{"id":"https://openalex.org/W4411250481","doi":"https://doi.org/10.47853/fas.2025.e26","title":"Development and evaluation of an oral liposomal vaccine for the prevention of Edwardsiellosis in Anguilla japonica caused by Edwardsiella piscicida","display_name":"Development and evaluation of an oral liposomal vaccine for the prevention of Edwardsiellosis in Anguilla japonica caused by Edwardsiella piscicida","publication_year":2025,"publication_date":"2025-05-01","ids":{"openalex":"https://openalex.org/W4411250481","doi":"https://doi.org/10.47853/fas.2025.e26"},"language":"en","primary_location":{"id":"doi:10.47853/fas.2025.e26","doi":"https://doi.org/10.47853/fas.2025.e26","is_oa":true,"landing_page_url":"https://doi.org/10.47853/fas.2025.e26","pdf_url":"https://www.e-fas.org/download/download_pdf?pid=fas-28-5-298","source":{"id":"https://openalex.org/S2738360252","display_name":"Fisheries and aquatic sciences","issn_l":"2234-1749","issn":["2234-1749","2234-1757"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","kci-registered","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fisheries and Aquatic Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.e-fas.org/download/download_pdf?pid=fas-28-5-298","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Young Min Woo","orcid":"https://orcid.org/0000-0003-0235-1667","observed_orcids":["https://orcid.org/0000-0003-0235-1667"]},"institutions":[{"id":"https://openalex.org/I4210123920","display_name":"Silla University","ror":"https://ror.org/02w3gk008","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210123920"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young Min Woo","raw_affiliation_strings":["Department of Pharmaceutical Engineering , Silla University , Busan 46958 , Korea"],"raw_orcid":"https://orcid.org/0000-0003-0235-1667","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering , Silla University , Busan 46958 , Korea","institution_ids":["https://openalex.org/I4210123920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080010097","display_name":"Keun Woo Lee","orcid":"https://orcid.org/0009-0006-9062-4782","observed_orcids":["https://orcid.org/0009-0006-9062-4782"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keun Woo Lee","raw_affiliation_strings":["Fisheries and Aquatic Sciences","HANKOOK LIPOSOME , Busan 46702 , Korea"],"raw_orcid":"https://orcid.org/0009-0006-9062-4782","affiliations":[{"raw_affiliation_string":"Fisheries and Aquatic Sciences","institution_ids":[]},{"raw_affiliation_string":"HANKOOK LIPOSOME , Busan 46702 , Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101974519","display_name":"Byung\u2010Chul Jeong","orcid":"https://orcid.org/0000-0002-3347-0143","observed_orcids":["https://orcid.org/0000-0002-3347-0143"]},"institutions":[{"id":"https://openalex.org/I4210128505","display_name":"Korea Financial Engineering Consulting (South Korea)","ror":"https://ror.org/048zkw057","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210128505"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byung-Chul Jeong","raw_affiliation_strings":["Central R&D Center , KOFEC , Naju 58318 , Korea"],"raw_orcid":"https://orcid.org/0000-0002-3347-0143","affiliations":[{"raw_affiliation_string":"Central R&D Center , KOFEC , Naju 58318 , Korea","institution_ids":["https://openalex.org/I4210128505"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jae Young Cha","orcid":"https://orcid.org/0009-0006-9795-7934","observed_orcids":["https://orcid.org/0009-0006-9795-7934"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jae Young Cha","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-9795-7934","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063466496","display_name":"Won-Sik Woo","orcid":"https://orcid.org/0000-0002-5958-1044","observed_orcids":["https://orcid.org/0000-0002-5958-1044"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Won-Sik Woo","raw_affiliation_strings":["Institute of Marine Industry , College of Marine Science , Gyeongsang National University , Tongyeong 53064 , Korea"],"raw_orcid":"https://orcid.org/0000-0002-5958-1044","affiliations":[{"raw_affiliation_string":"Institute of Marine Industry , College of Marine Science , Gyeongsang National University , Tongyeong 53064 , Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066920530","display_name":"Chan\u2010Il Park","orcid":"https://orcid.org/0000-0002-2501-1860","observed_orcids":["https://orcid.org/0000-0002-2501-1860"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chan-Il Park","raw_affiliation_strings":["Institute of Marine Industry , College of Marine Science , Gyeongsang National University , Tongyeong 53064 , Korea"],"raw_orcid":"https://orcid.org/0000-0002-2501-1860","affiliations":[{"raw_affiliation_string":"Institute of Marine Industry , College of Marine Science , Gyeongsang National University , Tongyeong 53064 , Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Young Jae Kim","orcid":"https://orcid.org/0009-0000-8230-1728","observed_orcids":["https://orcid.org/0009-0000-8230-1728"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Young Jae Kim","raw_affiliation_strings":["Korea Aquatic Biosecurity Technology , Busan 48564 , Korea"],"raw_orcid":"https://orcid.org/0009-0000-8230-1728","affiliations":[{"raw_affiliation_string":"Korea Aquatic Biosecurity Technology , Busan 48564 , Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060980341","display_name":"Dong\u2010Geun Lee","orcid":"https://orcid.org/0000-0002-3296-7561","observed_orcids":["https://orcid.org/0000-0002-3296-7561"]},"institutions":[{"id":"https://openalex.org/I4210123920","display_name":"Silla University","ror":"https://ror.org/02w3gk008","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210123920"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong-Geun Lee","raw_affiliation_strings":["Department of Pharmaceutical Engineering , Silla University , Busan 46958 , Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering , Silla University , Busan 46958 , Korea","institution_ids":["https://openalex.org/I4210123920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029932161","display_name":"Sang\u2010Hyeon Lee","orcid":"https://orcid.org/0000-0001-5427-9092","observed_orcids":["https://orcid.org/0000-0001-5427-9092"]},"institutions":[{"id":"https://openalex.org/I4210123920","display_name":"Silla University","ror":"https://ror.org/02w3gk008","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210123920"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang-Hyeon Lee","raw_affiliation_strings":["Department of Pharmaceutical Engineering , Silla University , Busan 46958 , Korea","Fisheries and Aquatic Sciences"],"raw_orcid":"https://orcid.org/0000-0001-5427-9092","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering , Silla University , Busan 46958 , Korea","institution_ids":["https://openalex.org/I4210123920"]},{"raw_affiliation_string":"Fisheries and Aquatic Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110008338","display_name":"Jun Cheul Ahn","orcid":"https://orcid.org/0000-0002-5726-1522","observed_orcids":["https://orcid.org/0000-0002-5726-1522"]},"institutions":[{"id":"https://openalex.org/I4210128505","display_name":"Korea Financial Engineering Consulting (South Korea)","ror":"https://ror.org/048zkw057","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210128505"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jun Cheul Ahn","raw_affiliation_strings":["Central R&D Center , KOFEC , Naju 58318 , Korea"],"raw_orcid":"https://orcid.org/0000-0002-5726-1522","affiliations":[{"raw_affiliation_string":"Central R&D Center , KOFEC , Naju 58318 , Korea","institution_ids":["https://openalex.org/I4210128505"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059274269","display_name":"Andre Kim","orcid":"https://orcid.org/0000-0002-0769-109X","observed_orcids":["https://orcid.org/0000-0002-0769-109X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Andre Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0769-109X","affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5059274269"],"corresponding_institution_ids":[],"apc_list":{"value":1990,"currency":"USD","value_usd":1990},"apc_paid":{"value":1990,"currency":"USD","value_usd":1990},"fwci":0.6007,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.58421228,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"28","issue":"5","first_page":"298","last_page":"306"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10450","display_name":"Aquaculture Nutrition and Growth","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/edwardsiellosis","display_name":"edwardsiellosis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/edwardsiella-piscicida","display_name":"Edwardsiella piscicida","score":0.9869999885559082},{"id":"https://openalex.org/keywords/japanese-eel","display_name":"Anguilla japonica","score":0.9829999804496765},{"id":"https://openalex.org/keywords/oral-vaccine","display_name":"oral vaccine","score":0.902999997138977},{"id":"https://openalex.org/keywords/inactivated-vaccine","display_name":"inactivated vaccine","score":0.7039999961853027},{"id":"https://openalex.org/keywords/vaccine-efficacy","display_name":"vaccine efficacy","score":0.6179999709129333},{"id":"https://openalex.org/keywords/fish-disease-prevention","display_name":"fish disease prevention","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4826953411102295},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42000266909599304},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3653297424316406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30866992473602295}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.47853/fas.2025.e26","doi":"https://doi.org/10.47853/fas.2025.e26","is_oa":true,"landing_page_url":"https://doi.org/10.47853/fas.2025.e26","pdf_url":"https://www.e-fas.org/download/download_pdf?pid=fas-28-5-298","source":{"id":"https://openalex.org/S2738360252","display_name":"Fisheries and aquatic sciences","issn_l":"2234-1749","issn":["2234-1749","2234-1757"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","kci-registered","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fisheries and Aquatic Sciences","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:69d85ea9e882489cbca9f4e097c59658","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/69d85ea9e882489cbca9f4e097c59658","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Fisheries and Aquatic Sciences, Vol 28, Iss 5, Pp 