{"id":"https://openalex.org/W4411238145","doi":"https://doi.org/10.1111/cas.70107","title":"Implication of KLHL Gene Family Member KLHL5 in Colorectal Cancer Progression and Prognosis","display_name":"Implication of KLHL Gene Family Member KLHL5 in Colorectal Cancer Progression and Prognosis","publication_year":2025,"publication_date":"2025-06-12","ids":{"openalex":"https://openalex.org/W4411238145","doi":"https://doi.org/10.1111/cas.70107","pmid":"https://pubmed.ncbi.nlm.nih.gov/40504175","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12400045"},"language":"en","primary_location":{"id":"doi:10.1111/cas.70107","doi":"https://doi.org/10.1111/cas.70107","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cas.70107","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.70107","source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.70107","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086741590","display_name":"Konomu Uno","orcid":"https://orcid.org/0009-0006-2164-5205","observed_orcids":["https://orcid.org/0009-0006-2164-5205"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Konomu Uno","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":"https://orcid.org/0009-0006-2164-5205","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068785582","display_name":"Hirotada Nishie","orcid":"https://orcid.org/0000-0003-2055-6519","observed_orcids":["https://orcid.org/0000-0003-2055-6519"]},"institutions":[{"id":"https://openalex.org/I4405284044","display_name":"Nagoya City University Midori Municipal Hospital","ror":"https://ror.org/02tfjxq18","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405284044"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotada Nishie","raw_affiliation_strings":["Department of Gastroenterology, Nagoya City University Midori Municipal Hospital, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nagoya City University Midori Municipal Hospital, Nagoya, Japan","institution_ids":["https://openalex.org/I4405284044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003825373","display_name":"Hiromi Hiyoshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromi Hiyoshi","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048464985","display_name":"Kyosuke HABU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43545212","display_name":"Ehime University","ror":"https://ror.org/017hkng22","country_code":"JP","type":"education","lineage":["https://openalex.org/I43545212"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kyosuke Habu","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Ehime, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Ehime, Japan","institution_ids":["https://openalex.org/I43545212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058773471","display_name":"Jun Nakayama","orcid":"https://orcid.org/0000-0001-8844-4295","observed_orcids":["https://orcid.org/0000-0001-8844-4295"]},"institutions":[{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Nakayama","raw_affiliation_strings":["Department of Oncogenesis and Growth Regulation, Research Institute, Osaka International Cancer Institute, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0001-8844-4295","affiliations":[{"raw_affiliation_string":"Department of Oncogenesis and Growth Regulation, Research Institute, Osaka International Cancer Institute, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043420489","display_name":"Sota Tate","orcid":"https://orcid.org/0000-0001-7050-4560","observed_orcids":["https://orcid.org/0000-0001-7050-4560"]},"institutions":[{"id":"https://openalex.org/I43545212","display_name":"Ehime University","ror":"https://ror.org/017hkng22","country_code":"JP","type":"education","lineage":["https://openalex.org/I43545212"]},{"id":"https://openalex.org/I4405287542","display_name":"Proteo-Science Center, Ehime University","ror":"https://ror.org/05ffb9p90","country_code":"JP","type":"facility","lineage":["https://openalex.org/I43545212","https://openalex.org/I4405287542"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sota Tate","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics Ehime University Graduate School of Medicine  Ehime Japan","Department of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Ehime, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics Ehime University Graduate School of Medicine  Ehime Japan","institution_ids":["https://openalex.org/I43545212"]},{"raw_affiliation_string":"Department of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Ehime, Japan","institution_ids":["https://openalex.org/I43545212","https://openalex.org/I4405287542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076418881","display_name":"Tomohisa Sakaue","orcid":"https://orcid.org/0000-0001-7724-2225","observed_orcids":["https://orcid.org/0000-0001-7724-2225"]},"institutions":[{"id":"https://openalex.org/I43545212","display_name":"Ehime University","ror":"https://ror.org/017hkng22","country_code":"JP","type":"education","lineage":["https://openalex.org/I43545212"]},{"id":"https://openalex.org/I4405287542","display_name":"Proteo-Science Center, Ehime University","ror":"https://ror.org/05ffb9p90","country_code":"JP","type":"facility","lineage":["https://openalex.org/I43545212","https://openalex.org/I4405287542"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohisa Sakaue","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics Ehime University Graduate School of Medicine  Ehime Japan","Department of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Ehime, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics Ehime University Graduate School of Medicine  Ehime Japan","institution_ids":["https://openalex.org/I43545212"]},{"raw_affiliation_string":"Department of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Ehime, Japan","institution_ids":["https://openalex.org/I43545212","https://openalex.org/I4405287542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060361397","display_name":"Eiji