{"id":"https://openalex.org/W4411368997","doi":"https://doi.org/10.21448/ijsm.1532874","title":"Antidepressant effects of Artemisia herba-alba (Asso.) essential oil in adult female rats","display_name":"Antidepressant effects of Artemisia herba-alba (Asso.) essential oil in adult female rats","publication_year":2025,"publication_date":"2025-06-17","ids":{"openalex":"https://openalex.org/W4411368997","doi":"https://doi.org/10.21448/ijsm.1532874"},"language":"en","primary_location":{"id":"doi:10.21448/ijsm.1532874","doi":"https://doi.org/10.21448/ijsm.1532874","is_oa":true,"landing_page_url":"https://doi.org/10.21448/ijsm.1532874","pdf_url":"https://dergipark.org.tr/en/download/article-file/4143438","source":{"id":"https://openalex.org/S2738340580","display_name":"International Journal of Secondary Metabolite","issn_l":"2148-6905","issn":["2148-6905"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","erih-plus","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310318258","host_organization_name":"International Journal of Secondary Metabolite","host_organization_lineage":["https://openalex.org/P4310318258"],"host_organization_lineage_names":["International Journal of Secondary Metabolite"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Secondary Metabolite","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://dergipark.org.tr/en/download/article-file/4143438","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107669076","display_name":"Lallia Amara","orcid":"https://orcid.org/0000-0003-2687-0613","observed_orcids":["https://orcid.org/0000-0003-2687-0613"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lallia Amara","raw_affiliation_strings":["Djillali Liabes"],"raw_orcid":"https://orcid.org/0000-0003-2687-0613","affiliations":[{"raw_affiliation_string":"Djillali Liabes","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065286488","display_name":"Mohamed Zairi","orcid":"https://orcid.org/0000-0002-5876-1035","observed_orcids":["https://orcid.org/0000-0002-5876-1035"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohamed Zairi","raw_affiliation_strings":["Djillali Liabes"],"raw_orcid":"https://orcid.org/0000-0002-5876-1035","affiliations":[{"raw_affiliation_string":"Djillali Liabes","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115918742","display_name":"Amine Achemaoui","orcid":"https://orcid.org/0000-0003-2892-9930","observed_orcids":["https://orcid.org/0000-0003-2892-9930"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amine Achemaoui","raw_affiliation_strings":["Djillali Liabes"],"raw_orcid":"https://orcid.org/0000-0003-2892-9930","affiliations":[{"raw_affiliation_string":"Djillali Liabes","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017471701","display_name":"Samira Meziani","orcid":"https://orcid.org/0000-0002-4027-9670","observed_orcids":["https://orcid.org/0000-0002-4027-9670"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samira Meziani","raw_affiliation_strings":["Djillali Liabes"],"raw_orcid":"https://orcid.org/0000-0002-4027-9670","affiliations":[{"raw_affiliation_string":"Djillali Liabes","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031143064","display_name":"Abbassia Encadreur Demmouche","orcid":"https://orcid.org/0000-0003-0811-7820","observed_orcids":["https://orcid.org/0000-0003-0811-7820"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abbassia Demmouche","raw_affiliation_strings":["Djillali Liabes"],"raw_orcid":"https://orcid.org/0000-0003-0811-7820","affiliations":[{"raw_affiliation_string":"Djillali Liabes","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0347,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.77931602,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"12","issue":"3","first_page":"710","last_page":"724"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13651","display_name":"Medicinal Plants and Bioactive Compounds","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artemisia-herba-alba","display_name":"Artemisia herba-alba","score":0.996999979019165},{"id":"https://openalex.org/keywords/essential-oils","display_name":"essential oils","score":0.9919999837875366},{"id":"https://openalex.org/keywords/antidepressant-effects","display_name":"antidepressant effects","score":0.8700000047683716},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.8809999823570251},{"id":"https://openalex.org/keywords/chronic-stress","display_name":"chronic stress","score":0.7409999966621399},{"id":"https://openalex.org/keywords/forced-swim-test","display_name":"forced swim test","score":0.9399999976158142},{"id":"https://openalex.org/keywords/open-field-test","display_name":"open field test","score":0.996999979019165},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.8140000104904175},{"id":"https://openalex.org/keywords/female-rats","display_name":"female rats","score":0.5929999947547913},{"id":"https://openalex.org/keywords/fluoxetine-comparison","display_name":"fluoxetine comparison","score":0.5509999990463257},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.4259999990463257}],"concepts":[{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.61131352186203},{"id":"https://openalex.org/C2777278459","wikidata":"https://www.wikidata.org/wiki/Q170885","display_name":"Essential