{"id":"https://openalex.org/W4411367703","doi":"https://doi.org/10.1172/jci187202","title":"Inhibiting inflammation in adipocytes accelerates mammary tumor development in mice","display_name":"Inhibiting inflammation in adipocytes accelerates mammary tumor development in mice","publication_year":2025,"publication_date":"2025-06-17","ids":{"openalex":"https://openalex.org/W4411367703","doi":"https://doi.org/10.1172/jci187202","pmid":"https://pubmed.ncbi.nlm.nih.gov/40526430","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12352902"},"language":"en","primary_location":{"id":"doi:10.1172/jci187202","doi":"https://doi.org/10.1172/jci187202","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci187202","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1172/jci187202","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109069160","display_name":"Dae-Seok Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dae-Seok Kim","raw_affiliation_strings":["Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042327774","display_name":"Toshiharu Onodera","orcid":"https://orcid.org/0000-0002-4439-0077","observed_orcids":["https://orcid.org/0000-0002-4439-0077"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Toshiharu Onodera","raw_affiliation_strings":["Department of Adipose Management, Osaka University Graduate School of Medicine, Osaka, Japan","Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-4439-0077","affiliations":[{"raw_affiliation_string":"Department of Adipose Management, Osaka University Graduate School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043113159","display_name":"Jan\u2010Bernd Funcke","orcid":"https://orcid.org/0000-0002-2596-3167","observed_orcids":["https://orcid.org/0000-0002-2596-3167"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan-Bernd Funcke","raw_affiliation_strings":["Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-2596-3167","affiliations":[{"raw_affiliation_string":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050399975","display_name":"Kyounghee Min","orcid":"https://orcid.org/0000-0002-2546-0236","observed_orcids":["https://orcid.org/0000-0002-2546-0236","https://orcid.org/0009-0005-8799-4849"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyounghee Min","raw_affiliation_strings":["Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049632099","display_name":"Qingzhang Zhu","orcid":"https://orcid.org/0000-0001-9382-8517","observed_orcids":["https://orcid.org/0000-0001-9382-8517"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2802239656"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qingzhang Zhu","raw_affiliation_strings":["Barnstable Brown Diabetes and Obesity Center, University of Kentucky College of Medicine, Lexington, Kentucky, USA","Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA","Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-9382-8517","affiliations":[{"raw_affiliation_string":"Barnstable Brown Diabetes and Obesity Center, University of Kentucky College of Medicine, Lexington, Kentucky, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"]},{"raw_affiliation_string":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qian Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qian Lin","raw_affiliation_strings":["Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104083759","display_name":"Shiuhwei Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shiuhwei Chen","raw_affiliation_strings":["Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012354889","display_name":"Chanmin Joung","orcid":"https://orcid.org/0000-0003-0004-3441","observed_orcids":["https://orcid.org/0000-0003-0004-3441"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chanmin Joung","raw_affiliation_strings":["Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Min Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48566637","display_name":"Ulsan National Institute of Science and Technology","ror":"https://ror.org/017cjz748","country_code":"KR","type":"education","lineage":["https://openalex.org/I48566637"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min Kim","raw_affiliation_strings":["Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, South Korea","Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, South Korea","institution_ids":["https://openalex.org/I48566637"]},{"raw_affiliation_string":"Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of","institution_ids":["https://openalex.org/I48566637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038727241","display_name":"Richard Wynn","orcid":"https://orcid.org/0000-0002-1879-2136","observed_orcids":["https://orcid.org/0000-0002-1879-2136"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Max Wynn","raw_affiliation_strings":["Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105102574","display_name":"Joselin Velasco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joselin Velasco","raw_affiliation_strings":["Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101932629","display_name":"Charlotte Lee","orcid":"https://orcid.org/0000-0002-0288-6023","observed_orcids":["https://orcid.org/0000-0002-0288-6023"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlotte Lee","raw_affiliation_strings":["Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA","Center for Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Center for Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116423685","display_name":"Megan Virostek","orcid":"https://orcid.org/0009-0005-4968-2529","observed_orcids":["https://orcid.org/0009-0005-4968-2529"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan Virostek","raw_affiliation_strings":["Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100323173","display_name":"Chao Li","orcid":"https://orcid.org/0000-0002-2060-4835","observed_orcids":["https://orcid.org/0000-0002-2060-4835"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chao Li","raw_affiliation_strings":["Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077747436","display_name":"Philipp E. Scherer","orcid":"https://orcid.org/0000-0003-0680-3392","observed_orcids":["https://orcid.org/0000-0003-0680-3392"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Philipp E. Scherer","raw_affiliation_strings":["Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-0680-3392","affiliations":[{"raw_affiliation_string":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5077747436"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":2.2024,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.87874021,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"135","issue":"16","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipocyte-inflammation","display_name":"adipocyte inflammation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/mammary-tumor-development","display_name":"mammary tumor development","score":0.902999997138977},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8220000267028809},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.9079999923706055},{"id":"https://openalex.org/keywords/adenoviral-gene-transfer","display_name":"adenoviral gene transfer","score":0.7730000019073486},{"id":"https://openalex.org/keywords/mmtv-pymt","display_name":"MMTV-PyMT","score":0.7049999833106995},{"id":"https://openalex.org/keywords/mammary-epithelial-cells","display_name":"mammary epithelial cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/cd36","display_name":"CD36","score":0.7210000157356262},{"id":"https://openalex.org/keywords/fatty-acid-uptake","display_name":"fatty acid uptake","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6549999713897705},{"id":"https://openalex.org/keywords/immunoregulatory-molecules","display_name":"immunoregulatory molecules","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7960184812545776},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4059934616088867},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3737986087799072},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3644505739212036},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3578900694847107},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3575107753276825},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3431471884250641},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32799023389816284}],"mesh":[{"descriptor_ui":"D000084582","descriptor_name":"Tumor-Associated Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000084582","descriptor_name":"Tumor-Associated Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci187202","doi":"https://doi.org/10.1172/jci187202","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci187202","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12352902","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12352902","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:40526430","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40526430","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f8fb3ba6ce404c41885689cb26afb3e2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f8fb3ba6ce404c41885689cb26afb3e2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Clinical Investigation, Vol 135, Iss 16 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1172/jci187202","doi":"https://doi.org/10.1172/jci187202","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci187202","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1042866216","display_name":"Laser Scanning Confocal for UT Southwestern Live Cell Imaging Facility","funder_award_id":"1s10od021684-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G58964009","display_name":null,"funder_award_id":"R01-DK127274","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6095495639","display_name":"Adiponectin, A Protein Secreted From Adipose Tissue","funder_award_id":"R01DK055758","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000864630","display_name":"A New Perspective on Leptin in Health and Disease","funder_award_id":"2r01dk127274-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000873327","display_name":"UT Southwestern NORC","funder_award_id":"P30DK127984","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000876382","display_name":"White Adipose Tissue Physiology, Mitochondrial Function and Adiponectin","funder_award_id":"R01DK099110","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000896027","display_name":"Competing Renewal P01","funder_award_id":"P01AG051459","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000898154","display_name":"UT