Kubota","orcid":"https://orcid.org/0000-0002-6694-8772","observed_orcids":["https://orcid.org/0000-0002-6694-8772"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Eiji Kubota","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042213269","display_name":"Mamoru Tanaka","orcid":"https://orcid.org/0000-0001-8416-5774","observed_orcids":["https://orcid.org/0000-0001-8416-5774"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mamoru Tanaka","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":"https://orcid.org/0000-0001-8416-5774","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051727905","display_name":"Takaya Shimura","orcid":"https://orcid.org/0000-0002-6048-0021","observed_orcids":["https://orcid.org/0000-0002-6048-0021"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takaya Shimura","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":"https://orcid.org/0000-0002-6048-0021","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047369080","display_name":"Hiromi Kataoka","orcid":"https://orcid.org/0000-0001-9491-0723","observed_orcids":["https://orcid.org/0000-0001-9491-0723"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromi Kataoka","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":"https://orcid.org/0000-0001-9491-0723","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008458565","display_name":"Takashi Joh","orcid":"https://orcid.org/0000-0002-3624-0597","observed_orcids":["https://orcid.org/0000-0002-3624-0597"]},"institutions":[{"id":"https://openalex.org/I4405254508","display_name":"Gamagori City Hospital","ror":"https://ror.org/01ws30v92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405254508"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Joh","raw_affiliation_strings":["Department of Gastroenterology, Gamagori Municipal Hospital, Gamagori, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Gamagori Municipal Hospital, Gamagori, Japan","institution_ids":["https://openalex.org/I4405254508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102915092","display_name":"Shigeki Higashiyama","orcid":"https://orcid.org/0000-0002-2417-3921","observed_orcids":["https://orcid.org/0000-0002-2417-3921"]},"institutions":[{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I43545212","display_name":"Ehime University","ror":"https://ror.org/017hkng22","country_code":"JP","type":"education","lineage":["https://openalex.org/I43545212"]},{"id":"https://openalex.org/I4405287542","display_name":"Proteo-Science Center, Ehime University","ror":"https://ror.org/05ffb9p90","country_code":"JP","type":"facility","lineage":["https://openalex.org/I43545212","https://openalex.org/I4405287542"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeki Higashiyama","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics Ehime University Graduate School of Medicine  Ehime Japan","Department of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Ehime, Japan","Department of Oncogenesis and Growth Regulation, Research Institute, Osaka International Cancer Institute, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0002-2417-3921","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics Ehime University Graduate School of Medicine  Ehime Japan","institution_ids":["https://openalex.org/I43545212"]},{"raw_affiliation_string":"Department of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Ehime, Japan","institution_ids":["https://openalex.org/I43545212","https://openalex.org/I4405287542"]},{"raw_affiliation_string":"Department of Oncogenesis and Growth Regulation, Research Institute, Osaka International Cancer Institute, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5060361397"],"corresponding_institution_ids":["https://openalex.org/I33858575"],"apc_list":{"value":2600,"currency":"USD","value_usd":2600},"apc_paid":{"value":2600,"currency":"USD","value_usd":2600},"fwci":0.4806,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.53474655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"116","issue":"9","first_page":"2580","last_page":"2591"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.2653999924659729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.2653999924659729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.2612000107765198,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.11580000072717667,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.953000009059906},{"id":"https://openalex.org/keywords/ring-e3-ubiquitin-ligase","display_name":"RING E3 ubiquitin ligase","score":0.902999997138977},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.968999981880188},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.800000011920929},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.4560000002384186},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/lymphovascular-invasion","display_name":"lymphovascular invasion","score":0.9139999747276306},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5040000081062317},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7450665235519409},{"id":"https://openalex.org/C2992694208","wikidata":"https://www.wikidata.org/wiki/Q8436","display_name":"Family member","level":2,"score":0.5197075009346008},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48689785599708557},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46283555030822754},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45634162425994873},{"id":"https://openalex.org/C5911399","wikidata":"https://www.wikidata.org/wiki/Q2278983","display_name":"Gene