{"id":"https://openalex.org/W4411299554","doi":"https://doi.org/10.1016/j.bmcl.2025.130309","title":"Design, synthesis, and investigation of lipid-lowering and hepatoprotective effects of clofibrate-vanillin derivative based on structural optimization","display_name":"Design, synthesis, and investigation of lipid-lowering and hepatoprotective effects of clofibrate-vanillin derivative based on structural optimization","publication_year":2025,"publication_date":"2025-06-14","ids":{"openalex":"https://openalex.org/W4411299554","doi":"https://doi.org/10.1016/j.bmcl.2025.130309","pmid":"https://pubmed.ncbi.nlm.nih.gov/40516765"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmcl.2025.130309","doi":"https://doi.org/10.1016/j.bmcl.2025.130309","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2025.130309","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yumiao Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yumiao Song","raw_affiliation_strings":["College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-xianyang New Ecomic Zone, Shaanxi Province 712046, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-xianyang New Ecomic Zone, Shaanxi Province 712046, People's Republic of China","institution_ids":["https://openalex.org/I75920027"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xinyi Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyi Shi","raw_affiliation_strings":["College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-xianyang New Ecomic Zone, Shaanxi Province 712046, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-xianyang New Ecomic Zone, Shaanxi Province 712046, People's Republic of China","institution_ids":["https://openalex.org/I75920027"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102028111","display_name":"Xinyu Zhang","orcid":"https://orcid.org/0000-0002-2715-4777","observed_orcids":["https://orcid.org/0000-0002-2715-4777"]},"institutions":[{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Zhang","raw_affiliation_strings":["College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-xianyang New Ecomic Zone, Shaanxi Province 712046, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-xianyang New Ecomic Zone, Shaanxi Province 712046, People's Republic of China","institution_ids":["https://openalex.org/I75920027"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065186938","display_name":"Ling Ding","orcid":"https://orcid.org/0000-0002-2348-1076","observed_orcids":["https://orcid.org/0000-0002-2348-1076"]},"institutions":[{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Ding","raw_affiliation_strings":["College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-xianyang New Ecomic Zone, Shaanxi Province 712046, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-xianyang New Ecomic Zone, Shaanxi Province 712046, People's Republic of China","institution_ids":["https://openalex.org/I75920027"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115061373","display_name":"Huizi Shangguan","orcid":"https://orcid.org/0009-0001-5940-2392","observed_orcids":["https://orcid.org/0009-0001-5940-2392"]},"institutions":[{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huizi Shangguan","raw_affiliation_strings":["College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-xianyang New Ecomic Zone, Shaanxi Province 712046, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-xianyang New Ecomic Zone, Shaanxi Province 712046, People's Republic of China","institution_ids":["https://openalex.org/I75920027"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xin Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405271309","display_name":"Shaanxi Administration of Traditional Chinese Medicine","ror":"https://ror.org/027hagy81","country_code":"CN","type":"government","lineage":["https://openalex.org/I4405271309"]},{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Wang","raw_affiliation_strings":["College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-xianyang New Ecomic Zone, Shaanxi Province 712046, People's Republic of China; Key Laboratory of Pharmacodynamics and Material Basis of Chinese Medicine, Shaanxi Administration of Traditional Chinese Medicine, Xianyang 712046, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-xianyang New Ecomic Zone, Shaanxi Province 712046, People's Republic of China; Key Laboratory of Pharmacodynamics and Material Basis of Chinese Medicine, Shaanxi Administration of Traditional Chinese Medicine, Xianyang 712046, People's Republic of China","institution_ids":["https://openalex.org/I4405271309","https://openalex.org/I75920027"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jiping Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405271309","display_name":"Shaanxi Administration of Traditional Chinese Medicine","ror":"https://ror.org/027hagy81","country_code":"CN","type":"government","lineage":["https://openalex.org/I4405271309"]},{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiping Liu","raw_affiliation_strings":["College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-xianyang New Ecomic Zone, Shaanxi Province 712046, People's Republic of China; Key Laboratory of Pharmacodynamics and Material Basis of Chinese Medicine, Shaanxi Administration of Traditional Chinese Medicine, Xianyang 712046, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-xianyang New Ecomic Zone, Shaanxi Province 712046, People's Republic of China; Key Laboratory of Pharmacodynamics and Material Basis of Chinese Medicine, Shaanxi Administration of Traditional Chinese Medicine, Xianyang 712046, People's Republic of China","institution_ids":["https://openalex.org/I4405271309","https://openalex.org/I75920027"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016141225","display_name":"Yongheng Shi","orcid":"https://orcid.org/0000-0002-4290-2593","observed_orcids":["https://orcid.org/0000-0002-4290-2593"]},"institutions":[{"id":"https://openalex.org/I4405271309","display_name":"Shaanxi Administration of Traditional Chinese Medicine","ror":"https://ror.org/027hagy81","country_code":"CN","type":"government","lineage":["https://openalex.org/I4405271309"]},{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongheng Shi","raw_affiliation_strings":["College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-xianyang New Ecomic Zone, Shaanxi Province 712046, People's Republic of China; Key Laboratory of Pharmacodynamics and Material Basis of Chinese Medicine, Shaanxi Administration of Traditional Chinese Medicine, Xianyang 712046, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-xianyang New Ecomic Zone, Shaanxi Province 712046, People's Republic of China; Key Laboratory of Pharmacodynamics and Material Basis of Chinese Medicine, Shaanxi Administration of Traditional Chinese Medicine, Xianyang 712046, People's Republic of China","institution_ids":["https://openalex.org/I4405271309","https://openalex.org/I75920027"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074637678","display_name":"Xinya