{"id":"https://openalex.org/W4411050826","doi":"https://doi.org/10.1016/b978-0-128-24465-4.00061-2","title":"Classical-NHEJ and DNA Damage Responses in V(D)J Recombination","display_name":"Classical-NHEJ and DNA Damage Responses in V(D)J Recombination","publication_year":2025,"publication_date":"2025-06-05","ids":{"openalex":"https://openalex.org/W4411050826","doi":"https://doi.org/10.1016/b978-0-128-24465-4.00061-2"},"language":"en","primary_location":{"id":"doi:10.1016/b978-0-128-24465-4.00061-2","doi":"https://doi.org/10.1016/b978-0-128-24465-4.00061-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-128-24465-4.00061-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Encyclopedia of Immunobiology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W7084130061","display_name":"Encyclopedia of Immunobiology"},"type":"reference-entry","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035696127","display_name":"Shan Zha","orcid":"https://orcid.org/0000-0002-6568-1818","observed_orcids":["https://orcid.org/0000-0002-6568-1818"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shan Zha","raw_affiliation_strings":["Vagelos College for Physicians and Surgeons, Columbia University, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vagelos College for Physicians and Surgeons, Columbia University, New York, NY, United States","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035696127"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"160","last_page":"176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/v-d-j-recombination","display_name":"V(D)J recombination","score":0.9670000076293945},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9190000295639038},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.9210000038146973},{"id":"https://openalex.org/keywords/antigen-receptor-gene-rearrangement","display_name":"antigen receptor gene rearrangement","score":0.6499999761581421},{"id":"https://openalex.org/keywords/lymphopoiesis","display_name":"lymphocyte development","score":0.9539999961853027},{"id":"https://openalex.org/keywords/ataxia-telangiectasia-mutated","display_name":"ATM kinase","score":0.8109999895095825},{"id":"https://openalex.org/keywords/translocation","display_name":"translocation","score":0.5659999847412109},{"id":"https://openalex.org/keywords/lymphoid-malignancies","display_name":"lymphoid malignancies","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C2780254951","wikidata":"https://www.wikidata.org/wiki/Q1093098","display_name":"V(D)J recombination","level":4,"score":0.4727780818939209},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.44480404257774353},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3155936002731323},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25923383235931396},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0345800518989563}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/b978-0-128-24465-4.00061-2","doi":"https://doi.org/10.1016/b978-0-128-24465-4.00061-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-128-24465-4.00061-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Encyclopedia of Immunobiology","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":240,"referenced_works":["https://openalex.org/W99705021","https://openalex.org/W104404459","https://openalex.org/W1226506766","https://openalex.org/W1410373437","https://openalex.org/W1516845708","https://openalex.org/W1550791622","https://openalex.org/W1660787335","https://openalex.org/W1866398330","https://openalex.org/W1888083613","https://openalex.org/W1892185927","https://openalex.org/W1897299346","https://openalex.org/W1911716715","https://openalex.org/W1963844762","https://openalex.org/W1964298731","https://openalex.org/W1966200086","https://openalex.org/W1966427800","https://openalex.org/W1967167923","https://openalex.org/W1968870521","https://openalex.org/W1970827792","https://openalex.org/W1972313386","https://openalex.org/W1972354683","https://openalex.org/W1974010399","https://openalex.org/W1974446138","https://openalex.org/W1977145510","https://openalex.org/W1978727038","https://openalex.org/W1979568780","https://openalex.org/W1979583222","https://openalex.org/W1979699797","https://openalex.org/W1979836429","https://openalex.org/W1980017984","https://openalex.org/W1984124362","https://openalex.org/W1985775217","https://openalex.org/W1986830781","https://openalex.org/W1987705460","https://openalex.org/W1987850577","https://openalex.org/W1988157092","https://openalex.org/W1988225111","https://openalex.org/W1988845313","https://openalex.org/W1989859525","https://openalex.org/W1991785605","https://openalex.org/W1992688638","https://openalex.org/W1992783373","https://openalex.org/W1993026474","https://openalex.org/W1995796643","https://openalex.org/W1997056099","https://openalex.org/W1998530321","https://openalex.org/W1999105804","https://openalex.org/W1999847386","https://openalex.org/W1999940496","https://openalex.org/W2001784394","https://openalex.org/W2002248349","https://openalex.org/W2003481312","https://openalex.org/W2003617431","https://openalex.org/W2003673339","https://openalex.org/W2004414241","https://openalex.org/W2005753349","https://openalex.org/W2007579374","https://openalex.org/W2011392023","https://openalex.org/W2011522975","https://openalex.org/W2012238315","https://openalex.org/W2012621186","https://openalex.org/W2012882202","https://openalex.org/W2014448626","https://openalex.org/W2015090136","https://openalex.org/W2015414930","https://openalex.org/W2017351036","https://openalex.org/W2017550130","https://openalex.org/W2018609920","https://openalex.org/W2021161606","https://openalex.org/W2021314470","https://openalex.org/W2024136433","https://openalex.org/W2029603562","https://openalex.org/W2032117887","https://openalex.org/W2033200608","https://openalex.org/W2033651349","https://openalex.org/W2034718433","https://openalex.org/W2036749550","https://openalex.org/W2037517612","https://openalex.org/W2038794308","https://openalex.org/W2039