{"id":"https://openalex.org/W4411048414","doi":"https://doi.org/10.1016/j.canlet.2025.217855","title":"Targeting the VIP-VPAC Pathway in Melanoma Models Inhibits Tumor Growth and Liver Metastasis","display_name":"Targeting the VIP-VPAC Pathway in Melanoma Models Inhibits Tumor Growth and Liver Metastasis","publication_year":2025,"publication_date":"2025-06-05","ids":{"openalex":"https://openalex.org/W4411048414","doi":"https://doi.org/10.1016/j.canlet.2025.217855","pmid":"https://pubmed.ncbi.nlm.nih.gov/40482913"},"language":"en","primary_location":{"id":"doi:10.1016/j.canlet.2025.217855","doi":"https://doi.org/10.1016/j.canlet.2025.217855","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.canlet.2025.217855","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.canlet.2025.217855","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049544665","display_name":"Wenxi Wang","orcid":"https://orcid.org/0009-0008-4225-3969","observed_orcids":["https://orcid.org/0009-0008-4225-3969"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Wenxi Wang","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA; Department of Oncology, Xiangya Hospital, Central South University (CSU), Changsha, China; Department of Radiation Oncology, Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen Center, China. Electronic address: csuwwx@gmail.com"],"raw_orcid":"https://orcid.org/0009-0008-4225-3969","affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA; Department of Oncology, Xiangya Hospital, Central South University (CSU), Changsha, China; Department of Radiation Oncology, Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen Center, China. Electronic address: csuwwx@gmail.com","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I150468666","https://openalex.org/I200296433","https://openalex.org/I4210159865","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101862293","display_name":"Hua Yang","orcid":"https://orcid.org/0000-0002-4313-6042","observed_orcids":["https://orcid.org/0000-0002-4313-6042"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Yang","raw_affiliation_strings":["Department of Ophthalmology, Emory University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071196557","display_name":"Tenzin Passang","orcid":"https://orcid.org/0000-0003-3393-8161","observed_orcids":["https://orcid.org/0000-0003-3393-8161"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tenzin Passang","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA"],"raw_orcid":"https://orcid.org/0000-0003-3393-8161","affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100367694","display_name":"Yiwen Helen Li","orcid":"https://orcid.org/0000-0002-9688-0393","observed_orcids":["https://orcid.org/0000-0002-9688-0393"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiwen Li","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","Department of Ophthalmology, Emory University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"Department of Ophthalmology, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100332176","display_name":"Hanwen Zhang","orcid":"https://orcid.org/0000-0001-8955-7494","observed_orcids":["https://orcid.org/0000-0001-8955-7494"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanwen Zhang","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114520783","display_name":"Shayna E. Jankowski","orcid":"https://orcid.org/0009-0003-9307-3400","observed_orcids":["https://orcid.org/0009-0003-9307-3400"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shayna E. Jankowski","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA"],"raw_orcid":"https://orcid.org/0009-0003-9307-3400","affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070513844","display_name":"Fanyuan Zeng","orcid":"https://orcid.org/0000-0001-6432-3114","observed_orcids":["https://orcid.org/0000-0001-6432-3114"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Fanyuan Zeng","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA; Department of Oncology, Xiangya Hospital, Central South University (CSU), Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA; Department of Oncology, Xiangya Hospital, Central South University (CSU), Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I150468666","https://openalex.org/I4210159865","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040841828","display_name":"Shuhua Wang","orcid":"https://orcid.org/0000-0001-8566-2262","observed_orcids":["https://orcid.org/0000-0001-8566-2262"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuhua Wang","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102786637","display_name":"Po-Chih Hsu","orcid":"https://orcid.org/0000-0003-2598-1776","observed_orcids":["https://orcid.org/0000-0003-2598-1776"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Po-Chih Hsu","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063239940","display_name":"Jian-Ming Li","orcid":"https://orcid.org/0000-0001-6368-759X","observed_orcids":["https://orcid.org/0000-0001-6368-759X"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian-Ming Li","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zihan Chen","orcid":"https://orcid.org/0009-0008-6132-7847","observed_orcids":["https://orcid.org/0009-0008-6132-7847"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zihan Chen","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA"],"raw_orcid":"https://orcid.org/0009-0008-6132-7847","affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032094154","display_name":"Gregory B. Lesinski","orcid":"https://orcid.org/0000-0002-8787-7678","observed_orcids":["https://orcid.org/0000-0002-8787-7678"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory B. Lesinski","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA"],"raw_orcid":"https://orcid.org/0000-0002-8787-7678","affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025834624","display_name":"Pia