{"id":"https://openalex.org/W4411204133","doi":"https://doi.org/10.1159/000546381","title":"Treatment of Older Adults with Newly Diagnosed Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia","display_name":"Treatment of Older Adults with Newly Diagnosed Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia","publication_year":2025,"publication_date":"2025-06-10","ids":{"openalex":"https://openalex.org/W4411204133","doi":"https://doi.org/10.1159/000546381","pmid":"https://pubmed.ncbi.nlm.nih.gov/40494331"},"language":"en","primary_location":{"id":"doi:10.1159/000546381","doi":"https://doi.org/10.1159/000546381","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000546381","pdf_url":"https://karger.com/aha/article-pdf/doi/10.1159/000546381/4388875/000546381.pdf","source":{"id":"https://openalex.org/S182948766","display_name":"Acta Haematologica","issn_l":"0001-5792","issn":["0001-5792","1421-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://karger.com/aha/article-pdf/doi/10.1159/000546381/4388875/000546381.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081803877","display_name":"Lourdes Mendez","orcid":"https://orcid.org/0000-0002-5922-2877","observed_orcids":["https://orcid.org/0000-0002-5922-2877"]},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lourdes M. Mendez","raw_affiliation_strings":["Section of Hematology, Department of Internal Medicine, Yale School of Medicine and Yale Comprehensive Cancer Center, Yale University, New Haven, Connecticut, USA","Section of Hematology, Department of Internal Medicine, Yale School of Medicine and Yale Comprehensive Cancer Center, Yale University, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology, Department of Internal Medicine, Yale School of Medicine and Yale Comprehensive Cancer Center, Yale University, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I2802730090","https://openalex.org/I32971472"]},{"raw_affiliation_string":"Section of Hematology, Department of Internal Medicine, Yale School of Medicine and Yale Comprehensive Cancer Center, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I2802730090","https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082924494","display_name":"Daniel J. DeAngelo","orcid":"https://orcid.org/0000-0001-7865-2306","observed_orcids":["https://orcid.org/0000-0001-7865-2306"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. DeAngelo","raw_affiliation_strings":["Division of Leukemia, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA","Division of Leukemia, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Leukemia, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Division of Leukemia, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023296232","display_name":"Marlise Rachael Luskin","orcid":"https://orcid.org/0000-0002-5781-4529","observed_orcids":["https://orcid.org/0000-0002-5781-4529"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marlise R. Luskin","raw_affiliation_strings":["Division of Leukemia, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA, marlise_luskin@dfci.harvard.edu","Division of Leukemia, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-5781-4529","affiliations":[{"raw_affiliation_string":"Division of Leukemia, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA, marlise_luskin@dfci.harvard.edu","institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"Division of Leukemia, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3288,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.40847526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"149","issue":"1","first_page":"61","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/philadelphia-chromosome-negative-acute-lymphoblastic-leukemia","display_name":"Philadelphia chromosome-negative acute lymphoblastic leukemia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.9829999804496765},{"id":"https://openalex.org/keywords/inotuzumab-ozogamicin","display_name":"inotuzumab ozogamicin","score":0.8169999718666077},{"id":"https://openalex.org/keywords/blinatumomab","display_name":"blinatumomab","score":0.9959999918937683},{"id":"https://openalex.org/keywords/venetoclax","display_name":"venetoclax","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bcl2-inhibitors","display_name":"BCL-2 inhibitor","score":0.9190000295639038},{"id":"https://openalex.org/keywords/reduced-intensity-chemotherapy","display_name":"reduced-intensity chemotherapy","score":0.7950000166893005},{"id":"https://openalex.org/keywords/allogeneic-stem-cell-transplantation","display_name":"allogeneic stem cell transplantation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.8769999742507935},{"id":"https://openalex.org/keywords/b-cell-acute-lymphoblastic-leukemia","display_name":"B-cell