{"id":"https://openalex.org/W4411203255","doi":"https://doi.org/10.3389/fphar.2025.1596655","title":"Mechanistic insights into the PAI-1 inhibitor PAItrap3: enhancing lipid metabolism in adipose tissue of diabetic db/db mice","display_name":"Mechanistic insights into the PAI-1 inhibitor PAItrap3: enhancing lipid metabolism in adipose tissue of diabetic db/db mice","publication_year":2025,"publication_date":"2025-06-12","ids":{"openalex":"https://openalex.org/W4411203255","doi":"https://doi.org/10.3389/fphar.2025.1596655","pmid":"https://pubmed.ncbi.nlm.nih.gov/40575785","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12197923"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2025.1596655","doi":"https://doi.org/10.3389/fphar.2025.1596655","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2025.1596655","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1596655/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1596655/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115595023","display_name":"Linxi Wang","orcid":"https://orcid.org/0009-0001-0197-3205","observed_orcids":["https://orcid.org/0009-0001-0197-3205"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linxi Wang","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210163933"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhouyangyang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhouyangyang Zhang","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210163933"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Menghua Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Menghua Lin","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210163933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061778776","display_name":"Liqin Qi","orcid":"https://orcid.org/0000-0001-8799-9643","observed_orcids":["https://orcid.org/0000-0001-8799-9643"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liqin Qi","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210163933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100644187","display_name":"Libin Liu","orcid":"https://orcid.org/0000-0002-0352-3865","observed_orcids":["https://orcid.org/0000-0002-0352-3865","https://orcid.org/0000-0002-4558-5167"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210119098","display_name":"Fujian Institute of Research on the Structure of Matter","ror":"https://ror.org/02j89k719","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098"]},{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391767757","display_name":"State Key Laboratory of Structural Chemistry","ror":"https://ror.org/023fpv336","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Libin Liu","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China","State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian College, University of Chinese Academy of Sciences, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210163933"]},{"raw_affiliation_string":"State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian College, University of Chinese Academy of Sciences, Fuzhou, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4210165038","https://openalex.org/I4391767757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100345082","display_name":"Zhuo Chen","orcid":"https://orcid.org/0000-0002-6351-8689","observed_orcids":["https://orcid.org/0000-0002-6351-8689"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210119098","display_name":"Fujian Institute of Research on the Structure of Matter","ror":"https://ror.org/02j89k719","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391767757","display_name":"State Key Laboratory of Structural Chemistry","ror":"https://ror.org/023fpv336","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]},{"id":"https://openalex.org/I64449678","display_name":"Putian University","ror":"https://ror.org/00jmsxk74","country_code":"CN","type":"education","lineage":["https://openalex.org/I64449678"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuo Chen","raw_affiliation_strings":["State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian College, University of Chinese Academy of Sciences, Fuzhou, China","Fujian Provincial Key Laboratory of Ecology Toxicological Effects and Control for Emerging Contaminants, Key Laboratory of Ecological Environment and Information Atlas, Fujian Provincial University, College of Environmental and Biological Engineering, Putian University, Putian, Fujian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian College, University of Chinese Academy of Sciences, Fuzhou, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4210165038","https://openalex.org/I4391767757"]},{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Ecology Toxicological Effects and Control for Emerging Contaminants, Key Laboratory of Ecological Environment and Information Atlas, Fujian Provincial University, College of Environmental and Biological Engineering, Putian University, Putian, Fujian, China","institution_ids":["https://openalex.org/I64449678"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000362996","display_name":"Shuzhi Tang","orcid":"https://orcid.org/0000-0001-6616-9018","observed_orcids":["https://orcid.org/0000-0001-6616-9018"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]},{"id":"https://openalex.org/I64449678","display_name":"Putian