{"id":"https://openalex.org/W4411248969","doi":"https://doi.org/10.3324/haematol.2024.287162","title":"Chemotherapy-free combination of ibrutinib and obinutuzumab for untreated advanced follicular lymphoma: results of a phase II study from the German Lymphoma Alliance","display_name":"Chemotherapy-free combination of ibrutinib and obinutuzumab for untreated advanced follicular lymphoma: results of a phase II study from the German Lymphoma Alliance","publication_year":2025,"publication_date":"2025-06-12","ids":{"openalex":"https://openalex.org/W4411248969","doi":"https://doi.org/10.3324/haematol.2024.287162","pmid":"https://pubmed.ncbi.nlm.nih.gov/40501414","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12666298"},"language":"en","primary_location":{"id":"doi:10.3324/haematol.2024.287162","doi":"https://doi.org/10.3324/haematol.2024.287162","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.2024.287162","pdf_url":"https://haematologica.org/article/download/12104/78477","source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://haematologica.org/article/download/12104/78477","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027857526","display_name":"Christian Schmidt","orcid":"https://orcid.org/0009-0008-7402-2807","observed_orcids":["https://orcid.org/0009-0008-7402-2807"]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Christian Schmidt","raw_affiliation_strings":["Department of Medicine III, University Hospital, LMU Munich, Munich. Christian_Schmidt@med.uni-muenchen.de","Department of Medicine III, University Hospital, LMU Munich, Munich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III, University Hospital, LMU Munich, Munich. Christian_Schmidt@med.uni-muenchen.de","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"raw_affiliation_string":"Department of Medicine III, University Hospital, LMU Munich, Munich","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006307715","display_name":"Gabriel Scheubeck","orcid":"https://orcid.org/0009-0004-2546-6154","observed_orcids":["https://orcid.org/0009-0004-2546-6154"]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Gabriel Scheubeck","raw_affiliation_strings":["Department of Medicine III, University Hospital, LMU Munich, Munich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III, University Hospital, LMU Munich, Munich","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064311858","display_name":"Vindi Jurinovi\u0107","orcid":"https://orcid.org/0009-0004-9087-0575","observed_orcids":["https://orcid.org/0009-0004-9087-0575"]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Vindi Jurinovic","raw_affiliation_strings":["Department of Medicine III, University Hospital, LMU Munich, Munich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III, University Hospital, LMU Munich, Munich","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060345625","display_name":"Martin S\u00f6kler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin S\u00f6kler","raw_affiliation_strings":["Department of Medicine II, University Hospital Tuebingen, Tuebingen, Germany; Department of Oncology- and Hematology, Spital Thun, Thun","Department of Medicine II, University Hospital Tuebingen, Tuebingen, Germany","Department of Oncology- and Hematology, Spital Thun, Thun"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine II, University Hospital Tuebingen, Tuebingen, Germany; Department of Oncology- and Hematology, Spital Thun, Thun","institution_ids":["https://openalex.org/I4210094118"]},{"raw_affiliation_string":"Department of Medicine II, University Hospital Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210094118"]},{"raw_affiliation_string":"Department of Oncology- and Hematology, Spital Thun, Thun","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018546005","display_name":"Roswitha Forstpointner","orcid":"https://orcid.org/0000-0002-8088-7603","observed_orcids":["https://orcid.org/0000-0002-8088-7603"]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Roswitha Forstpointner","raw_affiliation_strings":["Department of Medicine III, University Hospital, LMU Munich, Munich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III, University Hospital, LMU Munich, Munich","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022277766","display_name":"Christian Buske","orcid":"https://orcid.org/0000-0002-9782-9012","observed_orcids":["https://orcid.org/0000-0002-9782-9012"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Buske","raw_affiliation_strings":["Department of Medicine III, University Hospital Ulm, Ulm"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III, University Hospital Ulm, Ulm","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067716137","display_name":"Andreas Viardot","orcid":"https://orcid.org/0000-0001-9593-6327","observed_orcids":["https://orcid.org/0000-0001-9593-6327"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Viardot","raw_affiliation_strings":["Department of Medicine III, University Hospital Ulm, Ulm"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III, University Hospital Ulm, Ulm","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028510513","display_name":"Ulrich Bernd Keller","orcid":"https://orcid.org/0000-0002-8485-1958","observed_orcids":["https://orcid.org/0000-0002-8485-1958"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrich Keller","raw_affiliation_strings":["Department of Internal Medicine