{"id":"https://openalex.org/W4411192566","doi":"https://doi.org/10.3389/fimmu.2025.1590165","title":"B cell-extrinsic and intrinsic factors linked to early immune repletion after anti-CD20 therapy in patients with multiple sclerosis of African ancestry","display_name":"B cell-extrinsic and intrinsic factors linked to early immune repletion after anti-CD20 therapy in patients with multiple sclerosis of African ancestry","publication_year":2025,"publication_date":"2025-06-10","ids":{"openalex":"https://openalex.org/W4411192566","doi":"https://doi.org/10.3389/fimmu.2025.1590165","pmid":"https://pubmed.ncbi.nlm.nih.gov/40557147","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12185503"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2025.1590165","doi":"https://doi.org/10.3389/fimmu.2025.1590165","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1590165","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1590165/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1590165/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046300454","display_name":"Gregg J. Silverman","orcid":"https://orcid.org/0000-0001-9480-9457","observed_orcids":["https://orcid.org/0000-0001-9480-9457"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregg J. Silverman","raw_affiliation_strings":["NYU Grossman School of Medicine;","Department of Medicine, Division of Rheumatology, NYU Grossman School of Medicine, New York, NY,\u00a0United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Grossman School of Medicine;","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Medicine, Division of Rheumatology, NYU Grossman School of Medicine, New York, NY,\u00a0United States","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Abhimanyu N. Amarnani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhimanyu N. Amarnani","raw_affiliation_strings":["NYU Grossman School of Medicine;","Department of Medicine, Division of Rheumatology, NYU Grossman School of Medicine, New York, NY,\u00a0United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Grossman School of Medicine;","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Medicine, Division of Rheumatology, NYU Grossman School of Medicine, New York, NY,\u00a0United States","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Arnaldo A. Armini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arnaldo A. Armini","raw_affiliation_strings":["NYU Grossman School of Medicine;","Department of Pathology, NYU Grossman School of Medicine, New York, NY,\u00a0United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Grossman School of Medicine;","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Pathology, NYU Grossman School of Medicine, New York, NY,\u00a0United States","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085272629","display_name":"Angie H. Kim","orcid":"https://orcid.org/0009-0004-1343-3101","observed_orcids":["https://orcid.org/0009-0004-1343-3101"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angie Kim","raw_affiliation_strings":["NYU Grossman School of Medicine;","Department of Neurology, NYU Grossman School of Medicine, New York, NY,\u00a0United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Grossman School of Medicine;","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Neurology, NYU Grossman School of Medicine, New York, NY,\u00a0United States","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059170649","display_name":"Hannah Kopinsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Kopinsky","raw_affiliation_strings":["NYU Grossman School of Medicine;","Department of Neurology, NYU Grossman School of Medicine, New York, NY,\u00a0United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Grossman School of Medicine;","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Neurology, NYU Grossman School of Medicine, New York, NY,\u00a0United States","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065792746","display_name":"David Feny\u00f6","orcid":"https://orcid.org/0000-0001-5049-3825","observed_orcids":["https://orcid.org/0000-0001-5049-3825"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Fenyo","raw_affiliation_strings":["NYU Grossman School of Medicine;","Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY,\u00a0United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Grossman School of Medicine;","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY,\u00a0United States","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059662648","display_name":"Ilya Kister","orcid":"https://orcid.org/0000-0003-3549-949X","observed_orcids":["https://orcid.org/0000-0003-3549-949X"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilya Kister","raw_affiliation_strings":["NYU Multiple Sclerosis Comprehensive Care Center","Department of Neurology, NYU Grossman School of Medicine, New York, NY,\u00a0United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Multiple Sclerosis Comprehensive Care Center","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Neurology, NYU