{"id":"https://openalex.org/W4411201602","doi":"https://doi.org/10.1016/j.addr.2025.115639","title":"Aptamer-based applications in delivering cancer gene therapies and beyond: state of the art and the missing links to clinical translation","display_name":"Aptamer-based applications in delivering cancer gene therapies and beyond: state of the art and the missing links to clinical translation","publication_year":2025,"publication_date":"2025-06-11","ids":{"openalex":"https://openalex.org/W4411201602","doi":"https://doi.org/10.1016/j.addr.2025.115639","pmid":"https://pubmed.ncbi.nlm.nih.gov/40513886","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12958373"},"language":"en","primary_location":{"id":"doi:10.1016/j.addr.2025.115639","doi":"https://doi.org/10.1016/j.addr.2025.115639","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.addr.2025.115639","pdf_url":null,"source":{"id":"https://openalex.org/S114437232","display_name":"Advanced Drug Delivery Reviews","issn_l":"0169-409X","issn":["0169-409X","1872-8294"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Drug Delivery Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.addr.2025.115639","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079999923","display_name":"Gabriele Coppola","orcid":"https://orcid.org/0000-0001-9306-6735","observed_orcids":["https://orcid.org/0000-0001-9306-6735"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gabriele Coppola","raw_affiliation_strings":["Institute of Endotypes in Oncology, Metabolism and Immunology \"G. Salvatore\" (IEOMI) of the Italian National Research Council (CNR), Naples, Italy. Electronic address: gabrielecoppola@cnr.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Endotypes in Oncology, Metabolism and Immunology \"G. Salvatore\" (IEOMI) of the Italian National Research Council (CNR), Naples, Italy. Electronic address: gabrielecoppola@cnr.it","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107581952","display_name":"Fabiola Cennamo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabiola Cennamo","raw_affiliation_strings":["Institute of Endotypes in Oncology, Metabolism and Immunology \"G. Salvatore\" (IEOMI) of the Italian National Research Council (CNR), Naples, Italy. Electronic address: fabiolacennamo@cnr.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Endotypes in Oncology, Metabolism and Immunology \"G. Salvatore\" (IEOMI) of the Italian National Research Council (CNR), Naples, Italy. Electronic address: fabiolacennamo@cnr.it","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054865206","display_name":"Giuseppe Ciccone","orcid":"https://orcid.org/0000-0001-8621-8710","observed_orcids":["https://orcid.org/0000-0001-8621-8710"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Ciccone","raw_affiliation_strings":["Institute of Endotypes in Oncology, Metabolism and Immunology \"G. Salvatore\" (IEOMI) of the Italian National Research Council (CNR), Naples, Italy; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania \"Luigi Vanvitelli\", 81100 Caserta, Italy. Electronic address: giuseppeciccone@cnr.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Endotypes in Oncology, Metabolism and Immunology \"G. Salvatore\" (IEOMI) of the Italian National Research Council (CNR), Naples, Italy; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania \"Luigi Vanvitelli\", 81100 Caserta, Italy. Electronic address: giuseppeciccone@cnr.it","institution_ids":["https://openalex.org/I197809005","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008458909","display_name":"Maria Luigia Ibba","orcid":"https://orcid.org/0000-0003-4684-6178","observed_orcids":["https://orcid.org/0000-0003-4684-6178"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Luigia Ibba","raw_affiliation_strings":["Institute of Endotypes in Oncology, Metabolism and Immunology \"G. Salvatore\" (IEOMI) of the Italian National Research Council (CNR), Naples, Italy; Department of Precision Medicine, University of Campania \"Luigi Vanvitelli\", 80138 Caserta, Italy. Electronic address: marialuigiaibba@cnr.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Endotypes in Oncology, Metabolism and Immunology \"G. Salvatore\" (IEOMI) of the Italian National Research Council (CNR), Naples, Italy; Department of Precision Medicine, University of Campania \"Luigi Vanvitelli\", 80138 Caserta, Italy. Electronic address: marialuigiaibba@cnr.it","institution_ids":["https://openalex.org/I197809005","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051795758","display_name":"Annalisa Di Ruscio","orcid":"https://orcid.org/0000-0002-9705-4245","observed_orcids":["https://orcid.org/0000-0002-9705-4245"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Annalisa Di Ruscio","raw_affiliation_strings":["Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA; Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, Boston, MA 02215, USA. Electronic address: adirusci@bidmc.harvard.