{"id":"https://openalex.org/W4411064241","doi":"https://doi.org/10.1002/fsn3.70382","title":"Estimation and Validation of an Effective Ergothioneine Dose for Improved Sleep Quality Using Physiologically Based Pharmacokinetic Model","display_name":"Estimation and Validation of an Effective Ergothioneine Dose for Improved Sleep Quality Using Physiologically Based Pharmacokinetic Model","publication_year":2025,"publication_date":"2025-06-01","ids":{"openalex":"https://openalex.org/W4411064241","doi":"https://doi.org/10.1002/fsn3.70382","pmid":"https://pubmed.ncbi.nlm.nih.gov/40475978","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12138820"},"language":"en","primary_location":{"id":"doi:10.1002/fsn3.70382","doi":"https://doi.org/10.1002/fsn3.70382","is_oa":true,"landing_page_url":"https://doi.org/10.1002/fsn3.70382","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/fsn3.70382","source":{"id":"https://openalex.org/S2764587058","display_name":"Food Science & Nutrition","issn_l":"2048-7177","issn":["2048-7177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Science &amp; Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/fsn3.70382","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hitoshi Okumura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122276","display_name":"Suntory (Japan)","ror":"https://ror.org/02jg1fa85","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210122276"]},{"id":"https://openalex.org/I4405275719","display_name":"Suntory Global Innovation Center Ltd. (Japan)","ror":"https://ror.org/045pr7b22","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405275719"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hitoshi Okumura","raw_affiliation_strings":["Research Institute, Suntory Global Innovation Center Ltd., Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute, Suntory Global Innovation Center Ltd., Kyoto, Japan","institution_ids":["https://openalex.org/I4210122276","https://openalex.org/I4405275719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020112034","display_name":"Yudai Araragi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yudai Araragi","raw_affiliation_strings":["Faculty of Pharmacy, Kanazawa University, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Kanazawa University, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kentaro Nishioka","orcid":"https://orcid.org/0009-0005-4864-2584","observed_orcids":["https://orcid.org/0009-0005-4864-2584"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4210122276","display_name":"Suntory (Japan)","ror":"https://ror.org/02jg1fa85","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210122276"]},{"id":"https://openalex.org/I4405275719","display_name":"Suntory Global Innovation Center Ltd. (Japan)","ror":"https://ror.org/045pr7b22","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405275719"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kentaro Nishioka","raw_affiliation_strings":["Faculty of Pharmacy, Kanazawa University, Kanazawa, Japan","Research Institute, Suntory Global Innovation Center Ltd., Kyoto, Japan"],"raw_orcid":"https://orcid.org/0009-0005-4864-2584","affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Kanazawa University, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Research Institute, Suntory Global Innovation Center Ltd., Kyoto, Japan","institution_ids":["https://openalex.org/I4210122276","https://openalex.org/I4405275719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087037505","display_name":"Reiya Yamashita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Reiya Yamashita","raw_affiliation_strings":["Faculty of Pharmacy, Kanazawa University, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Kanazawa University, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103140914","display_name":"Toshihide Suzuki","orcid":"https://orcid.org/0000-0003-4796-0749","observed_orcids":["https://orcid.org/0000-0003-4796-0749"]},"institutions":[{"id":"https://openalex.org/I4210122276","display_name":"Suntory (Japan)","ror":"https://ror.org/02jg1fa85","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210122276"]},{"id":"https://openalex.org/I4405275719","display_name":"Suntory Global Innovation Center Ltd. (Japan)","ror":"https://ror.org/045pr7b22","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405275719"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihide Suzuki","raw_affiliation_strings":["Research Institute, Suntory Global Innovation Center Ltd., Kyoto, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4796-0749","affiliations":[{"raw_affiliation_string":"Research Institute, Suntory Global Innovation Center Ltd., Kyoto, Japan","institution_ids":["https://openalex.org/I4210122276","https://openalex.org/I4405275719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085897013","display_name":"Hiroshi Watanabe","orcid":"https://orcid.org/0009-0002-4102-532X","observed_orcids":["https://orcid.org/0009-0002-4102-532X"]},"institutions":[{"id":"https://openalex.org/I4210122276","display_name":"Suntory (Japan)","ror":"https://ror.org/02jg1fa85","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210122276"]},{"id":"https://openalex.org/I4405275719","display_name":"Suntory Global Innovation Center Ltd. (Japan)","ror":"https://ror.org/045pr7b22","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405275719"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Watanabe","raw_affiliation_strings":["Research Institute, Suntory Global Innovation Center Ltd., Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute, Suntory Global Innovation Center Ltd., Kyoto, Japan","institution_ids":["https://openalex.org/I4210122276","https://openalex.org/I4405275719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051094265","display_name":"Yukio Kato","orcid":"https://orcid.org/0000-0001-8135-5679","observed_orcids":["https://orcid.org/0000-0001-8135-5679"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukio Kato","raw_affiliation_strings":["Faculty of Pharmacy, Kanazawa University, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Kanazawa University, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110158978","display_name":"Norihito Murayama","orcid":"https://orcid.org/0000-0003-2895-7106","observed_orcids":["https://orcid.org/0000-0003-2895-7106"]},"institutions":[{"id":"https://openalex.org/I4210122276","display_name":"Suntory (Japan)","ror":"https://ror.org/02jg1fa85","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210122276"]},{"id":"https://openalex.org/I4405275719","display_name":"Suntory Global Innovation Center Ltd. (Japan)","ror":"https://ror.org/045pr7b22","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405275719"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norihito Murayama","raw_affiliation_strings":["Research Institute, Suntory Global Innovation Center Ltd., Kyoto, Japan"],"raw_orcid":"https://orcid.org/0000-0003-2895-7106","affiliations":[{"raw_affiliation_string":"Research Institute, Suntory Global Innovation Center Ltd., Kyoto, Japan","institution_ids":["https://openalex.org/I4210122276","https://openalex.org/I4405275719"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4210122276","https://openalex.org/I4405275719"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":3.8389,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.95235442,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"13","issue":"6","first_page":"e70382","last_page":"e70382"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.3662000000476837,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.3662000000476837,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.1873999983072281,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.12870000302791595,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ergothioneine","display_name":"ergothioneine","score":1.0},{"id":"https://openalex.org/keywords/sleep-quality","display_name":"sleep quality","score":0.9520000219345093},{"id":"https://openalex.org/keywords/effective-dose-estimation","display_name":"effective dose estimation","score":0.753000020980835},{"id":"https://openalex.org/keywords/physiologically-based-pharmacokinetic-model","display_name":"physiologically based pharmacokinetic modeling","score":0.8930000066757202},{"id":"https://openalex.org/keywords/antioxidant-supplementation","display_name":"antioxidant supplementation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/dose-optimization","display_name":"dose optimization","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8208823800086975},{"id":"https://openalex.org/C185867374","wikidata":"https://www.wikidata.org/wiki/Q2562769","display_name":"Physiologically based pharmacokinetic modelling","level":3,"score":0.7774471044540405},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7331991195678711},{"id":"https://openalex.org/C2777771644","wikidata":"https://www.wikidata.org/wiki/Q614788","display_name":"Ergothioneine","level":3,"score":0.6540523767471313},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6234841346740723},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5565391778945923},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.46912717819213867},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.41841262578964233},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3344743847846985},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24568966031074524},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.21597826480865479},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06000274419784546},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05496358871459961},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1002/fsn3.70382","doi":"https://doi.org/10.1002/fsn3.70382","is_oa":true,"landing_page_url":"https://doi.org/10.1002/fsn3.70382","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/fsn3.70382","source":{"id":"https://openalex.org/S2764587058","display_name":"Food