family","level":4,"score":0.4161189794540405},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40589916706085205},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32069310545921326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28161799907684326},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2619274854660034},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23135212063789368},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.13754740357398987},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.09937244653701782}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1111/cas.70107","doi":"https://doi.org/10.1111/cas.70107","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cas.70107","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.70107","source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.4718102","doi":"https://doi.org/10.2139/ssrn.4718102","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4718102","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:11211230","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12400045","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40504175","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40504175","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12400045","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12400045/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/cas.70107","doi":"https://doi.org/10.1111/cas.70107","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cas.70107","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.70107","source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1687677524","display_name":"Membrane trafficking system of PD-L1 in gastric cancer cells and its application to immunotherapy","funder_award_id":"17K09357","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320325453","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411238145.pdf","grobid_xml":"https://content.openalex.org/works/W4411238145.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1503238757","https://openalex.org/W1514375011","https://openalex.org/W1549827563","https://openalex.org/W1934094702","https://openalex.org/W1998493994","https://openalex.org/W2011217149","https://openalex.org/W2042126900","https://openalex.org/W2048000549","https://openalex.org/W2078115068","https://openalex.org/W2085963386","https://openalex.org/W2096235123","https://openalex.org/W2103288282","https://openalex.org/W2103883679","https://openalex.org/W2105829583","https://openalex.org/W2127594372","https://openalex.org/W2131324791","https://openalex.org/W2146303969","https://openalex.org/W2154941270","https://openalex.org/W2155376306","https://openalex.org/W2310046094","https://openalex.org/W2340386540","https://openalex.org/W2551027689","https://openalex.org/W2563329011","https://openalex.org/W2756069931","https://openalex.org/W2765224588","https://openalex.org/W2766813406","https://openalex.org/W2770459634","https://openalex.org/W2791753912","https://openalex.org/W2906473582","https://openalex.org/W2910507254","https://openalex.org/W2949816023","https://openalex.org/W2953719726","https://openalex.org/W2980426255","https://openalex.org/W2997247690","https://openalex.org/W3009097360","https://openalex.org/W3010910207","https://openalex.org/W3112295014","https://openalex.org/W3128646645","https://openalex.org/W3165521652","https://openalex.org/W3185992197","https://openalex.org/W4311283216"],"related_works":["https://openalex.org/W3112295014","https://openalex.org/W4415348872","https://openalex.org/W4413827523","https://openalex.org/W2884171730","https://openalex.org/W3015752518","https://openalex.org/W4408266989","https://openalex.org/W4392856022","https://openalex.org/W4220940274","https://openalex.org/W2888399404","https://openalex.org/W2907032599"],"abstract_inverted_index":{"The":[0,63],"KLHL":[1,52],"gene":[2],"family":[3,53],"member":[4],"KLHL5,":[5],"which":[6,204],"is":[7,18,175,205],"a":[8,27,39,230,245],"constituent":[9],"factor":[10],"of":[11,23,46,62,75,125,158,238],"the":[12,44,73,108,148,155,159,184,197,211,234],"RING":[13],"E3":[14],"ubiquitin":[15],"ligase":[16],"complex,":[17],"expressed":[19,93],"in":[20,29,77,94,97,173,196,233],"various":[21],"types":[22],"cancers":[24],"and":[25,82,101,135,210,213,236,240,248],"plays":[26,229],"role":[28,232],"cancer":[30,48],"pathophysiology.":[31],"In":[32],"this":[33],"study,":[34],"we":[35,167],"identified":[36],"KLHL5":[37,76,89,114,143,171,191,228],"as":[38,123,207,244],"potential":[40,246],"biomarker":[41,247],"for":[42,251],"predicting":[43],"prognosis":[45],"colorectal":[47,67],"(CRC)":[49],"from":[50,183],"42":[51],"genes":[54],"using":[55,79],"transcriptome":[56],"profiles":[57],"generated":[58],"by":[59],"RNA-seq":[60],"analysis":[61,182],"Cancer":[64],"Genome":[65],"Atlas":[66],"adenocarcinoma":[68],"(TCGA-COAD).":[69],"We":[70],"further":[71],"investigated":[72],"implication":[74],"CRC":[78,95,109,174,252],"pathological":[80],"examination":[81],"bioinformatics":[83,165],"analyses.":[84],"Clinicopathological":[85],"analyses":[86],"revealed":[87],"that":[88,169,190,227],"was":[90,116,193],"more":[91,194],"highly":[92,208],"than":[96],"adjacent":[98],"normal":[99],"mucosa,":[100],"its":[102],"expression":[103,115,146,152,172,192],"level":[104],"increased":[105],"concomitantly":[106],"with":[107,118,150,178],"stage":[110],"(p":[111,127,132,139,161],"<":[112,128,162],"0.05).":[113],"associated":[117,177],"poor":[119,179,218],"prognostic":[120],"factors":[121],"such":[122],"depth":[124],"invasion":[126,131],"0.001),":[129],"lymphovascular":[130],"=":[133,140],"0.029),":[134],"lymph":[136],"node":[137],"metastasis":[138],"0.025).":[141],"Notably,":[142],"exhibited":[144],"heterogeneous":[145],"within":[147],"tumor,":[149],"pronounced":[151,195],"observed":[153],"at":[154],"invasive":[156],"front":[157],"tumor":[160],"0.0001).":[163],"Through":[164],"analyses,":[166],"determined":[168],"elevated":[170],"significantly":[176],"prognosis.":[180],"Furthermore,":[181],"Gene":[185],"Expression":[186],"Omnibus":[187],"database":[188],"indicated":[189],"common":[198],"molecular":[199],"subtype":[200],"(CMS)":[201],"4":[202],"CRC,":[203,239],"characterized":[206],"advanced,":[209],"overall":[212],"recurrence-free":[214],"survival":[215],"rates":[216],"were":[217],"compared":[219],"to":[220],"other":[221],"CMS":[222],"groups.":[223],"Our":[224],"findings":[225],"indicate":[226],"pivotal":[231],"progression":[235],"development":[237],"can":[241],"be":[242],"used":[243],"therapeutic":[249],"target":[250],"treatment.":[253]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-06-13T00:00:00"}