143648","https://openalex.org/W2041286364","https://openalex.org/W2046589688","https://openalex.org/W2048250731","https://openalex.org/W2048421417","https://openalex.org/W2048976298","https://openalex.org/W2050291003","https://openalex.org/W2052981964","https://openalex.org/W2053926251","https://openalex.org/W2055148721","https://openalex.org/W2056508303","https://openalex.org/W2057562851","https://openalex.org/W2058957446","https://openalex.org/W2059678690","https://openalex.org/W2064631075","https://openalex.org/W2065666952","https://openalex.org/W2066664553","https://openalex.org/W2067228541","https://openalex.org/W2067488984","https://openalex.org/W2070369325","https://openalex.org/W2071411482","https://openalex.org/W2071674290","https://openalex.org/W2074713423","https://openalex.org/W2075750949","https://openalex.org/W2075784029","https://openalex.org/W2076561725","https://openalex.org/W2076910970","https://openalex.org/W2077436902","https://openalex.org/W2079466993","https://openalex.org/W2080152855","https://openalex.org/W2080290623","https://openalex.org/W2080576686","https://openalex.org/W2082981258","https://openalex.org/W2085422820","https://openalex.org/W2088013332","https://openalex.org/W2088091759","https://openalex.org/W2088909687","https://openalex.org/W2090836500","https://openalex.org/W2091884040","https://openalex.org/W2092470694","https://openalex.org/W2093448309","https://openalex.org/W2093554350","https://openalex.org/W2094917306","https://openalex.org/W2094950317","https://openalex.org/W2096782300","https://openalex.org/W2097517187","https://openalex.org/W2099645964","https://openalex.org/W2100213817","https://openalex.org/W2100557384","https://openalex.org/W2102618729","https://openalex.org/W2102757030","https://openalex.org/W2103007290","https://openalex.org/W2104631734","https://openalex.org/W2105719362","https://openalex.org/W2106336456","https://openalex.org/W2108547322","https://openalex.org/W2109272669","https://openalex.org/W2109456034","https://openalex.org/W2111772438","https://openalex.org/W2113650741","https://openalex.org/W2113688148","https://openalex.org/W2113824098","https://openalex.org/W2114708566","https://openalex.org/W2114983967","https://openalex.org/W2116232221","https://openalex.org/W2116718924","https://openalex.org/W2119786022","https://openalex.org/W2121859582","https://openalex.org/W2122241744","https://openalex.org/W2123215808","https://openalex.org/W2123645269","https://openalex.org/W2124173719","https://openalex.org/W2126357055","https://openalex.org/W2127111507","https://openalex.org/W2128325937","https://openalex.org/W2131571249","https://openalex.org/W2131978108","https://openalex.org/W2132029465","https://openalex.org/W2133596876","https://openalex.org/W2134230163","https://openalex.org/W2135812215","https://openalex.org/W2136399386","https://openalex.org/W2137239016","https://openalex.org/W2138637722","https://openalex.org/W2139201659","https://openalex.org/W2139891717","https://openalex.org/W2140336226","https://openalex.org/W2141530672","https://openalex.org/W2144252460","https://openalex.org/W2145409983","https://openalex.org/W2146355613","https://openalex.org/W2146507524","https://openalex.org/W2146532448","https://openalex.org/W2155169980","https://openalex.org/W2156925994","https://openalex.org/W2157088707","https://openalex.org/W2157899948","https://openalex.org/W2158099110","https://openalex.org/W2159314125","https://openalex.org/W2160089420","https://openalex.org/W2161516715","https://openalex.org/W2161767445","https://openalex.org/W2162412306","https://openalex.org/W2162868435","https://openalex.org/W2164362605","https://openalex.org/W2164995160","https://openalex.org/W2165718448","https://openalex.org/W2165789547","https://openalex.org/W2167148438","https://openalex.org/W2167412617","https://openalex.org/W2170879097","https://openalex.org/W2277729675","https://openalex.org/W2297808341","https://openalex.org/W2304399430","https://openalex.org/W2334548480","https://openalex.org/W2511852522","https://openalex.org/W2520634238","https://openalex.org/W2528384811","https://openalex.org/W2552954439","https://openalex.org/W2568353756","https://openalex.org/W2580932079","https://openalex.org/W2593504837","https://openalex.org/W2780663388","https://openalex.org/W2783008708","https://openalex.org/W2783460793","https://openalex.org/W2783951142","https://openalex.org/W2798183676","https://openalex.org/W2805361959","https://openalex.org/W2883664363","https://openalex.org/W2884662335","https://openalex.org/W2887233395","https://openalex.org/W2888681388","https://openalex.org/W2901549166","https://openalex.org/W2903372586","https://openalex.org/W2905081958","https://openalex.org/W2922330003","https://openalex.org/W2945777103","https://openalex.org/W2946302178","https://openalex.org/W2998349152","https://openalex.org/W2999144731","https://openalex.org/W3004050930","https://openalex.org/W3006876963","https://openalex.org/W3007027724","https://openalex.org/W3037558160","https://openalex.org/W3080185191","https://openalex.org/W3081551588","https://openalex.org/W3112685950","https://openalex.org/W3114767519","https://openalex.org/W3118639017","https://openalex.org/W3129392928","https://openalex.org/W3155078366","https://openalex.org/W3162932137","https://openalex.org/W3193296945","https://openalex.org/W3200681984","https://openalex.org/W3207230035","https://openalex.org/W4200540683","https://openalex.org/W4237747445","https://openalex.org/W4238328529","https://openalex.org/W4378894923","https://openalex.org/W4380356871","https://openalex.org/W6680730794"],"related_works":["https://openalex.org/W2395000780","https://openalex.org/W3037558160","https://openalex.org/W2756923968","https://openalex.org/W6963726248","https://openalex.org/W2081027780","https://openalex.org/W2059678690","https://openalex.org/W4225115378","https://openalex.org/W1579358829","https://openalex.org/W2327579913","https://openalex.org/W2014238550"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