III, Klinikum Rechts der Isar der TU M\u00fcnchen, Munich, Germany; Department of Hematology and Oncology, Charit\u00e9 University Hospital, Campus Benjamin Franklin, Berlin","Department of Hematology and Oncology, Charit\u00e9 University Hospital, Campus Benjamin Franklin, Berlin","Department of Internal Medicine III, Klinikum Rechts der Isar der TU M\u00fcnchen, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III, Klinikum Rechts der Isar der TU M\u00fcnchen, Munich, Germany; Department of Hematology and Oncology, Charit\u00e9 University Hospital, Campus Benjamin Franklin, Berlin","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Hematology and Oncology, Charit\u00e9 University Hospital, Campus Benjamin Franklin, Berlin","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Internal Medicine III, Klinikum Rechts der Isar der TU M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I2802619606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069246337","display_name":"Ullrich Graeven","orcid":"https://orcid.org/0000-0001-6082-7710","observed_orcids":["https://orcid.org/0000-0001-6082-7710"]},"institutions":[{"id":"https://openalex.org/I4210108587","display_name":"Kliniken Maria Hilf","ror":"https://ror.org/01wvejv85","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210108587"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ullrich Graeven","raw_affiliation_strings":["Department of Hematology, Oncology, Gastroenterology, Kliniken Maria Hilf GmbH, M\u00f6nchengladbach"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology, Gastroenterology, Kliniken Maria Hilf GmbH, M\u00f6nchengladbach","institution_ids":["https://openalex.org/I4210108587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107562083","display_name":"Reinhard Marks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Reinhard Marks","raw_affiliation_strings":["Department of Medicine I, University Hospital Freiburg, Freiburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine I, University Hospital Freiburg, Freiburg","institution_ids":["https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061229750","display_name":"Mathias H\u00e4nel","orcid":"https://orcid.org/0000-0002-4767-3275","observed_orcids":["https://orcid.org/0000-0002-4767-3275"]},"institutions":[{"id":"https://openalex.org/I4210162138","display_name":"Klinikum Chemnitz","ror":"https://ror.org/04wkp4f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162138"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mathias H\u00e4nel","raw_affiliation_strings":["Department of Medicine III, Klinikum Chemnitz GmbH, Chemitz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III, Klinikum Chemnitz GmbH, Chemitz","institution_ids":["https://openalex.org/I4210162138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068486169","display_name":"R\u00fcdiger Liersch","orcid":"https://orcid.org/0000-0003-0610-345X","observed_orcids":["https://orcid.org/0000-0003-0610-345X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R\u00fcdiger Liersch","raw_affiliation_strings":["GEHO, Practice for Hematology and Medical Oncology, M\u00fcnster"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GEHO, Practice for Hematology and Medical Oncology, M\u00fcnster","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005029408","display_name":"Jan D\u00fcrig","orcid":"https://orcid.org/0000-0002-7672-3905","observed_orcids":["https://orcid.org/0000-0002-7672-3905"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan D\u00fcrig","raw_affiliation_strings":["Department of Hematology, University Hospital Essen, Essen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, University Hospital Essen, Essen","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114444398","display_name":"Christiane Pott","orcid":"https://orcid.org/0009-0005-9260-8340","observed_orcids":["https://orcid.org/0009-0005-9260-8340"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christiane Pott","raw_affiliation_strings":["Department of Medicine II, University Hospital Schleswig-Holstein, Kiel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine II, University Hospital Schleswig-Holstein, Kiel","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033079310","display_name":"Eva Hoster","orcid":"https://orcid.org/0000-0002-0749-1389","observed_orcids":["https://orcid.org/0000-0002-0749-1389"]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I4405260893","display_name":"Institut f\u00fcr Medizinische Informationsverarbeitung, Biometrie und Epidemiologie","ror":"https://ror.org/04eb1yz45","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405260893","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eva Hoster","raw_affiliation_strings":["Department of Medicine III, University Hospital, LMU Munich, Munich, Germany; Institute for Medical Information Processing, Biometry, and Epidemiology, LMU Munich","Department of Medicine III, University Hospital, LMU Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III, University Hospital, LMU Munich, Munich, Germany; Institute for Medical Information Processing, Biometry, and Epidemiology, LMU Munich","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I4405260893","https://openalex.org/I8204097"]},{"raw_affiliation_string":"Department of Medicine III, University Hospital, LMU Munich, Munich, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111386733","display_name":"Michael