{"id":"https://openalex.org/W4411367168","doi":"https://doi.org/10.3390/cancers17122025","title":"The Role of Canine Models of Human Cancer: Overcoming Drug Resistance Through a Transdisciplinary \u201cOne Health, One Medicine\u201d Approach","display_name":"The Role of Canine Models of Human Cancer: Overcoming Drug Resistance Through a Transdisciplinary \u201cOne Health, One Medicine\u201d Approach","publication_year":2025,"publication_date":"2025-06-17","ids":{"openalex":"https://openalex.org/W4411367168","doi":"https://doi.org/10.3390/cancers17122025","pmid":"https://pubmed.ncbi.nlm.nih.gov/40563676","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12191360"},"language":"en","primary_location":{"id":"doi:10.3390/cancers17122025","doi":"https://doi.org/10.3390/cancers17122025","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers17122025","pdf_url":"https://www.mdpi.com/2072-6694/17/12/2025/pdf?version=1750254517","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/17/12/2025/pdf?version=1750254517","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051287878","display_name":"Sara Gargiulo","orcid":"https://orcid.org/0000-0003-1894-1047","observed_orcids":["https://orcid.org/0000-0003-1894-1047"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Sara Gargiulo","raw_affiliation_strings":["Core Research Laboratory (CRL), Istituto per lo Studio, la Prevenzione e la Rete Oncologica (ISPRO), 53100 Siena, Italy","Institute of Clinical Physiology, National Research Council, Via Fiorentina 1, 53100 Siena, Italy"],"raw_orcid":"https://orcid.org/0000-0003-1894-1047","affiliations":[{"raw_affiliation_string":"Core Research Laboratory (CRL), Istituto per lo Studio, la Prevenzione e la Rete Oncologica (ISPRO), 53100 Siena, Italy","institution_ids":[]},{"raw_affiliation_string":"Institute of Clinical Physiology, National Research Council, Via Fiorentina 1, 53100 Siena, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116100395","display_name":"Lidovina Vecchiarelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1326803253","display_name":"Department for Environment Food and Rural Affairs","ror":"https://ror.org/00tnppw48","country_code":"GB","type":"government","lineage":["https://openalex.org/I1326803253","https://openalex.org/I2802373619"]},{"id":"https://openalex.org/I174729306","display_name":"Animal and Plant Health Agency","ror":"https://ror.org/0378g3743","country_code":"GB","type":"government","lineage":["https://openalex.org/I1326803253","https://openalex.org/I174729306","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lidovina Vecchiarelli","raw_affiliation_strings":["Animal Welfare at Animal and Plant Health Agency , Department for Environment Food and Rural Affairs , Midlands , UK","Animal Welfare at Animal and Plant Health Agency, Department for Environment Food and Rural Affairs, Stafford ST18 0AR, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Welfare at Animal and Plant Health Agency , Department for Environment Food and Rural Affairs , Midlands , UK","institution_ids":["https://openalex.org/I1326803253","https://openalex.org/I174729306"]},{"raw_affiliation_string":"Animal Welfare at Animal and Plant Health Agency, Department for Environment Food and Rural Affairs, Stafford ST18 0AR, UK","institution_ids":["https://openalex.org/I1326803253","https://openalex.org/I174729306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067811689","display_name":"Eleonora Pagni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eleonora Pagni","raw_affiliation_strings":["FSA (Fondazione Salute Animale), Via Trecchi 20, 26100 Cremona, Italy","Veterinary Medical and Oncology Centre \u201cEtruria\u201d, Via Sandro Pertini 5-6, Monteriggioni, 53035 Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FSA (Fondazione Salute Animale), Via Trecchi 20, 26100 Cremona, Italy","institution_ids":[]},{"raw_affiliation_string":"Veterinary Medical and Oncology Centre \u201cEtruria\u201d, Via Sandro Pertini 5-6, Monteriggioni, 53035 Siena, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019925732","display_name":"Matteo Gramanzini","orcid":"https://orcid.org/0000-0002-5645-1527","observed_orcids":["https://orcid.org/0000-0002-5645-1527"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210166808","display_name":"Institute of Crystallography","ror":"https://ror.org/05wba8r86","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4210166808"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Gramanzini","raw_affiliation_strings":["Institute of Crystallography, National Research Council, Strada Provinciale 35d, n. 9-00010, Montelibretti, 34149 Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-5645-1527","affiliations":[{"raw_affiliation_string":"Institute of Crystallography, National Research Council, Strada Provinciale 35d, n. 9-00010, Montelibretti, 34149 