Grossman School of Medicine, New York, NY,\u00a0United States","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046300454"],"corresponding_institution_ids":["https://openalex.org/I57206974"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.2011,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.77174763,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"16","issue":null,"first_page":"1590165","last_page":"1590165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/african-ancestry","display_name":"African ancestry","score":0.824999988079071},{"id":"https://openalex.org/keywords/anti-cd20-therapy","display_name":"anti-CD20 therapy","score":0.9570000171661377},{"id":"https://openalex.org/keywords/ocrelizumab","display_name":"ocrelizumab","score":0.9800000190734863},{"id":"https://openalex.org/keywords/anti-drug-antibodies","display_name":"anti-drug antibodies","score":0.9599999785423279},{"id":"https://openalex.org/keywords/serum-drug-levels","display_name":"serum drug concentration","score":0.7129999995231628},{"id":"https://openalex.org/keywords/baff","display_name":"BAFF","score":0.8069999814033508},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.9710000157356262},{"id":"https://openalex.org/keywords/b-cell-survival","display_name":"B cell survival","score":0.9150000214576721},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.9229999780654907},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.8065646886825562},{"id":"https://openalex.org/C18031839","wikidata":"https://www.wikidata.org/wiki/Q5009796","display_name":"CD20","level":3,"score":0.647970974445343},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6210495233535767},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48789072036743164},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45797085762023926},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1114177405834198}],"mesh":[{"descriptor_ui":"D000069283","descriptor_name":"Rituximab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018951","descriptor_name":"Antigens, CD20","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D044383","descriptor_name":"Black People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044383","descriptor_name":"Black People","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.3389/fimmu.2025.1590165","doi":"https://doi.org/10.3389/fimmu.2025.1590165","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1590165","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1590165/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"doi:10.1101/2025.03.05.25321882","doi":"https://doi.org/10.1101/2025.03.05.25321882","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.03.05.25321882","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:10995302","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12185503","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12185503","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12185503","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:40557147","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40557147","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c25b4858557b4130ad52d1c6ff777cbf","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c25b4858557b4130ad52d1c6ff777cbf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 16 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2025.1590165","doi":"https://doi.org/10.3389/fimmu.2025.1590165","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1590165","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1590165/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1150758817","display_name":null,"funder_award_id":"T32-AR-069515","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7491831914","display_name":"Maternal Autoantibodies: Pathogenesis of Neonatal Lupus","funder_award_id":"R01AR042455","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7636941071","display_name":"Translational Basic and Clinical Research Training in Rheumatology","funder_award_id":"5t32ar069515-07","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8047817453","display_name":null,"funder_award_id":"P30CA016087","funder_id":"https://openalex.org/F4320332230","funder_display_name":"School of Medicine, New York University"},{"id":"https://openalex.org/G9000312709","display_name":null,"funder_award_id":"AR42455","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000900907","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016087","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000919603","display_name":"Thromboinflammatory pathways triggered by gut dysbiosis in patients with Lupus","funder_award_id":"R21AI180737","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332230","display_name":"School of Medicine, New York University","ror":"https://ror.org/0190ak572"},{"id":"https://openalex.org/F4320333910","display_name":"NYU Grossman School of Medicine","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411192566.pdf","grobid_xml":"https://content.openalex.org/works/W4411192566.