Unterhalt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Unterhalt","raw_affiliation_strings":["Department of Medicine III, University Hospital, LMU Munich, Munich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III, University Hospital, LMU Munich, Munich","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108511937","display_name":"Wolfgang Hiddemann","orcid":"https://orcid.org/0000-0003-3634-2558","observed_orcids":["https://orcid.org/0000-0003-3634-2558","https://orcid.org/0000-0001-7208-4117"]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang Hiddemann","raw_affiliation_strings":["Department of Medicine III, University Hospital, LMU Munich, Munich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III, University Hospital, LMU Munich, Munich","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5006307715","https://openalex.org/A5027857526","https://openalex.org/A5064311858"],"corresponding_institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"],"apc_list":{"value":2000,"currency":"EUR","value_usd":2157},"apc_paid":{"value":2000,"currency":"EUR","value_usd":2157},"fwci":2.2969,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.86435914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"110","issue":"12","first_page":"3022","last_page":"3031"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9077000021934509,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9077000021934509,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.09130000323057175,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ibrutinib","display_name":"ibrutinib","score":0.9350000023841858},{"id":"https://openalex.org/keywords/obinutuzumab","display_name":"obinutuzumab","score":1.0},{"id":"https://openalex.org/keywords/follicular-lymphoma","display_name":"follicular lymphoma","score":0.9729999899864197},{"id":"https://openalex.org/keywords/chemotherapy-free-regimen","display_name":"chemotherapy-free regimen","score":0.671999990940094},{"id":"https://openalex.org/keywords/bruton-tyrosine-kinase-inhibitors","display_name":"BTK inhibitors","score":0.9639999866485596},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.6100000143051147},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9940000176429749},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7940000295639038},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C2777607594","wikidata":"https://www.wikidata.org/wiki/Q389496","display_name":"Obinutuzumab","level":4,"score":0.8861621618270874},{"id":"https://openalex.org/C2779878957","wikidata":"https://www.wikidata.org/wiki/Q5984881","display_name":"Ibrutinib","level":4,"score":0.8559592962265015},{"id":"https://openalex.org/C2777058707","wikidata":"https://www.wikidata.org/wiki/Q123251","display_name":"Follicular lymphoma","level":3,"score":0.8073909282684326},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6533941030502319},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.566511332988739},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5108403563499451},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4920494258403778},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4723827838897705},{"id":"https://openalex.org/C154775046","wikidata":"https://www.wikidata.org/wiki/Q188","display_name":"German","level":2,"score":0.4189557433128357},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.2773502767086029},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.20199871063232422},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.17383894324302673},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008224","descriptor_name":"Lymphoma, Follicular","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008224","descriptor_name":"Lymphoma, Follicular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008224","descriptor_name":"Lymphoma, Follicular","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008224","descriptor_name":"Lymphoma, Follicular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.3324/haematol.2024.287162","doi":"https://doi.org/10.3324/haematol.2024.287162","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.2024.287162","pdf_url":"https://haematologica.org/article/download/12104/78477","source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},{"id":"pmid:40501414","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40501414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12666298","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12666298/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Text"},{"id":"pmh:oai:edoc.mdc-berlin.de:26072","doi":null,"is_oa":true,"landing_page_url":"https://orcid.org/0000-0002-8485-1958","pdf_url":"https://edoc.mdc-berlin.de/id/eprint/26072/1/26072oa.pdf","source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:epub.ub.uni-muenchen.de:130514","doi":null,"is_oa":true,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-130514-2","pdf_url":"https://epub.ub.uni-muenchen.de/130514/1/12104-Article_Text-87787-2-10-20251119.pdf","source":{"id":"https://openalex.org/S4306401845","display_name":"Open access LMU (Ludwid Maxmilian's Universitat Munchen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8204097","host_organization_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","host_organization_lineage":["https://openalex.org/I8204097"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica","raw_type":"doc-type:article"},{"id":"pmh:oai:bibliographie.ub.uni-due.de:ubo_mods_00238591","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pubmed/40501414","pdf_url":null,"source":{"id":"https://openalex.org/S7407055102","display_name":"Universit\u00e4tsbibliographie, Universit\u00e4t