{"id":"https://openalex.org/W4411339136","doi":"https://doi.org/10.3390/pharmaceutics17060780","title":"Cenostigma bracteosum Hydroethanolic Extract: Chemical Profile, Antibacterial Activity, Cytotoxicity, and Gel Formulation Development","display_name":"Cenostigma bracteosum Hydroethanolic Extract: Chemical Profile, Antibacterial Activity, Cytotoxicity, and Gel Formulation Development","publication_year":2025,"publication_date":"2025-06-14","ids":{"openalex":"https://openalex.org/W4411339136","doi":"https://doi.org/10.3390/pharmaceutics17060780","pmid":"https://pubmed.ncbi.nlm.nih.gov/40574092","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12196441"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics17060780","doi":"https://doi.org/10.3390/pharmaceutics17060780","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics17060780","pdf_url":"https://www.mdpi.com/1999-4923/17/6/780/pdf?version=1749873774","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/17/6/780/pdf?version=1749873774","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065268459","display_name":"Addison Ribeiro de Almeida","orcid":"https://orcid.org/0000-0003-3867-8899","observed_orcids":["https://orcid.org/0000-0003-3867-8899"]},"institutions":[{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Addison R. Almeida","raw_affiliation_strings":["Programa de P\u00f3s-Gradua\u00e7\u00e3o em Qu\u00edmica, Instituto de Qu\u00edmica, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59072-970, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-3867-8899","affiliations":[{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Qu\u00edmica, Instituto de Qu\u00edmica, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59072-970, Brazil","institution_ids":["https://openalex.org/I35046152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020390067","display_name":"Francisco Ayrton Senna Domingos Pinheiro","orcid":"https://orcid.org/0000-0002-5887-4240","observed_orcids":["https://orcid.org/0000-0002-5887-4240"]},"institutions":[{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Francisco A. S. D. Pinheiro","raw_affiliation_strings":["Departamento de Farm\u00e1cia, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil","Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Departamento de Farm\u00e1cia, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-5887-4240","affiliations":[{"raw_affiliation_string":"Departamento de Farm\u00e1cia, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil","institution_ids":["https://openalex.org/I35046152"]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Departamento de Farm\u00e1cia, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil","institution_ids":["https://openalex.org/I35046152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118212699","display_name":"Mar\u00edlia G. M. Fideles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mar\u00edlia G. M. Fideles","raw_affiliation_strings":["Departamento de Farm\u00e1cia, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farm\u00e1cia, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil","institution_ids":["https://openalex.org/I35046152"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Roberto B. L. Cunha","orcid":"https://orcid.org/0009-0002-0571-1955","observed_orcids":["https://orcid.org/0009-0002-0571-1955"]},"institutions":[{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Roberto B. L. Cunha","raw_affiliation_strings":["Departamento de Farm\u00e1cia, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil"],"raw_orcid":"https://orcid.org/0009-0002-0571-1955","affiliations":[{"raw_affiliation_string":"Departamento de Farm\u00e1cia, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil","institution_ids":["https://openalex.org/I35046152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044167978","display_name":"Vitor de Paiva Porf\u00edrio Confessor","orcid":"https://orcid.org/0000-0003-2443-0622","observed_orcids":["https://orcid.org/0000-0003-2443-0622"]},"institutions":[{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vitor P. P. Confessor","raw_affiliation_strings":["Departamento de Farm\u00e1cia, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil","Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Departamento de Farm\u00e1cia, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-2443-0622","affiliations":[{"raw_affiliation_string":"Departamento de Farm\u00e1cia, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil","institution_ids":["https://openalex.org/I35046152"]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Departamento de Farm\u00e1cia, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil","institution_ids":["https://openalex.org/I35046152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049573801","display_name":"K. Matsui","orcid":"https://orcid.org/0000-0003-2434-904X","observed_orcids":["https://orcid.org/0000-0003-2434-904X"]},"institutions":[{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"K\u00e1tia