{"id":"https://openalex.org/W4411286684","doi":"https://doi.org/10.1158/1557-3265.sabcs24-p4-12-05","title":"Abstract P4-12-05: Prescription patterns and preferences for CDK4/6 inhibitors among oncologists in Latin America","display_name":"Abstract P4-12-05: Prescription patterns and preferences for CDK4/6 inhibitors among oncologists in Latin America","publication_year":2025,"publication_date":"2025-06-13","ids":{"openalex":"https://openalex.org/W4411286684","doi":"https://doi.org/10.1158/1557-3265.sabcs24-p4-12-05"},"language":"en","primary_location":{"id":"doi:10.1158/1557-3265.sabcs24-p4-12-05","doi":"https://doi.org/10.1158/1557-3265.sabcs24-p4-12-05","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3265.sabcs24-p4-12-05","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078226702","display_name":"Alejandro Aranda-Gutierrez","orcid":"https://orcid.org/0000-0002-7325-8569","observed_orcids":["https://orcid.org/0000-0002-7325-8569"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alejandro Aranda-Gutierrez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092771329","display_name":"Andr\u00e9s Meraz-Brenez","orcid":"https://orcid.org/0000-0001-9400-3111","observed_orcids":["https://orcid.org/0000-0001-9400-3111"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andres Meraz-Brenez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086760064","display_name":"Daniela Vazquez\u2010Juarez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniela Vazquez-Juarez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Agatha Reyes Morales","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agatha Reyes Morales","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102551452","display_name":"Ahmad Wali Mushtaq","orcid":"https://orcid.org/0000-0003-2081-8726","observed_orcids":["https://orcid.org/0000-0003-2081-8726"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ahmad Wali Mushtaq","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058363564","display_name":"Brizio Moreno\u2010Jaime","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brizio Moreno-Jaime","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083739999","display_name":"Denis Landaverde","orcid":"https://orcid.org/0000-0002-6522-1061","observed_orcids":["https://orcid.org/0000-0002-6522-1061"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Denis U Landaverde","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009680708","display_name":"Fernando Enrique Petracci","orcid":"https://orcid.org/0000-0002-7701-3331","observed_orcids":["https://orcid.org/0000-0002-7701-3331"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fernando E. Petracci","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068844567","display_name":"Henry Idrobo","orcid":"https://orcid.org/0000-0002-7686-5874","observed_orcids":["https://orcid.org/0000-0002-7686-5874"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henry Idrobo Quintero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Joel Moreno R\u00edos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joel Moreno R\u00edos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Juan Carlos - Samam\u00e9 - P\u00e9rez Vargas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan Carlos - Samam\u00e9 - P\u00e9rez Vargas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Victor Acosta Mar\u00edn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victor Acosta Mar\u00edn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053079188","display_name":"William Armando Mantilla","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wiliam Armando Mantilla","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5031392838","display_name":"Cynthia Mayte Villarreal-Garza","orcid":"https://orcid.org/0000-0003-3587-339X","observed_orcids":["https://orcid.org/0000-0003-3587-339X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cynthia Villarreal-Garza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"12_Supplement","first_page":"P4","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdk4-6-inhibitors","display_name":"CDK4/6 inhibitors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prescribing-patterns","display_name":"prescribing