298-306 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.47853/fas.2025.e26","doi":"https://doi.org/10.47853/fas.2025.e26","is_oa":true,"landing_page_url":"https://doi.org/10.47853/fas.2025.e26","pdf_url":"https://www.e-fas.org/download/download_pdf?pid=fas-28-5-298","source":{"id":"https://openalex.org/S2738360252","display_name":"Fisheries and aquatic sciences","issn_l":"2234-1749","issn":["2234-1749","2234-1757"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","kci-registered","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fisheries and Aquatic Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7706619126","display_name":null,"funder_award_id":"RS-2023-00222422","funder_id":"https://openalex.org/F4320327819","funder_display_name":"Ministry of SMEs and Startups"}],"funders":[{"id":"https://openalex.org/F4320327819","display_name":"Ministry of SMEs and Startups","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411250481.pdf","grobid_xml":"https://content.openalex.org/works/W4411250481.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W796926966","https://openalex.org/W1520532399","https://openalex.org/W1546151618","https://openalex.org/W1966823964","https://openalex.org/W1993798463","https://openalex.org/W1996689601","https://openalex.org/W2001285947","https://openalex.org/W2013103459","https://openalex.org/W2017836050","https://openalex.org/W2026240178","https://openalex.org/W2054522946","https://openalex.org/W2056358454","https://openalex.org/W2060784443","https://openalex.org/W2084736695","https://openalex.org/W2086193996","https://openalex.org/W2096090772","https://openalex.org/W2115274139","https://openalex.org/W2120601511","https://openalex.org/W2150604710","https://openalex.org/W2153214872","https://openalex.org/W2168083472","https://openalex.org/W2192746655","https://openalex.org/W2240247888","https://openalex.org/W2327162478","https://openalex.org/W2738237731","https://openalex.org/W2750796244","https://openalex.org/W2753400916","https://openalex.org/W2765172851","https://openalex.org/W2997860565","https://openalex.org/W3015628458","https://openalex.org/W3090843724","https://openalex.org/W4285078293","https://openalex.org/W4296794947","https://openalex.org/W6682729831"],"related_works":["https://openalex.org/W3016382056","https://openalex.org/W2014830272","https://openalex.org/W7165957882","https://openalex.org/W2240247888","https://openalex.org/W2016045861","https://openalex.org/W2128651530","https://openalex.org/W2057181122","https://openalex.org/W2888655258","https://openalex.org/W2733274537","https://openalex.org/W2024101550"],"abstract_inverted_index":{"Edwardsiellosis,":[0,83],"caused":[1],"by":[2,55,96],"Edwardsiella":[3],"piscicida":[4,224],"infection":[5,108],"in":[6,168,234],"eels":[7,182],"(Anguilla":[8],"japonica),":[9],"is":[10,20,35,45,66],"a":[11,26,70,125],"major":[12],"problem":[13],"for":[14],"Korean":[15],"eel":[16],"farms,":[17],"so":[18],"there":[19],"an":[21,39,79,88,227],"urgent":[22],"need":[23],"to":[24,37,62,68,73,231],"develop":[25,38,78],"vaccine.":[27,165],"For":[28],"both":[29],"practical":[30],"and":[31,58,91,106],"cost":[32],"reasons,":[33],"it":[34,65],"preferable":[36],"oral":[40,74,80,102,118,156,164,172,180,201,218],"vaccine,":[41],"administration":[42,174],"of":[43,152,162,178],"which":[44],"significantly":[46],"more":[47],"efficient":[48],"than":[49,150],"injection":[50,104,133,187],"vaccines.":[51],"To":[52,77],"avoid":[53],"destruction":[54],"gastric":[56],"enzymes":[57],"ensure":[59],"safe":[60],"delivery":[61],"the":[63,92,115,140,153,160,163,176,179,190,198,217],"intestines,":[64],"essential":[67],"apply":[69],"coating":[71],"technology":[72],"vaccine":[75,81,157,173,202,219],"antigens.":[76],"against":[82],"liposomes":[84],"were":[85],"used":[86],"as":[87],"antigen":[89],"coating,":[90],"efficacy":[93,161,177],"was":[94,146],"evaluated":[95],"comparing":[97],"eels\u2019":[98],"mortality":[99,127,143],"rates":[100],"following":[101],"or":[103],"vaccination":[105],"expeirmental":[107],"with":[109],"E.":[110,223],"piscicida.":[111],"Eels":[112],"that":[113,130,151,183,216],"received":[114,184],"highest":[116,191],"concentration":[117],"vaccines":[119,134,188],"(20":[120],"mg/fish":[121,200],"dosage)":[122],"experienced":[123],"only":[124],"6%":[126],"rate;":[128],"those":[129],"got":[131],"intraperitoneal":[132,185],"had":[135,189],"10%":[136],"mortality.":[137],"In":[138],"addition,":[139],"control":[141],"group":[142,203],"rate":[144],"(46%)":[145],"4.18":[147],"times":[148],"higher":[149],"most":[154],"successful":[155],"group,":[158],"confirming":[159],"Antibody":[166],"agglutination":[167,208],"serum":[169],"extracted":[170],"after":[171],"confirmed":[175],"vaccine:":[181],"(I.P.)":[186],"antibody":[192,207],"agglutinationvalues":[193],"(28.25":[194],"\u00b1":[195,210],"0.43),":[196],"but":[197],"20":[199],"also":[204],"showed":[205],"high":[206],"(25.125":[209],"1.05).":[211],"These":[212],"results":[213],"conclusively":[214],"demonstrate":[215],"containing":[220],"liposome-coated":[221],"inactivated":[222],"can":[225],"generate":[226],"immune":[228],"response":[229],"sufficient":[230],"prevent":[232],"Edwardsiellosis":[233],"eels.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}