N. Matsui","raw_affiliation_strings":["Programa de P\u00f3s-Gradua\u00e7\u00e3o em Engenharia Qu\u00edmica, Departamento de Engenharia Qu\u00edmica, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Engenharia Qu\u00edmica, Departamento de Engenharia Qu\u00edmica, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil","institution_ids":["https://openalex.org/I35046152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009488446","display_name":"Weslley de Souza Paiva","orcid":"https://orcid.org/0000-0002-2022-5659","observed_orcids":["https://orcid.org/0000-0002-2022-5659"]},"institutions":[{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Weslley S. Paiva","raw_affiliation_strings":["Laborat\u00f3rio de Biotecnologia de Pol\u00edmeros Naturais-BIOPOL, Departamento de Bioqu\u00edmica, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59072-970, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-2022-5659","affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Biotecnologia de Pol\u00edmeros Naturais-BIOPOL, Departamento de Bioqu\u00edmica, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59072-970, Brazil","institution_ids":["https://openalex.org/I35046152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068873111","display_name":"Hugo Alexandre Oliveira Rocha","orcid":"https://orcid.org/0000-0003-2252-1221","observed_orcids":["https://orcid.org/0000-0003-2252-1221"]},"institutions":[{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Hugo A. O. Rocha","raw_affiliation_strings":["Laborat\u00f3rio de Biotecnologia de Pol\u00edmeros Naturais-BIOPOL, Departamento de Bioqu\u00edmica, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59072-970, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-2252-1221","affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Biotecnologia de Pol\u00edmeros Naturais-BIOPOL, Departamento de Bioqu\u00edmica, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59072-970, Brazil","institution_ids":["https://openalex.org/I35046152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005354311","display_name":"Gislene Ganade","orcid":"https://orcid.org/0000-0002-9291-1025","observed_orcids":["https://orcid.org/0000-0002-9291-1025"]},"institutions":[{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gislene Ganade","raw_affiliation_strings":["Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ecologia, Departamento de Ecologia, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59072-970, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ecologia, Departamento de Ecologia, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59072-970, Brazil","institution_ids":["https://openalex.org/I35046152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052488009","display_name":"Laila Salmen Esp\u00edndola","orcid":"https://orcid.org/0000-0002-1886-868X","observed_orcids":["https://orcid.org/0000-0002-1886-868X"]},"institutions":[{"id":"https://openalex.org/I150729083","display_name":"Universidade de Bras\u00edlia","ror":"https://ror.org/02xfp8v59","country_code":"BR","type":"education","lineage":["https://openalex.org/I150729083"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Laila S. Espindola","raw_affiliation_strings":["Laborat\u00f3rio de Farmacognosia, Campus Universit\u00e1rio Darcy Ribeiro, Universidade de Bras\u00edlia, Bras\u00edlia CEP 70910-900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Farmacognosia, Campus Universit\u00e1rio Darcy Ribeiro, Universidade de Bras\u00edlia, Bras\u00edlia CEP 70910-900, Brazil","institution_ids":["https://openalex.org/I150729083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016712682","display_name":"W.A. de Morais","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Waldenice A. Morais","raw_affiliation_strings":["Departamento de Farm\u00e1cia, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil","Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Departamento de Farm\u00e1cia, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farm\u00e1cia, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil","institution_ids":["https://openalex.org/I35046152"]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Departamento de Farm\u00e1cia, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil","institution_ids":["https://openalex.org/I35046152"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083865032","display_name":"Leandro De Santis Ferreira","orcid":"https://orcid.org/0000-0002-8408-5886","observed_orcids":["https://orcid.org/0000-0002-8408-5886"]},"institutions":[{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Leandro S. Ferreira","raw_affiliation_strings":["Departamento de Farm\u00e1cia, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil","Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Departamento de Farm\u00e1cia, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil","Programa de P\u00f3s-Gradua\u00e7\u00e3o em Qu\u00edmica, Instituto de