{"id":"https://openalex.org/W4411286232","doi":"https://doi.org/10.3390/ijms26125656","title":"Studies on the Protective Effect of Silybin Against Low-Dose Radiation-Induced Damage to the Immune System","display_name":"Studies on the Protective Effect of Silybin Against Low-Dose Radiation-Induced Damage to the Immune System","publication_year":2025,"publication_date":"2025-06-12","ids":{"openalex":"https://openalex.org/W4411286232","doi":"https://doi.org/10.3390/ijms26125656","pmid":"https://pubmed.ncbi.nlm.nih.gov/40565119","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12193130"},"language":"en","primary_location":{"id":"doi:10.3390/ijms26125656","doi":"https://doi.org/10.3390/ijms26125656","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26125656","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms26125656","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100433529","display_name":"Yu Zhang","orcid":"https://orcid.org/0000-0002-3087-8186","observed_orcids":["https://orcid.org/0000-0002-3087-8186","https://orcid.org/0009-0007-5691-3828"]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Zhang","raw_affiliation_strings":["Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China","School of Public Health, University of South China, Hengyang 421001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China","institution_ids":[]},{"raw_affiliation_string":"School of Public Health, University of South China, Hengyang 421001, China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053735608","display_name":"Yanan Yu","orcid":"https://orcid.org/0000-0002-8143-6978","observed_orcids":["https://orcid.org/0000-0002-8143-6978"]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanan Yu","raw_affiliation_strings":["Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China","School of Public Health, University of South China, Hengyang 421001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China","institution_ids":[]},{"raw_affiliation_string":"School of Public Health, University of South China, Hengyang 421001, China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022315541","display_name":"Yue Gao","orcid":"https://orcid.org/0000-0003-1131-5326","observed_orcids":["https://orcid.org/0000-0003-1131-5326"]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Gao","raw_affiliation_strings":["Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China","School of Public Health, University of South China, Hengyang 421001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China","institution_ids":[]},{"raw_affiliation_string":"School of Public Health, University of South China, Hengyang 421001, China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017842398","display_name":"Lanfang Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lanfang Ma","raw_affiliation_strings":["Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China","School of Life Science, Hebei University, Baoding 071000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China","institution_ids":[]},{"raw_affiliation_string":"School of Life Science, Hebei University, Baoding 071000, China","institution_ids":["https://openalex.org/I43337087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100335003","display_name":"Jie Xu","orcid":"https://orcid.org/0000-0001-7111-9912","observed_orcids":["https://orcid.org/0000-0001-7111-9912"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie Xu","raw_affiliation_strings":["Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lehan Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lehan Ding","raw_affiliation_strings":["Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China","School of Public Health, University of South China, Hengyang 421001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China","institution_ids":[]},{"raw_affiliation_string":"School of Public Health, University of South China, Hengyang 421001, China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hongling Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hongling Zhao","raw_affiliation_strings":["Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048383281","display_name":"Wenqing Hu","orcid":"https://orcid.org/0000-0001-5161-3980","observed_orcids":["https://orcid.org/0000-0001-5161-3980"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weixiang Hu","raw_affiliation_strings":["Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000544669","display_name":"Kai Hou","orcid":"https://orcid.org/0000-0001-7660-0393","observed_orcids":["https://orcid.org/0000-0001-7660-0393"]},"institutions":[{"id":"https://openalex.org/I37574244","display_name":"Sichuan Agricultural University","ror":"https://ror.org/0388c3403","country_code":"CN","type":"education","lineage":["https://openalex.org/I37574244"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Hou","raw_affiliation_strings":["College of Agronomy, Sichuan Agricultural University, Chengdu 611130, China"],"raw_orcid":"https://orcid.org/0000-0001-7660-0393","affiliations":[{"raw_affiliation_string":"College of Agronomy, Sichuan Agricultural University, Chengdu 611130, China","institution_ids":["https://openalex.org/I37574244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051676738","display_name":"Ping\u2010Kun Zhou","orcid":"https://orcid.org/0000-0001-7666-1209","observed_orcids":["https://orcid.org/0000-0001-7666-1209","https://orcid.org/0000-0002-5088-9608","https://orcid.org/0000-0002-9372-8150"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ping-Kun Zhou","raw_affiliation_strings":["Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000255101","display_name":"Hua Guan","orcid":"https://orcid.org/0000-0001-6329-6273","observed_orcids":["https://orcid.org/0000-0001-6329-6273"]},"institutions":[{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]},{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hua Guan","raw_affiliation_strings":["Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China","School of Life Science, Hebei University, Baoding 071000, China","School of Public Health, University of South China, Hengyang 421001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China","institution_ids":[]},{"raw_affiliation_string":"School of Life Science, Hebei University, Baoding 071000, China","institution_ids":["https://openalex.org/I43337087"]},{"raw_affiliation_string":"School of Public Health, University of South China, Hengyang 