{"id":"https://openalex.org/W4411527802","doi":"https://doi.org/10.2337/figshare.29212346.v1","title":"Inadequately controlled type 2 diabetes and hypercortisolism: improved glycemia with mifepristone treatment","display_name":"Inadequately controlled type 2 diabetes and hypercortisolism: improved glycemia with mifepristone treatment","publication_year":2025,"publication_date":"2025-06-23","ids":{"openalex":"https://openalex.org/W4411527802","doi":"https://doi.org/10.2337/figshare.29212346.v1"},"language":"en","primary_location":{"id":"doi:10.2337/figshare.29212346.v1","doi":"https://doi.org/10.2337/figshare.29212346.v1","is_oa":true,"landing_page_url":"https://doi.org/10.2337/figshare.29212346.v1","pdf_url":null,"source":null,"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Diabetes Association","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.2337/figshare.29212346.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091912602","display_name":"Ralph A. DeFronzo","orcid":"https://orcid.org/0000-0003-3839-1724","observed_orcids":["https://orcid.org/0000-0003-3839-1724"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralph A. DeFronzo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034671525","display_name":"Vivian Andrew Fonseca","orcid":"https://orcid.org/0000-0002-3381-7151","observed_orcids":["https://orcid.org/0000-0002-3381-7151"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vivian Fonseca","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005405894","display_name":"Vanita R. Aroda","orcid":"https://orcid.org/0000-0002-7706-4585","observed_orcids":["https://orcid.org/0000-0002-7706-4585"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vanita R. Aroda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055037280","display_name":"Richard Joseph Auchus","orcid":"https://orcid.org/0000-0001-6815-6181","observed_orcids":["https://orcid.org/0000-0001-6815-6181"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard J. Auchus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054058644","display_name":"Timothy Silleck Bailey","orcid":"https://orcid.org/0000-0003-4178-3462","observed_orcids":["https://orcid.org/0000-0003-4178-3462"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy Bailey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034012396","display_name":"Irina Bancos","orcid":"https://orcid.org/0000-0001-9332-2524","observed_orcids":["https://orcid.org/0000-0001-9332-2524"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irina Bancos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103165011","display_name":"Robert S. Busch","orcid":"https://orcid.org/0000-0002-7172-2815","observed_orcids":["https://orcid.org/0000-0002-7172-2815"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert S. Busch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040182038","display_name":"John B. Buse","orcid":"https://orcid.org/0000-0002-9723-3876","observed_orcids":["https://orcid.org/0000-0002-9723-3876","https://orcid.org/0000-0001-6894-4110"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John B. Buse","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066180898","display_name":"Elena A. Christofides","orcid":"https://orcid.org/0000-0002-1595-9906","observed_orcids":["https://orcid.org/0000-0002-1595-9906"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena A. Christofides","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081614166","display_name":"Bradley Eilerman","orcid":"https://orcid.org/0000-0003-3962-3136","observed_orcids":["https://orcid.org/0000-0003-3962-3136"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bradley Eilerman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086644070","display_name":"James W. Findling","orcid":"https://orcid.org/0000-0003-3101-5320","observed_orcids":["https://orcid.org/0000-0003-3101-5320"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James W. Findling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037652425","display_name":"Yehuda Handelsman","orcid":"https://orcid.org/0000-0001-7830-0247","observed_orcids":["https://orcid.org/0000-0001-7830-0247"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yehuda Handelsman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066700951","display_name":"Steven E. Kahn","orcid":"https://orcid.org/0000-0001-7307-9002","observed_orcids":["https://orcid.org/0000-0001-7307-9002"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven E. Kahn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113419301","display_name":"Harold J. Miller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harold J. Miller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011988555","display_name":"Jonathan G. Ownby","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan G. Ownby","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059717477","display_name":"John C. Parker","orcid":"https://orcid.org/0000-0003-0428-2706","observed_orcids":["https://orcid.org/0000-0003-0428-2706"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John