{"id":"https://openalex.org/W4411248972","doi":"https://doi.org/10.1021/acsmedchemlett.5c00293","title":"In this Issue Volume 16, Issue 6","display_name":"In this Issue Volume 16, Issue 6","publication_year":2025,"publication_date":"2025-06-12","ids":{"openalex":"https://openalex.org/W4411248972","doi":"https://doi.org/10.1021/acsmedchemlett.5c00293","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12169448"},"language":"en","primary_location":{"id":"doi:10.1021/acsmedchemlett.5c00293","doi":"https://doi.org/10.1021/acsmedchemlett.5c00293","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsmedchemlett.5c00293","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.5c00293?ref=article_openPDF","source":{"id":"https://openalex.org/S191852912","display_name":"ACS Medicinal Chemistry Letters","issn_l":"1948-5875","issn":["1948-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.5c00293?ref=article_openPDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027477082","display_name":"Simone V. Bigi-Botterill","orcid":"https://orcid.org/0000-0003-1309-2314","observed_orcids":["https://orcid.org/0000-0003-1309-2314"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Simone V. Bigi-Botterill","raw_affiliation_strings":["Section link copied!"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section link copied!","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5027477082"],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"6","first_page":"906","last_page":"906"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.5950000286102295},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7770000100135803},{"id":"https://openalex.org/keywords/kras-g12c","display_name":"KRAS G12C","score":0.9350000023841858},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9589999914169312},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7409999966621399},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.6973493099212646},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6322733163833618},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.49360597133636475},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0449921190738678},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.031096428632736206}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/acsmedchemlett.5c00293","doi":"https://doi.org/10.1021/acsmedchemlett.5c00293","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsmedchemlett.5c00293","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.5c00293?ref=article_openPDF","source":{"id":"https://openalex.org/S191852912","display_name":"ACS Medicinal Chemistry Letters","issn_l":"1948-5875","issn":["1948-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12169448","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12169448/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Med Chem Lett","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/acsmedchemlett.5c00293","doi":"https://doi.org/10.1021/acsmedchemlett.5c00293","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsmedchemlett.5c00293","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.5c00293?ref=article_openPDF","source":{"id":"https://openalex.org/S191852912","display_name":"ACS Medicinal Chemistry Letters","issn_l":"1948-5875","issn":["1948-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Medicinal Chemistry Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411248972.pdf","grobid_xml":"https://content.openalex.org/works/W4411248972.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4366779533","https://openalex.org/W2901669535","https://openalex.org/W4391751791","https://openalex.org/W4395702503","https://openalex.org/W4232477083","https://openalex.org/W4410152299","https://openalex.org/W4400618487","https://openalex.org/W3179724822","https://openalex.org/W4224321621","https://openalex.org/W3216190575"],"abstract_inverted_index":{"Focal":[0],"Adhesion":[1],"Kinase":[2],"(FAK)":[3],"plays":[4],"dual":[5],"roles":[6],"in":[7,43,73,84,98],"tumor":[8,100],"progression":[9],"through":[10],"both":[11,49],"kinase":[12,71],"and":[13,36,51,63,95,102],"scaffolding":[14,27],"functions.While":[15],"eight":[16],"kinase-selective":[17],"inhibitors":[18],"have":[19],"entered":[20],"clinical":[21,31,66],"trials,":[22],"their":[23],"inability":[24],"to":[25],"disrupt":[26],"domains":[28],"has":[29],"limited":[30],"success.In":[32],"this":[33],"issue,":[34],"Zhang":[35],"Rao":[37],"(DOI:":[38],"10.1021/":[39],"acsmedchemlett.5c00184)highlight":[40],"recent":[41],"advances":[42],"PRO-TAC-based":[44],"FAK":[45,59],"degraders":[46,94],"that":[47,56],"eliminate":[48],"functions.BSJ-04-146":[50],"B5":[52],"represent":[53],"promising":[54],"candidates":[55],"demonstrated":[57],"potent":[58],"degradation,":[60],"migration":[61],"inhibition,":[62],"improved":[64],"pharmacokinetics.Early":[65],"outcomes":[67],"of":[68,92],"ifebemtinib":[69],"(a":[70],"inhibitor)":[72],"combination":[74,96],"with":[75],"KRAS":[76],"G12C":[77],"inhibitor":[78],"garsorasib":[79],"showed":[80],"a":[81],"90.3%":[82],"ORR":[83],"NSCLC":[85],"patients.These":[86],"results":[87],"underscore":[88],"the":[89],"therapeutic":[90],"potential":[91],"FAK-targeting":[93],"regimens":[97],"addressing":[99],"malignancy":[101],"resistance":[103],"mechanisms.":[104]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2025-10-10T00:00:00"}