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA; Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, Boston, MA 02215, USA. Electronic address: adirusci@bidmc.harvard.edu","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013221860","display_name":"Aldo Di Vito","orcid":"https://orcid.org/0000-0003-3157-1028","observed_orcids":["https://orcid.org/0000-0003-3157-1028"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Aldo Di Vito","raw_affiliation_strings":["Institute of Endotypes in Oncology, Metabolism and Immunology \"G. Salvatore\" (IEOMI) of the Italian National Research Council (CNR), Naples, Italy. Electronic address: aldodivito@cnr.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Endotypes in Oncology, Metabolism and Immunology \"G. Salvatore\" (IEOMI) of the Italian National Research Council (CNR), Naples, Italy. Electronic address: aldodivito@cnr.it","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019658090","display_name":"Carla Lucia Esposito","orcid":"https://orcid.org/0000-0003-0624-6821","observed_orcids":["https://orcid.org/0000-0003-0624-6821"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Carla Lucia Esposito","raw_affiliation_strings":["Institute of Endotypes in Oncology, Metabolism and Immunology \"G. Salvatore\" (IEOMI) of the Italian National Research Council (CNR), Naples, Italy. Electronic address: carlalucia.esposito@cnr.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Endotypes in Oncology, Metabolism and Immunology \"G. Salvatore\" (IEOMI) of the Italian National Research Council (CNR), Naples, Italy. Electronic address: carlalucia.esposito@cnr.it","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064974581","display_name":"Silvia Catuogno","orcid":"https://orcid.org/0000-0002-1653-4205","observed_orcids":["https://orcid.org/0000-0002-1653-4205"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Silvia Catuogno","raw_affiliation_strings":["Institute of Endotypes in Oncology, Metabolism and Immunology \"G. Salvatore\" (IEOMI) of the Italian National Research Council (CNR), Naples, Italy. Electronic address: silvia.catuogno@cnr.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Endotypes in Oncology, Metabolism and Immunology \"G. Salvatore\" (IEOMI) of the Italian National Research Council (CNR), Naples, Italy. Electronic address: silvia.catuogno@cnr.it","institution_ids":["https://openalex.org/I4210155236"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5013221860","https://openalex.org/A5019658090","https://openalex.org/A5051795758","https://openalex.org/A5064974581"],"corresponding_institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210155236"],"apc_list":{"value":5550,"currency":"USD","value_usd":5550},"apc_paid":{"value":5550,"currency":"USD","value_usd":5550},"fwci":1.2742,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.77543705,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"224","issue":null,"first_page":"115639","last_page":"115639"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aptamers","display_name":"aptamers","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cancer-gene-therapy","display_name":"cancer gene therapy","score":0.9539999961853027},{"id":"https://openalex.org/keywords/gene-delivery","display_name":"gene delivery","score":0.7070000171661377},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.9120000004768372},{"id":"https://openalex.org/keywords/receptor-mediated-endocytosis","display_name":"receptor-mediated endocytosis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/nucleic-acid-aptamers","display_name":"nucleic acid aptamers","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.7614792585372925},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.6213923692703247},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4947161376476288},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.43807539343833923},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43740078806877136},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36994504928588867},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3638119697570801},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33526137471199036},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3184956908226013},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22078576683998108},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.10278457403182983}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.addr.2025.115639","doi":"https://doi.org/10.1016/j.addr.2025.115639","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.addr.2025.115639","pdf_url":null,"source":{"id":"https://openalex.org/S114437232","display_name":"Advanced Drug Delivery Reviews","issn_l":"0169-409X","issn":["0169-409X","1872-8294"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Drug Delivery Reviews","raw_type":"journal-article"},{"id":"pmid:40513886","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40513886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced drug delivery reviews","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12958373","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12958373/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12958373/pdf/nihms-2112342.