R. Mendoza","orcid":"https://orcid.org/0000-0002-5355-343X","observed_orcids":["https://orcid.org/0000-0002-5355-343X"]},"institutions":[{"id":"https://openalex.org/I1287435762","display_name":"WellStar Health System","ror":"https://ror.org/01kaqt385","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287435762"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pia R. Mendoza","raw_affiliation_strings":["Department of Pathology, Wellstar Health System, China","Department of Pathology, Wellstar Health System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Wellstar Health System, China","institution_ids":["https://openalex.org/I1287435762"]},{"raw_affiliation_string":"Department of Pathology, Wellstar Health System","institution_ids":["https://openalex.org/I1287435762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100414443","display_name":"Ying Li","orcid":"https://orcid.org/0000-0003-3149-8457","observed_orcids":["https://orcid.org/0000-0003-3149-8457","https://orcid.org/0000-0002-3671-5572"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Li","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","Department of Ophthalmology, Emory University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"Department of Ophthalmology, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048038422","display_name":"Cynthia R. Giver","orcid":"https://orcid.org/0000-0002-5621-1013","observed_orcids":["https://orcid.org/0000-0002-5621-1013"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia R. Giver","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057277785","display_name":"Hans E. Grossniklaus","orcid":"https://orcid.org/0000-0003-0178-9712","observed_orcids":["https://orcid.org/0000-0003-0178-9712"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hans E. Grossniklaus","raw_affiliation_strings":["Department of Ophthalmology and Winship Cancer Institute, Emory University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011386306","display_name":"Edmund K. Waller","orcid":"https://orcid.org/0000-0003-0816-6729","observed_orcids":["https://orcid.org/0000-0003-0816-6729"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edmund K. Waller","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA. Electronic address: ewaller@emory.edu"],"raw_orcid":"https://orcid.org/0000-0003-0816-6729","affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA. Electronic address: ewaller@emory.edu","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5011386306","https://openalex.org/A5049544665"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I150468666","https://openalex.org/I200296433","https://openalex.org/I4210159865","https://openalex.org/I4390039307"],"apc_list":{"value":4960,"currency":"USD","value_usd":4960},"apc_paid":{"value":4960,"currency":"USD","value_usd":4960},"fwci":1.94,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.84534855,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"628","issue":null,"first_page":"217855","last_page":"217855"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.7494999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.7494999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.0803999975323677,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uveal-melanoma","display_name":"uveal melanoma","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cutaneous-melanoma","display_name":"cutaneous melanoma","score":0.9359999895095825},{"id":"https://openalex.org/keywords/vasoactive-intestinal-peptide","display_name":"vasoactive intestinal peptide","score":0.9430000185966492},{"id":"https://openalex.org/keywords/vip-receptor-antagonist","display_name":"VIP receptor antagonist","score":0.7419999837875366},{"id":"https://openalex.org/keywords/vpac2","display_name":"VPAC2","score":0.9660000205039978},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cd146","display_name":"CD146","score":0.9039999842643738},{"id":"https://openalex.org/keywords/n-cadherin","display_name":"N-cadherin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8460000157356262},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.4950000047683716},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"immune checkpoint","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.7243466973304749},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6446769833564758},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6240362524986267},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45792871713638306},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34428003430366516},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24769747257232666}],"mesh":[{"descriptor_ui":"D000098943","descriptor_name":"Uveal Melanoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014604","descriptor_name":"Uveal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014604","descriptor_name":"Uveal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014604","descriptor_name":"Uveal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014604","descriptor_name":"Uveal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014660","descriptor_name":"Vasoactive Intestinal Peptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051239","descriptor_name":"Receptors, Vasoactive Intestinal Peptide, Type II","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051239","descriptor_name":"Receptors, Vasoactive Intestinal Peptide, Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051239","descriptor_name":"Receptors, Vasoactive Intestinal