patterns","score":0.8759999871253967},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9100000262260437},{"id":"https://openalex.org/keywords/abemaciclib","display_name":"abemaciclib","score":0.871999979019165},{"id":"https://openalex.org/keywords/palbociclib","display_name":"palbociclib","score":0.996999979019165},{"id":"https://openalex.org/keywords/ribociclib","display_name":"ribociclib","score":1.0},{"id":"https://openalex.org/keywords/latin-america","display_name":"Latin America","score":0.6909999847412109},{"id":"https://openalex.org/keywords/cost-and-accessibility","display_name":"cost and accessibility","score":0.3790000081062317},{"id":"https://openalex.org/keywords/endocrine-resistance","display_name":"endocrine therapy resistance","score":0.7089999914169312},{"id":"https://openalex.org/keywords/visceral-disease","display_name":"visceral disease","score":0.7170000076293945},{"id":"https://openalex.org/keywords/central-nervous-system-diseases","display_name":"central nervous system disorders","score":0.7260000109672546},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.6539999842643738},{"id":"https://openalex.org/keywords/liver-disease","display_name":"liver disease","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C158886217","wikidata":"https://www.wikidata.org/wiki/Q16799549","display_name":"Latin Americans","level":2,"score":0.7488354444503784},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.6513972878456116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5645078420639038},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3933144807815552},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.35862523317337036},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32134705781936646},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2713533341884613},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.130069762468338},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1557-3265.sabcs24-p4-12-05","doi":"https://doi.org/10.1158/1557-3265.sabcs24-p4-12-05","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3265.sabcs24-p4-12-05","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7138935250","https://openalex.org/W4399323939","https://openalex.org/W7129630984","https://openalex.org/W4408922463","https://openalex.org/W3129317593","https://openalex.org/W3119800811","https://openalex.org/W3032549624","https://openalex.org/W4410821028","https://openalex.org/W4397007143","https://openalex.org/W3028563436"],"abstract_inverted_index":{"Abstract":[0],"Currently,":[1],"three":[2,176],"CDK4/6":[3,47,70,178,352,379,465],"inhibitors":[4,48,466],"(abemaciclib,":[5],"palbociclib,":[6,358],"ribociclib)":[7],"are":[8],"FDA-approved":[9],"as":[10,305,348,399],"first-line":[11],"agents":[12,391],"for":[13,224,332,361,377,464],"the":[14,28,41,84,102,118,349,368,410,476],"treatment":[15],"of":[16,46,86,107,123,143,206,212,218,236,270,274,290,318,370,409,475],"metastatic":[17],"breast":[18,149],"cancer":[19],"(MBC).":[20],"However,":[21],"no":[22],"specific":[23,259,362],"recommendations":[24],"favor":[25],"one":[26],"over":[27],"others,":[29],"and":[30,43,91,135,194,248,279,288,297,328,335,343,357,462],"usage":[31],"is":[32,383],"variable":[33],"between":[34],"oncologists.":[35],"This":[36,199,381,403],"study":[37],"aims":[38],"to":[39,100,243,254],"investigate":[40],"preferences":[42,376,463],"prescription":[44],"patterns":[45,461],"among":[49,262,467],"oncologists":[50,63,110,144,155,171,468],"in":[51,66,76,112,159,167,230,307,373,469],"Latin":[52,60,87,114,411,470],"America.":[53],"We":[54],"conducted":[55,406],"an":[56],"online":[57,119],"survey":[58,73],"targeting":[59],"American":[61,88,115,412],"medical":[62,109],"with":[64,69,315,396],"experience":[65],"treating":[67],"MBC":[68],"inhibitors.":[71,179,380],"The":[72,121,221],"was":[74,201,227,239,250,266,283,310,324,339,405],"distributed":[75],"June":[77],"2024":[78,483],"through":[79],"email":[80],"lists":[81],"obtained":[82],"from":[83,126],"databases":[85],"oncology":[89],"societies":[90],"oncology-focused":[92],"social":[93],"media":[94],"groups.":[95],"Descriptive":[96],"statistics":[97],"were":[98,125,303],"employed":[99],"summarize":[101],"collected":[103],"variables.":[104],"A":[105],"total":[106],"116":[108],"practicing":[111,209],"20":[113],"countries":[116],"completed":[117],"survey.":[120],"majority":[122],"respondents":[124],"Mexico":[127],"(45%),":[128],"followed":[129,354],"by":[130,204,234,268,285,326,341,355],"Guatemala":[131],"(11%),":[132],"Argentina":[133],"(8%),":[134],"Colombia":[136],"(8%).":[137],"Regarding":[138,258],"their":[139,183],"practice":[140],"scope,":[141],"86%":[142],"did":[145],"not":[146,202],"exclusively":[147],"treat":[148],"cancer,":[150],"while":[151],"14%":[152],"did.":[153],"Most":[154],"(56%)":[156],"primarily":[157],"practiced":[158,166],"public":[160],"healthcare":[161],"settings,":[162],"whereas":[163],"41%":[164],"mainly":[165,240,251],"private":[168],"settings.":[169],"Ninety-seven":[170],"(84%)":[172],"had":[173],"used":[174],"all":[175],"approved":[177],"When":[180,312],"asked":[181],"about":[182],"general":[184],"preference,":[185],"66":[186],"(57%)":[187],"preferred":[188,192,197,325,340,360],"ribociclib,":[189],"35":[190],"(30%)":[191],"abemaciclib,":[193],"15":[195],"(13%)":[196],"palbociclib.":[198],"preference":[200],"impacted":[203],"country":[205],"practice,":[207,213],"time":[208],"oncology,":[210],"scope":[211],"patient":[214],"workload,":[215],"or":[216,320],"site":[217],"primary":[219],"care.":[220],"main":[222],"reason":[223],"choosing":[225],"ribociclib":[226,265,282],"its":[228,255],"benefit":[229],"overall":[231,371,397],"survival,":[232,395],"noted":[233],"77%":[235],"respondents.":[237,271],"Abemaciclib":[238],"favored":[241,351],"due":[242,253],"industry-sponsored":[244],"accessibility":[245],"programs":[246],"(62%)":[247],"palbociclib":[249,338],"selected":[252,267,304],"price":[256],"(38%).":[257],"clinical":[260,363],"scenarios,":[261],"premenopausal":[263],"women,":[264],"80%":[269],"In":[272],"cases":[273],"visceral":[275,277],"disease,":[276,281,322],"crisis,":[278],"bone-only":[280],"chosen":[284],"67%,":[286],"66%,":[287],"50%":[289],"respondents,":[291],"respectively.":[292,330,345],"Primary":[293],"endocrine":[294],"resistance":[295],"(47%)":[296],"central":[298],"nervous":[299],"system":[300],"disease":[301],"(53%)":[302],"scenarios":[306],"which":[308],"abemaciclib":[309,323,356],"favored.":[311],"managing":[313],"patients":[314,334],"a":[316,400],"history":[317],"heart":[319],"liver":[321],"53%":[327],"47%,":[329],"Lastly,":[331],"geriatric":[333],"male":[336],"patients,":[337],"58%":[342],"50%,":[344],"Ribociclib":[346],"emerged":[347],"most":[350],"inhibitor,":[353],"each":[359],"scenarios.":[364],"Our":[365],"findings":[366],"highlight":[367],"importance":[369],"survival":[372,398],"guiding":[374],"oncologists'":[375],"prescribing":[378],"observation":[382],"noteworthy":[384],"considering":[385],"that":[386],"pivotal":[387],"trials":[388],"evaluating":[389],"these":[390],"focused":[392],"on":[393,407],"progression-free":[394],"secondary":[401],"endpoint.":[402],"work":[404],"behalf":[408],"Breast":[413,479],"Cancer":[414,480,493],"Association":[415],"(LABCA).":[416],"Citation":[417],"Format:":[418],"Alejandro":[419],"Aranda-Gutierrez,":[420],"Andres":[421],"Meraz-Brenez,":[422],"Daniela":[423],"Vazquez-Juarez,":[424],"Agatha":[425],"Reyes":[426],"Morales,":[427],"Ahmad":[428],"Wali":[429],"Mushtaq,":[430],"Brizio":[431],"Moreno-Jaime,":[432],"Denis":[433],"U":[434],"Landaverde,":[435],"Fernando":[436],"E.":[437],"Petracci,":[438],"Henry":[439],"Idrobo":[440],"Quintero,":[441],"Joel":[442],"Moreno":[443],"R\u00edos,":[444],"Juan":[445],"Carlos":[446],"-":[447,449],"Samam\u00e9":[448],"P\u00e9rez":[450],"Vargas,":[451],"Victor":[452],"Acosta":[453],"Mar\u00edn,":[454],"Wiliam":[455],"Armando":[456],"Mantilla,":[457],"Cynthia":[458],"Villarreal-Garza.":[459],"Prescription":[460],"America":[471],"[abstract].":[472],"In:":[473],"Proceedings":[474],"San":[477,486],"Antonio":[478],"Symposium":[481],"2024;":[482],"Dec":[484],"10-13;":[485],"Antonio,":[487],"TX.":[488],"Philadelphia":[489],"(PA):":[490],"AACR;":[491],"Clin":[492],"Res":[494],"2025;31(12":[495],"Suppl):Abstract":[496],"nr":[497],"P4-12-05.":[498]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}