{"id":"https://openalex.org/W4411279837","doi":"https://doi.org/10.1007/s12031-025-02367-y","title":"Drp1-Mediated Mitochondrial Fission Is Essential for Chemical-Induced Neuronal Transdifferentiation from Human Primary Fibroblasts","display_name":"Drp1-Mediated Mitochondrial Fission Is Essential for Chemical-Induced Neuronal Transdifferentiation from Human Primary Fibroblasts","publication_year":2025,"publication_date":"2025-06-13","ids":{"openalex":"https://openalex.org/W4411279837","doi":"https://doi.org/10.1007/s12031-025-02367-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/40512396"},"language":"en","primary_location":{"id":"doi:10.1007/s12031-025-02367-y","doi":"https://doi.org/10.1007/s12031-025-02367-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12031-025-02367-y","pdf_url":null,"source":{"id":"https://openalex.org/S133939727","display_name":"Journal of Molecular Neuroscience","issn_l":"0895-8696","issn":["0895-8696","1559-1166"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046615473","display_name":"Jijuan Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jijuan Yang","raw_affiliation_strings":["Department of Rheumatology, General Hospital of Ningxia Medical University, No. 804 Shengli South Street, Xingqing District, Yinchuan, 750004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, General Hospital of Ningxia Medical University, No. 804 Shengli South Street, Xingqing District, Yinchuan, 750004, China","institution_ids":["https://openalex.org/I4210139449"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chun Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405280222","display_name":"Beijing University of Chinese Medicine Dongfang College","ror":"https://ror.org/02kz8qv88","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun Li","raw_affiliation_strings":["Bohai New Area, Beijing University of Chinese Medicine DongFang College, Cangzhou, 061108, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bohai New Area, Beijing University of Chinese Medicine DongFang College, Cangzhou, 061108, China","institution_ids":["https://openalex.org/I4405280222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055858962","display_name":"Chunhua Wang","orcid":"https://orcid.org/0000-0002-4490-0380","observed_orcids":["https://orcid.org/0000-0002-4490-0380"]},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunhua Wang","raw_affiliation_strings":["Ningxia Medical University, No. 1160 Shengli South Street, Xingqing District, Yinchuan, 750004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningxia Medical University, No. 1160 Shengli South Street, Xingqing District, Yinchuan, 750004, China","institution_ids":["https://openalex.org/I4210127460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031613988","display_name":"Xuemei Wang","orcid":"https://orcid.org/0000-0002-3527-2191","observed_orcids":["https://orcid.org/0000-0002-3527-2191"]},"institutions":[{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuemei Wang","raw_affiliation_strings":["Department of Rheumatology, General Hospital of Ningxia Medical University, No. 804 Shengli South Street, Xingqing District, Yinchuan, 750004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, General Hospital of Ningxia Medical University, No. 804 Shengli South Street, Xingqing District, Yinchuan, 750004, China","institution_ids":["https://openalex.org/I4210139449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100390372","display_name":"Jiaqi Liu","orcid":"https://orcid.org/0000-0002-9775-2342","observed_orcids":["https://orcid.org/0000-0002-9775-2342","https://orcid.org/0009-0002-0456-5060","https://orcid.org/0009-0006-8082-2793"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiaqi Liu","raw_affiliation_strings":["Shapotou District, Zhongwei Nanhuashan Vocational and Technical College, Ningxia Province, Zhongwei City, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shapotou District, Zhongwei Nanhuashan Vocational and Technical College, Ningxia Province, Zhongwei City, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nan Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Yu","raw_affiliation_strings":["Department of Rheumatology, General Hospital of Ningxia Medical University, No. 804 Shengli South Street, Xingqing District, Yinchuan, 750004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, General Hospital of Ningxia Medical University, No. 804 Shengli South Street, Xingqing District, Yinchuan, 750004, China","institution_ids":["https://openalex.org/I4210139449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043137187","display_name":"Wei Du","orcid":"https://orcid.org/0009-0003-1408-2772","observed_orcids":["https://orcid.org/0009-0003-1408-2772"]},"institutions":[{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenqing Du","raw_affiliation_strings":["Department of Rheumatology, General Hospital of Ningxia Medical University, No. 804 Shengli South Street, Xingqing District, Yinchuan, 750004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, General Hospital of Ningxia Medical University, No. 804 Shengli South Street, Xingqing District, Yinchuan, 750004, China","institution_ids":["https://openalex.org/I4210139449"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045140699","display_name":"Shuhong Chi","orcid":"https://orcid.org/0000-0003-1141-7605","observed_orcids":["https://orcid.org/0000-0003-1141-7605"]},"institutions":[{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shuhong Chi","raw_affiliation_strings":["Department of Rheumatology, General Hospital of Ningxia Medical University, No. 804 Shengli South Street, Xingqing District, Yinchuan, 750004, China. Nydzyfsk@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, General Hospital of Ningxia Medical University, No. 804 Shengli South Street, Xingqing District, Yinchuan, 750004, China. Nydzyfsk@163.com","institution_ids":["https://openalex.org/I4210139449"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5045140699"],"corresponding_institution_ids":["https://openalex.org/I4210139449"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08020065,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":"2","first_page":"75","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.6596999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.6596999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.15889999270439148,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.07240000367164612,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drp1","display_name":"Drp1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mitochondrial-fission","display_name":"mitochondrial