Rome, Italy","institution_ids":["https://openalex.org/I4210155236","https://openalex.org/I4210166808"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5051287878"],"corresponding_institution_ids":["https://openalex.org/I4210155236"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":1.312,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.76217765,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"17","issue":"12","first_page":"2025","last_page":"2025"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11214","display_name":"Human-Animal Interaction Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/canine-cancer-models","display_name":"dogs as cancer models","score":0.7080000042915344},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6610000133514404},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9449999928474426},{"id":"https://openalex.org/keywords/comparative-oncology","display_name":"comparative oncology","score":0.7850000262260437},{"id":"https://openalex.org/keywords/pet-dogs","display_name":"pet dogs","score":0.6230000257492065},{"id":"https://openalex.org/keywords/spontaneous-tumors","display_name":"spontaneous tumors","score":0.734000027179718},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.7929999828338623},{"id":"https://openalex.org/keywords/translational-cancer-research","display_name":"translational oncology","score":0.8500000238418579},{"id":"https://openalex.org/keywords/one-health","display_name":"One Health","score":0.6859999895095825},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.7089999914169312},{"id":"https://openalex.org/keywords/human-veterinary-medicine-collaboration","display_name":"human-veterinary medicine collaboration","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6588407754898071},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5733126401901245},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.48384514451026917},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48142334818840027},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.47265565395355225},{"id":"https://openalex.org/C3020340455","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Cancer drugs","level":3,"score":0.42203283309936523},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3377293646335602},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.21612408757209778},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21418875455856323},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16470947861671448},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.14342814683914185},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.10547110438346863}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/cancers17122025","doi":"https://doi.org/10.3390/cancers17122025","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers17122025","pdf_url":"https://www.mdpi.com/2072-6694/17/12/2025/pdf?version=1750254517","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"doi:10.20944/preprints202505.1036.v1","doi":"https://doi.org/10.20944/preprints202505.1036.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202505.1036.v1","pdf_url":"https://www.preprints.org/frontend/manuscript/091c1670eddf2c2ad834fda94ab8a41b/download_pub","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:40563676","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40563676","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12191360","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12191360/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/cancers17122025","doi":"https://doi.org/10.3390/cancers17122025","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers17122025","pdf_url":"https://www.mdpi.com/2072-6694/17/12/2025/pdf?version=1750254517","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324003","display_name":"Animal and Plant Health Agency","ror":"https://ror.org/0378g3743"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411367168.pdf","grobid_xml":"https://content.openalex.org/works/W4411367168.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W213597718","https://openalex.org/W1419112127","https://openalex.org/W1504344127","https://openalex.org/W1546243601","https://openalex.org/W1551721915","https://openalex.org/W1754876080","https://openalex.org/W1894349587","https://openalex.org/W1902777974","https://openalex.org/W1931173024","https://openalex.org/W1982661398","https://openalex.org/W1983148533","https://openalex.org/W1985773781","https://openalex.org/W1989736452","https://openalex.org/W1989755869","https://openalex.org/W1995370402","https://openalex.org/W2000834253","https://openalex.org/W2003162918","https://openalex.org/W2003366192","https://openalex.org/W2016646028","https://openalex.org/W2034980513","https://openalex.org/W2041304509","https://openalex.org/W2043541971","https://openalex.org/W2051502503","https://openalex.org/W2053787600","https://openalex.org/W2061572905","https://openalex.org/W2066112168","https://openalex.org/W2066782657","https://openalex.org/W2079540616","https://openalex.org/W2086213879","https://openalex.org/W2125215650","https://openalex.org/W2131822545","https://openalex.org/W2143847158","https://openalex.org/W2153157062","https://openalex.org/W2159854260","https://openalex.org/W2165941883","https://openalex.org/W2173218669","https://openalex.org/W2256501514","https://openalex.org/W2299671436","https://openalex.org