Xu","orcid":"https://orcid.org/0000-0002-3250-4399","observed_orcids":["https://orcid.org/0000-0002-3250-4399","https://orcid.org/0009-0001-4329-5393"]},"institutions":[{"id":"https://openalex.org/I4405271309","display_name":"Shaanxi Administration of Traditional Chinese Medicine","ror":"https://ror.org/027hagy81","country_code":"CN","type":"government","lineage":["https://openalex.org/I4405271309"]},{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinya Xu","raw_affiliation_strings":["College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-xianyang New Ecomic Zone, Shaanxi Province 712046, People's Republic of China; Key Laboratory of Pharmacodynamics and Material Basis of Chinese Medicine, Shaanxi Administration of Traditional Chinese Medicine, Xianyang 712046, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-xianyang New Ecomic Zone, Shaanxi Province 712046, People's Republic of China; Key Laboratory of Pharmacodynamics and Material Basis of Chinese Medicine, Shaanxi Administration of Traditional Chinese Medicine, Xianyang 712046, People's Republic of China","institution_ids":["https://openalex.org/I4405271309","https://openalex.org/I75920027"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068177321","display_name":"Yundong Xie","orcid":"https://orcid.org/0009-0008-9358-4864","observed_orcids":["https://orcid.org/0009-0008-9358-4864"]},"institutions":[{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yundong Xie","raw_affiliation_strings":["College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-xianyang New Ecomic Zone, Shaanxi Province 712046, People's Republic of China. Electronic address: eng522@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-xianyang New Ecomic Zone, Shaanxi Province 712046, People's Republic of China. Electronic address: eng522@126.com","institution_ids":["https://openalex.org/I75920027"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068177321"],"corresponding_institution_ids":["https://openalex.org/I75920027"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":0.6623,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.57760831,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"127","issue":null,"first_page":"130309","last_page":"130309"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clofibrate","display_name":"clofibrate","score":0.8109999895095825},{"id":"https://openalex.org/keywords/vanillin","display_name":"vanillin","score":0.7160000205039978},{"id":"https://openalex.org/keywords/lipid-lowering-drugs","display_name":"lipid-lowering drugs","score":0.7480000257492065},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.8880000114440918},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.9629999995231628},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.9139999747276306},{"id":"https://openalex.org/keywords/nrf2-ho-1-signaling-pathway","display_name":"Nrf2/HO-1 pathway","score":0.8939999938011169},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9100000262260437},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9929999709129333},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.671999990940094},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.8399999737739563},{"id":"https://openalex.org/keywords/total-cholesterol","display_name":"total cholesterol","score":0.8050000071525574},{"id":"https://openalex.org/keywords/structure-activity-optimization","display_name":"structure-activity optimization","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9110327959060669},{"id":"https://openalex.org/C2779496979","wikidata":"https://www.wikidata.org/wiki/Q2701912","display_name":"Clofibrate","level":2,"score":0.8382757902145386},{"id":"https://openalex.org/C111771559","wikidata":"https://www.wikidata.org/wiki/Q66295","display_name":"Derivative (finance)","level":2,"score":0.6491278409957886},{"id":"https://openalex.org/C2777340834","wikidata":"https://www.wikidata.org/wiki/Q33495","display_name":"Vanillin","level":2,"score":0.6086305975914001},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.5205786824226379},{"id":"https://openalex.org/C2992125399","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Lipid accumulation","level":2,"score":0.45937690138816833},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4423920512199402},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.35843244194984436},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.33527517318725586},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2779410779476166},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C106159729","wikidata":"https://www.wikidata.org/wiki/Q2294553","display_name":"Financial economics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002994","descriptor_name":"Clofibrate","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D002994","descriptor_name":"Clofibrate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002994","descriptor_name":"Clofibrate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002994","descriptor_name":"Clofibrate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmcl.2025.130309","doi":"https://doi.org/10.1016/j.bmcl.2025.130309","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2025.130309","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:40516765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40516765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6385085275","display_name":null,"funder_award_id":"2024-LJRC-04","funder_id":"https://openalex.org/F4320329789","funder_display_name":"Shaanxi University of Chinese Medicine"}],"funders":[{"id":"https://openalex.org/F4320329789","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1971977338","https://openalex.org/W1994896415","https://openalex.org/W2032344807","https://openalex.org/W2032913839","https://openalex.org/W2033724001","https://openalex.org/W2062401013","https://openalex.org/W2065257558","https://openalex.org/W2081476497","https://openalex.org/W2084774843","https://openalex.org/W2114566287","https://openalex.org/W2116672342","https://openalex.org/W2257176259","https://openalex.org/W2299403329","https://openalex.org/W2598060347","https://openalex.org/W2600119847","https://openalex.org/W2771532173","https://openalex.org/W2990768483","https://openalex.org/W3015471088","https://openalex.org/W3040871229","https://openalex.org/W3046248060","https://openalex.org/W3135024618","https://openalex.org/W4221057158","https://openalex.org/W4366350996","https://openalex.org/W4386226069","https://openalex.org/W4388460152","https://openalex.org/W4391062078","https://openalex.org/W4391533615","https://openalex.org/W4402372671"],"related_works":["https://openalex.org/W4406943863","https://openalex.org/W4281703280","https://openalex.org/W7151573915","https://openalex.org/W7124587985","https://openalex.org/W2805761163","https://openalex.org/W4415600007","https://openalex.org/W4415555967","https://openalex.org/W3162686321","https://openalex.org/W7212194764","https://openalex.org/W4410699149"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}