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W72113996","https://openalex.org/W1522374426","https://openalex.org/W1566766802","https://openalex.org/W1937030621","https://openalex.org/W1981016924","https://openalex.org/W1982661290","https://openalex.org/W2018822911","https://openalex.org/W2032111423","https://openalex.org/W2049306810","https://openalex.org/W2071892318","https://openalex.org/W2087788999","https://openalex.org/W2132499964","https://openalex.org/W2139167713","https://openalex.org/W2169804206","https://openalex.org/W2339811657","https://openalex.org/W2429252590","https://openalex.org/W2509106468","https://openalex.org/W2561881161","https://openalex.org/W2609734256","https://openalex.org/W2777074421","https://openalex.org/W2788933778","https://openalex.org/W2807882529","https://openalex.org/W2977443722","https://openalex.org/W3093238501","https://openalex.org/W3131726685","https://openalex.org/W3142530067","https://openalex.org/W3171160704","https://openalex.org/W3191878299","https://openalex.org/W3215794583","https://openalex.org/W4225308128","https://openalex.org/W4253381763","https://openalex.org/W4320892170","https://openalex.org/W4372332501","https://openalex.org/W4376617977","https://openalex.org/W4377565097","https://openalex.org/W4386095572","https://openalex.org/W4386757782","https://openalex.org/W4386999100","https://openalex.org/W4387059719","https://openalex.org/W4387261809","https://openalex.org/W4388528870","https://openalex.org/W4402097025","https://openalex.org/W4404214372","https://openalex.org/W4405967886","https://openalex.org/W4406098105","https://openalex.org/W4406115124","https://openalex.org/W4409129469"],"related_works":["https://openalex.org/W4409227442","https://openalex.org/W4225308128","https://openalex.org/W4389446185","https://openalex.org/W4212920523","https://openalex.org/W1860960053","https://openalex.org/W4366823416","https://openalex.org/W2800878729","https://openalex.org/W3205837751","https://openalex.org/W3090416272","https://openalex.org/W7117479768"],"abstract_inverted_index":{"Introduction:":[0],"Recent":[1],"investigations":[2],"have":[3],"identified":[4,133],"patients":[5,70,138,163,209],"of":[6,54,80,93,118,136,154,161,177,222,233,256],"African":[7],"ancestry":[8],"(AA)":[9],"with":[10,24,63,72,123,139,148,164,210,230],"Multiple":[11],"Sclerosis":[12],"(MS),":[13],"who":[14],"display":[15],"more":[16],"rapid":[17],"B-cell":[18,55],"repopulation":[19,79],"after":[20,144,212],"standard":[21],"semi-annual":[22],"infusions":[23],"an":[25,73,152,218],"anti-CD20":[26,64,74,145,213],"monoclonal":[27],"antibody":[28,75,214],"for":[29,87,116,184],"B":[30,83,124,141,167,186,203,224,257],"cell":[31,125,142,168,187,204,225,258],"depletion.":[32],"In":[33,67,112,207],"this":[34],"study,":[35],"we":[36,85,114,216],"explored":[37],"the":[38,91,107,165,185,231],"immunologic":[39],"and":[40,127,151,194,202,261,264],"genetic":[41,178,238],"factors,":[42,89],"with,":[43],"serum":[44,109],"drug":[45,110],"monitoring":[46],"that":[47,57,76,180],"may":[48,99,250,267],"contribute":[49,100],"to":[50,101,182,191,195,245,252,270],"a":[51,134,158],"faster":[52],"rate":[53],"repletion":[56,143,169],"follows":[58],"during":[59],"recovery":[60],"from":[61],"treatment":[62,146,215],"antibody.":[65],"Methods:":[66],"AA":[68,137,162,208],"MS":[69],"treated":[71],"had":[77,174],"early":[78,102,140,166,223],"peripheral":[81],"blood":[82],"cells,":[84],"assessed":[86],"extrinsic":[88],"including":[90],"presence":[92,232],"anti-drug":[94,149,172,234],"antibodies":[95,150,173,235],"against":[96],"ocrelizumab,":[97],"which":[98],"repletion.":[103],"We":[104],"also":[105],"documented":[106],"associated":[108,122,147,229],"levels.":[111],"addition,":[113],"examined":[115],"inheritance":[117],"intrinsic":[119],"gene":[120],"polymorphisms":[121,179],"survival":[126,188],"immune":[128],"function.":[129],"Results:":[130],"Our":[131],"findings":[132,266],"subset":[135],"absence":[153],"detectable":[155],"drug.":[156],"Furthermore,":[157],"separate":[159],"set":[160],"phenotype":[170],"without":[171],"significant":[175],"over-representation":[176],"map":[181],"genes":[183],"factor,":[189],"BAFF,":[190],"antibody-dependent":[192],"cytotoxicity,":[193],"pathways":[196],"involved":[197],"in":[198],"inflammation,":[199],"leukocyte":[200],"activation":[201],"differentiation.":[205],"Discussion:":[206],"MS,":[211],"found":[217],"unexpected":[219],"high":[220],"occurrence":[221],"replenishment.":[226],"This":[227],"was":[228],"and/or":[236],"specific":[237],"polymorphisms.":[239],"Larger":[240],"studies":[241],"are":[242],"now":[243],"needed":[244],"determine":[246],"whether":[247],"these":[248,265],"factors":[249],"lead":[251],"impaired":[253],"therapeutic":[254,275],"benefits":[255],"targeted":[259],"therapy":[260],"clinical":[262],"progression,":[263],"be":[268],"useful":[269],"guide":[271],"future":[272],"optimized":[273],"personalized":[274],"strategies.":[276]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
