{"id":"https://openalex.org/W4411368377","doi":"https://doi.org/10.3390/medicina61061103","title":"Identifying Predictors of Serious Adverse Events in Antidepressant Treatment from a Decade-Long Nationwide Pharmacovigilance Study: Impact of Dementia and Parkinson\u2019s Disease Treatment","display_name":"Identifying Predictors of Serious Adverse Events in Antidepressant Treatment from a Decade-Long Nationwide Pharmacovigilance Study: Impact of Dementia and Parkinson\u2019s Disease Treatment","publication_year":2025,"publication_date":"2025-06-17","ids":{"openalex":"https://openalex.org/W4411368377","doi":"https://doi.org/10.3390/medicina61061103","pmid":"https://pubmed.ncbi.nlm.nih.gov/40572791"},"language":"en","primary_location":{"id":"doi:10.3390/medicina61061103","doi":"https://doi.org/10.3390/medicina61061103","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina61061103","pdf_url":"https://www.mdpi.com/1648-9144/61/6/1103/pdf?version=1750227106","source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1648-9144/61/6/1103/pdf?version=1750227106","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jungmin Han","orcid":"https://orcid.org/0009-0001-4285-7614","observed_orcids":["https://orcid.org/0009-0001-4285-7614"]},"institutions":[{"id":"https://openalex.org/I31766871","display_name":"Sookmyung Women's University","ror":"https://ror.org/00vvvt117","country_code":"KR","type":"education","lineage":["https://openalex.org/I31766871"]},{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jungmin Han","raw_affiliation_strings":["Department of Pharmacy, School of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea","Department of Pharmacy, School of Pharmacy, Sookmyung Women\u2019s University, Seoul 02447, Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0001-4285-7614","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, School of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Department of Pharmacy, School of Pharmacy, Sookmyung Women\u2019s University, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I31766871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057632192","display_name":"Minsung Kim","orcid":"https://orcid.org/0000-0003-3711-3036","observed_orcids":["https://orcid.org/0000-0003-3711-3036"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Minsung Kim","raw_affiliation_strings":["Department of Pharmacy, School of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, School of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yujin Kim","orcid":"https://orcid.org/0009-0009-4172-4914","observed_orcids":["https://orcid.org/0009-0009-4172-4914"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yujin Kim","raw_affiliation_strings":["Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea","Institute of Regulatory Innovation through Science (IRIS), Kyung Hee University, Seoul 02447, Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0009-4172-4914","affiliations":[{"raw_affiliation_string":"Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Institute of Regulatory Innovation through Science (IRIS), Kyung Hee University, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072761752","display_name":"Soo Hyeon Lee","orcid":"https://orcid.org/0000-0002-9147-3596","observed_orcids":["https://orcid.org/0000-0002-9147-3596"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Soo Hyeon Lee","raw_affiliation_strings":["Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea","Institute of Regulatory Innovation through Science (IRIS), Kyung Hee University, Seoul 02447, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Institute of Regulatory Innovation through Science (IRIS), Kyung Hee University, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058413853","display_name":"Sooyoung Shin","orcid":"https://orcid.org/0000-0003-2388-1122","observed_orcids":["https://orcid.org/0000-0003-2388-1122"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sooyoung Shin","raw_affiliation_strings":["Department of Pharmacy, College of Pharmacy, Ajou University, Suwon 16499, Republic of Korea","Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, Suwon 16499, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-2388-1122","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, College of Pharmacy, Ajou University, Suwon 16499, Republic of Korea","institution_ids":["https://openalex.org/I57664883"]},{"raw_affiliation_string":"Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, Suwon 16499, Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011278142","display_name":"Yeo Jin Choi","orcid":"https://orcid.org/0000-0002-0635-4374","observed_orcids":["https://orcid.org/0000-0002-0635-4374"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yeo Jin Choi","raw_affiliation_strings":["Department of Pharmacy, School of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea","Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea","Institute of Regulatory Innovation through Science (IRIS), Kyung Hee University, Seoul 02447, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-0635-4374","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, School of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Institute of Regulatory Innovation through Science (IRIS), Kyung Hee University, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011278142","https://openalex.org/A5058413853"],"corresponding_institution_ids":["https://openalex.org/I35928602","https://openalex.org/I57664883"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2654},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2654},"fwci":2.6723,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.88705823,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"61","issue":"6","first_page":"1103","last_page":"1103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10376","display_name":"Suicide and Self-Harm Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serious-adverse-events","display_name":"serious