{"id":"https://openalex.org/W4411079631","doi":"https://doi.org/10.1016/j.cclet.2025.111422","title":"Oral administration of Bacillus spores for mitigation of radiation-induced intestinal injury by regulating gut microbiota","display_name":"Oral administration of Bacillus spores for mitigation of radiation-induced intestinal injury by regulating gut microbiota","publication_year":2025,"publication_date":"2025-06-06","ids":{"openalex":"https://openalex.org/W4411079631","doi":"https://doi.org/10.1016/j.cclet.2025.111422"},"language":"en","primary_location":{"id":"doi:10.1016/j.cclet.2025.111422","doi":"https://doi.org/10.1016/j.cclet.2025.111422","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cclet.2025.111422","pdf_url":null,"source":{"id":"https://openalex.org/S167919573","display_name":"Chinese Chemical Letters","issn_l":"1001-8417","issn":["1001-8417","1878-5964"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Chemical Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113985742","display_name":"Cuixia Zheng","orcid":"https://orcid.org/0009-0003-7247-9567","observed_orcids":["https://orcid.org/0009-0003-7247-9567"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I4210087761","display_name":"Henan University Huaihe Hospital and Huaihe Clinical Institute","ror":"https://ror.org/002mm7c07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cuixia Zheng","raw_affiliation_strings":["Department of Pharmacy, Huaihe hospital of Henan University, Kaifeng, 475000, China","Translational medicine Center, Huaihe hospital of Henan University, Kaifeng, 475000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Huaihe hospital of Henan University, Kaifeng, 475000, China","institution_ids":["https://openalex.org/I173899330","https://openalex.org/I4210087761"]},{"raw_affiliation_string":"Translational medicine Center, Huaihe hospital of Henan University, Kaifeng, 475000, China","institution_ids":["https://openalex.org/I173899330","https://openalex.org/I4210087761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015886228","display_name":"Yueyue Kong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yueyue Kong","raw_affiliation_strings":["Department of Pharmacy, Xinjiang Aksu First People's Hospital, Aksu, 843000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Xinjiang Aksu First People's Hospital, Aksu, 843000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100379558","display_name":"Xinxin Liu","orcid":"https://orcid.org/0000-0003-3924-7783","observed_orcids":["https://orcid.org/0000-0003-3924-7783"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210087761","display_name":"Henan University Huaihe Hospital and Huaihe Clinical Institute","ror":"https://ror.org/002mm7c07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xinxin Liu","raw_affiliation_strings":["School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China","Translational medicine Center, Huaihe hospital of Henan University, Kaifeng, 475000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"Translational medicine Center, Huaihe hospital of Henan University, Kaifeng, 475000, China","institution_ids":["https://openalex.org/I173899330","https://openalex.org/I4210087761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048965011","display_name":"Mengya Niu","orcid":"https://orcid.org/0000-0003-4888-8910","observed_orcids":["https://orcid.org/0000-0003-4888-8910"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengya Niu","raw_affiliation_strings":["School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070034960","display_name":"Shuang Li","orcid":"https://orcid.org/0000-0003-4073-6461","observed_orcids":["https://orcid.org/0000-0003-4073-6461"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I4210087761","display_name":"Henan University Huaihe Hospital and Huaihe Clinical Institute","ror":"https://ror.org/002mm7c07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Li","raw_affiliation_strings":["Translational medicine Center, Huaihe hospital of Henan University, Kaifeng, 475000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational medicine Center, Huaihe hospital of Henan University, Kaifeng, 475000, China","institution_ids":["https://openalex.org/I173899330","https://openalex.org/I4210087761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055649969","display_name":"Yang Liu","orcid":"https://orcid.org/0000-0003-4437-1279","observed_orcids":["https://orcid.org/0000-0003-4437-1279"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I4210087761","display_name":"Henan University Huaihe Hospital and Huaihe Clinical Institute","ror":"https://ror.org/002mm7c07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yang Liu","raw_affiliation_strings":["Translational medicine Center, Huaihe hospital of Henan University, Kaifeng, 475000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational medicine Center, Huaihe hospital of Henan University, Kaifeng, 475000, China","institution_ids":["https://openalex.org/I173899330","https://openalex.org/I4210087761"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Wang","raw_affiliation_strings":["School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031146709","display_name":"Hong Chen","orcid":"https://orcid.org/0000-0003-1904-0857","observed_orcids":["https://orcid.org/0000-0003-1904-0857"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I4210087761","display_name":"Henan University Huaihe Hospital and Huaihe Clinical Institute","ror":"https://ror.org/002mm7c07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chen Hong","raw_affiliation_strings":["Translational medicine Center, Huaihe hospital of