{"id":"https://openalex.org/W4411054751","doi":"https://doi.org/10.2967/jnumed.125.269601","title":"225 Ac \u03b1-Pretargeted Radioimmunotherapy of Human Epidermal Growth Factor Receptor 2\u2013Expressing Breast Cancer","display_name":"225 Ac \u03b1-Pretargeted Radioimmunotherapy of Human Epidermal Growth Factor Receptor 2\u2013Expressing Breast Cancer","publication_year":2025,"publication_date":"2025-06-05","ids":{"openalex":"https://openalex.org/W4411054751","doi":"https://doi.org/10.2967/jnumed.125.269601","pmid":"https://pubmed.ncbi.nlm.nih.gov/40473462","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12582181"},"language":"en","primary_location":{"id":"doi:10.2967/jnumed.125.269601","doi":"https://doi.org/10.2967/jnumed.125.269601","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.125.269601","pdf_url":"https://jnm.snmjournals.org/content/jnumed/early/2025/06/05/jnumed.125.269601.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://jnm.snmjournals.org/content/jnumed/early/2025/06/05/jnumed.125.269601.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040878207","display_name":"Sara S. Rinne","orcid":"https://orcid.org/0000-0003-2141-3982","observed_orcids":["https://orcid.org/0000-0003-2141-3982"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara S. Rinne","raw_affiliation_strings":["Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York","Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022499309","display_name":"Daniela Burnes Vargas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniela Burnes Vargas","raw_affiliation_strings":["Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017835396","display_name":"Shin Seo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shin Seo","raw_affiliation_strings":["Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086109194","display_name":"Darren R. Veach","orcid":"https://orcid.org/0000-0002-8201-622X","observed_orcids":["https://orcid.org/0000-0002-8201-622X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darren Veach","raw_affiliation_strings":["Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York","Department of Radiology, Weill Cornell Medicine, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Radiology, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068912186","display_name":"Michael R. McDevitt","orcid":"https://orcid.org/0000-0002-8855-0917","observed_orcids":["https://orcid.org/0000-0002-8855-0917"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. McDevitt","raw_affiliation_strings":["Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York","Department of Radiology, Weill Cornell Medicine, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Radiology, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009444815","display_name":"Brett A. Vaughn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brett A. Vaughn","raw_affiliation_strings":["Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, New York","Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101940737","display_name":"Hong Xu","orcid":"https://orcid.org/0000-0002-1276-4716","observed_orcids":["https://orcid.org/0000-0002-1276-4716","https://orcid.org/0000-0002-2000-6480"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Xu","raw_affiliation_strings":["Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101933418","display_name":"Hong-Fen Guo","orcid":"https://orcid.org/0000-0002-5111-6009","observed_orcids":["https://orcid.org/0000-0002-5111-6009"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong-Fen Guo","raw_affiliation_strings":["Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023828793","display_name":"Edward K. Fung","orcid":"https://orcid.org/0000-0002-3390-1548","observed_orcids":["https://orcid.org/0000-0002-3390-1548"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward K. Fung","raw_affiliation_strings":["Department of Medical Physics, Weill Cornell Medicine, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004111432","display_name":"Elisa de Stanchina","orcid":"https://orcid.org/0000-0002-3873-315X","observed_orcids":["https://orcid.org/0000-0002-3873-315X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elisa de Stanchina","raw_affiliation_strings":["Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York; and","Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York; and","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033161573","display_name":"Ileana C. Miranda","orcid":"https://orcid.org/0000-0003-3168-0515","observed_orcids":["https://orcid.org/0000-0003-3168-0515"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ileana C. Miranda","raw_affiliation_strings":["Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and Rockefeller University, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and Rockefeller University, New York, New York","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I4387153466","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015396908","display_name":"Steven M. Larson","orcid":"https://orcid.org/0000-0002-6111-7507","observed_orcids":["https://orcid.org/0000-0002-6111-7507"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven M. Larson","raw_affiliation_strings":["Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York","Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034081882","display_name":"Nai\u2010Kong V. Cheung","orcid":"https://orcid.org/0000-0001-6323-5171","observed_orcids":["https://orcid.org/0000-0001-6323-5171"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nai Kong V. Cheung","raw_affiliation_strings":["Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024255690","display_name":"Sarah M. Cheal","orcid":"https://orcid.org/0000-0003-1720-8994","observed_orcids":["https://orcid.org/0000-0003-1720-8994"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sarah M. Cheal","raw_affiliation_strings":["Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, New York; smc4002@med.cornell.edu","Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, New York; smc4002@med.cornell.edu","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024255690"],"corresponding_institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I4387153466"],"apc_list":null,"apc_paid":null,"fwci":4.9445,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.95969057,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"66","issue":"11","first_page":"1714","last_page":"1721"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-particle-radioimmunotherapy","display_name":"alpha particle radioimmunotherapy","score":0.7599999904632568},{"id":"https://openalex.org/keywords/pretargeted-radioimmunotherapy","display_name":"pretargeted radioimmunotherapy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bispecific-antibodies","display_name":"bispecific antibodies","score":0.7200000286102295},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.9769999980926514},{"id":"https://openalex.org/keywords/dosimetry","display_name":"dosimetry","score":0.6110000014305115},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.8119999766349792},{"id":"https://openalex.org/keywords/radiotherapy-dose-escalation","display_name":"radiation dose escalation","score":0.4259999990463257},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.9399999976158142},{"id":"https://openalex.org/keywords/therapeutic-index","display_name":"therapeutic index","score":0.5009999871253967},{"id":"https://openalex.org/keywords/alpha-emitters","display_name":"alpha-emitting radionuclides","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C2776146153","wikidata":"https://www.wikidata.org/wiki/Q7281276","display_name":"Radioimmunotherapy","level":4,"score":0.8650185465812683},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5478215217590332},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5391720533370972},{"id":"https://openalex.org/C2908728163","wikidata":"https://www.wikidata.org/wiki/Q415271","display_name":"Human Epidermal Growth Factor Receptor 2","level":4,"score":0.5027880668640137},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.39975741505622864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3865913450717926},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3518563508987427},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3302505314350128},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32168659567832947},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.15230032801628113},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12483960390090942},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.11882662773132324}],"mesh":[{"descriptor_ui":"D000186","descriptor_name":"Actinium","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000512","descriptor_name":"Alpha Particles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016499","descriptor_name":"Radioimmunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2967/jnumed.125.269601","doi":"https://doi.org/10.2967/jnumed.125.269601","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.125.269601","pdf_url":"https://jnm.snmjournals.org/content/jnumed/early/2025/06/05/jnumed.125.269601.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11391306","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12582181","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40473462","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40473462","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12582181","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12582181/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Nucl Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.2967/jnumed.125.269601","doi":"https://doi.org/10.2967/jnumed.125.269601","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.125.269601","pdf_url":"https://jnm.snmjournals.org/content/jnumed/early/2025/06/05/jnumed.125.269601.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6118086092","display_name":"DOTA-based pre-targeting of alpha emitters","funder_award_id":"R01CA233896","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411054751.pdf","grobid_xml":"https://content.openalex.org/works/W4411054751.