Science & Nutrition","issn_l":"2048-7177","issn":["2048-7177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Science &amp; Nutrition","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:10950951","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12138820","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12138820","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12138820","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Sci Nutr","raw_type":"Text"},{"id":"pmid:40475978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40475978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food science & nutrition","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/fsn3.70382","doi":"https://doi.org/10.1002/fsn3.70382","is_oa":true,"landing_page_url":"https://doi.org/10.1002/fsn3.70382","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/fsn3.70382","source":{"id":"https://openalex.org/S2764587058","display_name":"Food Science & Nutrition","issn_l":"2048-7177","issn":["2048-7177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Science &amp; Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G8010174836","display_name":null,"funder_award_id":"22H02781","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411064241.pdf","grobid_xml":"https://content.openalex.org/works/W4411064241.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W152943885","https://openalex.org/W1208125626","https://openalex.org/W1542232001","https://openalex.org/W1986656184","https://openalex.org/W1988144958","https://openalex.org/W1989971736","https://openalex.org/W1991359358","https://openalex.org/W1993933306","https://openalex.org/W2023122194","https://openalex.org/W2057024253","https://openalex.org/W2066612680","https://openalex.org/W2076973235","https://openalex.org/W2089133581","https://openalex.org/W2089558770","https://openalex.org/W2103995565","https://openalex.org/W2105412693","https://openalex.org/W2130361594","https://openalex.org/W2150060563","https://openalex.org/W2312578622","https://openalex.org/W2484758668","https://openalex.org/W2487967273","https://openalex.org/W2647573343","https://openalex.org/W2737925380","https://openalex.org/W2767173129","https://openalex.org/W2871858260","https://openalex.org/W2889643563","https://openalex.org/W2980097390","https://openalex.org/W2982706219","https://openalex.org/W3006616767","https://openalex.org/W3015947411","https://openalex.org/W3016938917","https://openalex.org/W3029714827","https://openalex.org/W3033176938","https://openalex.org/W3093558630","https://openalex.org/W3196729086","https://openalex.org/W3209825862","https://openalex.org/W4206657329","https://openalex.org/W4233697147","https://openalex.org/W4280593470","https://openalex.org/W4284968794","https://openalex.org/W4293685774","https://openalex.org/W4293766405"],"related_works":["https://openalex.org/W4284968794","https://openalex.org/W2042584507","https://openalex.org/W2048738773","https://openalex.org/W3101543948","https://openalex.org/W4391748825","https://openalex.org/W6958564041","https://openalex.org/W4410032208","https://openalex.org/W4414420042","https://openalex.org/W3158460792","https://openalex.org/W4415829062"],"abstract_inverted_index":{"ABSTRACT":[0],"A":[1],"four\u2010week":[2],"administration":[3],"of":[4,30,52,83],"20":[5],"mg/day":[6,51,82,108],"ergothioneine":[7],"(EGT),":[8],"a":[9,33,100,111,143],"strong":[10],"antioxidant,":[11],"improves":[12],"sleep":[13,118],"quality;":[14],"however,":[15],"its":[16],"effect":[17],"at":[18],"lower":[19,27,147],"doses":[20,29,149],"remains":[21],"unclear.":[22],"This":[23,136],"study":[24,140],"estimated":[25],"the":[26,124,129,138,152],"effective":[28,93,148],"EGT":[31,53,62,84,95,109,125],"using":[32],"physiologically":[34],"based":[35,150],"pharmacokinetic":[36],"(PBPK)":[37],"model":[38,69],"in":[39,123,128],"two":[40],"clinical":[41],"trials.":[42],"In":[43,97],"Study":[44,98],"1,":[45],"participants":[46,105],"received":[47,106],"5":[48],"or":[49,110],"10":[50],"for":[54,85,90,113],"8":[55,81,107],"weeks,":[56],"and":[57,60,73],"their":[58],"plasma":[59,94],"blood":[61],"concentrations":[63],"were":[64],"measured.":[65],"An":[66],"optimized":[67],"PBPK":[68,153],"incorporating":[70],"absorption,":[71],"distribution,":[72],"excretion":[74],"was":[75,88,120],"assembled.":[76],"Our":[77],"results":[78],"showed":[79],"that":[80],"16":[86,114],"weeks":[87],"optimal":[89],"attaining":[91],"an":[92],"concentration.":[96],"2,":[99],"randomized,":[101],"double\u2010blind,":[102],"placebo\u2010controlled":[103],"study,":[104],"placebo":[112,130],"weeks.":[115],"The":[116],"subjective":[117],"quality":[119],"significantly":[121],"improved":[122],"group":[126,131],"than":[127],"(":[132],"p":[133],"<":[134],"0.05).":[135],"is":[137],"first":[139],"to":[141,145],"propose":[142],"strategy":[144],"estimate":[146],"on":[151],"model.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}