Southwestern Medical Center Simmons Comprehensive Cancer Center","funder_award_id":"P30CA142543","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000918897","display_name":"Physiological Role of Dedifferentiating Dermal Adipose Tissue","funder_award_id":"R01DK131537","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1563676220","https://openalex.org/W1919137762","https://openalex.org/W1967404929","https://openalex.org/W1969057487","https://openalex.org/W1988774935","https://openalex.org/W2058648826","https://openalex.org/W2079263000","https://openalex.org/W2089258206","https://openalex.org/W2102144390","https://openalex.org/W2107962824","https://openalex.org/W2108218187","https://openalex.org/W2108473659","https://openalex.org/W2111950267","https://openalex.org/W2118278569","https://openalex.org/W2138673784","https://openalex.org/W2141189887","https://openalex.org/W2142891483","https://openalex.org/W2157404081","https://openalex.org/W2159558071","https://openalex.org/W2167409896","https://openalex.org/W2170368666","https://openalex.org/W2525253403","https://openalex.org/W2636415437","https://openalex.org/W2757536115","https://openalex.org/W2765628230","https://openalex.org/W2767463183","https://openalex.org/W2805456840","https://openalex.org/W2956024695","https://openalex.org/W2959497269","https://openalex.org/W2963279792","https://openalex.org/W2979927617","https://openalex.org/W2995669480","https://openalex.org/W2999709139","https://openalex.org/W3006205919","https://openalex.org/W3009660129","https://openalex.org/W3024014822","https://openalex.org/W3089174202","https://openalex.org/W3092226358","https://openalex.org/W3109445816","https://openalex.org/W3130791700","https://openalex.org/W3154559539","https://openalex.org/W3162500913","https://openalex.org/W3168251741","https://openalex.org/W3180882235","https://openalex.org/W3191720683","https://openalex.org/W4205498896","https://openalex.org/W4220981167","https://openalex.org/W4281724538","https://openalex.org/W4282573610","https://openalex.org/W4291993576","https://openalex.org/W4292838698","https://openalex.org/W4295907818","https://openalex.org/W4314937417","https://openalex.org/W4383737426","https://openalex.org/W4387406434","https://openalex.org/W4387704710","https://openalex.org/W4389916017"],"related_works":["https://openalex.org/W2109306696","https://openalex.org/W2024306347","https://openalex.org/W4361005815","https://openalex.org/W2563214611","https://openalex.org/W2991464300","https://openalex.org/W2949636451","https://openalex.org/W2166845850","https://openalex.org/W2585581495","https://openalex.org/W1989935936","https://openalex.org/W3024014822"],"abstract_inverted_index":{"Proinflammatory":[0],"signaling":[1],"in":[2,21,29,45,56,79,110,126,163,167,205],"adipocytes":[3,23],"is":[4],"essential":[5],"for":[6],"healthy":[7],"adipose":[8],"expansion,":[9],"remodeling,":[10],"and":[11,74,90,106],"tissue":[12],"integrity.":[13],"We":[14],"investigated":[15],"the":[16,30,39,80,150,158,168,173,176,195,203],"effects":[17],"of":[18,32,51,71,76,124,160,175,178],"targeting":[19],"inflammation":[20,53,125,180],"either":[22],"or":[24,144],"mammary":[25,33,58,81,92,101,127,137,187],"gland":[26,93,128],"epithelial":[27,129],"cells,":[28],"context":[31],"tumor":[34,59,102,138,142,154],"development,":[35],"by":[36,62,87,131,202],"locally":[37],"expressing":[38],"antiinflammatory":[40],"adenoviral":[41],"RID\u03b1/\u03b2":[42,132],"protein":[43],"complex":[44,196],"a":[46,57,183],"cell":[47,165],"type-specific":[48],"manner.":[49],"Suppression":[50],"adipocyte":[52,179],"(RIDad":[54],"mice)":[55,65,135],"model":[60],"driven":[61,201],"MMTV-PyMT":[63],"(PyMT-RIDad":[64],"led":[66],"to":[67,182],"an":[68],"elevated":[69],"number":[70],"tumor-associated":[72],"macrophages":[73],"upregulation":[75],"immunoregulatory":[77],"molecules":[78],"fat":[82],"pad.":[83],"This":[84,190],"was":[85],"accompanied":[86],"metabolic":[88],"dysfunction":[89],"abnormal":[91],"development.":[94],"Importantly,":[95],"this":[96],"phenotype":[97],"correlated":[98],"with":[99],"accelerated":[100],"onset,":[103],"enhanced":[104,118],"growth,":[105],"lung":[107],"metastasis.":[108],"Tumors":[109],"PyMT-RIDad":[111],"mice":[112],"exhibited":[113],"upregulated":[114],"CD36":[115],"expression,":[116],"suggesting":[117],"fatty":[119],"acid":[120],"uptake.":[121],"Conversely,":[122],"suppression":[123,159,177],"cells":[130],"expression":[133],"(RIDMMTV":[134],"decelerated":[136],"growth":[139],"without":[140],"affecting":[141],"onset":[143],"macrophage":[145],"accumulation.":[146],"These":[147],"findings":[148],"highlight":[149],"differential":[151],"impact":[152],"on":[153,194],"development":[155],"exerted":[156],"through":[157],"inflammatory":[161],"signals":[162],"different":[164],"types":[166],"microenvironment.":[169],"Our":[170],"results":[171],"underscore":[172],"role":[174],"leading":[181],"tumor-friendly":[184],"microenvironment,":[185],"promoting":[186],"cancer":[188,207],"progression.":[189],"study":[191],"sheds":[192],"light":[193],"interplay":[197],"between":[198],"inflammation,":[199],"specifically":[200],"adipocyte,":[204],"breast":[206],"pathogenesis.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-10T00:00:00"}
