{"id":"https://openalex.org/W4411273152","doi":"https://doi.org/10.1016/j.jbc.2025.109400","title":"Abstract 1532 Gene Expression and Lipid Profiling of Metabolically-driven Human Hepatocellular Carcinoma","display_name":"Abstract 1532 Gene Expression and Lipid Profiling of Metabolically-driven Human Hepatocellular Carcinoma","publication_year":2025,"publication_date":"2025-05-01","ids":{"openalex":"https://openalex.org/W4411273152","doi":"https://doi.org/10.1016/j.jbc.2025.109400"},"language":"en","primary_location":{"id":"doi:10.1016/j.jbc.2025.109400","doi":"https://doi.org/10.1016/j.jbc.2025.109400","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2025.109400","pdf_url":"https://www.jbc.org/action/showPdf?pii=S0021925825012499","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.jbc.org/action/showPdf?pii=S0021925825012499","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072919602","display_name":"Robert Nathaniel Helsley","orcid":"https://orcid.org/0000-0001-5000-3187","observed_orcids":["https://orcid.org/0000-0001-5000-3187"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Helsley","raw_affiliation_strings":["University of Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091415209","display_name":"Garrett Anspach","orcid":"https://orcid.org/0000-0002-8703-4857","observed_orcids":["https://orcid.org/0000-0002-8703-4857"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garrett Anspach","raw_affiliation_strings":["University of Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062202807","display_name":"Robert M Flight","orcid":"https://orcid.org/0000-0001-8141-7788","observed_orcids":["https://orcid.org/0000-0001-8141-7788"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Flight","raw_affiliation_strings":["University of Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092805348","display_name":"Nikitha Dharanipragada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikitha Dharanipragada","raw_affiliation_strings":["University of Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040212698","display_name":"Hunter Moseley","orcid":"https://orcid.org/0000-0003-3995-5368","observed_orcids":["https://orcid.org/0000-0003-3995-5368"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hunter Moseley","raw_affiliation_strings":["University of Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kentucky","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"301","issue":"5","first_page":"109400","last_page":"109400"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.6859999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.6859999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.164900004863739,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.09059999883174896,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9919999837875366},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9409999847412109},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6970000267028809},{"id":"https://openalex.org/keywords/lipidomics","display_name":"lipidomics","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cardiometabolic-disease","display_name":"cardiometabolic disease","score":0.6100000143051147},{"id":"https://openalex.org/keywords/tumor-lipid-metabolism","display_name":"tumor lipid metabolism","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7666760087013245},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5991457104682922},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5487872958183289},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47193214297294617},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4210849404335022},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41034039855003357},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36658021807670593},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3379843235015869},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29055315256118774}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jbc.2025.109400","doi":"https://doi.org/10.1016/j.jbc.2025.109400","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2025.109400","pdf_url":"https://www.jbc.org/action/showPdf?pii=S0021925825012499","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jbc.2025.109400","doi":"https://doi.org/10.1016/j.jbc.2025.109400","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2025.109400","pdf_url":"https://www.jbc.org/action/showPdf?pii=S0021925825012499","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411273152.pdf","grobid_xml":"https://content.openalex.org/works/W4411273152.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2052655934","https://openalex.org/W104645380","https://openalex.org/W2027213253","https://openalex.org/W2023641020","https://openalex.org/W2017047508","https://openalex.org/W2165201120","https://openalex.org/W2188530857","https://openalex.org/W2041199873","https://openalex.org/W1971081588","https://openalex.org/W1964194222"],"abstract_inverted_index":{"Background:":[0],"Metabolic":[1],"dysfunction-associated":[2],"steatotic":[3],"liver":[4],"disease":[5],"(MASLD)":[6],"is":[7],"the":[8,47,57],"fastest-growing":[9],"etiology":[10],"of":[11,59],"hepatocellular":[12],"carcinoma":[13],"(HCC).":[14],"This":[15],"work":[16],"identifies":[17],"novel":[18],"gene":[19],"and":[20,39,50,70],"lipid":[21],"associations":[22],"in":[23],"human":[24],"MASLD-driven":[25],"HCC":[26,36],"that":[27],"may":[28],"be":[29],"exploited":[30],"for":[31,73],"therapeutic":[32],"benefit.":[33],"Methods:":[34],"Human":[35],"tumor":[37],"(n=8)":[38,43],"adjacent":[40],"non-tumor":[41],"samples":[42],"were":[44,71],"obtained":[45],"from":[46],"Biospecimen":[48],"Procurement":[49],"Translational":[51],"Pathology":[52],"Shared":[53],"Resource":[54],"Facility":[55],"at":[56],"University":[58],"Kentucky":[60],"Markey":[61],"Cancer":[62],"Center.":[63],"All":[64],"patients":[65],"met":[66],"cardiometabolic":[67],"MASLD":[68],"criteria":[69],"negative":[72],"viral":[74],"hepatitis.":[75]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}