oil","level":2,"score":0.5362645387649536},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.43957841396331787},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42657023668289185},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41086938977241516},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.2683807611465454},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2513073682785034},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.17369338870048523},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.061414480209350586}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21448/ijsm.1532874","doi":"https://doi.org/10.21448/ijsm.1532874","is_oa":true,"landing_page_url":"https://doi.org/10.21448/ijsm.1532874","pdf_url":"https://dergipark.org.tr/en/download/article-file/4143438","source":{"id":"https://openalex.org/S2738340580","display_name":"International Journal of Secondary Metabolite","issn_l":"2148-6905","issn":["2148-6905"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","erih-plus","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310318258","host_organization_name":"International Journal of Secondary Metabolite","host_organization_lineage":["https://openalex.org/P4310318258"],"host_organization_lineage_names":["International Journal of Secondary Metabolite"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Secondary Metabolite","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:a7aa83a91f2145f0b3b405b5daaff83f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a7aa83a91f2145f0b3b405b5daaff83f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Secondary Metabolite, Vol 12, Iss 3, Pp 710-724 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.21448/ijsm.1532874","doi":"https://doi.org/10.21448/ijsm.1532874","is_oa":true,"landing_page_url":"https://doi.org/10.21448/ijsm.1532874","pdf_url":"https://dergipark.org.tr/en/download/article-file/4143438","source":{"id":"https://openalex.org/S2738340580","display_name":"International Journal of Secondary Metabolite","issn_l":"2148-6905","issn":["2148-6905"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","erih-plus","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310318258","host_organization_name":"International Journal of Secondary Metabolite","host_organization_lineage":["https://openalex.org/P4310318258"],"host_organization_lineage_names":["International Journal of Secondary Metabolite"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Secondary Metabolite","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411368997.pdf","grobid_xml":"https://content.openalex.org/works/W4411368997.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W119570941","https://openalex.org/W1559352360","https://openalex.org/W2017952084","https://openalex.org/W2051359437","https://openalex.org/W2089299823","https://openalex.org/W2090681969","https://openalex.org/W2102365516","https://openalex.org/W2127652169","https://openalex.org/W2162591677","https://openalex.org/W2298070637","https://openalex.org/W2330099529","https://openalex.org/W2418872436","https://openalex.org/W2744962460","https://openalex.org/W2748138222","https://openalex.org/W2887050784","https://openalex.org/W2909903816","https://openalex.org/W2976089272","https://openalex.org/W2989021190","https://openalex.org/W3015199542","https://openalex.org/W3023257781","https://openalex.org/W3082308610","https://openalex.org/W3108291996","https://openalex.org/W3111379039","https://openalex.org/W3128756137","https://openalex.org/W3136954866","https://openalex.org/W3162845490","https://openalex.org/W3165387602","https://openalex.org/W3177162384","https://openalex.org/W4237884497","https://openalex.org/W4403000485"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487"],"abstract_inverted_index":{"The":[0,36,82],"present":[1],"study":[2],"aimed":[3],"to":[4,27],"evaluate":[5],"the":[6,25,59,65,87,118,125,131,136,140,144,164],"antidepressant":[7,37,166],"effects":[8],"of":[9,33,39,47,80,109,127,133,152,168],"Artemisia":[10,169],"herba-alba":[11,41,111,170],"essential":[12,171],"oil":[13,172],"in":[14,117,139,173],"adult":[15,174],"female":[16,175],"rats.":[17,176],"A":[18],"depressive-like":[19],"state":[20],"was":[21,53],"induced":[22],"by":[23],"exposing":[24],"animals":[26],"various":[28],"stressors":[29],"over":[30],"a":[31,77,90,99],"periof":[32],"28":[34],"days.":[35],"potential":[38,165],"A.":[40,110],"EO":[42,112,145],"(administered":[43],"orally":[44],"at":[45,150],"doses":[46,151],"20":[48,153],"mg/kg":[49,154,159],"and":[50,64,98,121,130,157],"40":[51,158],"mg/kg)":[52],"assessed":[54],"using":[55],"neurobehavioral":[56],"tests,":[57],"namely":[58],"Forced":[60],"Swimming":[61],"Test":[62,68],"(FST)":[63],"Open":[66],"Field":[67],"(OFT).":[69],"In":[70],"addition,":[71],"cortisol":[72,148],"levels":[73,149],"were":[74,84],"measured":[75],"as":[76],"biochemical":[78],"marker":[79],"stress.":[81],"results":[83],"compared":[85],"across":[86],"following":[88],"groups:":[89],"non-depressed":[91],"control":[92],"group,":[93,97],"an":[94],"untreated":[95],"depressed":[96],"standard":[100],"treatment":[101],"group":[102],"receiving":[103],"fluoxetine":[104],"(10":[105],"mg/kg).":[106],"Oral":[107],"administration":[108],"significantly":[113,122,146],"reduced":[114],"immobility":[115],"time":[116],"FST":[119],"(p<0.0001),":[120],"increased":[123],"both":[124],"number":[126,132],"squares":[128],"crossed":[129],"entries":[134],"into":[135],"central":[137],"area":[138],"OFT":[141],"(p<0.0001).":[142],"Furthermore,":[143],"lowered":[147],"(p":[155],"<0.05)":[156],"(p<0.01).":[160],"These":[161],"findings":[162],"support":[163],"efficacy":[167]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}