C. Parker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085399860","display_name":"Athena Philis\u2010Tsimikas","orcid":"https://orcid.org/0000-0002-3986-9630","observed_orcids":["https://orcid.org/0000-0002-3986-9630"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Athena Philis-Tsimikas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059098934","display_name":"Richard E. Pratley","orcid":"https://orcid.org/0000-0002-2912-1389","observed_orcids":["https://orcid.org/0000-0002-2912-1389"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Pratley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045489578","display_name":"Julio Rosenstock","orcid":"https://orcid.org/0000-0001-8324-3275","observed_orcids":["https://orcid.org/0000-0001-8324-3275"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julio Rosenstock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028308806","display_name":"Michael Howard Shanik","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael H. Shanik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102859163","display_name":"Lance Alan Sloan","orcid":"https://orcid.org/0000-0002-0370-4914","observed_orcids":["https://orcid.org/0000-0002-0370-4914"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lance A. Sloan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061058170","display_name":"Guillermo E. Umpierrez","orcid":"https://orcid.org/0000-0002-3252-5026","observed_orcids":["https://orcid.org/0000-0002-3252-5026"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guillermo Umpierrez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118588502","display_name":"Samir Shambharkar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samir Shambharkar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048191133","display_name":"Iulia Cristina Tudor","orcid":"https://orcid.org/0000-0002-4229-2940","observed_orcids":["https://orcid.org/0000-0002-4229-2940"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iulia Cristina Tudor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114711401","display_name":"Tina K. Schlafly","orcid":"https://orcid.org/0009-0006-7769-3046","observed_orcids":["https://orcid.org/0009-0006-7769-3046"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tina K. Schlafly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112247083","display_name":"DANIEL F. EINHORN","orcid":"https://orcid.org/0000-0002-7846-9146","observed_orcids":["https://orcid.org/0000-0002-7846-9146"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Einhorn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.5156000256538391,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.5156000256538391,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.3125,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.03020000085234642,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hypercortisolism","display_name":"hypercortisolism","score":0.9760000109672546},{"id":"https://openalex.org/keywords/mifepristone","display_name":"mifepristone","score":0.9359999895095825},{"id":"https://openalex.org/keywords/glucocorticoid-receptor-antagonist","display_name":"glucocorticoid receptor antagonist","score":0.9490000009536743},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.7710000276565552},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.9279999732971191},{"id":"https://openalex.org/keywords/adrenal-imaging","display_name":"adrenal imaging","score":0.3440000116825104},{"id":"https://openalex.org/keywords/dexamethasone-suppression-test","display_name":"dexamethasone suppression test","score":0.8579999804496765},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.4020000100135803},{"id":"https://openalex.org/keywords/waist-circumference","display_name":"waist circumference","score":0.8140000104904175},{"id":"https://openalex.org/keywords/hypokalemia","display_name":"hypokalemia","score":0.6830000281333923},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.5879999995231628},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.5799999833106995},{"id":"https://openalex.org/keywords/adrenal-incidentaloma","display_name":"adrenal incidentaloma","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8349765539169312},{"id":"https://openalex.org/C2778826759","wikidata":"https://www.wikidata.org/wiki/Q411240","display_name":"Mifepristone","level":3,"score":0.7944628596305847},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6776860952377319},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6564764976501465},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6355527639389038},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6349897384643555},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.6115503311157227},{"id":"https://openalex.org/C2776193436","wikidata":"https://www.wikidata.org/wiki/Q236232","display_name":"Waist","level":3,"score":0.5626487135887146},{"id":"https://openalex.org/C2780004078","wikidata":"https://www.wikidata.org/wiki/Q4774743","display_name":"Antiglucocorticoid","level":4,"score":0.5381560921669006},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5340352058410645},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.4572990834712982},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.45094090700149536},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.4267573356628418},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.42303410172462463},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.38200029730796814},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3399204909801483},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.31712281703948975},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.23619520664215088},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.06887403130531311},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/figshare.29212346.v1","doi":"https://doi.org/10.2337/figshare.29212346.v1","is_oa":true,"landing_page_url":"https://doi.org/10.2337/figshare.29212346.v1","pdf_url":null,"source":null,"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Diabetes Association","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2337/figshare.29212346.v1","doi":"https://doi.org/10.2337/figshare.29212346.v1","is_oa":true,"landing_page_url":"https://doi.org/10.2337/figshare.29212346.v1","pdf_url":null,"source":null,"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Diabetes Association","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7161038063","https://openalex.org/W4409965452","https://openalex.org/W4389469295","https://openalex.org/W4400725727","https://openalex.org/W7163760606","https://openalex.org/W4416627435","https://openalex.org/W4396727627","https://openalex.org/W2021271765","https://openalex.org/W4385893392","https://openalex.org/W4409601954"],"abstract_inverted_index":{"Objective:":[0],"In":[1,41,227],"many":[2],"individuals,":[3],"type":[4],"2":[5],"diabetes":[6],"(T2D)":[7],"remains":[8],"poorly":[9],"controlled":[10,231],"despite":[11],"taking":[12],"multiple":[13,63],"glucose-lowering":[14,114],"therapies.":[15],"Several":[16],"studies":[17],"have":[18],"demonstrated":[19],"that":[20],"endogenous":[21],"hypercortisolism":[22,66],"is":[23],"prevalent":[24],"among":[25],"these":[26],"individuals.":[27],"We":[28],"tested":[29],"whether":[30],"cortisol-directed":[31,235],"therapy":[32,237],"improves":[33],"their":[34],"glycemic":[35],"control.":[36],"Research":[37],"Design":[38],"and":[39,65,117,120,161,175,212,233],"Methods:":[40],"this":[42],"prospective,":[43],"multi-center,":[44],"double-blind":[45],"study":[46,127],"(NCT05772169),":[47],"136":[48],"individuals":[49,228],"with":[50,198,215,229,238,242],"T2D":[51,232],"(hemoglobin":[52],"A1c":[53],"[HbA1c]":[54],"7.5%":[55],"to":[56,59,74,81,150,173,181,192],"11.5%":[57],"[58":[58],"102":[60],"mmol/mol]":[61],"on":[62,194],"medications)":[64],"(by":[67],"dexamethasone":[68],"suppression":[69],"test)":[70],"were":[71],"randomized":[72],"2:1":[73],"the":[75,105,126,136],"glucocorticoid-receptor":[76],"antagonist":[77],"mifepristone":[78,155,199,239],"(300":[79],"mg":[80,83],"900":[82],"once":[84],"daily;":[85],"n=91)":[86],"or":[87],"placebo":[88,142],"(n=45)":[89],"for":[90],"24":[91,134],"weeks,":[92,135],"stratified":[93],"by":[94],"presence/absence":[95],"of":[96,167,187,201],"an":[97],"adrenal":[98],"imaging":[99],"abnormality.":[100],"The":[101],"primary":[102],"endpoint":[103],"was":[104,129,145],"change":[106],"in":[107,113,125,143,158,221],"HbA1c.":[108],"Secondary":[109],"endpoints":[110],"included":[111,203],"changes":[112],"medications,":[115],"weight,":[116],"waist":[118,162],"circumference":[119,163],"safety.":[121],"Results:":[122],"Baseline":[123],"HbA1c":[124,144,241],"cohort":[128],"8.55%":[130],"(69.9":[131],"mmol/mol).":[132],"At":[133],"least-squares":[137],"mean":[138],"(LSM)":[139],"difference":[140],"from":[141],"-1.32%":[146],"(95%":[147],"CI,":[148,171,179],"-1.81":[149],"0.83;":[151],"P<0.001).":[152],"Participants":[153],"receiving":[154],"experienced":[156],"reductions":[157],"body":[159],"weight":[160],"(placebo-adjusted":[164],"LSM":[165],"differences":[166],"5.12":[168],"kg;":[169],"95%":[170,178],"8.20":[172],"-2.03":[174],"-5.1":[176],"cm;":[177],"8.23":[180],"-1.99,":[182],"respectively).":[183],"On":[184],"mifepristone,":[185],"46%":[186],"participants":[188],"discontinued":[189],"therapy,":[190],"compared":[191],"18%":[193],"placebo.":[195],"Adverse":[196],"events":[197],"(>10%":[200],"participants)":[202],"hypokalemia,":[204],"fatigue,":[205],"nausea,":[206],"vomiting,":[207],"headache,":[208],"peripheral":[209],"edema,":[210],"diarrhea,":[211],"dizziness,":[213],"consistent":[214],"mifepristone\u2019s":[216],"known":[217],"tolerability":[218,245],"profile.":[219,246],"Increases":[220],"blood":[222],"pressure":[223],"also":[224],"occurred.":[225],"Conclusions:":[226],"inadequately":[230],"hypercortisolism,":[234],"medical":[236],"reduced":[240],"a":[243],"manageable":[244]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2025-10-10T00:00:00"}