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1533229981","https://openalex.org/W1971234323","https://openalex.org/W1980998675","https://openalex.org/W2018649196","https://openalex.org/W2106506685","https://openalex.org/W2135593703","https://openalex.org/W2147077679","https://openalex.org/W2171140185","https://openalex.org/W2256347449","https://openalex.org/W2594312824","https://openalex.org/W2735086571","https://openalex.org/W2898436197","https://openalex.org/W2959679318","https://openalex.org/W2972399366","https://openalex.org/W2998664684","https://openalex.org/W3087647214","https://openalex.org/W3088420152","https://openalex.org/W3099316220","https://openalex.org/W3146209029","https://openalex.org/W3194196649","https://openalex.org/W3216611055","https://openalex.org/W4281785788","https://openalex.org/W4294051593","https://openalex.org/W4308766741","https://openalex.org/W4381615253","https://openalex.org/W4387034114","https://openalex.org/W4390672977","https://openalex.org/W4400008228","https://openalex.org/W4405317157"],"related_works":["https://openalex.org/W2809936210","https://openalex.org/W2137049679","https://openalex.org/W4405317157","https://openalex.org/W7151537011","https://openalex.org/W2159947891","https://openalex.org/W4387034114","https://openalex.org/W4393085465","https://openalex.org/W2735086571","https://openalex.org/W2563061044","https://openalex.org/W2339810454"],"abstract_inverted_index":{"Radioimmunotherapy":[0],"using":[1],"225Ac,":[2],"a":[3,26,33,95,100,121,168,256,280,330],"highly":[4],"cytotoxic":[5],"\u03b1-particle":[6],"emitter,":[7],"has":[8],"potential":[9],"for":[10,241,326,333],"treating":[11],"advanced":[12,308],"breast":[13,76,311],"cancer,":[14],"especially":[15],"human":[16,310],"epidermal":[17],"growth":[18],"factor":[19],"receptor":[20],"2":[21,132,304],"(HER2)\u2013positive":[22],"cases.":[23],"We":[24,79],"use":[25],"pretargeted":[27],"radioimmunotherapy":[28],"(PRIT)":[29],"approach":[30],"consisting":[31,98],"of":[32,67,83,99,102,105,111,134,158,204,207,307],"3-step":[34],"intravenous":[35],"regimen":[36,97,282],"(step":[37],"1:":[38],"bispecific":[39,106],"anti-HER2/anti-DOTA":[40],"antibody;":[41],"step":[42,46],"2:":[43],"clearing":[44],"agent;":[45],"3:":[47],"225Ac-radiolabeled":[48],"Proteus":[49],"DOTA,":[50],"or":[51,131],"[225Ac]Ac-Pr).":[52],"Our":[53],"goal":[54],"was":[55,71,146,283],"to":[56,108,152,261],"establish":[57,153],"curative":[58],"225Ac-PRIT":[59,96,135,258,281,299,327],"with":[60,129,222,313],"high":[61],"therapeutic":[62],"indices.":[63],"Methods:":[64],"The":[65],"impact":[66],"[225Ac]Ac-Pr":[68,84],"specific":[69],"activity":[70],"evaluated":[72,114],"in":[73,116,178,202,303],"the":[74,81,117,149,182,191,208,252,337],"BT-474":[75,118,150,192],"xenograft":[77,123,254],"model.":[78,124],"tested":[80],"effects":[82],"dosing":[85],"during":[86,228],"PRIT":[87],"on":[88,148],"tumor-targeting":[89],"efficiency":[90],"and":[91,120,199,212,243,247,266,297,328],"tissue":[92],"biodistribution.":[93],"Using":[94],"ratio":[101],"1.19":[103],"nmol":[104,110],"antibody":[107],"0.60\u20130.66":[109],"[225Ac]Ac-Pr,":[112],"we":[113],"therapy":[115],"model":[119,151],"patient-derived":[122,253],"BT-474-tumor\u2013bearing":[125],"mice":[126],"were":[127,176,215,219,245,301],"treated":[128,209],"1":[130,140],"cycles":[133],"(37":[136],"kBq/cycle)":[137],"separated":[138],"by":[139],"wk.":[141],"A":[142],"dose":[143,157,187],"escalation":[144],"study":[145,320],"performed":[147],"an":[154],"absorbed":[155],"radiation":[156,225],"approximately":[159],"40":[160],"Gy":[161],"(relative":[162],"biological":[163],"effectiveness":[164],"[RBE],":[165],"5)":[166,185,236],"as":[167,171],"nephrotoxic":[169],"dose,":[170],"no":[172,223,272],"such":[173],"histologic":[174,200],"findings":[175],"observed":[177],"prior":[179],"studies":[180],"at":[181,230],"20.7-Gy":[183],"(RBE,":[184,235],"renal":[186],"level.":[188],"Results:":[189],"In":[190,251],"model,":[193,255],"100%":[194],"(20/20)":[195],"achieved":[196],"complete":[197,264],"responses":[198],"cure":[201,315],"17":[203],"20":[205],"(85%)":[206],"animals.":[210],"One-cycle":[211],"2-cycle":[213],"treatments":[214],"equally":[216],"effective.":[217],"Treatments":[218],"well":[220],"tolerated,":[221],"chronic":[224,288],"toxicity":[226],"documented":[227],"necropsy":[229],"175":[231],"d.":[232],"Dosimetry":[233],"estimates":[234],"per":[237],"37":[238],"kBq":[239],"administered":[240],"tumors":[242],"kidneys":[244],"210":[246],"3.5":[248],"Gy,":[249],"respectively.":[250],"single":[257],"treatment":[259,273],"led":[260],"60%":[262],"(3/5)":[263],"response":[265],"prolonged":[267],"survival":[268],"(>93":[269],"d)":[270],"versus":[271],"(30":[274],"d;":[275],"P":[276],"=":[277],"0.0185).":[278],"Lastly,":[279],"identified":[284],"that":[285],"induces":[286],"severe":[287],"nephrotoxicity":[289],"(41.4":[290],"Gy/592":[291],"kBq;":[292],"RBE,":[293],"5).":[294],"Conclusion:":[295],"Safe":[296],"effective":[298],"regimens":[300],"developed":[302],"preclinical":[305,323],"models":[306],"HER2-positive":[309],"cancer":[312],"tumor":[314],"without":[316],"dose-limiting":[317],"nephrotoxicity.":[318],"This":[319],"establishes":[321],"crucial":[322],"dosimetry":[324],"benchmarks":[325],"provides":[329],"compelling":[331],"rationale":[332],"its":[334],"advancement":[335],"into":[336],"clinic.":[338]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-10-10T00:00:00"}
