{"id":"https://openalex.org/W4411245355","doi":"https://doi.org/10.1134/s263482762560001x","title":"Cu-Mediated Click Chemistry Approach: Synthesis, Characterization, and Anti-Mycobacterial Activity of 2-(4-((5-Bromo-3-formyl-1H-indol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-phenylacetamide Derivatives","display_name":"Cu-Mediated Click Chemistry Approach: Synthesis, Characterization, and Anti-Mycobacterial Activity of 2-(4-((5-Bromo-3-formyl-1H-indol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-phenylacetamide Derivatives","publication_year":2025,"publication_date":"2025-03-01","ids":{"openalex":"https://openalex.org/W4411245355","doi":"https://doi.org/10.1134/s263482762560001x"},"language":"en","primary_location":{"id":"doi:10.1134/s263482762560001x","doi":"https://doi.org/10.1134/s263482762560001x","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s263482762560001x","pdf_url":null,"source":{"id":"https://openalex.org/S4210236974","display_name":"Reviews and Advances in Chemistry","issn_l":"2634-8276","issn":["2634-8276","2634-8284"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-4"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reviews and Advances in Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078851026","display_name":"Parth Manvar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197181853","display_name":"Saurashtra University","ror":"https://ror.org/0250jpt55","country_code":"IN","type":"education","lineage":["https://openalex.org/I197181853"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Parth Manvar","raw_affiliation_strings":["Department of Chemistry, Saurashtra University, 360005, Rajkot, India","Department of Chemistry, Saurashtra University, Rajkot, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Saurashtra University, 360005, Rajkot, India","institution_ids":["https://openalex.org/I197181853"]},{"raw_affiliation_string":"Department of Chemistry, Saurashtra University, Rajkot, India","institution_ids":["https://openalex.org/I197181853"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023796802","display_name":"Dharmesh K. Katariya","orcid":"https://orcid.org/0009-0008-1862-4440","observed_orcids":["https://orcid.org/0009-0008-1862-4440"]},"institutions":[{"id":"https://openalex.org/I197181853","display_name":"Saurashtra University","ror":"https://ror.org/0250jpt55","country_code":"IN","type":"education","lineage":["https://openalex.org/I197181853"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dharmesh Katariya","raw_affiliation_strings":["Department of Chemistry, Saurashtra University, 360005, Rajkot, India","Department of Chemistry, Saurashtra University, Rajkot, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Saurashtra University, 360005, Rajkot, India","institution_ids":["https://openalex.org/I197181853"]},{"raw_affiliation_string":"Department of Chemistry, Saurashtra University, Rajkot, India","institution_ids":["https://openalex.org/I197181853"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102596631","display_name":"Amita Vyas","orcid":"https://orcid.org/0009-0000-6597-6467","observed_orcids":["https://orcid.org/0009-0000-6597-6467"]},"institutions":[{"id":"https://openalex.org/I197181853","display_name":"Saurashtra University","ror":"https://ror.org/0250jpt55","country_code":"IN","type":"education","lineage":["https://openalex.org/I197181853"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Amita Vyas","raw_affiliation_strings":["Department of Chemistry, Saurashtra University, 360005, Rajkot, India","Department of Chemistry, Saurashtra University, Rajkot, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Saurashtra University, 360005, Rajkot, India","institution_ids":["https://openalex.org/I197181853"]},{"raw_affiliation_string":"Department of Chemistry, Saurashtra University, Rajkot, India","institution_ids":["https://openalex.org/I197181853"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094239063","display_name":"Pooja Bhanderi","orcid":"https://orcid.org/0009-0000-1708-3349","observed_orcids":["https://orcid.org/0009-0000-1708-3349"]},"institutions":[{"id":"https://openalex.org/I197181853","display_name":"Saurashtra University","ror":"https://ror.org/0250jpt55","country_code":"IN","type":"education","lineage":["https://openalex.org/I197181853"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pooja Bhanderi","raw_affiliation_strings":["Department of Chemistry, Saurashtra University, 360005, Rajkot, India","Department of Chemistry, Saurashtra University, Rajkot, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Saurashtra University, 360005, Rajkot, India","institution_ids":["https://openalex.org/I197181853"]},{"raw_affiliation_string":"Department of Chemistry, Saurashtra University, Rajkot, India","institution_ids":["https://openalex.org/I197181853"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044820851","display_name":"Ranjan