{"id":"https://openalex.org/W4411283532","doi":"https://doi.org/10.1002/imt2.70055","title":"METTL5\u2010mediated 18S rRNA m6A modification enhances ribosome assembly and ABA response in Arabidopsis","display_name":"METTL5\u2010mediated 18S rRNA m6A modification enhances ribosome assembly and ABA response in Arabidopsis","publication_year":2025,"publication_date":"2025-06-13","ids":{"openalex":"https://openalex.org/W4411283532","doi":"https://doi.org/10.1002/imt2.70055","pmid":"https://pubmed.ncbi.nlm.nih.gov/40860432","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12371265"},"language":"en","primary_location":{"id":"doi:10.1002/imt2.70055","doi":"https://doi.org/10.1002/imt2.70055","is_oa":true,"landing_page_url":"https://doi.org/10.1002/imt2.70055","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/imt2.70055","source":{"id":"https://openalex.org/S4220650979","display_name":"iMeta","issn_l":"2770-596X","issn":["2770-596X","2770-5986"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","ki-jl-2","norway-1","oarl","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iMeta","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/imt2.70055","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ping Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162266279","display_name":"Temasek Life Sciences Laboratory","ror":"https://ror.org/0574eex11","country_code":"SG","type":"facility","lineage":["https://openalex.org/I162266279"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Ping Li","raw_affiliation_strings":["Temasek Life Sciences Laboratory, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temasek Life Sciences Laboratory, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I162266279","https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101590831","display_name":"Yu Zhang","orcid":"https://orcid.org/0000-0002-6552-7642","observed_orcids":["https://orcid.org/0000-0002-6552-7642"]},"institutions":[{"id":"https://openalex.org/I162266279","display_name":"Temasek Life Sciences Laboratory","ror":"https://ror.org/0574eex11","country_code":"SG","type":"facility","lineage":["https://openalex.org/I162266279"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yu Zhang","raw_affiliation_strings":["Temasek Life Sciences Laboratory, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temasek Life Sciences Laboratory, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I162266279","https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085230516","display_name":"Songyao Zhang","orcid":"https://orcid.org/0000-0003-2477-2884","observed_orcids":["https://orcid.org/0000-0003-2477-2884"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Songyao Zhang","raw_affiliation_strings":["Department of Biological Sciences, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077405397","display_name":"Jinqi Ma","orcid":"https://orcid.org/0000-0001-5674-4023","observed_orcids":["https://orcid.org/0000-0001-5674-4023"]},"institutions":[{"id":"https://openalex.org/I162266279","display_name":"Temasek Life Sciences Laboratory","ror":"https://ror.org/0574eex11","country_code":"SG","type":"facility","lineage":["https://openalex.org/I162266279"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jinqi Ma","raw_affiliation_strings":["Department of Biological Sciences, National University of Singapore, Singapore, Singapore","Temasek Life Sciences Laboratory, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Temasek Life Sciences Laboratory, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I162266279","https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084864563","display_name":"Sheng Fan","orcid":"https://orcid.org/0009-0008-1296-8306","observed_orcids":["https://orcid.org/0009-0008-1296-8306"]},"institutions":[{"id":"https://openalex.org/I162266279","display_name":"Temasek Life Sciences Laboratory","ror":"https://ror.org/0574eex11","country_code":"SG","type":"facility","lineage":["https://openalex.org/I162266279"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Sheng Fan","raw_affiliation_strings":["Temasek Life Sciences Laboratory, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temasek Life Sciences Laboratory, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I162266279","https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045281555","display_name":"Lisha Shen","orcid":"https://orcid.org/0000-0002-1808-6370","observed_orcids":["https://orcid.org/0000-0002-1808-6370"]},"institutions":[{"id":"https://openalex.org/I162266279","display_name":"Temasek Life Sciences Laboratory","ror":"https://ror.org/0574eex11","country_code":"SG","type":"facility","lineage":["https://openalex.org/I162266279"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Lisha Shen","raw_affiliation_strings":["Department of Biological Sciences, National University of Singapore, Singapore, Singapore","Temasek Life Sciences Laboratory, National University of Singapore, Singapore, Singapore"],"raw_orcid":"https://orcid.org/0000-0002-1808-6370","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Temasek Life Sciences Laboratory, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I162266279","https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045281555"],"corresponding_institution_ids":["https://openalex.org/I162266279","https://openalex.org/I165932596"],"apc_list":{"value":1320,"currency":"USD","value_usd":1320},"apc_paid":{"value":1320,"currency":"USD","value_usd":1320},"fwci":2.4285,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.89270609,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"4","issue":"4","first_page":"e70055","last_page":"e70055"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mettl5","display_name":"METTL5","score":0.9990000128746033},{"id":"https://openalex.org/keywords/18s-rrna","display_name":"18S rRNA","score":0.9120000004768372},{"id":"https://openalex.org/keywords/n6-methyladenosine","display_name":"N6-methyladenosine","score":0.9480000138282776},{"id":"https://openalex.org/keywords/m6a-methylation","display_name":"m6A RNA methylation","score":0.765999972820282},{"id":"https://openalex.org/keywords/ribosome-assembly","display_name":"ribosome