Henan University, Kaifeng, 475000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational medicine Center, Huaihe hospital of Henan University, Kaifeng, 475000, China","institution_ids":["https://openalex.org/I173899330","https://openalex.org/I4210087761"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5031146709","https://openalex.org/A5055649969","https://openalex.org/A5100379558"],"corresponding_institution_ids":["https://openalex.org/I173899330","https://openalex.org/I38877650","https://openalex.org/I4210087761"],"apc_list":null,"apc_paid":null,"fwci":1.1523,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.74537328,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"37","issue":"6","first_page":"111422","last_page":"111422"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.7538999915122986,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.7538999915122986,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.2401999980211258,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacillus-spores","display_name":"Bacillus spores","score":0.9200000166893005},{"id":"https://openalex.org/keywords/radiation-induced-intestinal-injury","display_name":"radiation enteritis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/radiation-protection","display_name":"radiation protection","score":0.8730000257492065},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9520000219345093},{"id":"https://openalex.org/keywords/bacillus-coagulans","display_name":"Bacillus coagulans","score":0.9430000185966492},{"id":"https://openalex.org/keywords/bacillus-subtilis","display_name":"Bacillus subtilis","score":1.0},{"id":"https://openalex.org/keywords/bacillus-licheniformis","display_name":"Bacillus licheniformis","score":1.0},{"id":"https://openalex.org/keywords/x-ray-resistance","display_name":"X-ray resistance","score":0.6919999718666077},{"id":"https://openalex.org/keywords/intestinal-epithelial-cell-apoptosis","display_name":"intestinal epithelial cell apoptosis","score":0.824999988079071},{"id":"https://openalex.org/keywords/intestinal-barrier-function","display_name":"intestinal barrier function","score":0.9399999976158142},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/lactobacillus","display_name":"Lactobacillus","score":0.9539999961853027},{"id":"https://openalex.org/keywords/abdominal-radiotherapy","display_name":"abdominal radiotherapy","score":0.5910000205039978},{"id":"https://openalex.org/keywords/gastrointestinal-toxicity","display_name":"gastrointestinal toxicity","score":0.45500001311302185},{"id":"https://openalex.org/keywords/body-weight-recovery","display_name":"body weight recovery","score":0.5}],"concepts":[{"id":"https://openalex.org/C174618031","wikidata":"https://www.wikidata.org/wiki/Q177332","display_name":"Spore","level":2,"score":0.7266255021095276},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5504693388938904},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.5193025469779968},{"id":"https://openalex.org/C2779150676","wikidata":"https://www.wikidata.org/wiki/Q2091405","display_name":"Bacillus (shape)","level":2,"score":0.45479682087898254},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41811397671699524},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.41686320304870605},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33172643184661865},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1866278052330017},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15784761309623718}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.cclet.2025.111422","doi":"https://doi.org/10.1016/j.cclet.2025.111422","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cclet.2025.111422","pdf_url":null,"source":{"id":"https://openalex.org/S167919573","display_name":"Chinese Chemical Letters","issn_l":"1001-8417","issn":["1001-8417","1878-5964"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Chemical Letters","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6230041631","display_name":null,"funder_award_id":"82303529","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6375313600","display_name":null,"funder_award_id":"2023M730971","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G7275543828","display_name":null,"funder_award_id":"82272847","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1983595394","https://openalex.org/W1984363929","https://openalex.org/W2198709783","https://openalex.org/W2604355116","https://openalex.org/W2809122762","https://openalex.org/W2858053598","https://openalex.org/W2907669409","https://openalex.org/W3095611411","https://openalex.org/W3095661830","https://openalex.org/W3129053190","https://openalex.org/W3129744915","https://openalex.org/W4200385254","https://openalex.org/W4221004762","https://openalex.org/W4230721573","https://openalex.org/W4307078161","https://openalex.org/W4375851252","https://openalex.org/W4381548307","https://openalex.org/W4386245811","https://openalex.org/W4388982259","https://openalex.org/W4390483127","https://openalex.org/W4392665647","https://openalex.org/W4393444061","https://openalex.org/W4396664002","https://openalex.org/W4399246656","https://openalex.org/W4400769053","https://openalex.org/W4402232314"],"related_works":["https://openalex.org/W4394676490","https://openalex.org/W4409541810","https://openalex.org/W6902280040","https://openalex.org/W2069876198","https://openalex.org/W4387206773","https://openalex.org/W2034223170","https://openalex.org/W4399999355","https://openalex.org/W7204240788","https://openalex.org/W4392710934","https://openalex.org/W2038859574"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-10-10T00:00:00"}