Duisburg-Essen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:bibliographie.ub.uni-due.de:ubo_mods_00246543","doi":null,"is_oa":false,"landing_page_url":"https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=105049089389","pdf_url":null,"source":{"id":"https://openalex.org/S7407055102","display_name":"Universit\u00e4tsbibliographie, Universit\u00e4t Duisburg-Essen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:04d0076b698e45e78baee0b679208333","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/04d0076b698e45e78baee0b679208333","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica, Vol 999, Iss 1 (2025)","raw_type":"article"},{"id":"pmh:oai:freidok.uni-freiburg.de:269649","doi":null,"is_oa":false,"landing_page_url":"https://freidok.uni-freiburg.de/data/269649","pdf_url":null,"source":{"id":"https://openalex.org/S4306401057","display_name":"FreiDok plus (Universit\u00e4tsbibliothek Freiburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161046081","host_organization_name":"University of Freiburg","host_organization_lineage":["https://openalex.org/I161046081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica. - (2025) , ISSN: 1592-8721","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3324/haematol.2024.287162","doi":"https://doi.org/10.3324/haematol.2024.287162","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.2024.287162","pdf_url":"https://haematologica.org/article/download/12104/78477","source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411248969.pdf","grobid_xml":"https://content.openalex.org/works/W4411248969.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W2012232903","https://openalex.org/W2117488094","https://openalex.org/W2133201432","https://openalex.org/W2133877408","https://openalex.org/W2152996672","https://openalex.org/W2154643481","https://openalex.org/W2169047291","https://openalex.org/W2171771895","https://openalex.org/W2761878534","https://openalex.org/W2765414225","https://openalex.org/W2806493073","https://openalex.org/W2806889830","https://openalex.org/W2891543930","https://openalex.org/W2970358718","https://openalex.org/W3012031439","https://openalex.org/W3042611862"],"related_works":["https://openalex.org/W2905419906","https://openalex.org/W4417012966","https://openalex.org/W4417004959","https://openalex.org/W4200471043","https://openalex.org/W2762113325","https://openalex.org/W3012031439","https://openalex.org/W4411317649","https://openalex.org/W2761878534","https://openalex.org/W3031050995","https://openalex.org/W3113332911"],"abstract_inverted_index":{"Immunochemotherapy":[0],"induces":[1],"long-term":[2],"responses":[3,223],"in":[4,28,63,117,201,211],"patients":[5,29,64,114,129,204],"with":[6,30,36,65],"follicular":[7,69,202],"lymphoma.":[8,33,70],"However,":[9,216],"the":[10,56,108,118,148,212,217],"toxicity":[11],"of":[12,59,76,105,111,151,155,166,179,193,197],"chemotherapy":[13],"remains":[14],"a":[15,47,132,139,152,194,208],"relevant":[16],"challenge.":[17],"The":[18,89,97,120,142,158,174,191],"Bruton":[19],"tyrosine":[20],"kinase":[21],"inhibitor":[22],"ibrutinib":[23,35,62,77,200],"has":[24],"shown":[25],"significant":[26],"activity":[27],"indolent":[31],"B-cell":[32],"Combining":[34],"obinutuzumab":[37,60,79,198],"may,":[38],"therefore,":[39],"be":[40],"an":[41,103,226],"attractive":[42],"chemotherapy-free":[43,57,195],"option.":[44],"We":[45],"conducted":[46],"prospective,":[48],"single-arm,":[49],"multicenter":[50],"phase":[51],"II":[52],"trial":[53,192],"to":[54,101,206],"evaluate":[55],"regimen":[58,196],"plus":[61],"previously":[66],"untreated":[67],"advanced-stage":[68],"Patients":[71],"received":[72],"six":[73],"21-day":[74],"cycles":[75,86],"and":[78,82,135,168,189,199,221,224],"for":[80,87],"induction":[81],"12":[83],"additional":[84],"2-month":[85],"maintenance.":[88],"primary":[90,213],"endpoint":[91],"was":[92,99,123,145,161],"1-year":[93,109,143,153],"progression-free":[94],"survival":[95,170],"(PFS).":[96],"study":[98],"powered":[100],"detect":[102],"improvement":[104,150,210],"10%":[106,209],"over":[107],"PFS":[110,144,154,160],"85%.":[112],"Ninety-eight":[113],"were":[115,171,182],"enrolled":[116],"trial.":[119],"median":[121,159,164],"follow-up":[122],"5.5":[124],"years.":[125],"After":[126],"induction,":[127],"five":[128],"(5%)":[130],"had":[131,138,225],"complete":[133],"response":[134,167],"82":[136],"(85%)":[137],"partial":[140],"response.":[141],"80%,":[146],"missing":[147],"prospected":[149],"85%":[156],"(P=0.93).":[157],"4.5":[162],"years;":[163],"duration":[165],"overall":[169],"not":[172],"reached.":[173],"most":[175],"common":[176],"adverse":[177],"events":[178],"grade":[180],"3/4":[181],"neutropenia,":[183],"lung":[184],"infection,":[185],"hypertension,":[186],"fatigue,":[187],"rash":[188],"thrombocytopenia.":[190],"lymphoma":[203],"failed":[205],"demonstrate":[207],"efficacy":[214],"endpoint.":[215],"combination":[218],"produced":[219],"durable":[220],"deep":[222],"acceptable":[227],"safety":[228],"profile.":[229],"Trial":[230],"registration,":[231],"EudraCT-Number:":[232],"2014-005164-15.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-10-10T00:00:00"}