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Adv Drug Deliv Rev","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.addr.2025.115639","doi":"https://doi.org/10.1016/j.addr.2025.115639","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.addr.2025.115639","pdf_url":null,"source":{"id":"https://openalex.org/S114437232","display_name":"Advanced Drug Delivery Reviews","issn_l":"0169-409X","issn":["0169-409X","1872-8294"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Drug Delivery Reviews","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1670549422","display_name":null,"funder_award_id":"28703","funder_id":"https://openalex.org/F4320324143","funder_display_name":"Fondazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G1853843537","display_name":null,"funder_award_id":"29052","funder_id":"https://openalex.org/F4320324143","funder_display_name":"Fondazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G3119830140","display_name":null,"funder_award_id":"28703","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G3765879905","display_name":null,"funder_award_id":"29052","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G5213634415","display_name":null,"funder_award_id":"22-0129","funder_id":"https://openalex.org/F4320312952","funder_display_name":"Worldwide Cancer Research"},{"id":"https://openalex.org/G654610066","display_name":null,"funder_award_id":"22\\u20130129C","funder_id":"https://openalex.org/F4320312952","funder_display_name":"Worldwide Cancer Research"},{"id":"https://openalex.org/G8869046766","display_name":null,"funder_award_id":"US23GR01","funder_id":"https://openalex.org/F4320323988","funder_display_name":"Ministero degli Affari Esteri e della Cooperazione Internazionale"},{"id":"https://openalex.org/G9000862650","display_name":"Understanding the role of cell-cycle specific RNAs in hematopoiesis","funder_award_id":"R01DK136116","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320312952","display_name":"Worldwide Cancer Research","ror":"https://ror.org/031tfbz57"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320323988","display_name":"Ministero degli Affari Esteri e della Cooperazione Internazionale","ror":"https://ror.org/02jkm3388"},{"id":"https://openalex.org/F4320324143","display_name":"Fondazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411201602.pdf","grobid_xml":"https://content.openalex.org/works/W4411201602.grobid-xml"},"referenced_works_count":139,"referenced_works":["https://openalex.org/W35884510","https://openalex.org/W43078083","https://openalex.org/W144423133","https://openalex.org/W347868629","https://openalex.org/W349290630","https://openalex.org/W1802218256","https://openalex.org/W1912498439","https://openalex.org/W1967827860","https://openalex.org/W1978611062","https://openalex.org/W1996962471","https://openalex.org/W2014909608","https://openalex.org/W2024682947","https://openalex.org/W2027213473","https://openalex.org/W2028777474","https://openalex.org/W2034451546","https://openalex.org/W2043915025","https://openalex.org/W2049397825","https://openalex.org/W2079321730","https://openalex.org/W2104525153","https://openalex.org/W2107230180","https://openalex.org/W2112084862","https://openalex.org/W2121674220","https://openalex.org/W2123175900","https://openalex.org/W2123973342","https://openalex.org/W2131246621","https://openalex.org/W2137649483","https://openalex.org/W2149147994","https://openalex.org/W2153438740","https://openalex.org/W2154283725","https://openalex.org/W2200390204","https://openalex.org/W2224498017","https://openalex.org/W2298953464","https://openalex.org/W2331897708","https://openalex.org/W2440692448","https://openalex.org/W2482628119","https://openalex.org/W2496766335","https://openalex.org/W2547782348","https://openalex.org/W2594133976","https://openalex.org/W2700040996","https://openalex.org/W2736520162","https://openalex.org/W2745738602","https://openalex.org/W2755544368","https://openalex.org/W2763302201","https://openalex.org/W2774522437","https://openalex.org/W2778827436","https://openalex.org/W2779911540","https://openalex.org/W2780439268","https://openalex.org/W2790409421","https://openalex.org/W2805807586","https://openalex.org/W2822438340","https://openalex.org/W2885214828","https://openalex.org/W2890535040","https://openalex.org/W2893133018","https://openalex.org/W2896471204","https://openalex.org/W2897058813","https://openalex.org/W2899354885","https://openalex.org/W2899618801","https://openalex.org/W2914821941","https://openalex.org/W2943867913","https://openalex.org/W2949188926","https://openalex.org/W2953209503","https://openalex.org/W2987527092","https://openalex.org/W2988773550","https://openalex.org/W2989616205","https://openalex.org/W2995953990","https://openalex.org/W2999259543","https://openalex.org/W3005119354","https://openalex.org/W3006494324","https://openalex.org/W3006627873","https://openalex.org/W3030089399","https://openalex.org/W3030913630","https://openalex.org/W3036363721","