adverse events","score":0.9620000123977661},{"id":"https://openalex.org/keywords/fluoxetine","display_name":"fluoxetine","score":0.6259999871253967},{"id":"https://openalex.org/keywords/duloxetine","display_name":"duloxetine","score":0.722000002861023},{"id":"https://openalex.org/keywords/amitriptyline","display_name":"amitriptyline","score":0.984000027179718},{"id":"https://openalex.org/keywords/escitalopram","display_name":"escitalopram","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dementia-treatment","display_name":"dementia treatment","score":0.6110000014305115},{"id":"https://openalex.org/keywords/treatment-of-parkinson-s-disease","display_name":"Parkinson's disease treatment","score":0.9409999847412109},{"id":"https://openalex.org/keywords/antiparkinsonian-drugs","display_name":"antiparkinsonian drugs","score":0.9160000085830688},{"id":"https://openalex.org/keywords/anti-dementia-drugs","display_name":"anti-dementia drugs","score":0.9570000171661377},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.47999998927116394},{"id":"https://openalex.org/keywords/polypharmacy","display_name":"polypharmacy","score":0.6430000066757202},{"id":"https://openalex.org/keywords/vascular-adverse-events","display_name":"vascular adverse events","score":0.5920000076293945},{"id":"https://openalex.org/keywords/pharmacovigilance","display_name":"pharmacovigilance","score":0.7519999742507935},{"id":"https://openalex.org/keywords/disproportionality-analysis","display_name":"disproportionality analysis","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C57658597","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Pharmacovigilance","level":3,"score":0.8679782748222351},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7780348062515259},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7116125822067261},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.656857967376709},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.544204592704773},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4931439757347107},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46965542435646057},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.335263729095459},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25987884402275085},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068736","descriptor_name":"Duloxetine Hydrochloride","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000068736","descriptor_name":"Duloxetine Hydrochloride","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000068736","descriptor_name":"Duloxetine Hydrochloride","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016907","descriptor_name":"Adverse Drug Reaction Reporting Systems","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D016907","descriptor_name":"Adverse Drug Reaction Reporting Systems","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D016907","descriptor_name":"Adverse Drug Reaction Reporting Systems","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D056910","descriptor_name":"Republic of Korea","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D056910","descriptor_name":"Republic of Korea","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D056910","descriptor_name":"Republic of Korea","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D060735","descriptor_name":"Pharmacovigilance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060735","descriptor_name":"Pharmacovigilance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060735","descriptor_name":"Pharmacovigilance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/medicina61061103","doi":"https://doi.org/10.3390/medicina61061103","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina61061103","pdf_url":"https://www.mdpi.com/1648-9144/61/6/1103/pdf?version=1750227106","source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},{"id":"pmid:40572791","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40572791","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina (Kaunas, Lithuania)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12195120","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12195120","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicina (Kaunas)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:0b96917be0bf41d380d60d0ff0d8b8cc","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0b96917be0bf41d380d60d0ff0d8b8cc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicina, Vol 61, Iss 6, p 1103 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/medicina61061103","doi":"https://doi.org/10.3390/medicina61061103","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina61061103","pdf_url":"https://www.mdpi.com/1648-9144/61/6/1103/pdf?version=1750227106","source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1039378590","display_name":null,"funder_award_id":"2021R1I1A1A01044500","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"},{"id":"https://openalex.org/G1805915753","display_name":null,"funder_award_id":"21153MFDS601","funder_id":"https://openalex.org/F4320322014","funder_display_name":"Ministry of Food and Drug Safety"},{"id":"https://openalex.org/G22398683","display_name":null,"funder_award_id":"21153MFDS 601","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"},{"id":"https://openalex.org/G2286594051","display_name":null,"funder_award_id":"21153MFDS601","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G3486990998","display_name":null,"funder_award_id":"2021R1I1A1A01044500","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G400076654","display_name":null,"funder_award_id":"2021R1C1C1003735","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G4668579687","display_name":null,"funder_award_id":"2021R1C1C1003735","funder_id":"https://openalex.org/F4320322014","funder_display_name":"Ministry of Food and Drug Safety"},{"id":"https://openalex.org/G5867630074","display_name":null,"funder_award_id":"2021R1I1A1A01044500","funder_id":"https://openalex.org/F4320322014","funder_display_name":"Ministry of Food and Drug Safety"},{"id":"https://openalex.org/G6793963800","display_name":null,"funder_award_id":"2021R1C1C1003735","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"}],"funders":[{"id":"https://openalex.org/F4320320751","display_name":"Ministry of Education - Singapore","ror":"https://ror.org/01kcva023"},{"id":"https://openalex.org/F4320322014","display_name":"Ministry of Food and Drug Safety","ror":"https://ror.org/01f7dp456"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411368377.pdf","grobid_xml":"https://content.openalex.org/works/W4411368377.