University","ror":"https://ror.org/00jmsxk74","country_code":"CN","type":"education","lineage":["https://openalex.org/I64449678"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuzhi Tang","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Ecology Toxicological Effects and Control for Emerging Contaminants, Key Laboratory of Ecological Environment and Information Atlas, Fujian Provincial University, College of Environmental and Biological Engineering, Putian University, Putian, Fujian, China","Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Ecology Toxicological Effects and Control for Emerging Contaminants, Key Laboratory of Ecological Environment and Information Atlas, Fujian Provincial University, College of Environmental and Biological Engineering, Putian University, Putian, Fujian, China","institution_ids":["https://openalex.org/I64449678"]},{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210163933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5115592130","display_name":"Lijing Wang","orcid":"https://orcid.org/0009-0002-9794-4210","observed_orcids":["https://orcid.org/0009-0002-9794-4210"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lijing Wang","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210163933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5115592130"],"corresponding_institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210163933"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.1817,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.70575035,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"16","issue":null,"first_page":"1596655","last_page":"1596655"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.38040000200271606,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.38040000200271606,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.29170000553131104,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.15719999372959137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8960000276565552},{"id":"https://openalex.org/keywords/db-db-mice","display_name":"db/db mice","score":0.8460000157356262},{"id":"https://openalex.org/keywords/white-adipose-tissue","display_name":"white adipose tissue","score":0.8539999723434448},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9929999709129333},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.8429999947547913},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.6359999775886536},{"id":"https://openalex.org/keywords/diacylglycerol","display_name":"diacylglycerol","score":0.9850000143051147},{"id":"https://openalex.org/keywords/lipidomics","display_name":"lipidomics","score":0.49399998784065247},{"id":"https://openalex.org/keywords/pgc-1alpha","display_name":"PGC-1\u03b1","score":0.7350000143051147},{"id":"https://openalex.org/keywords/ppargc1b","display_name":"PPARGC1B","score":0.906000018119812},{"id":"https://openalex.org/keywords/lc3b","display_name":"LC3B","score":0.6639999747276306},{"id":"https://openalex.org/keywords/parkin","display_name":"Parkin","score":0.7310000061988831},{"id":"https://openalex.org/keywords/fatty-acid-synthase","display_name":"fatty acid synthase","score":0.6800000071525574},{"id":"https://openalex.org/keywords/hsl","display_name":"HSL","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cpt1a","display_name":"CPT1A","score":0.7829999923706055},{"id":"https://openalex.org/keywords/acadm","display_name":"ACADM","score":0.9459999799728394}],"concepts":[{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.7179660201072693},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.6347761154174805},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4994950294494629},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4933413565158844},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4378981590270996},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4326939582824707},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.367759108543396},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3566855788230896}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2025.1596655","doi":"https://doi.org/10.3389/fphar.2025.1596655","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2025.1596655","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1596655/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmid:40575785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40575785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12197923","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12197923/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ec30ba5ae67942df9f6e28d9e94e59a7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ec30ba5ae67942df9f6e28d9e94e59a7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 16 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2025.1596655","doi":"https://doi.org/10.3389/fphar.2025.1596655","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2025.1596655","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1596655/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3644686360","display_name":null,"funder_award_id":"2019 \u5e749062","funder_id":"https://openalex.org/F4320321878","funder_display_name":"Natural Science Foundation of Fujian Province"},{"id":"https://openalex.org/G5646318330","display_name":"\u57fa\u4e8e\u9aa8\u9abc\u808c\u53ca\u8102\u80aa\u80fd\u91cf\u4ee3\u8c22\u901a\u8def\u4e32\u8bdd\u673a\u5236\u7814\u7a76\u78f7\u8102\u9170\u80c6\u78b1\u5728\u53f8\u7f8e\u683c\u9c81\u80bd\u51cf\u91cd\u4e2d\u7684\u4f5c\u7528","funder_award_id":"2024J01646","funder_id":"https://openalex.org/F4320321878","funder_display_name":"Natural Science Foundation of Fujian Province"},{"id":"https://openalex.org/G6914685282","display_name":null,"funder_award_id":"2020J011012","funder_id":"https://openalex.org/F4320321878","funder_display_name":"Natural Science Foundation of Fujian Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321878","display_name":"Natural Science Foundation of Fujian Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411203255.pdf","grobid_xml":"https://content.openalex.org/works/W4411203255.