fission","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.8379999995231628},{"id":"https://openalex.org/keywords/neuronal-transdifferentiation","display_name":"neuronal transdifferentiation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/direct-reprogramming","display_name":"direct reprogramming","score":0.5490000247955322},{"id":"https://openalex.org/keywords/human-foreskin-fibroblasts","display_name":"human foreskin fibroblasts","score":0.9309999942779541},{"id":"https://openalex.org/keywords/mdivi-1","display_name":"Mdivi-1","score":0.8169999718666077},{"id":"https://openalex.org/keywords/mitochondrial-fusion","display_name":"mitochondrial fusion","score":0.7789999842643738},{"id":"https://openalex.org/keywords/small-molecule-reprogramming","display_name":"small molecule reprogramming","score":0.5270000100135803},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8169999718666077},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C17619807","wikidata":"https://www.wikidata.org/wiki/Q6881852","display_name":"Mitochondrial fission","level":3,"score":0.7257285714149475},{"id":"https://openalex.org/C60870556","wikidata":"https://www.wikidata.org/wiki/Q2300675","display_name":"Transdifferentiation","level":3,"score":0.6588887572288513},{"id":"https://openalex.org/C2777977315","wikidata":"https://www.wikidata.org/wiki/Q7243056","display_name":"Primary (astronomy)","level":2,"score":0.4842910170555115},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.46682968735694885},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4378723204135895},{"id":"https://openalex.org/C39920043","wikidata":"https://www.wikidata.org/wiki/Q786278","display_name":"Neurochemistry","level":3,"score":0.42888009548187256},{"id":"https://openalex.org/C12294094","wikidata":"https://www.wikidata.org/wiki/Q929080","display_name":"Fission","level":3,"score":0.41249480843544006},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4011607766151428},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39070647954940796},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32034212350845337},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.1895780861377716},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12261393666267395},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.093028724193573},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C152568617","wikidata":"https://www.wikidata.org/wiki/Q2348","display_name":"Neutron","level":2,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034281","descriptor_name":"Dynamins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D034281","descriptor_name":"Dynamins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D034281","descriptor_name":"Dynamins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052999","descriptor_name":"Quinazolinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054338","descriptor_name":"Cell Transdifferentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063154","descriptor_name":"Mitochondrial Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s12031-025-02367-y","doi":"https://doi.org/10.1007/s12031-025-02367-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12031-025-02367-y","pdf_url":null,"source":{"id":"https://openalex.org/S133939727","display_name":"Journal of Molecular Neuroscience","issn_l":"0895-8696","issn":["0895-8696","1559-1166"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Neuroscience","raw_type":"journal-article"},{"id":"pmid:40512396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40512396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular neuroscience : MN","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1486333437","display_name":null,"funder_award_id":"2022AAC05057","funder_id":"https://openalex.org/F4320322877","funder_display_name":"Natural Science Foundation of Ningxia Province"}],"funders":[{"id":"https://openalex.org/F4320322877","display_name":"Natural Science Foundation of Ningxia Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W270596145","https://openalex.org/W1598578622","https://openalex.org/W1647075334","https://openalex.org/W1773217871","https://openalex.org/W1950098865","https://openalex.org/W1978268445","https://openalex.org/W1980026529","https://openalex.org/W1980135645","https://openalex.org/W1999053124","https://openalex.org/W2001819241","https://openalex.org/W2039426833","https://openalex.org/W2045085957","https://openalex.org/W2055572268","https://openalex.org/W2091311387","https://openalex.org/W2094162211","https://openalex.org/W2105043890","https://openalex.org/W2107257651","https://openalex.org/W2111642216","https://openalex.org/W2126624770","https://openalex.org/W2136541538","https://openalex.org/W2138839504","https://openalex.org/W2142084126","https://openalex.org/W2150256046","https://openalex.org/W2155643523","https://openalex.org/W2157879044","https://openalex.org/W2334626778","https://openalex.org/W2535606226","https://openalex.org/W2804669221","https://openalex.org/W2806136689","https://openalex.org/W2903477139","https://openalex.org/W2950152347","https://openalex.org/W3003568098","https://openalex.org/W3090664178","https://openalex.org/W3128376383","https://openalex.org/W3197212023","https://openalex.org/W4223893392","https://openalex.org/W4307551991","https://openalex.org/W4323354595","https://openalex.org/W4366520888","https://openalex.org/W4382460808","https://openalex.org/W4385987225","https://openalex.org/W4388500684","https://openalex.org/W4392814428"],"related_works":["https://openalex.org/W2924882577","https://openalex.org/W4392814428","https://openalex.org/W2150677449","https://openalex.org/W2469127708","https://openalex.org/W4404433830","https://openalex.org/W4400037063","https://openalex.org/W3090664178","https://openalex.org/W2344114748","https://openalex.org/W2111642216","https://openalex.org/W7198571365"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