/W2400379375","https://openalex.org/W2494292000","https://openalex.org/W2519363128","https://openalex.org/W2564241908","https://openalex.org/W2587424511","https://openalex.org/W2608049785","https://openalex.org/W2611731789","https://openalex.org/W2782104884","https://openalex.org/W2890038789","https://openalex.org/W2901798577","https://openalex.org/W2905950739","https://openalex.org/W2913965839","https://openalex.org/W2915991457","https://openalex.org/W2942540961","https://openalex.org/W2944729787","https://openalex.org/W2961076191","https://openalex.org/W2964855943","https://openalex.org/W2981440981","https://openalex.org/W3020763029","https://openalex.org/W3041373504","https://openalex.org/W3088179862","https://openalex.org/W3091781059","https://openalex.org/W3171936869","https://openalex.org/W3188946651","https://openalex.org/W3200591139","https://openalex.org/W4205259240","https://openalex.org/W4210806682","https://openalex.org/W4223922655","https://openalex.org/W4225147861","https://openalex.org/W4231246243","https://openalex.org/W4285388367","https://openalex.org/W4293776695","https://openalex.org/W4318483690","https://openalex.org/W4327599975","https://openalex.org/W4362507253","https://openalex.org/W4386495972","https://openalex.org/W4388695651","https://openalex.org/W4390694604","https://openalex.org/W4391540514","https://openalex.org/W4400676993","https://openalex.org/W4406984405","https://openalex.org/W4408060513","https://openalex.org/W6632614325","https://openalex.org/W6905605765","https://openalex.org/W6982936261"],"related_works":["https://openalex.org/W4360618575","https://openalex.org/W7132063966","https://openalex.org/W2937645739","https://openalex.org/W2789893390","https://openalex.org/W1894349587","https://openalex.org/W4362507253","https://openalex.org/W7167589137","https://openalex.org/W7130610711","https://openalex.org/W317723173","https://openalex.org/W4394996321"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Chemotherapy":[1],"is":[2,22],"a":[3,35,243],"primary":[4],"treatment":[5],"option":[6],"in":[7,51,59,64,80,150,184],"human":[8,41,196,223,240],"and":[9,26,46,92,141,174,197,201,205,224],"veterinary":[10,198],"oncology.":[11],"Like":[12],"humans,":[13],"canine":[14,120,164,225,232],"patients":[15],"often":[16],"develop":[17],"drug":[18,71],"resistance.":[19,72],"Comparative":[20],"oncology":[21,186],"gaining":[23],"increasing":[24],"interest,":[25],"spontaneous":[27,121,233],"tumors":[28,50,122,234],"of":[29,49,70,86,135,148,160,163,181,209,218],"companion":[30],"dogs":[31,52],"have":[32,155],"emerged":[33],"as":[34,235],"powerful":[36],"resource":[37],"for":[38,131,176,221,239],"better":[39],"understanding":[40],"cancer.":[42],"The":[43,105,115],"genetic,":[44],"molecular,":[45],"histological":[47],"features":[48],"are":[53,123],"more":[54],"closely":[55],"related":[56],"to":[57,99,167,214],"those":[58],"humans":[60,140],"than":[61],"the":[62,81,145,161,193,207,216,248],"ones":[63],"laboratory":[65],"animals,":[66],"including":[67],"complex":[68],"mechanisms":[69,134],"METHODS:":[73],"A":[74],"comprehensive":[75],"literature":[76,116],"search":[77],"was":[78],"conducted":[79],"electronic":[82],"database":[83],"Clarivate":[84],"Web":[85],"Science":[87],"(WOS):":[88],"Medical":[89],"Literature":[90],"Analysis":[91],"Retrieval":[93],"System":[94],"Online":[95],"(MEDLINE)":[96],"from":[97],"1990":[98],"2025":[100],"(updated":[101],"22":[102],"January":[103],"2025).":[104],"final":[106],"set":[107],"includes":[108],"59":[109],"relevant":[110],"full-text":[111],"English":[112],"articles.":[113],"RESULTS:":[114],"findings":[117],"suggest":[118],"that":[119],"valuable":[124],"model":[125],"systems":[126],"with":[127,139],"important":[128],"translational":[129,185,236],"implications":[130],"identifying":[132],"novel":[133],"chemotherapy":[136],"resistance":[137,220],"shared":[138],"may":[142,229],"help":[143],"advance":[144],"current":[146],"standard":[147],"care":[149],"precision":[151],"medicine.":[152],"CONCLUSIONS:":[153],"We":[154],"provided":[156],"an":[157],"updated":[158],"overview":[159],"role":[162],"tumor":[165],"models":[166,183,238],"study":[168],"oncotherapy":[169],"resistance,":[170],"focusing":[171],"on":[172,247],"limitations":[173],"opportunities":[175],"advancement.":[177],"Despite":[178],"complementary":[179],"benefits":[180],"such":[182],"research,":[187],"their":[188],"relevance":[189],"remains":[190],"underestimated.":[191],"Strengthening":[192],"collaboration":[194],"between":[195],"medicine":[199,203],"professionals":[200],"comparative":[202],"researchers,":[204],"obtaining":[206],"support":[208],"interdisciplinary":[210],"institutions,":[211],"could":[212],"contribute":[213],"addressing":[215],"problem":[217],"multidrug":[219],"both":[222],"patients.":[226],"Future":[227],"research":[228],"promote":[230],"using":[231],"therapeutic":[237],"chemoresistance,":[241],"through":[242],"multidisciplinary":[244],"approach":[245],"based":[246],"emerging":[249],"\"One":[250],"Health,":[251],"One":[252],"Medicine\"":[253],"paradigm.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-10-10T00:00:00"}