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1596389679","https://openalex.org/W1983984758","https://openalex.org/W1996329423","https://openalex.org/W2000050828","https://openalex.org/W2007505836","https://openalex.org/W2066275536","https://openalex.org/W2081415617","https://openalex.org/W2092328207","https://openalex.org/W2095659152","https://openalex.org/W2121591739","https://openalex.org/W2160909177","https://openalex.org/W2166644461","https://openalex.org/W2235086696","https://openalex.org/W2757913872","https://openalex.org/W2981499784","https://openalex.org/W3005211824","https://openalex.org/W3015301814","https://openalex.org/W3038279475","https://openalex.org/W3097383352","https://openalex.org/W3116405220","https://openalex.org/W3118728355","https://openalex.org/W3131283278","https://openalex.org/W3139057924","https://openalex.org/W3200057515","https://openalex.org/W3203708219","https://openalex.org/W4210956151","https://openalex.org/W4223592234","https://openalex.org/W4308648331","https://openalex.org/W4362671304","https://openalex.org/W4377042099","https://openalex.org/W4384447475","https://openalex.org/W4388142152","https://openalex.org/W4388671202","https://openalex.org/W4388945961","https://openalex.org/W4389560512","https://openalex.org/W4390205004","https://openalex.org/W4390498581","https://openalex.org/W4391788381","https://openalex.org/W4393074863","https://openalex.org/W4396854013","https://openalex.org/W4396871303","https://openalex.org/W4400001588","https://openalex.org/W4400412322","https://openalex.org/W4402969147","https://openalex.org/W4403910051","https://openalex.org/W4406609199","https://openalex.org/W4407597329","https://openalex.org/W4408980912"],"related_works":["https://openalex.org/W4408980912","https://openalex.org/W4229015734","https://openalex.org/W4407911749","https://openalex.org/W4309386973","https://openalex.org/W1614353414","https://openalex.org/W4417156533","https://openalex.org/W3035275089","https://openalex.org/W2559482258","https://openalex.org/W3011422859","https://openalex.org/W4281640709"],"abstract_inverted_index":{"Objective:":[0],"This":[1,177],"study":[2,178],"aimed":[3],"to":[4,54,82],"investigate":[5],"the":[6,121,125],"effects":[7],"of":[8],"PAItrap3,":[9],"a":[10],"novel":[11],"PAI-1":[12],"inhibitor,":[13],"on":[14,40],"lipid":[15,56,87,105,183,207],"metabolism,":[16,106,184],"and":[17,37,44,67,77,86,96,108,115,130,138,149,166,187],"autophagy":[18,68,126,188],"pathways":[19],"in":[20,59,120,194],"diabetic":[21,25,195],"mice.":[22,196],"Methods:":[23],"db/db":[24],"mice":[26],"were":[27,80,111,118,134,141,152],"administered":[28],"PAItrap3":[29,91,181],"(5.7":[30],"mg/kg/day,":[31],"IV)":[32],"for":[33,204],"21":[34],"consecutive":[35],"days,":[36],"its":[38,200],"impact":[39],"metabolic,":[41],"gene":[42,84],"expression,":[43],"lipidomic":[45],"profiles":[46],"was":[47,52],"assessed.":[48],"Western":[49],"blot":[50],"analysis":[51,144],"performed":[53],"examine":[55],"metabolism-related":[57],"proteins":[58],"white":[60],"adipose":[61],"tissue":[62],"(FASN,":[63],"HSL,":[64],"CPT1A,":[65],"ACADM)":[66],"markers":[69],"(LC3B,":[70],"P62,":[71],"Parkin,":[72],"PGC1\u03b1,":[73],"PPARGC1B).":[74],"Additionally,":[75],"RNA-seq":[76],"targeted":[78],"lipidomics":[79],"employed":[81],"analyze":[83],"expression":[85,132],"metabolic":[88,192,208],"alterations.":[89],"Results:":[90],"significantly":[92],"reduced":[93],"blood":[94],"glucose":[95],"glycated":[97],"hemoglobin":[98],"levels":[99,110,117,133,140],"while":[100,136],"improving":[101,191],"insulin":[102],"sensitivity.":[103],"In":[104],"FASN":[107],"HSL":[109],"upregulated,":[112],"whereas":[113],"CPT1A":[114],"ACADM":[116],"downregulated":[119],"DMP":[122],"group.":[123],"Regarding":[124],"pathway,":[127],"PPARGC1B,":[128],"LC3B,":[129],"PGC1\u03b1":[131],"increased,":[135],"P62":[137],"Parkin":[139],"decreased.":[142],"Lipidomics":[143],"revealed":[145],"that":[146,180],"triglycerides":[147],"(TG)":[148],"diacylglycerols":[150],"(DG)":[151],"generally":[153],"downregulated,":[154],"with":[155],"TG":[156],"(18:2/18:2/18:2)":[157],"(0.96":[158,163,169],"[0.8491,":[159,164,170],"1]),":[160,165],"LPI":[161],"(18:0)":[162],"MLCL":[167],"(14:3/20:4/22:6)":[168],"1])":[171],"identified":[172],"as":[173],"key":[174],"metabolites.":[175],"Conclusion:":[176],"finds":[179],"modulates":[182],"energy":[185],"homeostasis,":[186],"pathways,":[189],"thereby":[190],"dysfunction":[193],"These":[197],"findings":[198],"highlight":[199],"potential":[201],"therapeutic":[202],"value":[203],"treating":[205],"diabetes-associated":[206],"disorders.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":4}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2025-10-10T00:00:00"}