Qu\u00edmica, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59072-970, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-8408-5886","affiliations":[{"raw_affiliation_string":"Departamento de Farm\u00e1cia, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil","institution_ids":["https://openalex.org/I35046152"]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Departamento de Farm\u00e1cia, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59012-570, Brazil","institution_ids":["https://openalex.org/I35046152"]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Qu\u00edmica, Instituto de Qu\u00edmica, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59072-970, Brazil","institution_ids":["https://openalex.org/I35046152"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083865032"],"corresponding_institution_ids":["https://openalex.org/I35046152"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":1.7032,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.80956157,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"17","issue":"6","first_page":"780","last_page":"780"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroethanolic-leaf-extract","display_name":"hydroethanolic leaf extract","score":0.890999972820282},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8600000143051147},{"id":"https://openalex.org/keywords/carbopol-gel","display_name":"Carbopol gel","score":0.7540000081062317},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9089999794960022},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":1.0},{"id":"https://openalex.org/keywords/phenolic-acids","display_name":"phenolic acids","score":0.7870000004768372},{"id":"https://openalex.org/keywords/flavonoid-glycosides","display_name":"flavonoid glycosides","score":0.9829999804496765},{"id":"https://openalex.org/keywords/biflavonoids","display_name":"biflavonoids","score":0.9390000104904175},{"id":"https://openalex.org/keywords/secondary-metabolites","display_name":"secondary metabolites","score":0.8080000281333923},{"id":"https://openalex.org/keywords/caatinga","display_name":"Caatinga","score":0.7210000157356262},{"id":"https://openalex.org/keywords/skin-application","display_name":"skin application","score":0.4309999942779541},{"id":"https://openalex.org/keywords/mc3t3-e1-cells","display_name":"MC3T3-E1 cells","score":0.8299999833106995},{"id":"https://openalex.org/keywords/l929-fibroblasts","display_name":"L929 fibroblasts","score":0.9309999942779541}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6431108713150024},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.5633317232131958},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5137261152267456},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48967865109443665},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23504993319511414},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.11684709787368774},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1152152419090271},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11479008197784424},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11409768462181091},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/pharmaceutics17060780","doi":"https://doi.org/10.3390/pharmaceutics17060780","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics17060780","pdf_url":"https://www.mdpi.com/1999-4923/17/6/780/pdf?version=1749873774","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:40574092","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40574092","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12196441","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12196441/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3c2eb7e9237542ee866a7d6397948092","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3c2eb7e9237542ee866a7d6397948092","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 17, Iss 6, p 780 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics17060780","doi":"https://doi.org/10.3390/pharmaceutics17060780","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics17060780","pdf_url":"https://www.mdpi.com/1999-4923/17/6/780/pdf?version=1749873774","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1481512563","display_name":null,"funder_award_id":"542/2023","funder_id":"https://openalex.org/F4320323350","funder_display_name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa do Distrito Federal"},{"id":"https://openalex.org/G2462521957","display_name":null,"funder_award_id":"TED 42/2017","funder_id":"https://openalex.org/F4320310929","funder_display_name":"Universidade de Bras\u00edlia"},{"id":"https://openalex.org/G5509362765","display_name":null,"funder_award_id":"TED74/2016","funder_id":"https://openalex.org/F4320310929","funder_display_name":"Universidade de Bras\u00edlia"}],"funders":[{"id":"https://openalex.org/F4320310929","display_name":"Universidade de Bras\u00edlia","ror":"https://ror.org/02xfp8v59"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320323350","display_name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa do Distrito Federal","ror":"https://ror.org/04djvx395"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411339136.pdf","grobid_xml":"https://content.openalex.org/works/W4411339136.