421001, China","institution_ids":["https://openalex.org/I91935597"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5000255101"],"corresponding_institution_ids":["https://openalex.org/I43337087","https://openalex.org/I91935597"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"12","first_page":"5656","last_page":"5656"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.8208000063896179,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.8208000063896179,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12689","display_name":"Silymarin and Mushroom Poisoning","score":0.16670000553131104,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/silibinin","display_name":"silibinin","score":1.0},{"id":"https://openalex.org/keywords/low-dose-radiation","display_name":"low-dose radiation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/radiation-protection","display_name":"radiation protection","score":0.9869999885559082},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9919999837875366},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.9639999866485596},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.8637386560440063},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.8038747906684875},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43057870864868164},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4261242747306824},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41305166482925415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3923393487930298},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3209381103515625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09723609685897827}],"mesh":[{"descriptor_ui":"D000067996","descriptor_name":"RAW 264.7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077385","descriptor_name":"Silybin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011837","descriptor_name":"Radiation-Protective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms26125656","doi":"https://doi.org/10.3390/ijms26125656","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26125656","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12193130","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12193130/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12193130/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:40565119","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40565119","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms26125656","doi":"https://doi.org/10.3390/ijms26125656","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26125656","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3061245628","display_name":null,"funder_award_id":"82173466","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5062836221","display_name":null,"funder_award_id":"82473579","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6745785132","display_name":null,"funder_award_id":"32171238","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320325065","display_name":"Sichuan Agricultural University","ror":"https://ror.org/0388c3403"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411286232.pdf","grobid_xml":"https://content.openalex.org/works/W4411286232.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1511679319","https://openalex.org/W1975268962","https://openalex.org/W1991774681","https://openalex.org/W1997550798","https://openalex.org/W2032221129","https://openalex.org/W2049881915","https://openalex.org/W2062145190","https://openalex.org/W2074253122","https://openalex.org/W2098123089","https://openalex.org/W2130209511","https://openalex.org/W2136674954","https://openalex.org/W2148394610","https://openalex.org/W2174147756","https://openalex.org/W2339525891","https://openalex.org/W2505213728","https://openalex.org/W2519214071","https://openalex.org/W2598538589","https://openalex.org/W2770382994","https://openalex.org/W2883141755","https://openalex.org/W2902618770","https://openalex.org/W2908973547","https://openalex.org/W2912356303","https://openalex.org/W2972940388","https://openalex.org/W3013781266","https://openalex.org/W3152651516","https://openalex.org/W4283747149","https://openalex.org/W4309922305","https://openalex.org/W4323539333","https://openalex.org/W4390881186","https://openalex.org/W4399882198","https://openalex.org/W4406229610"],"related_works":["https://openalex.org/W4366367931","https://openalex.org/W1973854581","https://openalex.org/W2150258880","https://openalex.org/W4310038631","https://openalex.org/W1511679319","https://openalex.org/W4240932068","https://openalex.org/W6907389180","https://openalex.org/W4417400073","https://openalex.org/W7131447162","https://openalex.org/W3029551471"],"abstract_inverted_index":{"With":[0],"growing":[1],"public":[2],"concern":[3],"about":[4],"the":[5,22,32,49,55,69,87,115,131,162],"health":[6],"effects":[7,34,152],"of":[8,35,92],"low-dose":[9,16,38,83,154],"radiation,":[10],"numerous":[11],"studies":[12],"have":[13],"demonstrated":[14,111],"that":[15,66,112,148],"radiation":[17,84],"can":[18],"cause":[19],"damage":[20,42],"to":[21,166],"immune":[23,40,100,108,136,156],"system,":[24],"making":[25],"intervention":[26],"measures":[27],"essential.":[28],"This":[29],"study":[30],"investigated":[31],"protective":[33,151],"silybin":[36,67,113,149],"against":[37,153],"radiation-induced":[39,116,155,168],"system":[41,157],"and":[43,51,62,78,106,139],"its":[44,173],"underlying":[45],"mechanisms":[46],"at":[47],"both":[48],"cellular":[50,56,169],"animal":[52,88],"levels.":[53],"At":[54,86],"level,":[57,89],"CCK-8":[58],"assays,":[59],"ROS":[60,76],"measurements,":[61],"RT-qPCR":[63],"analysis":[64],"revealed":[65],"alleviated":[68],"reduction":[70,121],"in":[71,118,122,130,134,141],"RAW264.7":[72],"cell":[73,98,109,128,137],"proliferation,":[74],"intracellular":[75],"levels,":[77],"inflammatory":[79,127],"cytokine":[80],"expression":[81],"following":[82],"exposure.":[85],"comparative":[90],"analyses":[91],"post-irradiation":[93],"body":[94,119],"weight,":[95,120],"peripheral":[96,123],"blood":[97,124],"counts,":[99,126],"organ":[101],"coefficients,":[102],"spleen":[103,107,135],"HE/IHC":[104],"staining,":[105],"numbers":[110],"mitigated":[114],"decrease":[117],"leukocyte":[125],"infiltration":[129],"spleen,":[132],"decline":[133],"numbers,":[138],"increase":[140],"cGAS":[142,163],"protein-positive":[143],"cells.":[144],"These":[145],"findings":[146],"indicate":[147],"exerts":[150],"damage,":[158],"potentially":[159],"by":[160],"regulating":[161],"signaling":[164],"pathway":[165],"reduce":[167],"injury,":[170],"thereby":[171],"enhancing":[172],"radioprotective":[174],"properties.":[175]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-10-10T00:00:00"}