https://openalex.org/W3042581126","https://openalex.org/W3048788919","https://openalex.org/W3092811898","https://openalex.org/W3108624375","https://openalex.org/W3121560287","https://openalex.org/W3137153690","https://openalex.org/W3141575335","https://openalex.org/W3146144327","https://openalex.org/W3154617669","https://openalex.org/W3159457306","https://openalex.org/W3161260932","https://openalex.org/W3165143074","https://openalex.org/W3169818427","https://openalex.org/W3175906732","https://openalex.org/W3183432908","https://openalex.org/W3188304030","https://openalex.org/W3193427089","https://openalex.org/W3199084338","https://openalex.org/W3199552769","https://openalex.org/W3203760153","https://openalex.org/W3205198305","https://openalex.org/W3208662507","https://openalex.org/W4200304551","https://openalex.org/W4206205964","https://openalex.org/W4213092816","https://openalex.org/W4223968391","https://openalex.org/W4224275564","https://openalex.org/W4224306726","https://openalex.org/W4281769542","https://openalex.org/W4281773579","https://openalex.org/W4283778388","https://openalex.org/W4284671925","https://openalex.org/W4292702578","https://openalex.org/W4313362737","https://openalex.org/W4313645567","https://openalex.org/W4316466738","https://openalex.org/W4317597443","https://openalex.org/W4317600205","https://openalex.org/W4321378137","https://openalex.org/W4323854270","https://openalex.org/W4353090737","https://openalex.org/W4365148379","https://openalex.org/W4380201117","https://openalex.org/W4382400397","https://openalex.org/W4385262334","https://openalex.org/W4386476362","https://openalex.org/W4386865890","https://openalex.org/W4386942017","https://openalex.org/W4387077861","https://openalex.org/W4388086791","https://openalex.org/W4388296904","https://openalex.org/W4388892208","https://openalex.org/W4389514344","https://openalex.org/W4391221377","https://openalex.org/W4391958045","https://openalex.org/W4392283731","https://openalex.org/W4392367035","https://openalex.org/W4393316487","https://openalex.org/W4393581315","https://openalex.org/W4396546318","https://openalex.org/W4399865165","https://openalex.org/W4402047265","https://openalex.org/W4402381948","https://openalex.org/W4403600161","https://openalex.org/W6670021645","https://openalex.org/W6755192642","https://openalex.org/W6857433112"],"related_works":["https://openalex.org/W4402876386","https://openalex.org/W2153438740","https://openalex.org/W7167616607","https://openalex.org/W2760004176","https://openalex.org/W7134192977","https://openalex.org/W7149267615","https://openalex.org/W7212190124","https://openalex.org/W2046391187","https://openalex.org/W4292058855","https://openalex.org/W3179055535"],"abstract_inverted_index":{"The":[0,126],"possibility":[1],"of":[2,101,132,162,186],"correcting":[3],"genetic":[4],"and":[5,32,76,142],"epigenetic":[6,172],"alterations":[7],"through":[8],"gene":[9,72,95,103,139,188],"therapies":[10,73,104],"has":[11],"been":[12,22,65,106],"considered":[13],"a":[14],"cornerstone":[15],"in":[16,24,78,93,166],"oncology.":[17],"However,":[18],"modest":[19],"results":[20,83],"have":[21,64,105,151],"achieved":[23],"clinics,":[25],"mainly":[26],"due":[27],"to":[28,59,70,129,138,143,183],"inefficient":[29],"tumor":[30,79],"targeting":[31,68],"side":[33],"effects.":[34],"Nucleic":[35],"acid":[36],"aptamers":[37,63,86,163],"are":[38,174],"three-dimensional":[39],"folded":[40],"single-stranded":[41],"DNAs":[42],"or":[43,169],"RNAs":[44],"that":[45,85,149],"selectively":[46,77],"bind":[47],"receptors":[48],"on":[49],"cellular":[50],"membranes,":[51],"being":[52],"subsequently":[53],"internalized":[54],"via":[55],"receptor-mediated":[56],"endocytosis.":[57],"Thanks":[58],"this":[60],"capability,":[61],"internalizing":[62],"investigated":[66],"as":[67,164,170],"moieties":[69],"deliver":[71],"more":[74,178],"efficiently":[75],"cells.":[80],"Promising":[81],"preclinical":[82,114],"suggested":[84],"could":[87,119,150],"represent":[88],"the":[89,112,117,133,146,160,184],"long-awaited":[90],"step":[91],"forward":[92],"cancer":[94,187],"therapy.":[96],"Nevertheless,":[97],"no":[98],"clinical":[99,153],"trials":[100],"aptamer-based":[102],"carried":[107],"out":[108],"two":[109],"decades":[110],"after":[111],"first":[113],"application,":[115],"indicating":[116],"field":[118],"not":[120,181],"be":[121],"sufficiently":[122],"mature":[123],"for":[124],"translatability.":[125],"review":[127],"aims":[128],"update":[130],"thestate":[131],"art":[134],"regarding":[135,159],"aptamers'":[136],"contribution":[137],"therapy":[140],"delivery":[141,185],"critically":[144],"highlight":[145],"main":[147],"shortcomings":[148],"hindered":[152],"evaluations.":[154],"In":[155],"addition,":[156],"pioneering":[157],"insights":[158],"use":[161],"co-factors":[165],"CRISPR/Cas9":[167],"technology":[168],"direct":[171],"regulators":[173],"also":[175],"summarized,":[176],"revealing":[177],"extended":[179],"applicability":[180],"limited":[182],"therapies.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-10-10T00:00:00"}