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1985496159","https://openalex.org/W2048072806","https://openalex.org/W2075629449","https://openalex.org/W2087962857","https://openalex.org/W2114918609","https://openalex.org/W2117087393","https://openalex.org/W2160511843","https://openalex.org/W2590615570","https://openalex.org/W2791854575","https://openalex.org/W2907660099","https://openalex.org/W2922093197","https://openalex.org/W2947155157","https://openalex.org/W3019033252","https://openalex.org/W3045236173","https://openalex.org/W3090832694","https://openalex.org/W3139454107","https://openalex.org/W3161685762","https://openalex.org/W3201581417","https://openalex.org/W3214740153","https://openalex.org/W4224275734","https://openalex.org/W4283264914","https://openalex.org/W4283459915","https://openalex.org/W4310474366","https://openalex.org/W4312476304","https://openalex.org/W4365458827","https://openalex.org/W4377564884","https://openalex.org/W4383221674","https://openalex.org/W4386602201","https://openalex.org/W4388928943","https://openalex.org/W4390110168","https://openalex.org/W4394881495","https://openalex.org/W4395052433","https://openalex.org/W4405317677","https://openalex.org/W4405386398","https://openalex.org/W7009261596"],"related_works":["https://openalex.org/W6980124548","https://openalex.org/W2910588835","https://openalex.org/W1609970632","https://openalex.org/W2809705701","https://openalex.org/W3184813873","https://openalex.org/W2566763341","https://openalex.org/W7081938238","https://openalex.org/W7128386571","https://openalex.org/W2534193586","https://openalex.org/W7214712211"],"abstract_inverted_index":{"Background:Cenostigma":[0],"bracteosum":[1,59,116,170],"(Tul.)":[2],"Gagnon":[3],"&":[4],"G.P.":[5],"Lewis":[6],"(Fabaceae),":[7],"popularly":[8],"known":[9],"as":[10],"\u201ccatingueira\u201d,":[11],"is":[12,31],"a":[13,54,217,234,246],"plant":[14],"widely":[15],"distributed":[16],"in":[17,41,86,122,253],"the":[18,25,42,65,135,150,157,186,201,208,225,238,242],"Caatinga":[19,248],"biome,":[20],"which":[21],"comprises":[22],"11%":[23],"of":[24,32,57,114,124,149,203,207,237,241,245],"Brazilian":[26],"territory.":[27],"While":[28],"this":[29],"species":[30],"interest":[33],"given":[34],"local":[35],"knowledge,":[36],"formal":[37],"reports":[38],"are":[39],"lacking":[40],"literature,":[43],"warranting":[44],"targeted":[45],"investigation.":[46],"This":[47],"study":[48],"aimed":[49],"to":[50,192],"prepare":[51,61],"and":[52,67,71,77,112,120,128,142,152,164,179,195,211,257],"characterize":[53],"hydroethanolic":[55,255],"extract":[56,83,95,117,151,172,256],"C.":[58,115,169],"leaves,":[60],"carbopol":[62],"gels":[63,109,153,221],"containing":[64,110],"extract,":[66],"evaluate":[68],"their":[69],"cytotoxicity":[70,131],"antibacterial":[72,147,174],"activity":[73,148,175,265],"against":[74,161,176,266],"Staphylococcus":[75],"aureus":[76,163,178],"Escherichia":[78],"coli.":[79,166],"Methods:":[80],"The":[81,94,130,146,168,219],"initial":[82],"was":[84,98,132,154],"prepared":[85,119,220],"an":[87],"ultrasonic":[88],"bath":[89],"using":[90,138,156],"ethanol/water":[91],"(70:30,":[92],"v/v).":[93],"(1":[96],"mg/mL)":[97],"analyzed":[99],"by":[100,134,198],"liquid":[101],"chromatography":[102],"coupled":[103],"with":[104,216,264],"mass":[105],"spectrometry":[106],"(UHPLC-MS/MS).":[107],"Carbopol-based":[108],"1%":[111],"3%":[113],"were":[118,182],"characterized":[121],"terms":[123],"pH,":[125],"conductivity,":[126],"spreadability,":[127],"rheology.":[129],"determined":[133],"MTT":[136],"method":[137,160],"MC3T3-E1":[139],"pre-osteoblast":[140],"cells":[141,188],"L929-CCL1":[143],"fibroblast":[144],"cells.":[145],"evaluated":[155],"agar":[158],"diffusion":[159],"S.":[162,177,267],"E.":[165,180],"Results:":[167],"leaves":[171,254],"demonstrated":[173],"coli,":[181],"not":[183],"cytotoxic":[184],"for":[185,261],"assessed":[187],"at":[189],"concentrations":[190],"up":[191],"100":[193],"\u03bcg/mL,":[194],"its":[196],"analysis":[197,228],"UHPLC-MS/MS":[199],"allowed":[200],"annotation":[202],"18":[204],"metabolites,":[205],"mainly":[206],"phenolic":[209],"acid":[210],"flavonoids":[212],"glycoside":[213],"classes,":[214],"together":[215],"biflavonoid.":[218],"remained":[222],"stable":[223],"over":[224],"30-day":[226],"post-production":[227],"period.":[229],"Conclusions:":[230],"These":[231],"findings":[232],"provide":[233],"better":[235],"understanding":[236],"chemical":[239],"diversity":[240],"secondary":[243],"metabolites":[244],"common":[247],"biome":[249],"species\u2014C.":[250],"bracteosum\u2014specifically":[251],"present":[252],"gel":[258],"formulation":[259],"adapted":[260],"skin":[262],"application":[263],"aureus.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-06-17T00:00:00"}