Peptide, Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.canlet.2025.217855","doi":"https://doi.org/10.1016/j.canlet.2025.217855","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.canlet.2025.217855","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},{"id":"pmid:40482913","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40482913","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.canlet.2025.217855","doi":"https://doi.org/10.1016/j.canlet.2025.217855","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.canlet.2025.217855","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000881663","display_name":"Winship Cancer Institute Cancer Center Support Grant","funder_award_id":"P30CA138292","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320314475","display_name":"Abraham J. and Phyllis Katz Foundation","ror":"https://ror.org/03430yw55"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333204","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961"},{"id":"https://openalex.org/F4320333982","display_name":"Integrated Cellular Imaging Core, Emory University","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W15707869","https://openalex.org/W1526940895","https://openalex.org/W1902144921","https://openalex.org/W1939349037","https://openalex.org/W1941374799","https://openalex.org/W1971135127","https://openalex.org/W1973100947","https://openalex.org/W1975162531","https://openalex.org/W1980584604","https://openalex.org/W1981002635","https://openalex.org/W1993046965","https://openalex.org/W1999724461","https://openalex.org/W2003796168","https://openalex.org/W2010440893","https://openalex.org/W2016288274","https://openalex.org/W2027029136","https://openalex.org/W2027604371","https://openalex.org/W2033668318","https://openalex.org/W2044736401","https://openalex.org/W2049073719","https://openalex.org/W2056016404","https://openalex.org/W2056737202","https://openalex.org/W2060408665","https://openalex.org/W2084778362","https://openalex.org/W2092595276","https://openalex.org/W2095479209","https://openalex.org/W2096882849","https://openalex.org/W2101322033","https://openalex.org/W2134739117","https://openalex.org/W2147356181","https://openalex.org/W2157703252","https://openalex.org/W2160088320","https://openalex.org/W2163684066","https://openalex.org/W2165644319","https://openalex.org/W2194683416","https://openalex.org/W2218151226","https://openalex.org/W2300492004","https://openalex.org/W2399697781","https://openalex.org/W2516337088","https://openalex.org/W2552406608","https://openalex.org/W2563871566","https://openalex.org/W2570152363","https://openalex.org/W2614902590","https://openalex.org/W2620911791","https://openalex.org/W2787459613","https://openalex.org/W2795989238","https://openalex.org/W2905560237","https://openalex.org/W2913613732","https://openalex.org/W2946657092","https://openalex.org/W2950989394","https://openalex.org/W3014374354","https://openalex.org/W3165582094","https://openalex.org/W4200169299","https://openalex.org/W4206773095","https://openalex.org/W4297369619","https://openalex.org/W4307778558","https://openalex.org/W4309944312","https://openalex.org/W4313478591","https://openalex.org/W4399149817","https://openalex.org/W6681862697"],"related_works":["https://openalex.org/W1987957059","https://openalex.org/W2441312314","https://openalex.org/W7162761843","https://openalex.org/W4317821416","https://openalex.org/W307508395","https://openalex.org/W4243042356","https://openalex.org/W1970788444","https://openalex.org/W2055031207","https://openalex.org/W1549808030","https://openalex.org/W4396624985"],"abstract_inverted_index":{"Uveal":[0],"melanoma":[1,43,59,71,95,129,175],"(UVM)":[2],"is":[3],"resistant":[4],"to":[5,18],"immune":[6,32],"checkpoint":[7,33],"therapy":[8],"and":[9,34,62,68,82,88,100,107,115,127,138,166,177,204],"chemotherapy,":[10],"resulting":[11],"in":[12,37,42,90,125,146,159,202],"high":[13],"mortality":[14],"rates,":[15],"primarily":[16],"due":[17],"liver":[19,169,200],"metastases.":[20],"While":[21],"vasoactive":[22],"intestinal":[23],"peptide":[24],"(VIP)":[25],"signaling":[26,81,145,198],"has":[27],"been":[28],"identified":[29],"as":[30,110],"an":[31],"therapeutic":[35,216],"target":[36],"pancreatic":[38],"cancer,":[39],"its":[40,83],"role":[41],"remains":[44],"unexplored.":[45],"This":[46],"study":[47],"investigated":[48],"the":[49,76,105,121,164,186],"impact":[50],"of":[51,78,120,168],"a":[52,179,214],"novel":[53,215],"VIP":[54,79,122,196,209],"receptor":[55,80,123,197,210],"antagonist,":[56],"ANT308,":[57],"on":[58,85,134],"cell":[60,72,86,96,135],"behavior":[61],"tumor":[63,147,183,188],"growth.":[64],"Using":[65],"both":[66,104],"murine":[67],"human":[69,128],"UVM/cutaneous":[70],"lines,":[73],"we":[74],"examined":[75],"inhibition":[77],"effects":[84,133],"migration":[87],"proliferation":[89],"vitro.":[91],"Mechanistically,":[92],"ANT308":[93,154],"downregulated":[94],"adhesion":[97],"molecule":[98],"(MCAM)":[99],"N-cadherin":[101],"expression":[102,158],"at":[103,185],"RNA":[106,113],"protein":[108,140],"levels,":[109],"demonstrated":[111],"by":[112],"sequencing":[114],"Western":[116],"blot":[117],"analyses.":[118],"Knockdown":[119],"VPAC2":[124],"mouse":[126],"cells":[130],"produced":[131],"similar":[132],"migration,":[136],"proliferation,":[137],"MCAM":[139,157],"expression,":[141],"further":[142],"implicating":[143],"VIP-VPAC2":[144],"progression.":[148],"In":[149,190],"vivo":[150],"studies":[151],"revealed":[152],"that":[153,195],"treatment":[155],"decreased":[156],"intraocular":[160,172],"primary":[161,187],"tumors,":[162],"reduced":[163,182],"number":[165],"size":[167],"metastases":[170],"following":[171],"or":[173],"subcutaneous":[174],"injection,":[176],"showed":[178],"trend":[180],"toward":[181],"volume":[184],"site.":[189],"conclusion,":[191],"our":[192],"findings":[193],"indicate":[194],"promotes":[199],"metastasis":[201],"melanoma,":[203],"targeting":[205],"this":[206],"pathway":[207],"with":[208],"antagonists":[211],"may":[212],"represent":[213],"strategy":[217],"for":[218],"treating":[219],"metastatic":[220],"UVM.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2025-10-10T00:00:00"}