatory":[26],"form":[27],"of":[28,54,63,107,127,143,156],"programmed":[29],"cell":[30],"death,":[31],"as":[32,160],"central":[34],"mechanism":[35],"linking":[36],"these":[37,144,190],"two":[38],"pathologies.":[39],"We":[40],"address":[41],"how":[42,68],"inflammasome":[43,163],"activation":[44,86],"stimulates":[45],"pyroptosis":[47],"initiation":[48],"subsequently":[50],"releases":[51],"cascade":[53],"inflammatory":[55,177],"cytokines":[56],"that":[57,83],"drive":[58],"acute":[60,134],"lung":[61,192],"injury":[62],"ARDS.":[64,151],"Subsequently,":[65],"we":[66],"elucidate":[67],"this":[69,157],"sustained":[70],"pyroptotic":[71],"inflammation,":[72],"combined":[73],"shifts":[75],"in":[76,149],"macrophage":[77],"polarization,":[78],"creates":[79],"pro-fibrotic":[81],"microenvironment":[82],"promotes":[84],"fibroblast":[85],"extracellular":[88],"matrix":[89],"deposition,":[90],"thereby":[91],"mechanistically":[92],"driving":[93],"transition":[95],"from":[96,103,133],"to":[98,109,136,175],"PF.":[99],"The":[100],"pathological":[101],"landscape,":[102],"early":[105],"stage":[106],"PF,":[110],"is":[111,146],"further":[112],"shaped":[113],"by":[114],"dynamic":[116],"interaction":[117],"between":[118],"necroptosis,":[120],"ferroptosis,":[122],"temporal":[125],"dominance":[126],"each":[128],"pathway":[129],"influencing":[130],"progression":[132],"inflammation":[135],"chronic":[137],"fibrosis.":[138],"Particularly,":[139],"clinical":[141],"relevance":[142],"mechanisms":[145],"also":[147],"addressed":[148],"COVID-19-induced":[150],"Therefore,":[152],"targeting":[153],"key":[154],"regulators":[155],"axis,":[158],"such":[159],"NLRP3":[162],"effector":[166],"protein":[167],"Gasdermin":[168],"D,":[169],"presents":[170],"promising":[172],"therapeutic":[173],"strategy":[174],"alleviate":[176],"responses":[178],"upon":[179],"tissue":[180],"damage":[181],"halt":[183],"fibrotic":[184],"progression,":[185],"offering":[186],"new":[187],"hope":[188],"for":[189],"diseases.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}