assembly","score":0.8700000047683716},{"id":"https://openalex.org/keywords/abscisic-acid-response","display_name":"abscisic acid response","score":0.9350000023841858},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.9419999718666077},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9649999737739563},{"id":"https://openalex.org/keywords/translation-biology","display_name":"translation (biology)","score":0.7179999947547913},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.9440000057220459}],"concepts":[{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.7955117225646973},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.6101150512695312},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.566620945930481},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4514259397983551},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4257006049156189},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3643544912338257},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3288097381591797},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2305947244167328},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2259921133518219},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20972517132759094},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1002/imt2.70055","doi":"https://doi.org/10.1002/imt2.70055","is_oa":true,"landing_page_url":"https://doi.org/10.1002/imt2.70055","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/imt2.70055","source":{"id":"https://openalex.org/S4220650979","display_name":"iMeta","issn_l":"2770-596X","issn":["2770-596X","2770-5986"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","ki-jl-2","norway-1","oarl","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iMeta","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11180314","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12371265","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40860432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40860432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iMeta","raw_type":"Letter"},{"id":"pmh:oai:pubmedcentral.nih.gov:12371265","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12371265/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Imeta","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ab8d113c395743c9969279028c8d48e4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ab8d113c395743c9969279028c8d48e4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"iMeta, Vol 4, Iss 4, Pp n/a-n/a (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/imt2.70055","doi":"https://doi.org/10.1002/imt2.70055","is_oa":true,"landing_page_url":"https://doi.org/10.1002/imt2.70055","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/imt2.70055","source":{"id":"https://openalex.org/S4220650979","display_name":"iMeta","issn_l":"2770-596X","issn":["2770-596X","2770-5986"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","ki-jl-2","norway-1","oarl","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iMeta","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4381756097","display_name":null,"funder_award_id":"NRF-CRP22-2019-0001","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"},{"id":"https://openalex.org/G4789271885","display_name":null,"funder_award_id":"NRF\u2010CRP22\u20102019\u20100001","funder_id":"https://openalex.org/F4320320709","funder_display_name":"National Research Foundation Singapore"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320698","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49"},{"id":"https://openalex.org/F4320320709","display_name":"National Research Foundation Singapore","ror":"https://ror.org/03cpyc314"},{"id":"https://openalex.org/F4320322878","display_name":"Henan University","ror":"https://ror.org/003xyzq10"},{"id":"https://openalex.org/F4320326604","display_name":"Temasek Life Sciences Laboratory","ror":"https://ror.org/0574eex11"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411283532.pdf","grobid_xml":"https://content.openalex.org/works/W4411283532.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W776567260","https://openalex.org/W1986304086","https://openalex.org/W2071804506","https://openalex.org/W2155373804","https://openalex.org/W2155769677","https://openalex.org/W2472887612","https://openalex.org/W2899846659","https://openalex.org/W2962780260","https://openalex.org/W3114666624","https://openalex.org/W3159905233","https://openalex.org/W4205209265","https://openalex.org/W4206334732","https://openalex.org/W4292774516","https://openalex.org/W4318217575","https://openalex.org/W4321116369","https://openalex.org/W4323359282","https://openalex.org/W4375859037","https://openalex.org/W4401927436","https://openalex.org/W4405573738"],"related_works":["https://openalex.org/W4414380253","https://openalex.org/W4401927436","https://openalex.org/W3018971779","https://openalex.org/W4205209265","https://openalex.org/W3114666624","https://openalex.org/W4306940099","https://openalex.org/W4417449632","https://openalex.org/W3048492349","https://openalex.org/W3042695719","https://openalex.org/W7043021375"],"abstract_inverted_index":{"METTL5":[0],"catalyzes":[1],"the":[2,18,23,30,35,59,70],"N6-methyladenosine":[3],"(m6A)":[4],"methylation":[5],"at":[6],"A1771":[7],"in":[8,76],"18S":[9],"rRNA,":[10],"a":[11],"modification":[12],"essential":[13],"for":[14],"its":[15],"association":[16],"with":[17],"ribosomal":[19],"protein":[20],"RPL24A,":[21],"facilitating":[22],"assembly":[24],"of":[25,32,61,72],"80S":[26],"ribosome.":[27],"This":[28,74],"facilitates":[29],"translation":[31,71],"mRNAs":[33],"encoding":[34],"detoxifying":[36],"glutathione":[37],"S-transferase":[38],"(GST)":[39],"enzymes,":[40],"thereby":[41],"maintaining":[42],"normal":[43],"reactive":[44],"oxygen":[45],"species":[46],"(ROS)":[47],"levels":[48],"and":[49,66,80],"ensuring":[50],"proper":[51],"abscisic":[52],"acid":[53],"(ABA)":[54],"responses.":[55],"In":[56],"mettl5":[57],"mutants,":[58],"absence":[60],"m6A1771":[62],"compromises":[63],"RPL24A":[64],"incorporation":[65],"ribosome":[67],"assembly,":[68],"impairing":[69],"GSTs.":[73],"results":[75],"ROS":[77],"excessive":[78],"accumulation":[79],"hypersensitivity":[81],"to":[82],"ABA.":[83]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-10-10T00:00:00"}