acute lymphoblastic leukemia","score":0.6399999856948853},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.8500000238418579},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.7746933698654175},{"id":"https://openalex.org/C2778904597","wikidata":"https://www.wikidata.org/wiki/Q1129111","display_name":"Philadelphia chromosome","level":4,"score":0.6582390069961548},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6534308195114136},{"id":"https://openalex.org/C2781107101","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Acute lymphocytic leukemia","level":4,"score":0.45167723298072815},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4127086102962494},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.35365554690361023},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3352201581001282},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18263468146324158},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14205557107925415},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.1295870840549469},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12082687020301819}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010677","descriptor_name":"Philadelphia Chromosome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000546381","doi":"https://doi.org/10.1159/000546381","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000546381","pdf_url":"https://karger.com/aha/article-pdf/doi/10.1159/000546381/4388875/000546381.pdf","source":{"id":"https://openalex.org/S182948766","display_name":"Acta Haematologica","issn_l":"0001-5792","issn":["0001-5792","1421-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica","raw_type":"journal-article"},{"id":"pmid:40494331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40494331","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta haematologica","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1159/000546381","doi":"https://doi.org/10.1159/000546381","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000546381","pdf_url":"https://karger.com/aha/article-pdf/doi/10.1159/000546381/4388875/000546381.pdf","source":{"id":"https://openalex.org/S182948766","display_name":"Acta Haematologica","issn_l":"0001-5792","issn":["0001-5792","1421-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411204133.pdf","grobid_xml":"https://content.openalex.org/works/W4411204133.grobid-xml"},"referenced_works_count":113,"referenced_works":["https://openalex.org/W1685744202","https://openalex.org/W1904414599","https://openalex.org/W1911319577","https://openalex.org/W1978302657","https://openalex.org/W1989658067","https://openalex.org/W2008009748","https://openalex.org/W2013624622","https://openalex.org/W2015345028","https://openalex.org/W2026450884","https://openalex.org/W2044141667","https://openalex.org/W2052739233","https://openalex.org/W2052846308","https://openalex.org/W2060605982","https://openalex.org/W2060716454","https://openalex.org/W2061585822","https://openalex.org/W2063898537","https://openalex.org/W2068412287","https://openalex.org/W2070520252","https://openalex.org/W2085656861","https://openalex.org/W2105908490","https://openalex.org/W2125277492","https://openalex.org/W2141795335","https://openalex.org/W2159447912","https://openalex.org/W2166306614","https://openalex.org/W2191333253","https://openalex.org/W2216772862","https://openalex.org/W2336673742","https://openalex.org/W2385009615","https://openalex.org/W2511409090","https://openalex.org/W2529791032","https://openalex.org/W2554580516","https://openalex.org/W2560140376","https://openalex.org/W2590406062","https://openalex.org/W2591709377","https://openalex.org/W2591881278","https://openalex.org/W2613210669","https://openalex.org/W2779241561","https://openalex.org/W2781552270","https://openalex.org/W2783753259","https://openalex.org/W2787145330","https://openalex.org/W2791182448","https://openalex.org/W2806642795","https://openalex.org/W2807805118","https://openalex.org/W2903270680","https://openalex.org/W2904038758","https://openalex.org/W2908746540","https://openalex.org/W2920855865","https://openalex.org/W2978348183","https://openalex.org/W2990275329","https://openalex.org/W2993435749","https://openalex.org/W2996312365","https://openalex.org/W3011896065","https://openalex.org/W3040724477","https://openalex.org/W3048352978","https://openalex.org/W3063038225","https://openalex.org/W3083130770","https://openalex.org/W3093090760","https://openalex.org/W3114168415","https://openalex.org/W3133547570","https://openalex.org/W3134387429","https://openalex.org/W3169193862","https://openalex.org/W3196943407","https://openalex.org/W3209864524","https://openalex.org/W4205311773","https://openalex.org/W4206124498","https://openalex.org/W4213043726","https://openalex.org/W4224096030","https://openalex.org/W4229013347","https://openalex.org/W4229076819","https://openalex.org/W4281689171","https://openalex.org/W4283074795","https://openalex.org/W4285029703","https://openalex.org/W4310108129","https://openalex.org/W4310119332","https://openalex.org/W4310163206","https://openalex.org/W4310443772","https://openalex.org/W4311201797","https://openalex.org/W4315621308","https://openalex.org/W4321764647","https://openalex.org/W4321996904","https://openalex.org/W4376272046","https://openalex.org/W4380563796","https://openalex.org/W4382138720","https://openalex.org/W4382631133","https://openalex.org/W4383872780","https://openalex.org/W4386272446","https://openalex.org/W4386985990","https://openalex.org/W4387966287","https://openalex.org/W4389233356","https://openalex.org/W4389243287","https://openalex.org/W4389246574","https://openalex.org/W4389248031","https://openalex.org/W4390275130","https://openalex.org/W4390431304","https://openalex.org/W4390619255","https://openalex.org/W4390732990","https://openalex.org/W4391607922","https://openalex.org/W4395068292","https://openalex.org/W4400805568","https://openalex.org/W4400940914","https://openalex.org/W4401441260","https://openalex.org/W4402144664","https://openalex.org/W4402194344","https://openalex.org/W4403039618","https://openalex.org/W4403508383","https://openalex.org/W4404402772","https://openalex.org/W4404784473","https://openalex.org/W4405042692","https://openalex.org/W4405042767","https://openalex.org/W4405044303","https://openalex.org/W4405044813","https://openalex.org/W4405126172","https://openalex.org/W4405130232"],"related_works":["https://openalex.org/W4388947552","https://openalex.org/W4323294250","https://openalex.org/W2745220417","https://openalex.org/W2914373601","https://openalex.org/W7136082913","https://openalex.org/W2727781251","https://openalex.org/W7128787998","https://openalex.org/W4395449992","https://openalex.org/W3132086411","https://openalex.org/W3083176511"],"abstract_inverted_index":{"BACKGROUND:":[0],"Approximately":[1],"half":[2],"of":[3,7,21,31,38,56,68,103,116,133,137,144,188,197],"newly":[4],"diagnosed":[5],"cases":[6],"acute":[8],"lymphoblastic":[9],"leukemia":[10],"(ALL)":[11],"occur":[12],"in":[13,60,139],"adults,":[14],"but":[15,180],"adults":[16,141,165],"experience":[17],"significantly":[18],"higher":[19],"rates":[20],"treatment":[22,55,89,189,198],"failure":[23],"and":[24,35,83,112,154,195],"treatment-related":[25],"mortality":[26],"due":[27],"to":[28,184],"frequent":[29],"presence":[30],"adverse":[32],"disease":[33],"biology":[34],"limited":[36],"tolerability":[37],"conventional":[39],"chemotherapy.":[40,97],"SUMMARY:":[41],"Here,":[42],"we":[43,129,160],"discuss":[44,100,130],"recent":[45],"data":[46],"from":[47],"clinical":[48],"trials":[49,64],"investigating":[50],"new":[51],"approaches":[52,125],"for":[53,109,126,163],"initial":[54],"Philadelphia":[57],"chromosome-negative":[58],"ALL":[59,138,145,149,168],"older":[61,140,164],"adults.":[62],"These":[63],"investigate":[65],"the":[66,72,77,84,101,114,134,186,193],"incorporation":[67],"novel":[69],"agents":[70],"including":[71,142],"anti-CD22":[73],"antibody-drug":[74],"conjugate":[75],"inotuzumab,":[76],"CD19-CD3":[78],"bi-specific":[79],"T-cell":[80,122],"engager":[81],"blinatumomab,":[82],"BCL2":[85],"inhibitor":[86],"venetoclax":[87],"into":[88],"regimens,":[90],"with":[91,146,150,166,169],"some":[92],"studies":[93],"attenuating":[94],"or":[95],"omitting":[96],"We":[98],"also":[99],"role":[102],"allogeneic":[104],"stem":[105],"cell":[106],"transplantation":[107],"consolidation":[108,124],"this":[110],"population":[111],"highlight":[113,161],"possibility":[115],"frontline":[117],"CD19-directed":[118],"chimeric":[119],"antigen":[120],"receptor":[121],"therapy":[123],"B-ALL.":[127],"Finally,":[128],"improved":[131],"understanding":[132],"genetic":[135],"diversity":[136],"occurrence":[143],"TP53":[147],"mutation,":[148],"myeloid":[151],"gene":[152],"mutations,":[153],"therapy-related":[155],"ALL.":[156],"KEY":[157],"MESSAGE:":[158],"Overall,":[159],"progress":[162],"Ph-negative":[167],"patients":[170],"more":[171],"frequently":[172],"achieving":[173],"a":[174],"measurable":[175],"residual":[176],"disease-negative":[177],"complete":[178],"remission,":[179],"significant":[181],"work":[182],"remains":[183],"improve":[185],"safety":[187],"as":[190,192],"well":[191],"depth":[194],"durability":[196],"response.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