Khunt","orcid":"https://orcid.org/0000-0001-8155-5320","observed_orcids":["https://orcid.org/0000-0001-8155-5320"]},"institutions":[{"id":"https://openalex.org/I197181853","display_name":"Saurashtra University","ror":"https://ror.org/0250jpt55","country_code":"IN","type":"education","lineage":["https://openalex.org/I197181853"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Ranjan Khunt","raw_affiliation_strings":["Department of Chemistry, Saurashtra University, 360005, Rajkot, India","Department of Chemistry, Saurashtra University, Rajkot, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Saurashtra University, 360005, Rajkot, India","institution_ids":["https://openalex.org/I197181853"]},{"raw_affiliation_string":"Department of Chemistry, Saurashtra University, Rajkot, India","institution_ids":["https://openalex.org/I197181853"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044820851"],"corresponding_institution_ids":["https://openalex.org/I197181853"],"apc_list":null,"apc_paid":null,"fwci":0.2637,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.31700859,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"15","issue":"1","first_page":"16","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-2-3-triazole-derivatives","display_name":"1,2,3-triazole derivatives","score":0.8569999933242798},{"id":"https://openalex.org/keywords/acetanilide","display_name":"acetanilide","score":0.7390000224113464},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/antimycobacterial-activity","display_name":"antimycobacterial activity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C69610077","wikidata":"https://www.wikidata.org/wiki/Q912270","display_name":"Click chemistry","level":2,"score":0.7669123411178589},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6597471237182617},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.49092844128608704},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3620380759239197},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.32775425910949707}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1134/s263482762560001x","doi":"https://doi.org/10.1134/s263482762560001x","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s263482762560001x","pdf_url":null,"source":{"id":"https://openalex.org/S4210236974","display_name":"Reviews and Advances in Chemistry","issn_l":"2634-8276","issn":["2634-8276","2634-8284"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-4"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reviews and Advances in Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W3086436846","https://openalex.org/W3118908164","https://openalex.org/W3164438890","https://openalex.org/W4211101544","https://openalex.org/W4386607694","https://openalex.org/W4394880018","https://openalex.org/W4401332819","https://openalex.org/W4401610878","https://openalex.org/W4406155201","https://openalex.org/W4406240380","https://openalex.org/W4406240467","https://openalex.org/W4407212218","https://openalex.org/W4407407689"],"related_works":["https://openalex.org/W7163820485","https://openalex.org/W2415842791","https://openalex.org/W2041703590","https://openalex.org/W1980725549","https://openalex.org/W4224126595","https://openalex.org/W2945793477","https://openalex.org/W2329299010","https://openalex.org/W4381949971","https://openalex.org/W2937398387","https://openalex.org/W4312678572"],"abstract_inverted_index":{"This":[0,82],"study":[1],"presents":[2],"the":[3,40,74,84],"synthesis":[4],"and":[5,31],"optimization":[6,88],"of":[7,9,28,46,89],"series":[8],"2-(4-((5-bromo-3-formyl-1H-indol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-phenylacetamide":[10],"derivatives":[11,59,91],"(8a-8t),":[12],"synthesized":[13,48],"through":[14],"a":[15,19,24,67],"multi-step":[16],"process":[17],"using":[18],"click":[20],"chemistry":[21],"approach":[22],"in":[23],"mixed":[25],"solvent":[26],"system":[27],"tert-butanol,":[29],"DMF,":[30],"water,":[32],"catalyzed":[33],"by":[34],"copper.":[35],"Optimal":[36],"reaction":[37],"conditions":[38],"provide":[39],"highest":[41],"yield.":[42],"Subsequent":[43],"vitro":[44],"evaluation":[45],"20":[47],"compounds":[49,69],"for":[50,86],"anti-mycobacterial":[51],"activity":[52],"against":[53],"Mycobacterium":[54],"tuberculosis":[55],"revealed":[56],"that":[57],"most":[58],"were":[60],"ineffective":[61],"due":[62],"to":[63,92],"solubility":[64],"issues.":[65],"Only":[66],"few":[68],"showed":[70],"moderate":[71],"activity,":[72],"with":[73],"reference":[75],"drug":[76],"Rifampicin":[77],"demonstrating":[78],"significantly":[79],"higher":[80],"efficacy.":[81],"underscores":[83],"need":[85],"further":[87],"these":[90],"improve":[93],"their":[94],"biological":[95],"activity.":[96]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