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1762345916","https://openalex.org/W2017331060","https://openalex.org/W2026141431","https://openalex.org/W2076143792","https://openalex.org/W2077611326","https://openalex.org/W2133866312","https://openalex.org/W2141809037","https://openalex.org/W2149463687","https://openalex.org/W2149485684","https://openalex.org/W2333095586","https://openalex.org/W2568301711","https://openalex.org/W2574434645","https://openalex.org/W2592772094","https://openalex.org/W2599639076","https://openalex.org/W2611085069","https://openalex.org/W2618699239","https://openalex.org/W2788337440","https://openalex.org/W2913215159","https://openalex.org/W2913988157","https://openalex.org/W2953153530","https://openalex.org/W2969694781","https://openalex.org/W3023410008","https://openalex.org/W3038335210","https://openalex.org/W3138499315","https://openalex.org/W3142616464","https://openalex.org/W3191905711","https://openalex.org/W4200423697","https://openalex.org/W4283161580","https://openalex.org/W4292229870","https://openalex.org/W4311511485","https://openalex.org/W4320728510","https://openalex.org/W4368359338","https://openalex.org/W4378640337","https://openalex.org/W4382810539","https://openalex.org/W4386317290","https://openalex.org/W4388485257","https://openalex.org/W4390112550","https://openalex.org/W4392058431","https://openalex.org/W4392183056","https://openalex.org/W4392731282","https://openalex.org/W4396534201","https://openalex.org/W4396696102","https://openalex.org/W4399752899","https://openalex.org/W4401241477","https://openalex.org/W4406246670"],"related_works":["https://openalex.org/W2125179413","https://openalex.org/W2719570687","https://openalex.org/W2894377005","https://openalex.org/W2066240751","https://openalex.org/W3120767282","https://openalex.org/W3128299827","https://openalex.org/W2898439368","https://openalex.org/W2181320814","https://openalex.org/W3105953293","https://openalex.org/W2328148312"],"abstract_inverted_index":{"Backgrounds":[0],"and":[1,10,18,30,75,90,94,124,148,150,188,199,211,223,236,246,262],"Objectives:":[2],"This":[3],"study":[4,98],"aims":[5],"to":[6,19,39,51,60,70,162,232],"characterize":[7],"the":[8,40,72,77,103,117,128,218,228,258],"prevalence":[9],"severity":[11],"of":[12,79,86,135,191,242,260],"antidepressant-associated":[13],"adverse":[14,26],"drug":[15],"events":[16,27],"(ADEs)":[17],"identify":[20,61],"predictors":[21,62,166,250],"strongly":[22],"associated":[23,63,167],"with":[24,64,131,168,234],"serious":[25],"(SAEs).":[28],"Materials":[29],"Methods:":[31],"Disproportionality":[32],"analysis":[33,67,230],"on":[34,257,264],"antidepressant-related":[35,113,265],"ADEs":[36,138,222],"spontaneously":[37],"reported":[38],"Korea":[41],"Adverse":[42],"event":[43],"Reporting":[44],"System":[45],"(KIDS":[46],"KAERS":[47],"DB)":[48],"from":[49],"2014":[50],"2023":[52],"was":[53,58,68,100,116],"performed.":[54],"Multiple":[55],"logistic":[56],"regression":[57],"conducted":[59],"SAEs.":[65,137,164],"Sensitivity":[66,207],"performed":[69],"validate":[71],"overall":[73],"findings":[74],"assess":[76],"robustness":[78],"associations":[80],"across":[81],"subgroups":[82],"defined":[83],"by":[84,102,122],"completeness":[85],"demographic":[87],"data":[88],"(age":[89],"sex),":[91],"elderly":[92],"age-stratification,":[93],"causality":[95],"assessment.":[96],"The":[97,165,240],"protocol":[99],"approved":[101],"Kyung":[104],"Hee":[105],"University":[106],"institutional":[107],"review":[108],"board.":[109],"Results:":[110],"Among":[111],"21,103":[112],"ADEs,":[114],"duloxetine":[115],"most":[118,160],"etiologic":[119],"medication,":[120],"followed":[121],"amitriptyline":[123],"escitalopram.":[125],"Fluoxetine":[126],"is":[127],"only":[129],"agent":[130],"a":[132],"high":[133],"likelihood":[134],"reporting":[136],"involving":[139],"vascular":[140],"(extracardiac)":[141],"disorders":[142,153],"(ROR":[143,154],"42.42,":[144],"95%":[145,156,178,185,196,204],"CI":[146,157,179,186,197,205],"13.19\u2013136.42)":[147],"liver":[149],"biliary":[151],"system":[152],"7.84,":[155],"3.77\u201316.29)":[158],"were":[159,173,225],"likely":[161],"be":[163],"substantial":[169],"increased":[170],"SAE":[171,252],"risk":[172],"fluoxetine":[174],"use":[175],"(OR":[176,183,194,202],"2.71,":[177],"1.68\u20134.39),":[180],"male":[181],"sex":[182,224,247],"1.48,":[184],"1.11\u20131.98),":[187],"concomitant":[189,244],"administration":[190],"antiparkinsonian":[192],"treatment":[193,201],"8.29,":[195],"3.61\u201319.06)":[198],"antidementia":[200],"2.94,":[203],"1.34\u20136.05).":[206],"analyses":[208],"demonstrated":[209],"similar":[210],"consistent":[212],"findings.":[213],"However,":[214],"reversed":[215],"trends":[216],"in":[217,227],"association":[219],"between":[220],"SOC-based":[221],"observed":[226],"sensitivity":[229],"restricted":[231],"cases":[233],"\u201ccertain\u201d":[235],"\u201cprobable\u201d":[237],"causality.":[238],"Conclusions:":[239],"type":[241],"antidepressant,":[243],"medications,":[245],"are":[248,267],"major":[249],"for":[251],"risk.":[253],"Further":[254],"controlled":[255],"studies":[256],"impact":[259],"comorbidities":[261],"polypharmacy":[263],"SAEs":[266],"warranted.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}