{"id":"https://openalex.org/W4411285828","doi":"https://doi.org/10.1158/1078-0432.29313257","title":"Supplementary Figure S4 from A Phase I, First-in-Human, Dose-Escalation, Expansion Trial of Cytokine-Encoding Synthetic mRNA Mixture Alone or with Cemiplimab in Advanced Solid Tumors","display_name":"Supplementary Figure S4 from A Phase I, First-in-Human, Dose-Escalation, Expansion Trial of Cytokine-Encoding Synthetic mRNA Mixture Alone or with Cemiplimab in Advanced Solid Tumors","publication_year":2025,"publication_date":"2025-06-13","ids":{"openalex":"https://openalex.org/W4411285828","doi":"https://doi.org/10.1158/1078-0432.29313257"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.29313257","doi":"https://doi.org/10.1158/1078-0432.29313257","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.29313257","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.29313257","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005521408","display_name":"Oliver Edgar Bechter","orcid":"https://orcid.org/0000-0003-0667-3284","observed_orcids":["https://orcid.org/0000-0003-0667-3284"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oliver Bechter","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0667-3284","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077331259","display_name":"Carmen Loquai","orcid":"https://orcid.org/0009-0009-4797-2281","observed_orcids":["https://orcid.org/0009-0009-4797-2281"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmen Loquai","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-4797-2281","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060793722","display_name":"St\u00e9phane Champiat","orcid":"https://orcid.org/0000-0002-0741-2118","observed_orcids":["https://orcid.org/0000-0002-0741-2118"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephane Champiat","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0741-2118","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028034211","display_name":"Jean\u2010Fran\u00e7ois Baurain","orcid":"https://orcid.org/0000-0003-4876-4600","observed_orcids":["https://orcid.org/0000-0003-4876-4600"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Francois Baurain","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4876-4600","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061072132","display_name":"Jean\u2010Jacques Grob","orcid":"https://orcid.org/0000-0002-0667-153X","observed_orcids":["https://orcid.org/0000-0002-0667-153X","https://orcid.org/0000-0002-1014-4062"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Jacques Grob","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0667-153X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007887862","display_name":"Jochen Sven Utikal","orcid":"https://orcid.org/0000-0001-5316-0241","observed_orcids":["https://orcid.org/0000-0001-5316-0241"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jochen Utikal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5316-0241","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043348199","display_name":"Sylvie Rottey","orcid":"https://orcid.org/0000-0003-2060-3725","observed_orcids":["https://orcid.org/0000-0003-2060-3725"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sylvie Rottey","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2060-3725","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068271097","display_name":"Alfonso Berrocal","orcid":"https://orcid.org/0009-0001-7457-7879","observed_orcids":["https://orcid.org/0009-0001-7457-7879"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alfonso Berrocal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-7457-7879","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067776208","display_name":"Jessica C. Hassel","orcid":"https://orcid.org/0000-0001-7575-6230","observed_orcids":["https://orcid.org/0000-0001-7575-6230"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica C. Hassel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7575-6230","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009056091","display_name":"Ana Maria Arance","orcid":"https://orcid.org/0000-0003-2896-1957","observed_orcids":["https://orcid.org/0000-0003-2896-1957"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Arance","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2896-1957","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025411417","display_name":"Miguel F. Sanmamed","orcid":"https://orcid.org/0000-0002-7295-6074","observed_orcids":["https://orcid.org/0000-0002-7295-6074"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miguel F. Sanmamed","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7295-6074","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111714527","display_name":"Marye J. Boers\u2010Sonderen","orcid":"https://orcid.org/0009-0005-9624-9189","observed_orcids":["https://orcid.org/0009-0005-9624-9189"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marye Boers-Sonderen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-9624-9189","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087859996","display_name":"Brian Gastman","orcid":"https://orcid.org/0000-0003-2691-3409","observed_orcids":["https://orcid.org/0000-0003-2691-3409"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Gastman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2691-3409","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015140027","display_name":"Christoffer Gebhardt","orcid":"https://orcid.org/0000-0001-7090-9584","observed_orcids":["https://orcid.org/0000-0001-7090-9584"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christoffer Gebhardt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7090-9584","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086534625","display_name":"Brant Delafontaine","orcid":"https://orcid.org/0000-0001-5762-2423","observed_orcids":["https://orcid.org/0000-0001-5762-2423"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brant Delafontaine","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5762-2423","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075617216","display_name":"U\u011fur \u015eahin","orcid":"https://orcid.org/0000-0003-0363-1564","observed_orcids":["https://orcid.org/0000-0003-0363-1564"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ugur Sahin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0363-1564","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000036560","display_name":"\u00d6zlem T\u00fcreci","orcid":"https://orcid.org/0000-0002-0623-1497","observed_orcids":["https://orcid.org/0000-0002-0623-1497"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u00d6zlem T\u00fcreci","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0623-1497","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080342701","display_name":"Patrick Brueck","orcid":"https://orcid.org/0009-0008-5015-8486","observed_orcids":["https://orcid.org/0009-0008-5015-8486"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick Brueck","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-5015-8486","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091526303","display_name":"Giovanni Abbadessa","orcid":"https://orcid.org/0009-0007-2823-1870","observed_orcids":["https://orcid.org/0009-0007-2823-1870"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giovanni Abbadessa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-2823-1870","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020885566","display_name":"Rahul Marpadga","orcid":"https://orcid.org/0009-0005-2307-2669","observed_orcids":["https://orcid.org/0009-0005-2307-2669"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rahul Marpadga","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-2307-2669","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105412377","display_name":"Helen H. Lee","orcid":"https://orcid.org/0009-0007-6273-456X","observed_orcids":["https://orcid.org/0009-0007-6273-456X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helen Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-6273-456X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102416931","display_name":"Yue Yang","orcid":"https://orcid.org/0009-0009-5625-6826","observed_orcids":["https://orcid.org/0009-0009-5625-6826"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yue Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-5625-6826","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079000247","display_name":"Barbara Buday","orcid":"https://orcid.org/0009-0002-8677-7461","observed_orcids":["https://orcid.org/0009-0002-8677-7461"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Buday","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-8677-7461","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109142154","display_name":"Gianfranco Di Genova","orcid":"https://orcid.org/0009-0006-6293-613X","observed_orcids":["https://orcid.org/0009-0006-6293-613X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gianfranco Di Genova","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-6293-613X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100752802","display_name":"Hong Wang","orcid":"https://orcid.org/0000-0002-8787-715X","observed_orcids":["https://orcid.org/0000-0002-8787-715X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8787-715X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016132611","display_name":"Binfeng Xia","orcid":"https://orcid.org/0009-0003-6454-0401","observed_orcids":["https://orcid.org/0009-0003-6454-0401"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Binfeng Xia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-6454-0401","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009084008","display_name":"Joon Sang Lee","orcid":"https://orcid.org/0000-0003-0838-6166","observed_orcids":["https://orcid.org/0000-0003-0838-6166"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joon Sang Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0838-6166","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025478490","display_name":"C\u00e9l\u00e8ste Lebb\u00e9","orcid":"https://orcid.org/0000-0002-5854-7290","observed_orcids":["https://orcid.org/0000-0002-5854-7290"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C\u00e9leste Lebbe","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5854-7290","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.03759999945759773,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cemiplimab","display_name":"cemiplimab","score":0.9169999957084656},{"id":"https://openalex.org/keywords/mrna-vaccines","display_name":"mRNA vaccines","score":0.3179999887943268},{"id":"https://openalex.org/keywords/advanced-solid-tumors","display_name":"advanced solid tumors","score":0.6769999861717224},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitor-combination-therapy","display_name":"immune checkpoint inhibitor combination","score":0.6150000095367432},{"id":"https://openalex.org/keywords/cd3","display_name":"CD3","score":0.578000009059906},{"id":"https://openalex.org/keywords/cytotoxic-cd8-t-cells","display_name":"CD8+ cytotoxic T lymphocytes","score":0.7300000190734863},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.7950000166893005},{"id":"https://openalex.org/keywords/mcp-counter","display_name":"MCP-counter","score":0.5860000252723694},{"id":"https://openalex.org/keywords/tumor-response","display_name":"tumor response","score":0.5080000162124634},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C125411270","wikidata":"https://www.wikidata.org/wiki/Q18653","display_name":"Encoding (memory)","level":2,"score":0.5200000405311584},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.4712548553943634},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4392918348312378},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.32249099016189575},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.28827396035194397},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.263300359249115},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.20662423968315125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18050411343574524},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0892581045627594},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06833764910697937},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.29313257","doi":"https://doi.org/10.1158/1078-0432.29313257","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.29313257","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.29313257","doi":"https://doi.org/10.1158/1078-0432.29313257","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.29313257","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4411285206","https://openalex.org/W4411286286","https://openalex.org/W4408930624","https://openalex.org/W4365511968","https://openalex.org/W3104104380","https://openalex.org/W4403419953","https://openalex.org/W4405454546","https://openalex.org/W4255203751","https://openalex.org/W4361953228","https://openalex.org/W2993204321"],"abstract_inverted_index":{"Summary":[0],"of":[1],"MCP-counter":[2],"and":[3,11,23,37,40],"IHC":[4],"evaluable":[5],"data*":[6],"relative":[7],"to":[8,17],"the":[9,18],"CD3":[10],"CD8/cytotoxic":[12],"cell":[13],"populations":[14],"in":[15,27],"relation":[16],"dose":[19],"level,":[20],"tumor":[21],"type,":[22],"best":[24],"percentage":[25],"change":[26],"target":[28],"lesion":[29],"diameters":[30],"from":[31],"baseline":[32],"(iRECIST).":[33],"A)":[34],"Escalation":[35],"monotherapy":[36],"escalation":[38],"combination":[39,43],"B)":[41],"Expansion":[42]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
